Conserved Protein Domain Family
Syja_N

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pfam02383: Syja_N (This model is not part of the current CDD release)
SacI homology domain
This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.
Statistics
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PSSM-Id: 514902
Aligned: 425 rows
Threshold Bit Score: 123.071
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q54X05          79 FAILGYIIs-eKSSHLLVATKIRNEgELlgSyPINTIIETSWIKIdlSylsSYqsneiqTEegwattLVdDsnidssvss 157  Dictyosteliu...
XP_032515169    92 FGIVGFIRf-lEGYYIILVTKRGKI-AVigShSIYKIEDTAMIYI--P---ND------SS------R--P--------- 141 
12_pfamImport    1 FGIVGFVRl-lEGYYMILITKRRRV-AVigReIIYKIEDTSMIYL--P---ND------AY------R--I--------- 50  
XP_001993324    85 YGVLGFVRf-lEGYYLVLVTKRKCC-AHigMhLVYTIKDTVMVRV--N---EV------TS------QR-Q--------- 135 
XP_049537038    80 YGVLGFVQf-lEGYYLLLVTKRTRC-AFigKhIIYAIKDTAMIRV--N---E-------TA------GK-Q--------- 129 
EDS29967        80 YGVLGFVKf-lEGYYLILVTKRTRC-AFigKhIIYTIKDTAMIRV--N---EP------PA------GK-Q--------- 130 
XP_004989879   103 FGIFGVVRf-lSGYYILVITKRRKV-AMigGhIVYRIEDMFMAAV--Y---NT------SL------SN-A--------- 153 
XP_001743806     1 M-IFVLFQsflKGYYLIVVTKRKQV-ASigAhAIYRVEDTIMISL--F---SK------SV------AG-P--------- 51  
XP_011610408    92 FGIVGFVRf-lEGYYIVLITKRRKM-ADigGhSIYKIEDTSMIYI--P---ND------SV------R--V--------- 141  torafugu
XP_002125633   103 FGIVGFIRf-kEGYYLILITKRIKV-AEigGhSIYKIEDTSMINI--P---NS------NV------K--V--------- 152  vase tunicate
Q54X05         158 nsnnnynnnyndnnennnnssgssffsflssssspsnnnnnnnnnnnnsnnnnnnnsnnnnsnnsgntnydslssssggn 237  Dictyosteliu...
XP_032515169       --------------------------------------------------------------------------------     
12_pfamImport      --------------------------------------------------------------------------------     
XP_001993324       --------------------------------------------------------------------------------     
XP_049537038       --------------------------------------------------------------------------------     
EDS29967           --------------------------------------------------------------------------------     
XP_004989879       --------------------------------------------------------------------------------     
XP_001743806       --------------------------------------------------------------------------------     
XP_011610408       --------------------------------------------------------------------------------      torafugu
XP_002125633       --------------------------------------------------------------------------------      vase tunicate
Q54X05         238 snnnnnyDSsygnnnnnnnnnnnnSNNNNNnnnNNnnnnnnnsnnnndptvkqmlKDLQtfpldGtHFYceLYDLTNYFP 317  Dictyosteliu...
XP_032515169   142 --------L---------------HPDEQR---YV--------------------KMFLaidlsTnFYYsySYDVTHTLQ 175 
12_pfamImport   51 --------P---------------NVNEPR---YL--------------------KIFQsvdlsSnFYFsySYDVTHTLQ 84  
XP_001993324   136 --------P---------------HPHEER---YK--------------------KMFQnidlrInFYFsySYDLTRTLQ 169 
XP_049537038   130 --------M---------------HPLEQR---YV--------------------KMFTnvdlnSnFYFsySYDLTHSLQ 163 
EDS29967       131 --------I---------------HPLEQR---YV--------------------KMFSnvdmkSnFYFsySYDLTRSLQ 164 
XP_004989879   154 -------TI---------------PPDEKR---YT--------------------KMFQnvdttSnFYFsyTYDLTRPLQ 188 
XP_001743806    52 --------D---------------LPEEER---YR--------------------RIFHnvdltSnFYFshTYDLTRPVQ 85  
XP_011610408   142 --------T---------------HPDEGR---YI--------------------RIFQnvdlsSnFYFsySYDLSHSLQ 175  torafugu
XP_002125633   153 --------T---------------HPEEWR---YL--------------------RSFQtvdlsSnFYYshSYDLTNNLQ 186  vase tunicate
Q54X05         318 SNLNT----------------------------------------------------------------PHQYCSEFTWN 333  Dictyosteliu...
XP_032515169   176 MNMAPprklapalfpkpvtaavyqsnlnsnkectcnkkkddedifetwkaqleerqnkpgqkkklefgvRTVPEWRFVWN 255 
12_pfamImport   85 VNMSIaqnipndlp-----------------------------------------------ngegvfvtRSYPNKIFVWN 117 
XP_001993324   170 YNESApryvgakvnlerdeplpdw---------------------------nkltnnvaqehervdyafRSDSRKRFVWN 222 
XP_049537038   164 YNLSVpkfvgnrcdivndep----------------------------------lvwqnrtgermtyafRGVARERFVWN 209 
EDS29967       165 YNLSEpryvgvdsdferddp----------------------------------lvwkaspgerttygfRGVPRSRFVWN 210 
XP_004989879   189 SNMYIpsedeaag-------------------------------------------------rvaarprPIRPNTKFVWN 219 
XP_001743806    86 SNMYLpsdlerqr-------------------------------------------------laepkppVLKPDETFLWN 116 
XP_011610408   176 YNLTLlqrpyelwtsppssaeeevqtq--------------------tkpdsfdifedeglpaqmvygvRNEPYYKYVWN 235  torafugu
XP_002125633   187 HNFMLlhhnrsddvik-------------------------------------------rpklwqthgrDMKPCKRFVWN 223  vase tunicate
Q54X05         334 EWMRKPf------ENASLShlcvvLLQGYASV-KSISNLNV-SIAYLMKRSKLNPGTHFYSPGINENASPANEYESELIM 405  Dictyosteliu...
XP_032515169   256 SHLLSVvhs-qlhPDWILY-----IVHGFIEQsNLNIFGRPiYLTLIARRSNRYAGTRFLKRGANMHGDVANEVETEQIV 329 
12_pfamImport  118 DYLLKDvrd-klhPDWILN-----IMHGFISQsNVSIFGRPiYITLIARRSNRYAGTRFLKRGANKNGEVGNEVETEQIV 191 
XP_001993324   223 AYLLQPmeg-imlKDWLLE-----VTHGYVKQsCFSIFGRHvNVCLIARRSTRFAGTRFLKRGANFQGDVANEVETEQIV 296 
XP_049537038   210 AFLLRPmcn-vvhKDWMLD-----IIHGFISQsSISIFGRQvYVCLIARRSTRFAGTRFLKRGANFHGDVANEVETEQIV 283 
EDS29967       211 TYLLKPmdc-ilhRDWKLE-----VIHGFISQsSISIFGRPiYVCLIARRSTRFAGTRFLKRGANYLGDVANEVETEQIV 284 
XP_004989879   220 HFLTTPyan-kvdRRWVIH-----AMHGFIAQsNLNVFGRPiFVTLIARRSRFYAGTRYLKRGTDEKGNPANDVETEQIV 293 
XP_001743806   117 HFLLHPfhd-tlrPEWLIS-----LTHGFVSQsDINIYGRHiYVTLIARRSRHYAGTRFLKRGCDNAGHCANHVESEQIV 190 
XP_011610408   236 GKLLERikd-ivhQDWLMY-----IIHGFCGQsKLLIYGRPvHITLIARRSSKFAGTRFLKRGANCEGDVANEVETEQIV 309  torafugu
XP_002125633   224 NYLLDGlqddhitDIWVLY-----VIHGHIDQsCVSVYGKSiYITLIGRRSSSYAGTRFLKRGCNVKGDVGNEVETEQIV 298  vase tunicate
Q54X05         406 WkVQDkqsilinniasssnsnlsdldkksnsnnnnnnnnnnnnnnnnnnststasttatataissslsissttaslslss 485  Dictyosteliu...
XP_032515169   330 YdAMIrsk------------------------------------------------------------------------ 337 
12_pfamImport  192 QdHGAsc------------------------------------------------------------------------- 198 
XP_001993324   297 SdG----------------------------------------------------------------------------- 299 
XP_049537038   284 LdG----------------------------------------------------------------------------- 286 
EDS29967       285 LdG----------------------------------------------------------------------------- 287 
XP_004989879   294 HdASTlc------------------------------------------------------------------------- 300 
XP_001743806   191 HdASEis------------------------------------------------------------------------- 197 
XP_011610408   310 HdASVms------------------------------------------------------------------------- 316  torafugu
XP_002125633   299 HcATSss------------------------------------------------------------------------- 305  vase tunicate
Q54X05         486 sstapntitttstaipkvdlnknndtddsnnnnnsnggltnnttniipnnnniNEKviqwTSHVWRRGTVPLWWRAFSkn 565  Dictyosteliu...
XP_032515169   338 ---------------------------------------------------srPSIi--fSSFVQMRGSIPSFWSQDIs- 363 
12_pfamImport  199 ---------------------------------------------------qnNMYi---SSFLQMRGSVPGLWSQDIs- 223 
XP_001993324   300 ------------------------------------------------------QRl---CAFTQMRGSIPSHWSQDIs- 321 
XP_049537038   287 ------------------------------------------------------NRm---CSFTQLRGSVPSHWSQDVs- 308 
EDS29967       288 ------------------------------------------------------TRm---SSFTQLRGSVPSHWSQDVs- 309 
XP_004989879   301 ---------------------------------------------------hrSGRf---TSFLQVRGSVPLYWQQEQn- 325 
XP_001743806   198 ---------------------------------------------------hrRAFi---TSYIQMRGSVPVHWEQDHa- 222 
XP_011610408   317 ---------------------------------------------------ftAGSy---SSFVQVRGSVPLYWSQDIs- 341  torafugu
XP_002125633   306 ---------------------------------------------------lhHTPf---TSYVQHRGSVPCQWFQDIta 331  vase tunicate
Q54X05         566 qgsneielflkdrGkenpNPF----------EKSESYYQNLLNRYekfyqenkdtNlAgiptIQLINLLkqendKQ---E 632  Dictyosteliu...
XP_032515169   364 ------------kMv--pKPAimidrsdpyaEIPAKHINNLMQRY----------GsP----IMILNLVkk--rEKkkhE 413 
12_pfamImport  224 ------------kMv--pKPTisfelndpfhEISGAHFNNLYKRY----------GsP----TVIINLVkk--rEKkvhE 273 
XP_001993324   322 ------------kMv--pKPPiqldicdpyaQTPSRHFERLLFHY----------GaP----LIMLNLVkk--rERrkhE 371 
XP_049537038   309 ------------kMv--pKPQiaidlsdpygETAGKHYQRLMFHY----------GaP----VVILNLVkt--rEKrrhE 358 
EDS29967       310 ------------kMv--pKPQialdlsdpynETAGKHYERLMYHH----------GsP----IIILNLVkk--rEKrrhE 359 
XP_004989879   326 ------------sMk--aKRAisiarsdpfaSLASMHFERLLHRY----------GsP----VIAFNLVkr--lERkprE 375 
XP_001743806   223 ------------gMk--aKPPisiaradpfaSAAAMHFERLFHKF----------GaP----IIAFDLVkk--kERrprE 272 
XP_011610408   342 ------------tMm--pKPPirldqadpyaHVAGLHFDQMLQRF----------GsP----IIILNLVkk--rEKrkhE 391  torafugu
XP_002125633   332 ------------sVvp-sKPPititsdnpyaQPTSLHFQQLLERF----------GsP----VVVLNLVrk--rEKrfhE 382  vase tunicate
Q54X05         633 VILSQLYQKSCEnVTTyl--nVDLQMYTFDWINILK 666  Dictyostelium discoideum AX4
XP_032515169   414 SLLTDVISNAVKyLNQflppdKLIQYFHLDMARMNK 449 
12_pfamImport  274 SQLSDHLVSAVKyLNKflppcHHIQYIHFDMARMNK 309 
XP_001993324   372 SIISKELENSIRyLNQflppqHRMKHIHFDMARQTR 407 
XP_049537038   359 CLLSEEMQSTVNyLNQflppqFRIRYIEFDMARKSR 394 
EDS29967       360 SVLSDEMVVSVDyLNQflppdFRIRYIDFDMARKSR 395 
XP_004989879   376 ALLYEGMKDALAyINQflgedEAVRHFAWDMARCNK 411 
XP_001743806   273 SILLNAYTAALGyLNKflpkeSAIQHVSWDMAKSNK 308 
XP_011610408   392 KILSEELYPAVInLNQflppeNCIDYIAWDMARYTK 427  torafugu
XP_002125633   383 SVLGIEFSSAINyLNQflstkQQIKYHAFDMAHSLR 418  vase tunicate
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