Conserved Protein Domain Family
Dishevelled

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pfam02377: Dishevelled 
Dishevelled specific domain
This domain is specific to the signalling protein dishevelled. The domain is found adjacent to the PDZ domain pfam00595, often in conjunction with DEP (pfam00610) and DIX (pfam00778). Much of it is disordered and yet conserved.
Statistics
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PSSM-Id: 460544
Aligned: 17 rows
Threshold Bit Score: 73.2463
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_571832     86 SDGCSVAESQSE-----RPP-SHERSQGIGDSRPPSFHPKAA-GSRH-GVD-DETETDSVVShr-rdRDRD-RSRRKHSH 154
EKC26253      87 DTQSQCTDSGTG-----DVHvPQERVGGIGDSRPPSFHANASvGSRDqTCD-TCTETDSVLSsrrdgRSRHyRNHHRLNN 160
EEC06168      11 DNASQCTETPSQrletrLAP---ERS---GDGRPPSFHPNLF-DCRD-GDT-TFTESESMQSh--------sSLPSSVGS 73 
3_pfamImport   1 DGTSQCTESASH-----------------SDGKNPSERHKDHhGVHGhPEDlAYTETESVISs---rPGAHhGHHEARGH 60 
XP_003127548  90 DAGSQGTDGHAD-----LPP-PLERTGGIGDSRPPSFHPNVA-SSRD-GMD-NETGTESVVSh---rRERA-RRRNREE- 155
1_pfamImport   1 GSDLVSIATPTD-----VAPpPTERMGGIGDSRPPSFQPV----SPPpGGE-GETGGEQVDLf---rRRRQrRRRRPETS 67 
XP_023207223  93 DTPSVATPSS-------LAPpPIERTGGIGDSRPPSFHAAAVcH--------DDLQGSEVKSp---aPSSEkQRRR---- 150
XP_022534185  95 EVRPQPSPPPPP-----LPPpPAERTGGIGDSRPPSFHPNAA-GSVE-TLD-EQTETESVVSf---rRERP-RHRENMEP 162
EDM04961     105 ESRTELVPPPPP-----LPPlPPERTSGIGDSRPPSFHPNVS-SSHE-NLE-PETETESVVSl---rRDRP-RRRDSSEH 172
XP_009073270  33 DTGSQCTESHTD-----LPP-PIERTGGIGDSRPPSFHPNAA-SSRD-GLD-NETGTESVISh---rRDRH-RRRNREGH 99  rifleman
NP_571832    155 EHsGGKQNG-YSRGG---R--GMDLGGYdicDSRSSLMSSELESSSCFDS--DDGSTSRFSSVTEQSGS----SKLMtKK 222
EKC26253     161 DPnAPRLNG-HPKRD---R----HRHMY---GDTSTMASSDLDTTSFFDSe-DD---SRFSTVTDTTNR----SSSRyGR 221
EEC06168      74 LAvAGRSNG-HAKGAhgmR-------QY---ETPSVLTTSDIETTSFLDSe-DE-TTSRISTTTEESSV----SRIY-AR 135
3_pfamImport  61 DK-YLKFNG-HHH-----RgpPPSHGHHhhhYESSSILSSEIETTSFLENleDDDASSRITTTTGRATNlsvdRATLgRR 133
XP_003127548 156 ---AARTNG-HPRGD---R--RRDLGLPp--DSASTVLSSELESSSFIDSd-EDDNTSRLSSSTEQSTS----SRLI-RK 218
1_pfamImport  68 RMeRPH-HP-HGGQQg-dAgaRPNPLS----SSGSSEESSCLETTSFCSSe-ED-SGGRFSQSAEQSSS----SPRLvRR 134
XP_023207223 151 ---GGHLNG-HAHQAadhKgaGPAGGG----DSSSNQQSSELETTSFCSSe-ED-SGGRFSQSTGQSSS----SPRLiRR 216
XP_022534185 163 HV-GPRMNG-PSRLE---R----HLAGY---ESATTVMSSELDTTSFCDSd-DDDTMSRFSSSTEQSTA----SRLL-KR 224
EDM04961     173 GA-GGHRPGvPSRLE---R----HLAGY---ESSSTLMTSELESTSLGDSd-EDDSMSRFSSSTEQSSA----SRLL-KR 235
XP_009073270 100 ED-VPRLNG-HPKLD---Rh-REHPPGY---DSSSTMMSSELESSSFIDSe-DDDNTSRLSSSTEQSTS----SRLI-RK 164 rifleman
NP_571832    223 PRRRRRKTRAQQMERSSSFSSITDSTMSL 251
EKC26253     222 QRRRRRKHKLPPISRASSFSSITDSTMSL 250
EEC06168     136 HRRRRRK-KMPPMSRVRAFTSVLFSFFCY 163
3_pfamImport 134 RPQRRRRHRAP-MSRTSSYSSITDSTMSL 161
XP_003127548 219 HKRRRRKQRMRQTDRASSFSSITDSTMSL 247
1_pfamImport 135 QRRRRRRPETSRMERSASFSSITDSTMSV 163
XP_023207223 217 QRRRHRKPKTPRMEKSASFSSVTDSTMSL 245
XP_022534185 225 H-RRRRKQRPPRLERASSFSSVTDSTMSL 252
EDM04961     236 H-RRRRKQRPPRMERTSSFSSVTDSTMSL 263
XP_009073270 165 HKRRRRKQRMRQIDRSSSFSSITDSTMSL 193 rifleman
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