5HK3,2MF2,6A6X,5HJZ


Conserved Protein Domain Family
PemK_toxin
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pfam02452: PemK_toxin 
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PemK-like, MazF-like toxin of type II toxin-antitoxin system
PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.
Links
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Statistics
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PSSM-Id: 426779
Aligned: 154 rows
Threshold Bit Score: 46.0598
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5HK3_B            5 RAEIYWADLgP--PS-GSQ----PAK-RRPVLVIQSD-PYNaSR-LaTVIAAVITsNDA-Laa------------mPGNV 61  Mycobacteriu...
Q5JE12            4 KGKFVLVPF-PftNLkATK--------LRPALVL--------YEgKeDVVVAFVSsRIDtFd-------------pGTDV 53  Thermococcus...
EAW45852          5 KGDVILAPF-PftDFsETK--------LRPAVVLWVS-----SRgSnNIIICFIYsQNLiNl-------------qPEEF 57  Nodularia sp...
Q8KUV1            5 KGDIVLVPF-PftDLsRTK--------LRPAVVLWVD-----PL-GpDITVCFISsKHLsEv-------------tCDEV 56  Synechococcu...
Q7NPC9            9 FGDIILVAF-PfsDLkTKK--------KRPAVVVSSS-FYQ-TR-YpDVILMAVTsQIQtPq-------------yPGEV 63  Gloeobacter ...
Q8YYT8            6 FGDVILVPF-PftDQtTTK--------KRPSVVVSST-DYQ-RQ-RsDLILIAVTsTTNpVt-------------sFAEM 60  Nostoc sp. P...
Q3ASU9            8 KYDVVVVRF-PfaSSlKYK--------ARPAVVVSSE-IYNkNS-RaTLLILAISsSIKnKl-------------dF-EI 62  Chlorobium c...
jgi:RoseRS_2934   5 RGDVVLVPF-PfsDLsTTK--------VRPAVVVSSS-LYH-AT-EpDLILAAITsRVAaSs-------------gPLDC 59  Roseiflexus ...
P72898            5 QAEVVLCEF-YfsDLkQNK--------LRPVVVFKDNlPFD------DFVGMPVSsRVGqLn--------------DDEI 55  Synechocysti...
Q5JGK3            4 QGEIWTAPF-PyyELqGNSqkfvLKDkIRPVIIVSEN-KFNsDN-L-DVIVCQVS-RHKdYrilslppelkrrviiISNS 78  Thermococcus...

5HK3_B           62 DLPa-tTTRlp-----rdSVVNVTAIVTLNKTDl---TdRVGEVPASLMHEVDRGLRRVL 112 Mycobacterium tuberculosis H37Rv
Q5JE12           54 RIEt-sHPQfrgiglkvpSIIKLTKIATLHKGLl---IgVLGELPEDLVQEVNSKLCSNL 109 Thermococcus kodakarensis KOD1
EAW45852         58 LISd-sDPEfantglklsSKVIVSRIVTIDRNLi---TrRIGNLGIKQLEELNTRLIQIF 113 Nodularia spumigena CCY9414
Q8KUV1           57 VLTp-eDSEfaqtglkvaSKIRVTKIVTLDRQLl---QrQLGSLGQQQLQQLNEALRLAF 112 Synechococcus elongatus PCC 7942
Q7NPC9           64 LI-----ADwqaagllkaSVTKPV-LATVETELi---IrKLGQLASADQEAVRATLLIIF 114 Gloeobacter violaceus
Q8YYT8           61 TI-----TEwkaagllkpSIIKPV-LTTIDKMLv---IkKLGELQEVDTQALHNLLQIIL 111 Nostoc sp. PCC 7120
Q3ASU9           63 EL-----SDwqsagllkpSIFKSS-IATIEKEYi---VsKLGVLSDVDVKRLEKMIDVIC 113 Chlorobium chlorochromatii CaD3
jgi:RoseRS_2934  60 VL-----HDwqvaglrypSAVKPV-LFTLDPTRv---IyHVGALTPVDLAEVAQRLRRAL 110 Roseiflexus sp. RS-1
P72898           56 VLDe---sDfiegllskcSKVMVRKIFVISKQVv---IkKHGTLSTQSFSKLHLTFCRYF 109 Synechocystis sp. PCC 6803
Q5JGK3           79 NLVpgtGRLrn------iSIIKPFKLFTLPKDIvlngK-LIGKLDRPTLKQLLSNIHSLF 131 Thermococcus kodakarensis KOD1
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