7K1W


Conserved Protein Domain Family
Syja_N

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pfam02383: Syja_N 
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SacI homology domain
This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.
Statistics
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PSSM-Id: 460545
Aligned: 451 rows
Threshold Bit Score: 116.132
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7K1W_F        104 F--GVVGF--VRf----------------lEGYYIVLITKRRKM-ADig----------ghAIYKVEDTNMIYIp----- 147 
EDO07509       67 YadAILGLinIN------------------RSLYLNVVVAVESV-ADvsfdeatavdcrksTIYRVKRVNLFPI------ 121 
Q7RJM2        596 K--TINGD--IKdlinnyyfngsnyedtekRDSYFMGIKNEntehi----------knedkLILKMDIQKILKM------ 655  Plasmodium yo...
XP_002953781   69 P--YILGYvvIG------------------Q-WGLLLVAEKFRVsAIlpg---------thEVKTVTKSHWLKIplqinl 118 
XP_003059495   47 D--ACLGVvaVG------------------D-AVLLLLARKTKVaATlpn---------ghEVMSVQEARWHRA------ 90  
Q57WG4        116 A--ALFGC--LRl-----------------DRMYFLVATKVEEA-AVlpf---------ggAILRVGGTEWISFgipgse 164  Trypanosoma b...
XP_003283904  116 L--AILGY--IIs----------------eKSSHLLVATKIRNEgELlg----------cyPINTIIETSWIKIdlsyls 165 
EFA80244       93 N--ALLGY--IVa----------------eRYSYLLVATKTRNEgDIlg----------vhPIYVVMETQWIKIelsyls 142 
EGG23944      141 C--AILGY--IVa----------------dRSAHLLVATKVRSEgELlg----------lhPISVVLESSWIKIelsyps 190 
Q54X05         79 F--AILGY--IIs----------------eKSSHLLVATKIRNEgELlg----------syPINTIIETSWIKIdlsyls 128  Dictyostelium...
7K1W_F        148 ND------SVR--------------------------------------------------------------------- 152 
EDO07509      122 --------DNFleevggddvkyddpvll---------------------------------------------------- 141 
Q7RJM2            --------------------------------------------------------------------------------      Plasmodium yo...
XP_002953781  119 SM------QSVqvcnllynrgyqagitveg-------------------------------------------------- 142 
XP_003059495   91 --------ALrn-------------------------------------------------------------------- 94  
Q57WG4        165 PLyltsg------------------------------------------------------------------------- 171  Trypanosoma b...
XP_003283904  166 SYqsneiqNDEawtttfveetnidpsvssstsgallnnn----------------------------------------- 204 
EFA80244      143 SCklpispHTPqtngnlcaistvvdn------------------------------------------------------ 168 
EGG23944      191 SYqpkmdtNSSattsssttsnlnsssssvqqqqqqqqqqqqqqqdlnnnndnnvnnnnn-----------sfnihgsnfs 259 
Q54X05        129 SYqsneiqTEEgwattlvddsnidssvssnsnnnynnnyndnnennnnssgssffsflssssspsnnnnnnnnnnnnsnn 208  Dictyostelium...
7K1W_F        153 -------------------------------------V---------------THPDEAR---YLRIF------------ 165 
EDO07509      142 ---------------------geeginssksqwdgskSpvalr------dsgsQSFENDQnsgVIKDIsdll-------- 186 
Q7RJM2        656 ---------------------------------------------------------------IQKILct---------- 662  Plasmodium yo...
XP_002953781  143 ------------------swhgmvegmggglwgawgkApeagak----dekamKDEIEKG---IERLLsfp--------- 188 
XP_003059495   95 -----------------------------------paR---------------ASTREER-------------------- 104 
Q57WG4            --------------------------------------------------------------------------------      Trypanosoma b...
XP_003283904  205 ---------sflnsfsssssppssnanynnsnnsdlpTta------------tSSNItsndpt----------------- 246 
EFA80244      169 -----------------------tsntnhnshgssssSns------------gSFSS----------------------- 190 
EGG23944      260 tigsfsvgsygssigslpntsnlsssvggstqlhfngQsqhsqqqqsqqtqqtQQSQQSQsqdDNGLPsesnit------ 333 
Q54X05        209 nnnnnsnnnnsnnsgntnydslssssggnsnnnnnydSsygnnnn-nnnnnnnNSNNNNNnnnNNNNNnnnnsnnnndpt 287  Dictyostelium...
7K1W_F        166 -----QNVD---LSSn--FYF--SYs--yDLSHSLQYNltvlrmplemlkseMTQnr---------------------qe 210 
EDO07509      187 ---------------ttgHYFsrSA----DLTRSLQRQ--------------WEQgyvplrprrfatlpetvdatshkes 233 
Q7RJM2        663 -----------------hMYY--SYd--fDLTQCIQKK--------------RRKnieekekapllh--hysslnkrksf 705  Plasmodium yo...
XP_002953781  189 ---------------idgAHF---LcdtlDITRPFPSY------------------------------------------ 208 
XP_003059495  105 -----ANVAsmtEATmdnLYY---YcetfDATRAFAHA--------------CRNaasts---------------vtptk 147 
Q57WG4        172 drnrlKEFEtysHEGg--YYY--Sdd--cDLRRPFP-------------------------------------------- 201  Trypanosoma b...
XP_003283904  247 vkeilKDLQtfpFDGt--HFYceNY----DLTNYFPSN--------------YNTt------------------------ 282 
EFA80244      191 -----FNLQlypLEGt--HFYceTY----DLTNYFPSS--------------PKA------------------------- 220 
EGG23944      334 tqtllNNLQsypIDGt--HFYceSY----DLTNYFPSN--------------RTT------------------------- 368 
Q54X05        288 vkqmlKDLQtfpLDGt--HFYceLY----DLTNYFPSN--------------LNT------------------------- 322  Dictyostelium...
7K1W_F        211 SFDIFEdeglitqggsgvfgicsepyMk------------YV-------------WNGELL-Diik--stVHRdWLLY-- 260 
EDO07509      234 ESSPRS--------------------TkssetlfdmadpmFN-------------WSKGMShDi------PSH-WLTP-- 271 
Q7RJM2        706 LKMCEK--------------------K-------------FM-------------WNYQMIkKmknrckiDDN-WFCP-- 736  Plasmodium yo...
XP_002953781  209 --RAVK--------------------Dps---------wdFV-------------WNRWMSaPfrn--lgLDH-LCPP-- 239 
XP_003059495  148 EPPPPD--------------------Pe------------WV-------------WNAWLAkP-------LND-LCIPra 174 
Q57WG4        202 ----------------------------------------FVsskdgngpqfhsdWSRQLRkPfit--agVES-CCSV-- 236  Trypanosoma b...
XP_003283904  283 PFQYCS--------------------E-------------FA-------------WNEWMRkP-------FEN-ASLShl 308 
EFA80244      221 PDQFSP--------------------E-------------FT-------------WNEWLRrP-------FRT-FSLPfl 246 
EGG23944      369 PYQFNS--------------------E-------------FT-------------WNEWIRrP-------FDQ-VSLSnl 394 
Q54X05        323 PHQYCS--------------------E-------------FT-------------WNEWMRkP-------FEN-ASLShl 348  Dictyostelium...
7K1W_F        261 ---IIHGFCgq-------------------skLliygRPvYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILC- 317 
EDO07509      272 ---LIQGYVgy-------------------mqQlwnqKNlQIMLIGRRCVYRSGTRLNARGIDVEGHVGNFVESELRIRv 329 
Q7RJM2        737 ---IIQGYIsy-------------------tsIemnkKRiELFLVSRRSSILGGTRFNKRGINDDGYVANFVESEQIIRi 794  Plasmodium yo...
XP_002953781  240 ---LLQGLCesr------------------llEdfdnAKyWVACISRRGCLHPGPRYKARGLNDYAEPGNELEVEQVIWr 298 
XP_003059495  175 cpaLLQGLAesralid------------------avgapwRVAVFGRRSRAHPGTRYIARGLNADAAPGNEVEMEQIAWr 236 
Q57WG4        237 ---LLRGFAaek------------------evLlkdgSIlHVLLCGRQNNLNPGPRYFGRGLNAVNAVGNDHVYEYVMWr 295  Trypanosoma b...
XP_003283904  309 cvvLLQGYVsi--------------------kPlstlNA-SIGYIMKRSKLNPGTHFFSPGINENASPANEYENELIMWk 367 
EFA80244      247 cvvLLQGYAsikqlnnssksllplnspittnlIhktkNLaSICYLMKKSKLNPETYFYGHGINDKGGAANEYECEIILWr 326 
EGG23944      395 cvvLLQGYAsi--------------------rYiqalNT-TTCYIMKRSKLNPETLYHGHGINDRAGASNEYECEIIMWk 453 
Q54X05        349 cvvLLQGYAsv--------------------kSisnlNV-SIAYLMKRSKLNPGTHFYSPGINENASPANEYESELIMWk 407  Dictyostelium...
7K1W_F        318 DASv---------------------------------------------------------------------------- 321 
EDO07509      330 DQ------------------------------------------------------------------------------ 331 
Q7RJM2        795 DNRdnifyksrfdkvdvdsyvkkidvskdkengeikmkkslygmegkvmknkvpstkeidenkyegk-eiemkcfnkllv 873  Plasmodium yo...
XP_002953781  299 QQQr---------------------------------------------------------------------------- 302 
XP_003059495  237 EEEeeeeekggpetkgndasa----------------------------------------------------------- 257 
Q57WG4        296 QGG----------------------------------------------------------------------------- 298  Trypanosoma b...
XP_003283904  368 YEDqqiiisspdssknnnnannnntgvnskdskdvnnsdn---------------------------------------- 407 
EFA80244      327 LT------------------------------------------------------------------------------ 328 
EGG23944      454 YT------------------------------------------------------------------------------ 455 
Q54X05        408 VQDkqsilinniasssnsnlsdldkksnsnnnnnnnnnnnnnnnnnnststasttatataissslsissttaslslssss 487  Dictyostelium...
7K1W_F        322 --------------------------------------------------mSFTagsySSYVQVRGSVPLYWSQDIst-- 349 
EDO07509      332 ----------------------------------------------------GSw---KSFVQIRGSVPVFWGQRNif-- 354 
Q7RJM2        874 dnnsnqeiisksdasekemkptkmniyrniinkhiykrtnelnrnkclnnlLNFenriISLVQIRGSVPLFWKQHSm--- 950  Plasmodium yo...
XP_002953781  303 ---------------------------------------------------DGSlllwSRYTWRRGSAPLWWGVSIknng 331 
XP_003059495  258 ---------------------------------sagggviggetnqnqtpkKTArarwSAYVWRRGSVPIRWGQEIkqs- 303 
Q57WG4        299 ---------------------------------------------------GNGpiqfAKHTILRGTVPVHWSTRIskt- 326  Trypanosoma b...
XP_003283904  408 ---------------snnsdekkhkedekhenhdnskketnlknenivfksGDKvikwTSHIWRRGTVPLWWRAFSknqg 472 
EFA80244      329 ---------------------------------------------------GINtiswTSYLWRRGTIPLWWRARSkhqg 357 
EGG23944      456 ---------------------------------------------------TSQtiqwTSNVWRRGTIPIWWRSRLkqng 484 
Q54X05        488 tapntitttstaipkvdlnknndtddsnnnnnsnggltnnttniipnnnniNEKviqwTSHVWRRGTVPLWWRAFSknqg 567  Dictyostelium...
7K1W_F        350 ----------mMp---KPPitldq-adpfaHVAALHFD----QM--FQRF---------------------GsP----II 384 
EDO07509      355 ----------aHpyftRPIne-------seQAFLLHYR----HL--QRLF---------------------GeDv--dVC 388 
Q7RJM2        951 ----------------SSHvniqrssllsiKAFKEHNK----KL--IHNY---------------------GnN----IY 983  Plasmodium yo...
XP_002953781  332 ig--------eaeikiRPHnt--------fKGSKRYVR----RL--QERYtpnpqldpdppvagadgepsrHvP----VT 385 
XP_003059495  304 --------------igDAEitvaa--ddpyAGTATYFR----KLveTSRPpasavggdgg--ggaaepaspPfP----VT 357 
Q57WG4        327 --------------isEPAmmfsqnkeevlRGCDSYFSfvftQLvaIMRYdsgeq------------ltgrGpR----LR 376  Trypanosoma b...
XP_003283904  473 nei-elflkdrGkdnpNPF-----------EKSEIYYQ----NL--LNRYqkfye-----------ynkdsNlAgipsIQ 523 
EFA80244      358 nd---------llvkdNPF-----------EYSDKYFT----GI--LDRYssi---------------yetNtAalptIN 396 
EGG23944      485 sd---------lqvkdNAF-----------ENSEQYYL----NL--LNRYqhf---------------ydnNkNslpnIN 523 
Q54X05        568 sneielflkdrGkenpNPF-----------EKSESYYQ----NL--LNRYekfyq-----------enkdtNlAgiptIQ 619  Dictyostelium...
7K1W_F        385 ILNLVke--rEKrk-------hERILSEELVAAVTYLNqf------------lpPEhtIVYIPWDMAKYTK 434 
EDO07509      389 MLTLL-----DNkaseiflleaIDHLNHTFDYL----------------------P--IHLVKYNYNVKVK 430 
Q7RJM2        984 YINLL-----SQnk------nnEKKLTKKLIELINCVKkddt--------ykekDF--LNYIEYDFHISVK 1033 Plasmodium yoelii yoelii
XP_002953781  386 FVSLLrkglpDRdr-------sEAKLASAFDFVVAQLRke------------hgMN--LTYIALDWHEMDK 435 
XP_003059495  358 CVNLLrcapgKP----------EMVLSEHFHEAVRGVRkgtnpdsraspptpssAA--LAVVNFDWHGNMK 416 
Q57WG4        377 CVNMLr----QShh------ssEEALTKHFTEAVTKSQaalqq-------afpgSQ--LDLVHVDWLNMLK 428  Trypanosoma brucei
XP_003283904  524 LVDLLkqegdKQ----------ELILSQLYQKCCENVIsy------------lnVD--LQIYSFDWINSLK 570 
EFA80244      397 LVSLLkm-ddPQ----------EGPLGQLYQKLCNRVAst------------vnLN--LNLQSFDWHIHLK 442 
EGG23944      524 LVNLLkt-ddPQ----------ESLLSQLYQKSCEKVMsl------------vnVN--LNLISFDWSGILK 569 
Q54X05        620 LINLLkqendKQ----------EVILSQLYQKSCENVTty------------lnVD--LQMYTFDWINILK 666  Dictyostelium discoide...
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