Conserved Protein Domain Family
HORMA
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pfam02301: HORMA 
HORMA domain
The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognize chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.
Links
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Statistics
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PSSM-Id: 426710
Aligned: 115 rows
Threshold Bit Score: 60.3741
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFJ00812           18 SLEAVKTLVAAGLGCIAFLRDLLP--EDNFTKTSFsafddsfgmstdgrtptpassqkpggFKVMTITRNST-------- 87  Schizophyl...
EME46196           35 SSKLVTEFFEFACNAILFQRGVYP--PEDFAPVKK--------------------------YGLNMM------------- 73  Dothistrom...
XP_011107312       89 SAKMVSEFFEYSIHSILFQRGVYP--PDDFAPVKK--------------------------YGLNML------------- 127 Dactylelli...
EPE04486           22 SAKLVSEFFQYSIHSILFQRGVYP--AEDFTSVKK--------------------------YGLNMLGRSTEhhgttgsg 73  Ophiostoma...
EJT72915           32 SAKLVAEFFQYSIHTILFQRGVYP--AEDFTAIKK--------------------------YGLNML------------- 70  Gaeumannom...
EGS20224           23 SAKLVAEFFQYSIHTILFQRGVYP--AEDFTAVKK--------------------------YGLNML------------- 61  Chaetomium...
jgi:THITE_2039922  21 SAKLVAEFFQYSIHTILFQRGVYP--AEDFTAVKK--------------------------YGLNML------------- 59  Thielavia ...
XP_001903599       30 SAKLVAEFFQYSIHTILFQRGVYP--AEDFSAVKK--------------------------YGLNML------------- 68  Podospora ...
EGY15545           22 SAKLVAEFFQYSIHTILFQRGVYP--AEDFSVVKK--------------------------YGLNMLa------------ 61  Verticilli...
XP_003668671        5 ITKWLKIYLKSYINLILYYRNVYPstTFDFTTYQT--------------------------FNLPQF------------- 45  Naumovozym...

EFJ00812           88 --EEADR---LLNYVENGIFDALQ----KQYLESFIFGIY-LDKDKpndVVEAYTFNFEYhqvpgtd-vvipimaTIRKT 156 Schizophyl...
EME46196           74 ----VSIddqVKAYVKK-IMSQLSkwmqKSKISKLVIVVTnKETGE---HVERWQFDVNMflgeskkkratssgn----- 140 Dothistrom...
XP_011107312      128 ----VNTddqVKAYIKK-IMSQLSkwmlGGKISKFILVISdKDSGE---KLERWQFDVQIlakskkkkgdaeadtVMGGT 199 Dactylelli...
EPE04486           74 anKAVSAddqVRAYIKK-IMGQLDrwmaGGQISKLVLVITdKDTGD---HVERWQFDVQItaskkksktkgssaaATTAD 149 Ophiostoma...
EJT72915           71 ----VSAddqVKAYIKK-IMGQLDrwmvKGKISKLVIVITdKDTGE---HVERWQFDVQIfggksksssksktaaAAAAA 142 Gaeumannom...
EGS20224           62 ----VSSddqVRAYIKK-IMLQLDkwmlAGKVQKLVIVITdKDTGE---HVERWQFDVQIlqktskrskpsskssATPSA 133 Chaetomium...
jgi:THITE_2039922  60 ----VSSddqVRAYIKK-IMTQLDkwmvGGKVSKLVIVITdKDTGE---HVERWQFDVQIlakpkskssskskpsTTSGG 131 Thielavia ...
XP_001903599       69 ----VSSddqVRSYIRK-IMSQLDkwmlGGKISKLVIVITdKDTGE---HVERWQFDVQIfkkassssksktstpIGden 140 Podospora ...
EGY15545           62 --AAVSSddqVRAYIKK-IMGQLDrwmkYGKISKLVIVITsKDTGE---HVERWQFDVQIfnqhksakskaak------- 128 Verticilli...
XP_003668671       46 --TPINRhpqLQSYIEELILDLLSk---LNHIYHISLCIInKSNEI---CVEKYVLDFGEfkhittttnnarddgDDDe- 116 Naumovozym...

EFJ00812          157 LGNLSlgagddslqrarstgddplqqalnqGKAPTFGDVKARVKVRVVSIYARDIDLTVT---Pgsseashllydadgas 233 Schizophyl...
EME46196          141 ----------------kensepaadeapaaAVEKSESDVQAEIQALFRQITASVSFLPML---D---------------- 185 Dothistrom...
XP_011107312      200 Dkenaga-----------------gtsteaTMEKTEKEIQEEIQSIFRQITASVTFLPML---Dn--------------- 244 Dactylelli...
EPE04486          150 kenndgg-----------------saaappAPEKTEAEIQAEIAAIFRQITASVTFLPQL---A---------------- 193 Ophiostoma...
EJT72915          143 VAGAGgqenaeaaga-----gaaaaaaaatAPEKTEAEIQAEIAAIFRQITASVTFLPQL---A---------------- 198 Gaeumannom...
EGS20224          134 deneagss---------------staaassPPEKTEAEIQAEIAALFRQITASVTFLPQL---Q---------------- 179 Chaetomium...
jgi:THITE_2039922 132 ADqenapshadse------nsraaaappapAADKTEAEIQAEIAAIFRQITASVTFLPQLpggH---------------- 189 Thielavia ...
XP_001903599      141 tgee-------------------rptatekEKDKTEAEIQQEIAAIFRQITASVTFLPQL---S---------------- 182 Podospora ...
EGY15545          129 ------------------adqenaapvtedAPDKTEKEIQDEIAAIFRQITASVTFLPQL---D---------------- 171 Verticilli...
XP_003668671      117 -----------------------------dNQILSESEVFDEFRSSLNSLISHLEKLPKI---K---------------- 148 Naumovozym...

EFJ00812          234 aqyvdvallssqssrgtEkRYANFKVFYNAS------TPIDYeapgfkpgdvdkdrwyIMTHAIDEIPERYTMGKLDTGH 307 Schizophyl...
EME46196          186 -------------------GNCTFNVLVYADad--seVPLEWg---------------DSDAKEVKNAEKVMLRSFSTNS 229 Dothistrom...
XP_011107312      245 -------------------NHCTFNVLVYADgd--aeVPMEWg---------------DGEDLGIQDAEQVQLRSWSSSS 288 Dactylelli...
EPE04486          194 -------------------GDCTFNVLVYADad--seVPVEWg---------------DSDAKEIVNGERVQLRGFSTSS 237 Ophiostoma...
EJT72915          199 -------------------GDCTFNVLVYADad--seVPVEWg---------------DSDAKEIENGERVQLRGFSTAS 242 Gaeumannom...
EGS20224          180 -------------------GDCTFNVLVYADas--seVPVEWg---------------DSDPKEIENGERVQLRSFSTSN 223 Chaetomium...
jgi:THITE_2039922 190 -------------------GGCTFNVLVYVDdaetveVPVEWg---------------DSDAKEIANGERVQLRGFSTHC 235 Thielavia ...
XP_001903599      183 -------------------GNCTFNVLVYADad--seVPVEWg---------------DSDAKEIKDAEKVQLRGFSTAN 226 Podospora ...
EGY15545          172 -------------------GDCTFNVLVYADad--seVPVEWg---------------DSDAKEIENAERVQLRGFSTSN 215 Verticilli...
XP_003668671      149 -----------------D-NMVTFQIVINAV-------------------------------------------ELQLGH 167 Naumovozym...

EFJ00812          308 H 308 Schizophyllum commune H4-8
EME46196          230 H 230 Dothistroma septosporum NZE10
XP_011107312      289 H 289 Dactylellina haptotyla CBS 200.50
EPE04486          238 H 238 Ophiostoma piceae UAMH 11346
EJT72915          243 H 243 Gaeumannomyces tritici R3-111a-1
EGS20224          224 H 224 Chaetomium thermophilum var. thermophilum DSM 1495
jgi:THITE_2039922 236 H 236 Thielavia terrestris NRRL 8126
XP_001903599      227 H 227 Podospora anserina S mat+
EGY15545          216 H 216 Verticillium dahliae VdLs.17
XP_003668671      168 H 168 Naumovozyma dairenensis CBS 421
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