Conserved Protein Domain Family
Latrophilin

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pfam02354: Latrophilin 
Latrophilin Cytoplasmic C-terminal region
This family consists of the cytoplasmic C-terminal region in latrophilin. Latrophilin is a synaptic Ca2+ independent alpha- latrotoxin (LTX) receptor and is a novel member of the secretin family of G-protein coupled receptors that are involved in secretion. Latrophilin mRNA is present only in neuronal tissue. Lactrophillin interacts with G-alpha O.
Statistics
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PSSM-Id: 460538
Aligned: 10 rows
Threshold Bit Score: 492.461
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_021330394 1105 RHSYCCSrt-stTSSHGSLKNSALRTNNRYYTGSqtrhaavhrQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMG 1183
O88917       1151 RHIHQVS-----LGPRGRSALPESQKDPGGQSGPgdpltfglcPSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMG 1225 Norway rat
XP_005170999 1123 R-THCCSgksveSTISTSTKTSTARTPGRYSTNS---------QSRIRRMWNDTVRKQSESSFITADMNSSATLNRGTMA 1192
XP_021322317  535 RQSQCCRth-psEGPHSVNKSSASRSTARYSSAT---------QSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTG 604 
XP_015204622 1147 RHSYCCSrt-snANSHGSLKTSAMRTNNRYYTGSqarhgsahrQSRIRRMWNDTVRKQTESSFMAGDINSTPSLNRATMG 1225 spotted gar
AWP03986     1106 RQSQCCGal-psEGSHSSAKAATSRSTARYSSAT---------QSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTG 1175 turbot
XP_025756156  991 RQSQCCGal-psEGSHSSAKTATSRSTARYSSAT---------QSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTG 1060 Nile tilapia
XP_023809941 1102 RHTYCCGgltatESSHGSAKTSATRTSARYSSGT---------QSRIRRMWNDTVRKQSESSFISGDINSTSTLNQG--- 1169 Japanese medaka
XP_031602951 1133 R-THCCSgksveTSISSSSKTTTSRTPGRYSTGS---------QSRIRRMWNDTVRKQ-ESSFITGDINSSATLNRGAMA 1201 Oreochromis a...
XP_016846886  933 RHASCCLrs-ppGATLGSLKTSAIRSNNRYYTGT---------QSRIRRMWNDTVRKQTESSFMAGDLNSTPTLNRGTMG 1002 green anole
XP_021330394 1184 NHLLTNPVLQTRTGSSPYNTLLAET--FTPPSPGVFNST------GtfrdpKSTLSkN-RDHGGMETLPLNGNFNNSYSL 1254
O88917       1226 NHLLTNPVLQPRGGTSPYNTLIAESvgFNPSSPPVFNSP------GsyrepKHPLG-G-REACGMDTLPLNGNFNNSYSL 1297 Norway rat
XP_005170999 1193 NHLISNALLRPHGT-NPYNTLLGESavYNNPTANMFNTQ------E------GILNnA-RDSSVMDTLPLNGNHGNSYGV 1258
XP_021322317  605 NYLLTNPLLRPHDTNNRYNNLLAETivCSTPSPPAFHSP------G-----QRSLSnS-RDVSTMDTLPLNDNFNNSYSL 672 
XP_015204622 1226 NHLLTNPVLQTRSGTSPYNTLLAESvgFNPPSPNVFNST------GtfrdpKSTLSkS-RDTCGMETLPLNGNFNNSYSL 1298 spotted gar
AWP03986     1176 NYLLTNPLLRTHDT-NPYNNLLAETvvCNTPSPPAFHSP------G-----QHSLSnS-RDISAMDTLPLNGNFNNSYSL 1242 turbot
XP_025756156 1061 NYLLTNPLLRTHDT-NPYNNLLAETvvCNTPSPPAFHSP------Gq-----qSLSnS-RDISAMDTLPLNGNFNNSYSL 1127 Nile tilapia
XP_023809941 1170 ----------------------------------------------------HSMNnAvRDTSAMDTLPLNGNFNNSYSL 1197 Japanese medaka
XP_031602951 1202 NHLITNALLRPHGTNNPYNTLLGDSavYNNPAVGMYNTQapyrdtK------GILNnA-RDSSVMDTLPLNGNHANNYSM 1274 Oreochromis a...
XP_016846886 1003 NHLLTNPVLQTRGGTSPYNTLIAESvgFNPASPPVFNSP------GsfresKHPLNnS-RDACGMDTLPLNGNFNNSYSL 1075 green anole
XP_021330394 1255 RSVGGSgapggscdflgggggdspppllNPRGSETLGGi----RRNLSDaAAFEKMIISELVHNNLR------------- 1317
O88917       1298 RSGDFP----------------------PGDGGPEPPR-----GRNLADaAAFEKMIISELVHNNLR------------- 1337 Norway rat
XP_005170999 1259 AAGDYL----------------------------TYSS-----RGSEPP-TTLEKKILKELTANYAP------------- 1291
XP_021322317  673 REDDYE----------------------DPAITCPTGC-----EIRLDD-AAFEKMIISELVHNNLR------------- 711 
XP_015204622 1299 RS---Ggssdssg---------gpppllNPRGTENLGG-----RRNLSDaAAFEKMIISELVHNNLR------------- 1348 spotted gar
AWP03986     1243 REDDYEa--------------------------vAVRAagdlgALNLDD-VAFEKMIISEIVHNNLR------------- 1282 turbot
XP_025756156 1128 RDDDYE----------------------AVGVRAPGDLg----GLNLDD-ATFEKLIISEIVHNNLR------------- 1167 Nile tilapia
XP_023809941 1198 RNGDFD------------------------ESVQVVDC-----GLSLDD-AAFEKMIISELVHNNLRacnksqqqpsslr 1247 Japanese medaka
XP_031602951 1275 ASSEYLsdc-----------------vqILDRSAGYGT-----HSNHKE-TTLEKKILKELTSNYIP------------- 1318 Oreochromis a...
XP_016846886 1076 RSGDFS-----------------------ADGTKMADC-----RRNLNDaAAFEKMIISELVHNNLR------------- 1114 green anole
XP_021330394 1318 ----------GGggvgggdrtcg---slarghghlgMG--RAG-------------------GGVEPVIGmedde---df 1360
O88917       1338 ----------GA------------------------SGgaKGPppepp---------vppvpGVSEDEAG---------- 1364 Norway rat
XP_005170999 1292 ----------SYlntqerqgkahqgtltnklnnhlaNGgvAGS-------------------SSIPKDDVmvldnp-gaf 1341
XP_021322317  712 ----------PRrnqssskcqa-----drnsspqenCAdiDE--------------------GVGDRNECenaet----d 752 
XP_015204622 1349 ----------GGverggsl----------akghhssGQgaGGEsgq-------------ssrGGGGEEDAmva------- 1388 spotted gar
AWP03986     1283 ----------PRgapkgrdaqr-----dralppqtrVTvdrggggsgsedda------------------ivadhaeass 1329 turbot
XP_025756156 1168 ----------PRgapkgrdapre---rdrvlppqtrVTvdRGGg------------------GSGSEDDAivadhadass 1216 Nile tilapia
XP_023809941 1248 hplrhqqppqYHhhhhter----------appkvtvVG------------------------GRGSEGPSivad------ 1287 Japanese medaka
XP_031602951 1319 ----------SYlnnheratter---nhnlmnklvnSSmanggslaggsssssssgvggcvggSKEDNGPmvldnp--va 1383 Oreochromis a...
XP_016846886 1115 ----------GGgsgvvkggggstetsnppgpppppSVgaGGG-------------------GTNNEDDAivp------- 1158 green anole
XP_021330394 1361 rsrEARQRTPQDVEL------LYKALEEPLLLQRAQSVLYQS---------------DPDESESYTADLTESLGHSGhsa 1419
O88917       1365 ---GPGGADRAEIEL------LYKALEEPLLLPRAQSVLYQS---------------DLDESESCTAEDGATSRPLS--- 1417 Norway rat
XP_005170999 1342 hrhDD--GGGLSLEL------IREESQAPLLPPRPPPPENHAplhtft----ahrrlPQENSESFFPLLPNDTHSSHtht 1409
XP_021322317  753 tsaMPLSSCHPAMELlllnpnHREALEVPLLPQRTHSLIYASqkv----------irPHKISRDTQQDEGEVKKEDD--- 819 
XP_015204622 1389 ----dapQENIDIEL------MYKALEEPLLLQRAQSILYQS---------------DPEESESYTAELTEGLDAQL--- 1440 spotted gar
AWP03986     1330 pqrGSGRGGHTTLELllh-phHKEALEAPLLPQRTHSLLYSNqkaprrlegqgghgsETVTTMEDTGS------------ 1396 turbot
XP_025756156 1217 pqrGSGRGGHATLELllh-phHKEVLEAPLLPQRTHSLLYSSqka---------prcLEGQSSHGSETVTAEEDMGS--- 1283 Nile tilapia
XP_023809941 1288 assLVHVSDAVGLELh-----NQQDLEAPLIPQRTHSLLYAPqkk----------vkTDGEVDTFVSQLTPTNPDDNl-- 1350 Japanese medaka
XP_031602951 1384 fphEE----NLGLEI------IREESNAPLLPPRPPPPDSHPpppppphsfsrprriPQETSESFFPLLTNEHTDEHt-- 1451 Oreochromis a...
XP_016846886 1159 dapSLTHEENMEIEL------MYKALEEPLLLQRAQSILYQS---------------DLEESESCTADLTEGGDGQA--- 1214 green anole
XP_021330394 1420 qsaagqghsgppDSP--ARDSLYTSITNLRD--SP------YPDSSP-------EPLEVV----PRSAQP---------- 1468
O88917       1418 ------------SPP--GRDSLYASGANLRD--SPs-----YPDSSP-------EGPNEA----LPPPPPap-------- 1457 Norway rat
XP_005170999 1410 p-------rahtHSP--LRDSLYTSMPTLTD--LP--------HGTD-------DLINGL----HDDEDEeeeedgeeee 1459
XP_021322317  820 ------------SSPn-NRDSLYTSMPNLKD--SD--------LVIG-------EEENSP----CSSAQSe--------- 856 
XP_015204622 1441 ------------QSP--NRDSLYTSMTNLRD--SP------YPDSSP-------EPLEVV----PRSAQP---------- 1477 spotted gar
AWP03986     1397 ------------HSPnnNRDSLYTSMPNLRDspSP--------SALPyp----pEEEEEEedelSPSPRSe--------- 1443 turbot
XP_025756156 1284 ------------HSPsnNRDSLYTSMPNLRD--SP------SPSASPyppeeeeEEEEEL----SPSPQSe--------- 1330 Nile tilapia
XP_023809941 1351 ------------ESP--NRDSLYTSMPNLRD--SP------CPESSP-------DVVEDL----SPTKESe--------- 1388 Japanese medaka
XP_031602951 1452 ------------HSPn-HRDSLYTSMPVLTD--LPdgqmngLTDGEE-------DSSGEL----QPCKSAta-------- 1497 Oreochromis a...
XP_016846886 1215 ------------PSP--NRDSLYTSMTNLRD--SP------YPDSSP-------EAVGEV----LPHAQA---------- 1251 green anole
XP_021330394 1469 ---------------PEELYYSSgRPAIGSRGa--PMQTFYQAppRRPSTEAHPAP---E--APHSEG----DGQMQLVT 1522
O88917       1458 -------------pgPPEIYYTSrPPALVARN---PLQGYYQV--RRPSHEGYLAApslE--GPGPDG----DGQMQLVT 1513 Norway rat
XP_005170999 1460 gselhlangkgvimeSDDVYYKS-MPNLGSRNhiqELESYYQM--GRGGSDGFIAPpekE--DSSPEEq--pPDPSQLVT 1532
XP_021322317  857 ---------------TQEQCCKS-LPDLGDGT---PAMSYYQI----------SASlslE--AESAND-----GQMQLIT 900 
XP_015204622 1478 ---------------PEELYYGSgRPAMGSRG---QMQTFYQPqaRRPSGEGYLVQvgmE--PGMSEG----DGQMQLVT 1533 spotted gar
AWP03986     1444 ---------------SEDAYHKS-MPELGDAP---QPLSYYHI--NRGTSDGCIISpnnE--DCAQEGeapsDGQMQLIT 1500 turbot
XP_025756156 1331 ---------------SEDAYHKS-MPELGDAP---QPLSYYHI--NRGTSDGCIIPpnnE--DCAHDGeapaDGQMQLIT 1387 Nile tilapia
XP_023809941 1389 ---------------SEDVYYKS-MPNLGAGH---QLQAYYQI--GQENHDGYIIPvtkE--DCITEGdv-rEGQMQLVT 1444 Japanese medaka
XP_031602951 1498 -------------peLDDVYYKS-MPNLGSRNhlhELQSYYHM--GRGGSDGYMVSgskDesDSSPEEp--pVDPSHLVT 1559 Oreochromis a...
XP_016846886 1252 ---------------INEIYYTN-RPALVPRN---QLQAYYQV--RRPSNDGYLVPgslE--NPAVEG----DGQMQLVT 1304 green anole
XP_021330394 1523 SL 1524
O88917       1514 SL 1515 Norway rat
XP_005170999 1533 SL 1534
XP_021322317  901 SL 902 
XP_015204622 1534 SL 1535 spotted gar
AWP03986     1501 SL 1502 turbot
XP_025756156 1388 SL 1389 Nile tilapia
XP_023809941 1445 SL 1446 Japanese medaka
XP_031602951 1560 SL 1561 Oreochromis aureus
XP_016846886 1305 SL 1306 green anole
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