1CF7,4YO2,1CF7


Conserved Protein Domain Family
E2F_TDP

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pfam02319: E2F_TDP 
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E2F/DP family winged-helix DNA-binding domain
This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Statistics
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PSSM-Id: 426717
Aligned: 171 rows
Threshold Bit Score: 48.572
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1CF7_A            8 HEKSLGLLTTKFVSLLqeakDGVLDLKLAADTLA-------------------VrQKRRIYDITNVLEGIGLIEKKSK-- 66  human
EIJ87361          8 ERTGLKAFSAMILSIMq--kEKSIEYTKVADIIMsmteg---------tgddkN-VKRRVYDALNVMCAVNLIKKE---- 71  Nematocida p...
XP_002996121     13 KKDGMKYITSSVYNIIk--nNDGVTYAYICENIQmts--------------kkT-LYRRIYDVLNVMKAVQIIDKKNK-- 73  Nosema ceran...
EOB15196         13 KKEGLKYIASAVYKLIk--eENGCTYSYICDNIPlpn--------------rrT-LHRRIYDVLNVMKAVNLIDSKNK-- 73  Nosema bomby...
XP_018678602     56 KGWGLRRFSTIVCDKVk--eKGRTTYNEVADEIIyelsslekk-dlqfvfdekN-IRRRVYDAFNVLMAINVIAKD-K-- 128 wild Malaysi...
XP_015688293     65 TGWGLREFSKIVSKKVe--aKGRTTYNEVADEIFaelksith---nglefdekN-IRRRVYDAFNVLIAIRVIAKD-K-- 135 malo sina
EFJ49667         21 SAGGLRLFSLKVVEKIr--sRVRTTYNAVANELVsdqnmsg-----gnardgkS-IRRRCYDAINVLLACGLIMKDDK-- 90  Volvox carte...
XP_005851360      1 -GKGLRHFSLKVCEKVe--sKGDTTYEEVANELIadlaaevaagtveqlhdekN-IRRRVYDALNVLEAIGMINKN-K-- 73  Chlorella va...
A0BSR6          135 SQKGLRNLSVKVRDIVle-lKS-TSYKDVAQRLIqdlgsdgqiveldnpkdeqN-IKRRVYDALNVMIASKVLRKEGKrv 211 Paramecium t...
jgi:OSTLU_38105  74 EQKGLRHFSMRVCEKVe--eKKHTSYNEVANELVeelrvtaee--tnadfdekN-VRRRVYDALNVLMALEIIRKK-K-- 145 Ostreococcus...
1CF7_A           67 -NSIQW---KG 73  human
EIJ87361         72 -KKMAYltdNQ 81  Nematocida parisii ERTm3
XP_002996121     74 ----KY---FM 77  Nosema ceranae BRL01
EOB15196         74 ----KY---FL 77  Nosema bombycis CQ1
XP_018678602    129 -KEIKW---VG 135 wild Malaysian banana
XP_015688293    136 -KEIKW---MG 142 malo sina
EFJ49667         91 -KQIVW---RG 97  Volvox carteri f. nagariensis
XP_005851360     74 -KAIQW---KG 80  Chlorella variabilis
A0BSR6          212 iSDVYCkhrMR 222 Paramecium tetraurelia
jgi:OSTLU_38105 146 -KEIFW---NG 152 Ostreococcus lucimarinus CCE9901
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