5MR4,5MR4,4UX8,6Q2N,2GH0,5VZ4,5VZ4


Conserved Protein Domain Family
GDNF

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pfam02351: GDNF (This model is not part of the current CDD release)
GDNF/GAS1 domain
This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.
Statistics
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PSSM-Id: 514878
Aligned: 109 rows
Threshold Bit Score: 35.1861
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5MR4_C        251 CLDLRGVCRTDHLCRSRLADFHANCRASY-QTVTSCPa-------dNYQACLGSYagm-igfDMTPNYVDSSPTgiVVSP 321 human
22_pfamImport   1 CIQAKKKCQANPTCNAAYQHHLYSCIYSI-------StpspseqpsVPAECLEAA--------------QQLRN--SSLM 57 
5_pfamImport    1 CNHALTVCESSPDCRRIFDDFKNNCKVTKeNTCETNK----------PEECHRDW--------------LRLRK--TPLF 54 
XP_002126873   60 CLEALNRCKNSSNCGSAFRAVKKKCKITG-ARCDAPIs--------DQPKCAENI-----------DILRSTYF--PLDD 117
31_pfamImport   1 CFDIMKSCRRHKDCREALVKLKTKCEVRA-------------------GSCNANMrnlpvcaDIMDLLSGSQFF--DPNQ 59 
XP_026696354   60 CFDIMKSCRHHKECREALVKLKTKCAVKA-------------------GSCNTNMrnlptcaKIMDLLTNARFF--NPDQ 118
XP_029684299   33 CLRAGDACSGDDTCSPRLR-TLRQCVAGD-------Gsvkl--gpgARNQCENAM--------------TALLS--TPLH 86  torafugu
XP_041444036   36 CVHANELCTADQSCSSRYR-TLRQCLAGR----DRDAl-------lSSQECKNAM--------------EVLQE--SPLY 87  African clawed...
XP_029688427   56 CIQASEMCNQNPNCSSRYR-VMRQCLVGK-EKDAMLD---------NNRECQAAL--------------EVLLG--SPLY 108 torafugu
XP_046756386  138 CIVAEQLCLLDSLCNATYR-TLENCDLAK-TRFVTLDh-------dSRVRCLNAE--------------LYLGN--SSLL 192 chicken
5MR4_C        322 WCSCRGSG---NMEEECEKFLRDFTENPC 347 human
22_pfamImport  58 GCSCHRRM---KNQATCLDIYWTV--HHA 81 
5_pfamImport   55 GCICPQN----QVKKRCDRIFSLINENPC 79 
XP_002126873  118 KCKCYAVGlvgKKLKRCQEIRNSVYANPC 146
31_pfamImport  60 KCSC--N----KERGHCAAIHQKIYKNPC 82 
XP_026696354  119 KCSC--N----KKRGHCAAIHKKIYENPC 141
XP_029684299   87 GCQCKRGM---KKEKNCLSIYWSL--HQS 110 torafugu
XP_041444036   88 LCRCRRGM---KKELQCLQVYWGI---HA 110 African clawed frog
XP_029688427  109 DCRCKRGM---KKELQCLQNYWTI---HM 131 torafugu
XP_046756386  193 HCKCHRRM---KRQEHCLRIFWTV--HSS 216 chicken
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