Conserved Protein Domain Family
Latrophilin

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pfam02354: Latrophilin (This model is not part of the current CDD release)
Latrophilin Cytoplasmic C-terminal region
This family consists of the cytoplasmic C-terminal region in latrophilin. Latrophilin is a synaptic Ca2+ independent alpha- latrotoxin (LTX) receptor and is a novel member of the secretin family of G-protein coupled receptors that are involved in secretion. Latrophilin mRNA is present only in neuronal tissue. Lactrophillin interacts with G-alpha O.
Statistics
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PSSM-Id: 514881
Aligned: 8 rows
Threshold Bit Score: 411.185
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O88917       1151 RHIHQVS-----LGPRGRSALPESQKDPGGQSGPgdpltfglcPSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGtmg 1225 Norway rat
5_pfamImport    1 RHTYCCGgltatESSHGSAKTSATRTSARYSSGT---------QSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGh-- 69  
1_pfamImport    1 RQSQCCGal-paEGPHAAAKAATSRSTARYSSAT---------QSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGmtg 70  
2_pfamImport    1 RHSYCCSrt-snANSHGSLKTSAMRTNNRYYTGSqarhgsahrQSRIRRMWNDTVRKQTESSFMAGDINSTPSLNRAtmg 79  
XP_029686909 1088 RQSQCCGal-ppEGPHA-AKAATSRSTAHYSSAT---------QSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGmtg 1156 torafugu
XP_029706211 1128 R-THCCSgksveTSLSSSSKTTTSRTPGRYSTGS---------QSRIRRMWNDTVRKQ-ESSFITGDINSSATLNRGama 1196 torafugu
XP_068075512 1100 RHSYCCSrt-stTSSHGSLKNSALRTNNRYYTGSqtrhaavhrQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGtmg 1178 zebrafish
XP_056707005  933 RHASCCLrs-ppGATLGSLKTSAIRSNNRYYTGT---------QSRIRRMWNDTVRKQTESSFMAGDLNSTPTLNRGtmg 1002 tarantolino
O88917       1226 nhlltnpvlqprggtspyntliaesvgfnpssppvfnspgsyrepkhPLG-G-REACGMDTLPLNGNFNNSYSLRSGDFP 1303 Norway rat
5_pfamImport   70 -----------------------------------------------SMNnAvRDTSAMDTLPLNGNFNNSYSLRNGDFD 102 
1_pfamImport   71 nylltnpllrthdtnpynn------llaetvvcntpsppafhspgqhSLSnS-RDISAMDTLPLNGNFNNSYSLRDDTYE 143 
2_pfamImport   80 nhlltnpvlqtrsgtspyntllaesvgfnppspnvfnstgtfrdpksTLSkS-RDTCGMETLPLNGNFNNSYSLRSVGPG 158 
XP_029686909 1157 nylltnpllrthdtnpynn------llaetvvcntpsppafhspgqqSLSnS-RDISAMDTLPLNGNFNNSYSLRDDDYE 1229 torafugu
XP_029706211 1197 nhlltnallrphgtnnpyntllgdsavynnpavgmyntqapyrdtksILNnA-RDSGVMDTLPLNGNHANNYSMASSEYL 1275 torafugu
XP_068075512 1179 nhlltnpvlqtrtgsspyntl--laetftppspgvfnstgtfrdpksTLSkN-RDHGGMETLPLNGNFNNSYSLRSVGGS 1255 zebrafish
XP_056707005 1003 nhlltnpvlqtrggtspyntliaesvgfnpasppvfnspgsfreskhPLNnS-RDACGMDTLPLNGNFNNSYSLRSGDFP 1081 tarantolino
O88917       1304 p----------------------gDGGPEPPR-----GRNLADaAAFEKMIISELVHNNLRGA----------------- 1339 Norway rat
5_pfamImport  103 ------------------------ESVQVVDC-----GLSLDD-AAFEKMIISELVHNNLRYHhhhhter---------- 142 
1_pfamImport  144 ----------------------------SVRAagdlgGLHLDD-VAFEKMIISEIVHNNLRPRggpkgrdhpre---qer 191 
2_pfamImport  159 gaggcdflggd--ssggpppllnpRGTENLGG-----RRNLSDaAAFEKMIISELVHNNLRGGverggsl---------- 221 
XP_029686909 1230 a----------------------vGVRGPGELg----GLNLDD-AAFEKMIISEIVHNNLRPRgapkgrdapre---rdr 1279 torafugu
XP_029706211 1276 sdcv-----------------qilERNSSYDT-----QSNHKE-TTLEKKILKELASNYIPSYlnnheratter---nhn 1329 torafugu
XP_068075512 1256 gapggscdflgggggdspppllnpRGSETLGGi----RRNLSDaAAFEKMIISELVHNNLRGGggvgggdrtcg---sla 1328 zebrafish
XP_056707005 1082 a-----------------------DGTKMADC-----RRNLSDaAAFEKMIISELVHNNLRGGgsglvkgggvsteppnp 1133 tarantolino
O88917       1340 -------SGgakgpppe-------ppvppvpGVSEDEAG-------------GPGGADRAEIEL-----LYKALEEPLLL 1387 Norway rat
5_pfamImport  143 appkvtvVG----------------------GRGSEGPSivad------assLVHVSDAVGLELh----NQQDLEAPLIP 190 
1_pfamImport  192 apppqtrLTvvadhe-------------------------------aasprrGSGRGGHATLELllhphHKEVLEAPLLP 240 
2_pfamImport  222 akghhssGQgagges-----------gqssrGGGGEEDAmva-----------dapQENIDIEL-----MYKALEEPLLL 274 
XP_029686909 1280 glppqtrLTmdr----------------gggGSGSEDDAivadhaessppqrGSARGGHTTLELllhphHKEVLEAPLLP 1343 torafugu
XP_029706211 1330 lmnklvnSSmanggslagvsssnagvggcmssSKADNGPivlnnh--gtfphEE----NLGLEM-----IREESNAPLLP 1398 torafugu
XP_068075512 1329 rghghlgMGra-------------------gGGVEPVIGmedde---dfrsrEARQRTPQDVEL-----LYKALEEPLLL 1381 zebrafish
XP_056707005 1134 pvpppppSVaag-----------------ggGANSEDDAivp-------dapSLTHEENMEIEL-----MYKALEEPLLL 1184 tarantolino
O88917       1388 PRAQSVLYQS---------------DLDESESCTAEDGATSRPLS---------------SPP--GRDSLYASGANLRDS 1435 Norway rat
5_pfamImport  191 QRTHSLLYAPqkk----------vkTDGEVDTFVSQLTPTNPDDNl--------------ESP--NRDSLYTSMPNLRDS 244 
1_pfamImport  241 QRTHSLLYSAqkaprrl--egpggsEAVTAAETPAP------------------------SRP--NRDSLYTSMPNLRDS 292 
2_pfamImport  275 QRAQSILYQS---------------DPEESESYTAELTEGLDAQL---------------QSP--NRDSLYTSMTNLRDS 322 
XP_029686909 1344 QRTHSLLYSAqka---------prnMEGQGGHGSETVTAVEDTGS---------------HSPsnNRDSLYTSMPNLRD- 1398 torafugu
XP_029706211 1399 PRPPPPDSHPpppppphgfsrprriPQETSESFFPLLTNDHADEHt--------------HSPt-HRDSLYTSMPVLTDL 1463 torafugu
XP_068075512 1382 QRAQSVLYQS---------------DPDESESYTADLTESLGHSGhsaqsaagqghsgppDSP--ARDSLYTSITNLRDS 1444 zebrafish
XP_056707005 1185 QRAQSILYQS---------------DLEESESCTADLTEGGDGQA---------------PSP--NRDSLYTSMTNLRDS 1232 tarantolino
O88917       1436 Ps-----YPDSSP---EGPNEALPPPPPappgPPEIYYTSrPPALVARN---PLQGYYQV--RRPSHEGYLAApslE--G 1500 Norway rat
5_pfamImport  245 P------CPESSP---DVVEDLSPTKESe---SEDVYYKS-MPNLGAGH---QLQAYYQI--GQENHDGYIIPvtkE--D 304 
1_pfamImport  293 P--------SASPyppDGEQLASSSPRSe---SEDAYHKS-MPELGDGP---QPLSYYHI--NRGTSDGCIPPpggE--G 353 
2_pfamImport  323 P------YPDSSP---EPLEVVPRSAQP----PEELYYGSgRPAMGSRG---QMQTFYQPqaRRPSGEGYLVQvgmE--P 384 
XP_029686909 1399 -------SPSASPyplDEDEELSPSPRSe---GEDGYHKS-MPELGDTP---QPVSYYHI--NRGASDGCIISpnnE--E 1460 torafugu
XP_029706211 1464 PdvqmngLTDGEE---DSSGELQPCKSAtapeLDDVYYKS-MPNLGSRNhlhELQSYYHM--GRGGSDGYVVSgskDesD 1537 torafugu
XP_068075512 1445 P------YPDSSP---EPLEVVPRSAQP----PEELYYSSgRPAIGSRGa--PMQTFYQAppRRPSTEAHPAP---E--A 1504 zebrafish
XP_056707005 1233 P------YPDSSP---EAVGEVLPHAQA----INEIYYTN-RPALVPRN---QLQAYYQV--RRPSNDGYLVPgslE--G 1291 tarantolino
O88917       1501 PGPDG----DGQMQLVTSL 1515 Norway rat
5_pfamImport  305 CITEGdv-rEGQMQLVTSL 322 
1_pfamImport  354 CAQEGaepaDGQMQLITSL 372 
2_pfamImport  385 GMSEG----DGQMQLVTSL 399 
XP_029686909 1461 CVPEGgapnDGQMQLITSL 1479 torafugu
XP_029706211 1538 SSPEEp--pIDPSHLVTSL 1554 torafugu
XP_068075512 1505 PHSEG----DGQMQLVTSL 1519 zebrafish
XP_056707005 1292 PAVEG----DGQMQLVTSL 1306 tarantolino
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