3EQ5


Conserved Protein Domain Family
Ski_Sno_DHD
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pfam02437: Ski_Sno_DHD (This model is not part of the current CDD release)
SKI/SNO/DAC Dachshund homology domain
This entry represents a domain known as the Dachshund homology domain (DHD) that is about 100 amino acids long and found in members of Ski/Sno family. This domain contains a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development. The SKI-DHD adopts a mixed alpha/beta structure which includes features found in the forkhead/winged-helix family of DNA binding proteins, although SKI-DHD is not a DNA binding domain.
Links
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Statistics
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PSSM-Id: 514933
Aligned: 17 rows
Threshold Bit Score: 151.704
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3EQ5_A        22 SMPSDSSt---ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREF--TLQQINTVCDELYIYCSRCTSDQLHILKVL- 95  human
XP_011605191  81 ENIPQNN----ECKMVELRGAKVASFTVDGCELICLPQAFDLFLKHLvgGLHTVYTKLKRLEITPVVCNVEQVRILRGL- 155
EEC10548      99 DASAT------DCRLIDYRGAKVAAFYVAGEYLLCLPQAFELFLKHLvgGLHTVYTKLKRLDITPIVCNVEQVRILRGL- 171
EFN61391     113 QN---------QVGTVSLYGIHIVSLVIEGQERLCLAQISNTLLKQF--SYNEIHNRRVALGITCVQCTPVQLEILRRA- 180
7_pfamImport   9 IIPADPNs--cQRSETILENEVISCFIVGGEKRLCLPQILNTVLTDF--SLQQINSVCDELHIFCSRCTPEQLEVLKVT- 83 
EEC16019      84 LTPPDQSrc-sERSETQLESYSISCFSVGGERRLCLPQILSTVLAEF--SQPQINGVCDELHIFCSRCNAEQLDVLKAT- 159
6_pfamImport  10 LTAPDRSp--sQRCETLLQGERITCFLVGGEKRLCLPQILNSILRDF--SLAQINQVCDSLQIFCSRCNPEQLDELKET- 84 
EFX79843      27 LSAADRGwshaERNETQLEGQPIACFTVGGEPRLCLPQILNSVLRQF--YVMQIHAVCDELQINCSRCTAEQLDSLKAAp 104
XP_069985012  32 AN---------QVGTVMLYGVPIVSLNIDNCERLCLAQISNTLLKEF--SYNEIHNRRVALGITCVQCTPVQLEILRRA- 99  Pacific white s...
NP_001132986  60 rGNTNTN----ECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLvgGLHTVYTKLKRLDISPVVCTVEQVRILRGL- 134 human

3EQ5_A        96 GILPFNAPSCGLITLTDAQRLCNALLR 122 human
XP_011605191 156 GAIQPGVNRCKLISRKDFETLYNDCTN 182
EEC10548     172 GAIQPGVNRCKLLSCKDFDALYKDCTT 198
EFN61391     181 GAMPVSSRRCGMITRREAERLCKSFLG 207
7_pfamImport  84 GILPASAPSCGLITKTDAERLCAALLF 110
EEC16019     160 GVIPSSAPSCGLITKSDAERLCAALIH 186
6_pfamImport  85 GILPKSAPSCGLITKTDAERLCSTLLH 111
EFX79843     105 AILPRSAASCGLITKTDAQRLCSALLR 131
XP_069985012 100 GAMPISSRRCGMITKREAERLCKSFLG 126 Pacific white shrimp
NP_001132986 135 GAIQPGVNRCKLITRKDFETLFTDCTN 161 human
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