3EQ5


Conserved Protein Domain Family
Ski_Sno
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pfam02437: Ski_Sno 
SKI/SNO/DAC family
This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homolog, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.
Links
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Statistics
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PSSM-Id: 460558
Aligned: 23 rows
Threshold Bit Score: 129.703
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3EQ5_A        23 MPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREF--TLQQINTVCDELYIYCSRCTSDQLHILKVLGILPF 100
XP_011605191  81 eNIPQNNECKMVELRGAKVASFTVDGCELICLPQAFDLFLKHLvgGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQP 160
EKC27827      58 aCNPDNNVCKVITYRGEKVAAFTVNGIELICLPQAFELFLKHLvgGLHTVYTKLKRLDITPVVCNVEQVRILRGLGAIQP 137
KOB66933      86 TSDPSANECKLVDYRGQKVAAFIIQGDTMLCLPQAFELFLKHLvgGLHTVYTKLKRLDIVPLVCNVEQVRILRGLGAIQP 165
XP_002407755  97 pSDASATDCRLIDYRGAKVAAFYVAGEYLLCLPQAFELFLKHLvgGLHTVYTKLKRLDITPIVCNVEQVRILRGLGAIQP 176
CAP20864      86 nsspttLTVKLVPFRGHSVAAFDIDGKEMICLPQVYEIFLKNMvgGLHTVYTKLKRLYIHPVVCNVEQVRALRSLGAIQP 165
EKC34205      59 D-----NEVGTVVLFGVPIVCLYVENRERLCLAQISNTLLRNF--SYNEIHNRRVALGITCLQCTPVQLEILRRTGAMPV 131
EKC29506      20 syvarpNQVSTVMLHGVPIVSLYIDGKERLCLAQISNTLLKQY--SYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPI 97 
XP_003242376  40 VLFCLSNQVGTVILYGVPIVSLQMDNQERLCLAQISNTLLHRF--SYNEIHNRRVALGITCVQCTPVQLEMLRRAGAMPV 117
EFN61391     108 qshpkqNQVGTVSLYGIHIVSLVIEGQERLCLAQISNTLLKQF--SYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPV 185

3EQ5_A       101 NAPSCGLITLTDAQRLCNALLR 122
XP_011605191 161 GVNRCKLISRKDFETLYNDCTN 182
EKC27827     138 GVNRCKLISCKEFDVLYDDCTN 159
KOB66933     166 GVNRCKLLSCKDFDVLYRDCTT 187
XP_002407755 177 GVNRCKLLSCKDFDALYKDCTT 198
CAP20864     166 GVNRCKLLETRDFEKLYDDCTS 187
EKC34205     132 SSRRCGLITKREAERLVKSFLE 153
EKC29506      98 SSRRCGMITMREAERLVKSFLE 119
XP_003242376 118 SSRRCGMITRREAERLCNSFLG 139
EFN61391     186 SSRRCGMITRREAERLCKSFLG 207
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