4QSH,4JX6,3HB9,7ZYZ,3BG3,5KS8,1U5J


Conserved Protein Domain Family
PYC_OADA
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pfam02436: PYC_OADA (This model is not part of the current CDD release)
Conserved carboxylase domain
This domain represents a conserved region in pyruvate carboxylase (PYC), oxaloacetate decarboxylase alpha chain (OADA), and transcarboxylase 5s subunit. The domain is found adjacent to the HMGL-like domain (pfam00682) and often close to the biotin_lipoyl domain (pfam00364) of biotin requiring enzymes.
Links
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Statistics
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PSSM-Id: 514932
Aligned: 341 rows
Threshold Bit Score: 115.25
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4QSH_A        829 VYIHEMPGGQYTNLQQQAIAVGLGDRWDEVKEMYTVVNQMFGDIvKVTPSSKVVGDLALFMVQNelseedvyekGDTIDF 908  Listeria mono...
WP_013256558  301 IPFSPMPGGALTANTQMMRDNGILDKYTEVAAAMGEVVMKGGYGtSVTPVSQFYFQQAFNNVMV----------GPWKKI 370  Sediminispiro...
WP_012856406  303 IPFSPMPGGALTANTQMLRDNNILHKFPDVIKAMREVVEKGGYGtSVTPVSQFYFQQAFNNVMF----------GPWKKI 372  Sulfurospiril...
Q0P9W6        303 IPFSPMPGGALTANTQMMRDNNILDKFPQVIHAMREVVEKGGFGtSVTPVSQFYFQQAFNNVMF----------GSWKKI 372  Campylobacter...
WP_012109448  303 IPFSPMPGGALTANTQMMRDNNILDKFPQVIKAMREVVEKGGFGtSVTPVSQFYFQQAFNNVMF----------GDWKKI 372  Campylobacter...
WP_013327175  303 IPFSPMPGGALTANSQMMRDNGIMDKFPDVIAAMQEVVEKGGYGtSVTPVSQFYFQQALNNVMQ----------GPWKAI 372  Sulfurimonas ...
WP_012082674  304 IPFSPMPGGALTANTQMMRDNKILHKYPEVIKAMREVVEKGGFGtSVTPVSQFYWQQAFNNVMF----------GPWKKI 373  Nitratiruptor...
5_pfamImport    1 IPFSPMPGGALTANTQMMRDNGTLDKFPAVIKAMQEVVVRGGFGtSVTPVSQFYWQQAYANVMF----------GPWKQI 70  
WP_013554200  303 IPFAPMPGGALTANTQMMRDSGNLDKFDEVIEGMTEVVEKGGYGtSVTPVSQFYWQQAYANVMF----------GPWKKI 372  Nitratifracto...
WP_013606247  301 IVFSPLPGGALTANTQMLRDNNLMDKYPAIVEAMAETVAKGGYGtSVTPVSQFYFQQAFNNVMF----------GPWKKI 370  Sphaerochaeta...

4QSH_A        909 PDSVIEFFMGEIGQPYGGFPEKLQKLVLkgRTPlTDRPGAL----MEPVNfveVKAELKE-KMGY------EPtEKDVIS 977  Listeria mono...
WP_013256558  371 AEGYGKMVLGYFGKTPVAPDPEIVKLAS--EQL-GLEPTTKipvdINDED---SSKGIGAaKKMLeeaklpIS-DENIFI 443  Sediminispiro...
WP_012856406  373 AEGYGKMVLGYFGKTPVAPDSEVVSLAS--EQL-KLPPTTKnaldLADAD---DTKSLLHvKQILekenleVS-EENLLI 445  Sulfurospiril...
Q0P9W6        373 AEGYGKMVLGYFGKTPVAPDANIIELAS--KQL-NLEPTTElainIADKD---ESKSIAYtKTLLekegieTS-EENIFV 445  Campylobacter...
WP_012109448  373 ADGYGKMVLGYFGRTPVKPDSEIVKMAE--KQL-GLAPTKEhaidIADKD---EKKSIKYaAEVLkreniePN-EENIFI 445  Campylobacter...
WP_013327175  373 APGYGKMVLGYFGKTPVAPDPEIVKIAS--EQL-KLEPTTEkaldLADAD---PAKSLESwINRLkdedieIT-EENIFI 445  Sulfurimonas ...
WP_012082674  374 APGYGRMVLGYFGKTPVAPDPEVVKLAS--EQL-GLEPTKEnpldIADRD---ETKSIAYwKKKLedenieTT-EENIFI 446  Nitratiruptor...
5_pfamImport   71 APGYGRMVLGYFGKTPVEADPEIIKLAS--EKL-KLEPTKEnpldIADRD---EKKKISVwKQRLeienipVT-EENIFI 143 
WP_013554200  373 APGYGKMVLGYFGRTPMPPDPEIVELAR--EQL-HLEPTEEnpldIADRD---EKKSIAYwKAVLqaegieAT-EENIFI 445  Nitratifracto...
WP_013606247  371 AEGYGKMVLGYFGKTPVAPDPVVVKACA--DAM-GLAPTTEkvvdINEKD---PKKGIAAaKAMLekeglpIT-DENIFI 443  Sphaerochaeta...

4QSH_A        978 YILYPKVFLDYQEminkygdvtvldtptfykGMR-L-----------------------GETIEVELEKGKILLIK 1029 Listeria monocyto...
WP_013256558  444 AAACKEKGIQFLK------------------GEAkVnvrkidpnaak-aeaaggeaksgAGNYTVNVGGKRFNVTL 500  Sediminispirochae...
WP_012856406  446 AAACKEKGIAFLK------------------GEAkVnvrkvsak--------keetpscITDFTVSVNGEKYHVKS 495  Sulfurospirillum ...
Q0P9W6        446 AAACKEKGIAFLK------------------GEAkVnirklasm--------pkpmsadENKFTVAVNGNKYHVEV 495  Campylobacter jejuni
WP_012109448  446 ALACKEKGIAFLK------------------GEGkVmvrkkadmpka-asknnakkcdeVKTYSVLVNGNSYNVQV 502  Campylobacter hom...
WP_013327175  446 AAACQEKGIAFLK------------------GEGeLnvrkisemk-----kdcegssmgNGNYTVVVDGQKFSVQV 498  Sulfurimonas auto...
WP_012082674  447 AAACGDKGIAFLK------------------GESpLmvrkisem-------eeekvgktSGIYTVIVDGEKFVVEV 497  Nitratiruptor sp....
5_pfamImport  144 AAACDEKGIAFLK------------------GESpLnvrkkeneinnsnnktkgdnkmaNGNYTVVVDGQRFNVTV 201 
WP_013554200  446 AAACDKKGIAYLK------------------GESpLmvrkgaqne-----tkqsegaemAGNYTVIVDGKKYSVQV 498  Nitratifractor sa...
WP_013606247  444 AASCKEKGILFLT------------------GKSqVngmykinr--------teeaakkKGEYTVTVNGKAYGVKL 493  Sphaerochaeta glo...
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