8DH7


Conserved Protein Domain Family
AcetylCoA_hydro
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pfam02550: AcetylCoA_hydro (This model is not part of the current CDD release)
Acetyl-CoA hydrolase/transferase N-terminal domain
This family contains several enzymes which take part in pathways involving acetyl-CoA. Acetyl-CoA hydrolase EC:3.1.2.1 catalyzes the formation of acetate from acetyl-CoA, CoA transferase (CAT1) EC:2.8.3.- produces succinyl-CoA, and acetate-CoA transferase EC:2.8.3.8 utilizes acyl-CoA and acetate to form acetyl-CoA.
Links
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Statistics
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PSSM-Id: 515005
Aligned: 6 rows
Threshold Bit Score: 257.473
Created: 13-Feb-2025
Updated: 25-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8DH7_B  12 RYAPYLKKVKEa-hELIPLFKNGQYLGWSGFTGVGTPKAVPEALI-DHVEKNNLQGKLRFNLFVGA--SAGpEENRWAEH 87  brewer's yeast
P52043   1 METQWTRMTAN---EAAEIIQHNDMVAFSGFTPAGSPKALPTAIArRANEQHEAKKPYQIRLLTGAsiSAA-ADDVLSDA 76  Escherichia coli K-12
P73661   6 RQEQLAQLRSQypeKFASYSEIFSHIHRGDRLFISTACGEPQYLVqELVNYVQAHPKSLFDAEVLQvwTLG-LAPYTDSK 84  Synechocystis sp. PCC...
O28424   3 YQKEYERKLISp-eEAANLVKDGMHIEIGG--SANTALIIDKYLAkRKDELSHVEVGTFIDIAHYEflKADpEQEKIKWE 79  Archaeoglobus fulgidus
O29120   9 YREEYEKKLISp-eEAAGLVESGMHIELGG--AANTALIIDKYLAkRKDELENVKVGTFIDLAHYEflKADpNGEVFEWS 85  Archaeoglobus fulgidus
P32316  12 RYAPYLKKVKEa-hELIPLFKNGQYLGWSGFTGVGTPKAVPEALI-DHVEKNNLQGKLRFNLFVGA--SAGpEENRWAEH 87  Saccharomyces cerevis...

8DH7_B  88 DMIIKR-APHQVGKPIAKAINQGRIEFFDKHLSMFPQ--DLTYGFYTrerkdnkiLDYTIIEATAIKEDG--SIVPG--P 160 brewer's yeast
P52043  77 DAVSWR-APYQTSSGLRKKINQGAVSFVDLHLSEVAQ--MVNYGFFGd-------IDVAVIEASALAPDGrvWLTSG--I 144 Escherichia coli K-12
P73661  85 FAKNFRhNSFFIGHHTRSAVNEGLADYTPIFLSQVPG--LFEQGFVP--------IDVALIQTSYPDDHG--YVNLG--V 150 Synechocystis sp. PCC...
O28424  80 SCFLYEpVRKCSKELGPCVHRPGVLSDAGYIAKELGGvlKGGKKYT----------DIAFLVTTPMDRHG--FFNFG--V 145 Archaeoglobus fulgidus
O29120  86 SGFLYRpVRKTSKELGPCVFRPNLYHDVPKIVREFS------KDYDP--------IDIAYLVTTPMDKHG--YFNFG--L 147 Archaeoglobus fulgidus
P32316  88 DMIIKR-APHQVGKPIAKAINQGRIEFFDKHLSMFPQ--DLTYGFYTrerkdnkiLDYTIIEATAIKEDG--SIVPGpsV 162 Saccharomyces cerevis...

8DH7_B 161 SvggspefiTVSDKVIIEVntat-psfEGIHDIDMPVNPPFRKP-YPYLKVDDKCgvDSIPVDPEKVVAIVE 230 brewer's yeast
P52043 145 Gnap--twlLRAKKVIIELnhyhdprvAELADIVIPGAPPRRNS-VSIFHAMDRVgtRYVQIDPKKIVAVVE 213 Escherichia coli K-12
P73661 151 S--------VDIVKAAVEQ--------ACLVIAQMNSQVPRIHG--DGFIALEKL--DYIIAHD------EP 196 Synechocystis sp. PCC 6803
O28424 146 T--------CTFLKSIAEG--------AEKVVVVVKKDMPWVNGgYDECIHISEV--DYIVEDNEFPTPFLP 199 Archaeoglobus fulgidus
O29120 148 T--------CSHMKALAEV--------AEKVVVVVKENMPWVNGgYDECIHISEV--DYIVEDNEMPVPFIP 201 Archaeoglobus fulgidus
P32316 163 Ggsp--efiTVSDKVIIEVntat-psfEGIHDIDMPVNPPFRKP-YPYLKVDDKCgvDSIPVDPEKVVAIVE 230 Saccharomyces cerevisiae S288C
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