1CF7,4YO2,1CF7


Conserved Protein Domain Family
E2F_TDP
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pfam02319: E2F_TDP (This model is not part of the current CDD release)
E2F/DP family winged-helix DNA-binding domain
This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Links
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Statistics
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PSSM-Id: 514856
Aligned: 159 rows
Threshold Bit Score: 39.7581
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1CF7_A          9 EKSLGLLTTKFVSLLqeakDGVLDLKLAADTLA----------------------VrQKRRIYDITNVLEGIGLIEKKSK 66  human
A0BSR6        136 QKGLRNLSVKVRDIVle-lKS-TSYKDVAQRLIqdlgsdgqiv---eldnpkdeqN-IKRRVYDALNVMIASKVLRKEGK 209 Paramecium tet...
XP_001420110   75 QKGLRHFSMRVCEKVe--eKKHTSYNEVANELVeelrvtaee-----tnadfdekN-VRRRVYDALNVLMALEIIRKK-K 145
XP_002949174   22 AGGLRLFSLKVVEKIr--sRVRTTYNAVANELVsdqnmsg--------gnardgkS-IRRRCYDAINVLLACGLIMKDDK 90 
XP_005851360    1 GKGLRHFSLKVCEKVe--sKGDTTYEEVANELIadlaaevaag---tveqlhdekN-IRRRVYDALNVLEAIGMINKN-K 73 
Q9FNY3         51 GGGLRQFSVMVCQKLe--aKKITTYKEVADEIIsdfatikqnaekplneneynekN-IRRRVYDALNVFMALDIIARD-K 126 thale cress
13_pfamImport   2 GGGLRQFSIIVCKKVe--nKRTTTYSEVADEIIaefaaahskt--avsldefdekN-IRRRVYDALNVLMALDIITRD-K 75 
XP_009392536   57 GWGLRRFSTIVCDKVk--eKGRTTYNEVADEIIyelsslekk----dlqfvfdekN-IRRRVYDAFNVLMAINVIAKD-K 128
EIJ87361        9 RTGLKAFSAMILSIMq--kEKSIEYTKVADIIMsmteg------------tgddkN-VKRRVYDALNVMCAVNLIKKE-- 71 
XP_015631692   65 GWGLREFSKIVSKKVe--aKGRTTYNEVADEIFaelksitq------nglefdekN-IRRRVYDAFNVLIAIRVIAKD-K 134 Japanese rice

1CF7_A         67 ---NSIQW---KG 73  human
A0BSR6        210 rviSDVYCkhrMR 222 Paramecium tetraurelia
XP_001420110  146 ---KEIFW---NG 152
XP_002949174   91 ---KQIVW---RG 97 
XP_005851360   74 ---KAIQW---KG 80 
Q9FNY3        127 ---KEIRW---KG 133 thale cress
13_pfamImport  76 ---KEIRW---KG 82 
XP_009392536  129 ---KEIKW---VG 135
EIJ87361       72 ---KKMAYltdNQ 81 
XP_015631692  135 ---KEIKW---MG 141 Japanese rice
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