Conserved Protein Domain Family
Dishevelled

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pfam02377: Dishevelled (This model is not part of the current CDD release)
Dishevelled specific domain
This domain is specific to the signalling protein dishevelled. The domain is found adjacent to the PDZ domain pfam00595, often in conjunction with DEP (pfam00610) and DIX (pfam00778). Much of it is disordered and yet conserved.
Statistics
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PSSM-Id: 514898
Aligned: 14 rows
Threshold Bit Score: 76.3841
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_571832     86 SDGCSVAESQSE-----RPP-SHERSQGIGDSRPPSFHPKAA-GSRH-GVDDETETDSVVShrrdRDRD-RSRRKHSHEH 156
XP_028917704  87 EPGSVGPDNPPE-----LPP-PMERTGGIGDSRPPSFHPHTG-GSQE-NLDNDTETDSLVS----AQRE-RPRRRDGPEH 153
EEC06168      11 DNASQCTETPSQrletrLAP---ERS---GDGRPPSFHPNLF-DCRD-GDTTFTESESMQSh-------sSLPSSVGSLA 75 
EDO39599      95 DQQSIISASPSD-----LHV-PVQRTGGIGDSRPPSFHH----GGHStAGDFDSEVDSTISs--rRGGSsRRKERHSSRG 162
3_pfamImport   1 GSDLVSIATPTD-----VAPpPTERMGGIGDSRPPSFQPV----SPPpGGEGETGGEQVDLf--rRRRQrRRRRPETSRM 69 
4_pfamImport   1 DTPSVATPSS-------LAPpPIERTGGIGDSRPPSFHAAAVcH-------DDLQGSEVKSp--aPSSEkQRRR------ 58 
NP_001165527 105 ESRTELVPPPPP-----LPPlPPERTSGIGDSRPPSFHPNVS-SSHE-NLEPETETESVVSl--rRDRP-RRRDSSEHGA 174
XP_003966937  92 vvppvettaqpsppppplppppAERTGGIGDSRPPSFHPNAT-GSVE-TLDDQTETESVVSf--rRERP-RHRESMEPH- 165 torafugu
XP_015152606  90 DTGSQCTESHAD-----LPP-PIERTGGIGDSRPPSFHPNAA-SSRD-GLDNETGTESVISh--rRDRH-RRRNREGHED 158 chicken
NP_001343310  90 DAGSQGTDSHTD-----LPP-PLERTGGIGDSRPPSFHPNVA-SSRD-GMDNETGTESMVSh--rRERA-RRRNRDE--- 155 house mouse
NP_571832    157 sGGKQNG-YSRGG---R--GMDLGGYdicDSRSSLMSSELESSSCFDS-DDGSTSRFSSVTEQSGSSKLMtKKPRRRRRK 229
XP_028917704 154 -VPRVNG-TAKGE---R--RREPGGY---DSSSTLMSSELETTSFFDSdEDDSTSRFSSSTEQSSASRLM-RRHKRRRRK 222
EEC06168      76 vAGRSNG-HAKGAhgmR-------QY---ETPSVLTTSDIETTSFLDSeDE-TTSRISTTTEESSVSRIY-ARHRRRRRK 142
EDO39599     163 iGHRSH--RSGVRqgeR------------FDTTSTMSSDIETTSYMDSsDD--QSRFSSTTE---GSHLLsGRHRRRRRR 223
3_pfamImport  70 eRPH-HP-HGGQQg-dAgaRPNPLS----SSGSSEESSCLETTSFCSSeED-SGGRFSQSAEQSSSSPRLvRRQRRRRRR 141
4_pfamImport  59 -GGHLNG-HAHQAadhKgaGPAGGG----DSSSNQQSSELETTSFCSSeED-SGGRFSQSTGQSSSSPRLiRRQRRRHRK 131
NP_001165527 175 -GGHRPGvPSRLE---R----HLAGY---ESSSTLMTSELESTSLGDSdEDDSMSRFSSSTEQSSASRLL-KRH-RRRRK 241
XP_003966937 166 -GPRMNG-QSRLE---R----HLAGY---ESSSTMMSSELETTSFCDSeDDDTMSRFSSATEQSTASRLL-KRH-RRRRK 231 torafugu
XP_015152606 159 -VPRING-HPKLD---Rh-REHPPGY---DSSSTMMSSELESSSFIDSdDDDNTSRLSSSTEQSTSSRLI-RKHKRRRRK 228 chicken
NP_001343310 156 -AARTNG-HPRGD---R--RRDLGLPp--DSASTVLSSELESSSFIDSdEEDNTSRLSSSTEQSTSSRLV-RKHKCRRRK 225 house mouse
NP_571832    230 TRAQQMERSSSFSSITDSTMSL 251
XP_028917704 223 QKVPRIERSSSFSSITDSTMSL 244
EEC06168     143 -KMPPMSRVRAFTSVLFSFFCY 163
EDO39599     224 PRMPRVQRCSSFSTITESTMSL 245
3_pfamImport 142 PETSRMERSASFSSITDSTMSV 163
4_pfamImport 132 PKTPRMEKSASFSSVTDSTMSL 153
NP_001165527 242 QRPPRMERTSSFSSVTDSTMSL 263
XP_003966937 232 QRPPRLERTSSFSSMTDSTMSL 253 torafugu
XP_015152606 229 QRMRQIDRSSSFSSITDSTMSL 250 chicken
NP_001343310 226 QRLRQTDRASSFSSITDSTMSL 247 house mouse
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