Conserved Protein Domain Family
TrkH
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pfam02386: TrkH 
Cation transport protein
This family consists of various cation transport proteins (Trk) and V-type sodium ATP synthase subunit J or translocating ATPase J EC:3.6.1.34. These proteins are involved in active sodium up-take utilising ATP in the process. TrkH a member of the family from E. coli is a hydrophobic membrane protein and determines the specificity and kinetics of cation transport by the TrK system in E. coli.
Links
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Statistics
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PSSM-Id: 280534
Aligned: 9 rows
Threshold Bit Score: 390.246
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P28584  301 PSSQELNKLAQTKSFQKLLGLRRDegdhdyFDGAPHKYMVTKKKKISRTQSCNIPTYt-----aSPSPKT----SGQVVE 371  Saccharomyces cerev...
Q10065  354 AHQNVVRGSAITIAPTPVPRHNRR------PIYFADDTNGAEQEKGAHRLDGRGRKR-------GKSFAV----TPTLHR 416  Schizosaccharomyces...
P47946  316 LRPANTIDGIVRSSLSSSSLSKDTep---sTVDMHIAFTGLNKPTIERERNLKLR----------KKSRFykksLRSRFS 382  Schizosaccharomyces...
P12685  624 KKPNFRKRGWNNKIFEHGPYASDSdr--nyPDNSNTGNSILHYAESILHHDGSHKNGs-----eEASSDS----NENIYS 692  Saccharomyces cerev...
Q9HPA9   77 HGMVIAAGGWFAIAVVGALPFLFTaw--ltPPAAMARFVPTDATWTAVSVGNTTTL---------SSLAYfrqpLHALFE 145  Halobacterium salin...
P23849   38 SLFVFFITFVIFFCIGGGAWYTTKks--giQLRTRDGFIIIVMFWILFSVISAFPLWid----sELNLTF----IDALFE 107  Escherichia coli K-12
P44843   35 GGKAFMQAFMLSLIAGTLLWWPCHhh--kqELRSRDGFLIVVAFWLVLGSLATLPLLlf----dSPHLTI----ASAVFE 104  Haemophilus influen...
O83176  103 HIQNITLGIFALIAFKAQKKFA--------ERAVSNPSQTLIVSFLVVIFIGTHLLMfpgatphSQPLPM----LTALFT 170  Treponema pallidum
P75323   24 ISQRIFHFYIYCILLGAVLLFL--------PFALKTDYQKVISYEVDLQGHTISKQT--------ASYGF----LDALFL 83   Mycoplasmoides pneu...

P28584  372 NHRNLAKSAPSSFVDEEMSfsPQESLNLQFQAHppkpkrregdighpfTRTMSTNYLSWqPTFG---RNSVFIGLTKQQK 448  Saccharomyces cerev...
Q10065  417 NERSMSVLPFQLAKSFTSAl-PRRLTFNRTHTK---------------ASTMSLPYLSYnATVG---RNSAFYALTPVER 477  Schizosaccharomyces...
P47946  383 RGLHRPIRWTKSFTS------NRRNLTLERVLSsafakkr-epsissrHTTMSLPYLSYnPTVD---RNSAFVALSKEQR 452  Schizosaccharomyces...
P12685  693 TNGGSDHNGLNNYPTYNDDeeGYYGLHFDTDYDldprhdl--------skgsgkTYLSWqPTIG---RNSNFLGLTRAQK 761  Saccharomyces cerev...
Q9HPA9  146 SMSGWTGSGLTMAIHEPSL--PRSIQWWRSLTQwv-----------ggVGVVVLTVSIL-ARPG---SGSYALYRSEA-- 206  Halobacterium salin...
P23849  108 GVSGITTTGATVIDDVSSL--PRAYLYYRSQLNfi-----------ggLGVIVLAVAVL-PLLG---IGGAKLYQSEMPG 170  Escherichia coli K-12
P44843  105 AFSGLTTTGATVMTGLDNL--PKSILFYRQFLQwl-----------ggMGIIVLAVAII-PLLG---IGGTQLYRAESSG 167  Haemophilus influen...
O83176  171 ATSAVCVTGLSVIDVATQL--STWGKAILAALIqi-----------ggLGFMVFSFFGM-ITI----KKKMSLESRLVAS 232  Treponema pallidum
P75323   84 AVSAFSDTGLSTTVVSETY--SVFGQTVLAILLql-----------ggIGFVVIAFLVW-RLFKlhkKGKYSFYEKLMLQ 149  Mycoplasmoides pneu...

P28584  449 EELGGVEYRALRLLCCILMVYYIGFNILAFVTIVPWACTRHHYSEI-----------------IrrngvsPTW------- 504  Saccharomyces cerev...
Q10065  478 EELAGIEYESLRILTVILVVYFLFWHILGLVAFLIFIYTAKTSGRV-----------------VtdgginRGW------- 533  Schizosaccharomyces...
P47946  453 DELGGIEYRALKCVCSMVTLYFIIFNIAAFVTFIVFAYTAVGSREV-----------------IdsydlrRGW------- 508  Schizosaccharomyces...
P12685  762 DELGGVEYRAIKLLCTILVVYYVGWHIVAFVMLVPWIILKKHYSEV-----------------VrddgvsPTW------- 817  Saccharomyces cerev...
Q9HPA9  207 --REKKIHPSVVSTVRTVWKLVVGYTVVGVAVLFVAIRASD-YGAA-----------------L------PVWda----a 256  Halobacterium salin...
P23849  171 PFKDDKLTPRLADTSRTLWITYSLLGIACIVCY---------RLAG-----------------M------PLF------- 211  Escherichia coli K-12
P44843  168 PLKDQKSLPKISEVAKALWIIYASLTVLCAIAY---------WLSG-----------------M------NLF------- 208  Haemophilus influen...
O83176  233 HLVSDSDMGSLSHNLKLIIFSTFFIEALSALFLFVGFSQTEGYTIQ------------------------SLG------- 281  Treponema pallidum
P75323  150 SERGGSKLGTTSEMIVVSVLFLFMVELLYGFLYTILFYFIPAFESAsvfqssgkvsnqlkaliVdstkrlPVVhnlnlaf 229  Mycoplasmoides pneu...

P28584  505 -WGFFTAMSAFSNLGLSLTA-DSMVSFDTA--PYPLIFMMFFIIIGNTGFPIMLRFIIWIMFKTSRDl---SQFKESLGF 577  Saccharomyces cerev...
Q10065  534 -WAAFTSSSLFDNLGYSLNS-DSLNSFQKA--IFPQVLGTILIFLGNTFFPIMLRFIIWIMIRTTRFs---PNFQQALYF 606  Schizosaccharomyces...
P47946  509 -WALFSSASSFNDLGFSLIP-SSFVPMNRN--IFLLLISSLFIIAGNTGFPCFFRTFIWTTYKLYPFs---FEKKEAMAF 581  Schizosaccharomyces...
P12685  818 -WGFWTAMSAFNDLGLTLTP-NSMMSFNKA--VYPLIVMIWFIIIGNTGFPILLRCIIWIMFKISPDl---SQMRESLGF 890  Saccharomyces cerev...
Q9HPA9  257 wQALNHTMTGLTTGGFSVTD-NSIATYDA---PVIEAALLPIMVAGAIAFPIHYRLLADRDHGVLR-------------- 318  Halobacterium salin...
P23849  212 -DAICHGISTVSLGGFSTHS-ESIGYFNN---YLVELVAGSFSLLSAFNFTLWYIVISRKTIKP---------------L 271  Escherichia coli K-12
P44843  209 -DAIGHSFSTISNGGFSTHD-ASIGYFNQ---ASIYWVTTIFMLIGGVNFSLHISAFLALGKRNIW-----------RNY 272  Haemophilus influen...
O83176  282 -NAYFHAISAFCNAGFSLYP-NSLESFVSN--PWITFPIAFTIILGGISFVVIDEVLCRVHGSIKNIffkgKNILGSLSL 357  Treponema pallidum
P75323  230 qYGFFHSLSAVNNAGIDLLGaNSFAPYRTNwgIVIQWLAISQIIFGGIGYPVLFDAYEAIKKRRLYG----KYYKHQFSL 305  Mycoplasmoides pneu...

P28584  578 LLDHPRRCFTLLFPSGPTWWLFTTLVVLNATDWILFIILDF----------------NSAVVRQVAKGYRALMGLFQSVC 641  Saccharomyces cerev...
Q10065  607 LFEHPRRSFTLLFPSKTTWVLFLNLTLLNFASFFFFMVLDL----------------GNSYVDKIPVGYRIMNAIFQNAA 670  Schizosaccharomyces...
P47946  582 LLDHPRRCFTLLFPSGATWVLFFVLLLLNVIDLVLFMVLDT----------------GSKAVASLPKGIRVVNAIFQSVC 645  Schizosaccharomyces...
P12685  891 LLDHPRRCFTLLFPKAATWWLLLTLAGLNITDWILFIILDF----------------GSTVVKSLSKGYRVLVGLFQSVS 954  Saccharomyces cerev...
Q9HPA9  319 -GDLQTRWLFVLLGGGVVVLAAQNVAAVPVTPDAVTQWTPAi---------------GDVPVLSPAQADAARDATFQWVS 382  Halobacterium salin...
P23849  272 IRDIELRFF-LLIALGVIIVTSFQVW----------------------------------HIGMYDLHGSFIHSFFLASS 316  Escherichia coli K-12
P44843  273 WKDPEFRFF-LTMQIIFIGIVSLSLY-------------------------------GYGLVSDIN--EAVTKGALQLTS 318  Haemophilus influen...
O83176  358 NTFVVLKATVLLLAVSFVGIYLLE---------------------------------HTHSMKVYQVGTQYLAAFFQAVT 404  Treponema pallidum
P75323  306 FTKLAVLTNLIVTAWCFLMLLMVEFIVITSLTNTIAHLNVEkaylveglknksnqelQSLIFGPIPAASRVMQLWFGVIS 385  Mycoplasmoides pneu...

P28584  642 TRTA-GFNVVDLSKLHPSIQVSYMLMMYVSVLP--LAISIRRTNVYEEQSLGLY-DSGQDDENItHEddiketdhdgese 717  Saccharomyces cerev...
Q10065  671 TRSA-GFTVVDLSQIAPAVMVTYMFMMYISAYP--IAMSIRQTNVYEERSLGIY-AADTENDDDnNInnnnn-------- 738  Schizosaccharomyces...
P47946  646 TRTA-GFTSVSISELHPAVLVSYMVMMYISVYP--VAINMRNTNVYEERSLGVY-RTEDDEG------------------ 703  Schizosaccharomyces...
P12685  955 TRTA-GFSVVDLSQLHPSIQVSYMLMMYVSVLP--LAISIRRTNVYEEQSLGLYgDMGGEPEDTdTEddgndedddeene 1031 Saccharomyces cerev...
Q9HPA9  383 ALTCtGFQSAPIGNWIAGGKILVVGAMTIGGAAgsTVGGIKIIRAYTAVRGFIW-QFSRVFLPSnAV------------- 448  Halobacterium salin...
P23849  317 MLTDnGLATQDYASWPTHTIVFLLLSSFFGGCIgsTCGGIKSLRFLILFKQSKH-EINQLSHPR-AL------------- 381  Escherichia coli K-12
P44843  319 MSMTaGYTIFDIDNLPPFIGLLLVISAVIGGCGgsTTGGLKAIRTLILWKQIDR-ELHSLIHPN-LV------------- 383  Haemophilus influen...
O83176  405 LRTA-GFSTIPFSNLRTATLFFMTFIMFVGGASgsTAGGIKLNTAAAIIASFRS-FIHHDPKPR--I------------- 467  Treponema pallidum
P75323  386 SRSA-GFSVFPWSAESDIIKGIMVIAMFIGGSPssTAGGIRTTTLAVIFLTLKA-KFRGQKEVK--V------------- 448  Mycoplasmoides pneu...

P28584  718 e--------------------rdtvstkskpkkqSPKSFVGAHLRRQLSFDLWY----LFLGLFIICICEGRKIEDVNKp 773  Saccharomyces cerev...
Q10065  739 -----------------------------dnntpKRKNFLMDHIQRQLSHDLWY----LFLGYFIITIVEGRRLESEAEp 785  Schizosaccharomyces...
P47946  704 ------------------------------------KSFLKDHLTEQLSYDLWY----IFLGLFIICICEGGKISNPLDt 743  Schizosaccharomyces...
P12685 1032 shegqssqrsssnnnnnnnrkkkkkkktenpneiSTKSFIGAHLRKQLSFDLWF----LFLGLFIICICEGDKIKDVQEp 1107 Saccharomyces cerev...
Q9HPA9  449 ----------------------------------VTARIDGRTLDRDAMEQEFSeaaiVALLWVVLLFATSLVLVNLAGp 494  Halobacterium salin...
P23849  382 ----------------------------------LSVNVGGKIVTDRVMRSVWS----FFFLYTLFTVFFILVLNGMG-- 421  Escherichia coli K-12
P44843  384 ----------------------------------QPIRIGKNRLAPRMIESIWA----FFIIFILVYWGCVFAVILCG-- 423  Haemophilus influen...
O83176  468 ----------------------------------RNLVIQGKQVERSFLILGFG----ICTVCLAGFCLS---LTDNIP- 505  Treponema pallidum
P75323  449 ----------------------------------FKRSIDGQTVINAFLVAVFG----LVSVVLIAILLP---LSMQQP- 486  Mycoplasmoides pneu...

P28584  774 dFNVFAILFEVVSAYGTVGLSLGypnTNTSLSAQFTVLSKLVIIAMLIRGRNRGLPYTLDRAIMlPSDKLEQI 846  Saccharomyces cerevisiae S...
Q10065  786 qFTLFAILFEVISGYGTVGLSLGy-kNDPSLTAQFRKISKLVMVALQIRGRHRGLPSALDRAVLmPSDKNFDR 857  Schizosaccharomyces pombe ...
P47946  744 dFSIFTVLFEVVSAYGTVGLSTGlssSNCSLSARFTTISKLVIIALELRGRHRGLPRAVDRAILlPSEKNNLK 816  Schizosaccharomyces pombe ...
P12685 1108 nFNIFAILFEIVSAYGTVGLSLGypdTNQSFSRQFTTLSKLVIIAMLIRGKNRGLPYSLDRAIIlPSDRLEHI 1180 Saccharomyces cerevisiae S...
Q9HPA9  495 sFSYADALFEVASAQGNVGLSSG------ITGPDMSPIAEAMFLFNMWIGRLEIIPVLVFAR-----AAISGL 556  Halobacterium salinarum
P23849  422 -YDFLTSFATVAACINNMGLGFG---ATASSFGVLNDIAKCLMCIAMILGRLEIYPVIILFS-----GFFWRS 485  Escherichia coli K-12
P44843  424 -MNTFDAMGAVFATLTNAGPGLG---FIHESFIGVPESAKLVFSFAMICGRLEMFSLIVLFI-----PSYWKK 487  Haemophilus influenzae Rd ...
O83176  506 ---FIYLLFESVSAFATVGLSVG-------ITANLSTAGLMILLILMFTGRVGTLTILTAASKE-EQDMSVEY 567  Treponema pallidum
P75323  487 -LSFVDSLFETTSAFGTVGLSSGa-tKIMALEPTRNLFNYLTLGLLMIMGQVGVSSSVLTFVKKhPQGNSFSY 557  Mycoplasmoides pneumoniae ...
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