4MZP,1M1F,6KYT,7BYE,7D28,5HK0,5WYG


Conserved Protein Domain Family
PemK_toxin
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pfam02452: PemK_toxin (This model is not part of the current CDD release)
PemK-like, MazF-like toxin of type II toxin-antitoxin system
PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.
Links
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Statistics
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PSSM-Id: 514941
Aligned: 132 rows
Threshold Bit Score: 49.1669
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4MZP_A        16 RRGDVYLADLsp--vqGsE----QGG-VRPVVIIQNDTGN-KYs-pTVIVAAITgRIn-KAKI------------PTHVE 73  Staphylococcus ...
WP_011831532   2 EPGDIVLMLFpygdgkAdK--------VHPALVL-------EVeehVVYVAYGTsKRvtEAA-------------AIDTA 53  Methylibium pet...
Q602Q5         4 ERGQIVRVPFpftdraAsK--------NRPALVLSGASAF-NTpagHVVLAMITsAKnpSWP-------------L-DCA 60  Methylococcus c...
Q82VX8         4 ERFTVLKVPFpftdrtAaK--------NRPALVLSDAATF-NDpigHSVLAMITsAAnpAWP-------------L-DCL 60  Nitrosomonas eu...
P73488         6 EQFDVVIVPVpftdrqSdI--------RRPALILSDAPAF-NNrigHSVMAMITsAKnaPWP-------------L-DTP 62  Synechocystis s...
Q5JE12         3 LKGKFVLVPFpftnlkAtK--------LRPALVL-------YEgkeDVVVAFVSsRIdtFDP-------------GTDVR 54  Thermococcus ko...
Q4JWS2        93 DAGEVVWADIcpkkgiPpE--------RRAVLVVGRKSH-------RLLTLLISsREefADQ-------------PTWVP 144 Corynebacterium...
Q73XU1        98 dPGEIVWTWVvy--edDpS----RGK-DRPVLVVGRDRs-------TLLGLMVSsQErhAAD-------------PEWVG 150 Mycobacterium a...
Q9RD03        48 dPGEIVWTWVpy--eeAdG----RGK-DRPVLVVAREAAG------TVLAVQLSsRRhdGD--------------REWVP 100 Streptomyces co...
Q5JGK3         3 EQGEIWTAPFpyyelqGnSqkfvLKDkIRPVIIVSENKFNsDNl--DVIVCQVS-RHkdYRILslppelkrrviiISNSN 79  Thermococcus ko...

4MZP_A        74 IEKKk--YKLDk----dSVILLEQIRTLDKKRL---Ke-KLTY-LSDDKMKEVDNALMISL 123 Staphylococcus aureus subsp. aureu...
WP_011831532  54 VSISdpaDVHAsgllrpTAFHLETRARFPKNKV---Lr-RIGA-IPHHKYRQLYRAAVKVG 109 Methylibium petroleiphilum
Q602Q5        61 Ie-----DLAAaglpapSVVRCK-LFTLDARLI---Rg-VLGA-LAETDAQRTAQTFARLL 110 Methylococcus capsulatus
Q82VX8        61 Id-----DLVSaglpapSVVRFK-LFTLDHRLI---Rg-ELGR-LAVSDSIQVTRSLYQLF 110 Nitrosomonas europaea
P73488        63 Ie-----DTRSaglftpSVVRMK-LFTLEHKYI---Ld-CVGS-LSKQDRLMVKSAFPHVF 112 Synechocystis sp. PCC 6803
Q5JE12        55 IETSh-pQFRGiglkvpSIIKLTKIATLHKGLL---Ig-VLGE-LPEDLVQEVNSKLCSNL 109 Thermococcus kodakarensis KOD1
Q4JWS2       145 IGTGpwsSGADr----dSWVRIDKVLQVPET-----HiqRRGIpLPSRRFDRVANVLRQEY 196 Corynebacterium jeikeium K411
Q73XU1       151 IGSGswdYEGRp-----SWVRLDRVLVVPEEGI---Rr-EGAI-LDREVFDVVAARLRAQy 201 Mycobacterium avium subsp. paratub...
Q9RD03       101 IGSGpwdRSGRd-----SWVDVDRVLRLHDAGM---Rr-EACA-LDRMRFDLVRQRLREry 151 Streptomyces coelicolor
Q5JGK3        80 LVPGtgrLRNI------SIIKPFKLFTLPKDIVlngK--LIGK-LDRPTLKQLLSNIHSLF 131 Thermococcus kodakarensis KOD1
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