pfam02547: Queuosine_synth (This model is not part of the current CDD release)
Queuosine biosynthesis protein
Queuosine (Q) biosynthesis protein, or S-adenosylmethionine:tRNA -ribosyltransferase-isomerase, is required for the synthesis of the queuosine precursor (oQ). It catalyzes the transfer and isomerisation of the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to form epoxyqueuosine (oQ-tRNA). Q is a hypermodified nucleoside usually found at the first position of the anticodon of asparagine, aspartate, histidine, and tyrosine tRNAs. In Streptococcus gordonii , QueA has been shown to play a role in the regulation of arginine deiminase genes.
Jiyao W et al.(2023). "The conserved domain database in 2023.",