Conserved Protein Domain Family
HORMA

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pfam02301: HORMA (This model is not part of the current CDD release)
HORMA domain
The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognise chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.
Statistics
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PSSM-Id: 514846
Aligned: 109 rows
Threshold Bit Score: 58.4867
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003035714  22 VKTLVAAGLGCIAFLRDLLP--EDNFTKTSFsafddsfgmstdgrtptpassqkpggFKVMTITRNSt----------EE 89 
EME46196      39 VTEFFEFACNAILFQRGVYP--PEDFAPVKK--------------------------YGLNMM----------------- 73 
XP_001536233  22 VAEFFEYSIHSILFQRGVYP--ADDFTAVKK--------------------------YGLNML----------------- 56 
XP_001903599  34 VAEFFQYSIHTILFQRGVYP--AEDFSAVKK--------------------------YGLNML----------------- 68 
EPE04486      26 VSEFFQYSIHSILFQRGVYP--AEDFTSVKK--------------------------YGLNMLGRSTehhgttgsganKA 77 
XP_009225889  36 VAEFFQYSIHTILFQRGVYP--AEDFTAIKK--------------------------YGLNML----------------- 70 
XP_006695109  27 VAEFFQYSIHTILFQRGVYP--AEDFTAVKK--------------------------YGLNML----------------- 61 
XP_003651112  25 VAEFFQYSIHTILFQRGVYP--AEDFTAVKK--------------------------YGLNML----------------- 59 
EPS44689      93 VSEFFEYSIHSILFQRGVYP--PDDFAPVKK--------------------------YGLNML----------------- 127
XP_003668671   9 LKIYLKSYINLILYYRNVYPstTFDFTTYQT--------------------------FNLPQF---------------TP 47 
XP_003035714  90 ADR---LLNYVENGIFDALQ----KQYLESFIFGIY-LDKDKpndVVEAYTFNFEYHQVPGT-DVVIPIMATIRKTLGNl 160
EME46196      74 VSIddqVKAYVKK-IMSQLSkwmqKSKISKLVIVVTnKETGE---HVERWQFDVNMFLGESKkKRATSSGNkensep--- 146
XP_001536233  57 VSSddqVKAYIKK-IMSQLNkwmiGGKISKLVIVITsKDTGE---HVERWQFDVQIFNNGRSsRNRSTQKASPDnenapi 132
XP_001903599  69 VSSddqVRSYIRK-IMSQLDkwmlGGKISKLVIVITdKDTGE---HVERWQFDVQIFKKASSsSKSKTSTPIGdentge- 143
EPE04486      78 VSAddqVRAYIKK-IMGQLDrwmaGGQISKLVLVITdKDTGD---HVERWQFDVQITASKKKsKTKGSSAAATTADkenn 153
XP_009225889  71 VSAddqVKAYIKK-IMGQLDrwmvKGKISKLVIVITdKDTGE---HVERWQFDVQIFGGKSKsSSKSKTAAAAAAAVAGa 146
XP_006695109  62 VSSddqVRAYIKK-IMLQLDkwmlAGKVQKLVIVITdKDTGE---HVERWQFDVQILQKTSKrSKPSSKSSATPSAdene 137
XP_003651112  60 VSSddqVRAYIKK-IMTQLDkwmvGGKVSKLVIVITdKDTGE---HVERWQFDVQILAKPKSkSSSKSKPSTTSGGADqe 135
EPS44689     128 VNTddqVKAYIKK-IMSQLSkwmlGGKISKFILVISdKDSGE---KLERWQFDVQILAKSKKkKGDAEADTVMGGTDken 203
XP_003668671  48 INRhpqLQSYIEELILDLLSk---LNHIYHISLCIInKSNEI---CVEKYVLDFGEFKHITTtTNNARDDGDDD------ 115
XP_003035714 161 slgagddslqrarstgddplqqalNQGKAPTFGDVKARVKVRVVSIYARDIDLTVT---Pgsseashllydadgasaqyv 237
EME46196     147 ------------------aadeapAAAVEKSESDVQAEIQALFRQITASVSFLPML---D-------------------- 185
XP_001536233 133 p-----------------tntaatTPPPEKSEKEIQEEIQAIFRQITASVTFLPVL---D-------------------- 172
XP_001903599 144 ------------------erptatEKEKDKTEAEIQQEIAAIFRQITASVTFLPQL---S-------------------- 182
EPE04486     154 dg-----------------gsaaaPPAPEKTEAEIQAEIAAIFRQITASVTFLPQL---A-------------------- 193
XP_009225889 147 ggqenaeaa-----gagaaaaaaaATAPEKTEAEIQAEIAAIFRQITASVTFLPQL---A-------------------- 198
XP_006695109 138 ags---------------sstaaaSSPPEKTEAEIQAEIAALFRQITASVTFLPQL---Q-------------------- 179
XP_003651112 136 napshads------ensraaaappAPAADKTEAEIQAEIAAIFRQITASVTFLPQLpggH-------------------- 189
EPS44689     204 ag-----------------agtstEATMEKTEKEIQEEIQSIFRQITASVTFLPML---Dn------------------- 244
XP_003668671 116 ------------------------EDNQILSESEVFDEFRSSLNSLISHLEKLPKI---K-------------------- 148
XP_003035714 238 dvallssqssrgtEkRYANFKVFYNAS------TPIDYeapgfkpgdvdkdrwyimTHAIDEIPERYTMGKLDTGHH 308
EME46196     186 ---------------GNCTFNVLVYADad--seVPLEWgd---------------sDAKEVKNAEKVMLRSFSTNSH 230
XP_001536233 173 ---------------GNCTFNVLVYADad--seVPMEWgd---------------sDAKEIENGEKVQLRSFSTSNH 217
XP_001903599 183 ---------------GNCTFNVLVYADad--seVPVEWgd---------------sDAKEIKDAEKVQLRGFSTANH 227
EPE04486     194 ---------------GDCTFNVLVYADad--seVPVEWgd---------------sDAKEIVNGERVQLRGFSTSSH 238
XP_009225889 199 ---------------GDCTFNVLVYADad--seVPVEWgd---------------sDAKEIENGERVQLRGFSTASH 243
XP_006695109 180 ---------------GDCTFNVLVYADas--seVPVEWgd---------------sDPKEIENGERVQLRSFSTSNH 224
XP_003651112 190 ---------------GGCTFNVLVYVDdaetveVPVEWgd---------------sDAKEIANGERVQLRGFSTHCH 236
EPS44689     245 ---------------NHCTFNVLVYADgd--aeVPMEWgd---------------gEDLGIQDAEQVQLRSWSSSSH 289
XP_003668671 149 -------------D-NMVTFQIVINAV-------------------------------------------ELQLGHH 168
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