1HM2,2X03,1N7Q,1F1S


Conserved Protein Domain Family
Lyase_8

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pfam02278: Lyase_8 (This model is not part of the current CDD release)
Polysaccharide lyase family 8, super-sandwich domain
This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
Statistics
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PSSM-Id: 514832
Aligned: 72 rows
Threshold Bit Score: 191.717
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1HM2_A       340 HHQFWNGDYVQHLRPAYSFNVRMVSKRTRRSESGNKENLLGRYLSDGATNIQLRgPEYYNIMPVWEWDKIPGITSRDYLT 419 Pedobacter hepa...
EMD42021     446 NRMFYANDYMVQRGPGYVTTIRMYSNRTHNTEcVNSQNPLGFHLADGVQYTYLQgGEYEDIAAAWDWNLIPGITTDYGGT 525
ESK88903     390 nrFFYVNDYMVHRGENYLSTVKMFSTRTQNTEcTNSQNPLGFHLADGVHYNYIVgDEYEDIAASWNWNLIPGITVDYGAT 469
XP_001873208 432 nNMFYDNDYMVHRGRNYVSTLKMYSSRTQNTEcTNLQNPFGFHLSDGVLYTYLRgNEYEDISAAWDWNLIPGITVDYGAT 511
XP_007324928 397 nRMFYNNDYMVHRGPNYVTTVKMYSTRTKYGEcLNSQNILGFHLSDGAVYTYLKgNEYEDIAVAWDWNLIPGITTDYEAT 476
XP_001828748 351 TRMFFANDYMVHRGPNFFSSLKMYSSRTLNTEcINSQNPLGFHLSDGTLYTYLRgNEYTDISAAWDWDLIPGTTVDYRNT 430
EGN94568     380 NRMFYSSDYMVQRGGGYVTTLKMKAKRIGNSEcVNAQSPYGFHLSDGTVYNYLQgNEYEDIAAAWDWNLIPGITVDYGAT 459
XP_007390454 409 NRMFFANDYMVQRGSGYVTTVKMYSNRTKNSEcLNDQNPFGFHLSDGTVYTYMQgDEYEDIAAAWDWNLIPGTSVDYDAT 488
XP_001747490 390 HRHFYDSDYTIMRGDGFQYSIRMYSARTVNARCVNDEGKQSQFTANGMVALYYTgYDYDSIFPTWNWQQLPGTLLDQLPT 469
XP_001750488 308 HRHFFNSDYAIMRGENFQYSIHMFSARTANAMCVNTESKRSQFTASGMVARYYTgDEYESVFPTWNWQQLPGTLLDQQDE 387
1HM2_A       420 DRPLtklwgeqgSNDFAGGVSDgVYGASAYALDYD-S--LQAKKAWFFFDKEIVCLGAGINSNAPEn-ITTTLNQSWLNG 495 Pedobacter hepa...
EMD42021     526 VLDGsrtq-hkgVEAFAGGVSDgKIGIAAMRYTNPatnaLSWQKTWFFLEDDVEHVMVPVHNSTSDapVLSVLDQKRRHG 604
ESK88903     470 ALSCdrtg-ftgIEKFVGGVSDgKIGLAAMRYTNPftrsLRFQKVWFFLDGDVQHVIISNIGSNTTspVYSVLDQRRHSG 548
XP_001873208 512 PLNCdgta-asgVEAFVGGVSTgQVGVAAMRYTNPnttaLHWQKAWFFLQDDVQHVMVSGVASSSGapVYSVLDQRLHNG 590
XP_007324928 477 KLTCssg--vtgIEDFVGGVSNdDTGIAVMRYTNPltgdLNWQKAWFFLEGDVQHTMISNITSTSDspVFSVLDQRLHDD 554
XP_001828748 431 LLHCsgat-vtgRESFVGGLSDgKTGIAAMRYTNPttrsLRWQKTWFFLNDGAQHVVINILASSSGapVYSVLDQKRRNG 509
EGN94568     460 TLGCsttk-rtgDQSLVGGASDgNIGVAAMRYENPltksLNWRKTWFFLDNDVQYVMVAQITSTTQapVFSVLDQRKLNG 538
XP_007390454 489 PLSCnqve-ftgLNSFVGGVSDsSIGIAAMMYTNPvteaLSWQKAWFFLEDDVQHVMIPIITSTPNasVFSVLDQKRHNG 567
XP_001747490 470 APSCgttt-wqtNTEEVGGVSNgKLGAAFMAQHQFrP--MSCVRSWGMFPDALIATAHSITAPDDIasVFTLADRRAAST 546
XP_001750488 388 APNCsttl-msaHTSEVGGVSNgVLGAAFMTQRARrP--LKCVRSWAMYPDALFATAHRISVPDKVpvVFTLEDARARST 464
1HM2_A       496 p--------vISTAgktgRGKITTFKAQGQFWllhdaiGYYFPEG-A---NLSLSTQ----SQKGNWFHINnsHSKDEVS 559 Pedobacter hepa...
EMD42021     605 avlv-----------dgvPVHEINVTGVRTLWhd--qvGYVLGGPhGlplELSVRTG----LRTGNWSSIGt-SKAGNAT 666
ESK88903     549 svyvnseqlqLQ------ENQVTNVTNVTSLWhg--gvGYTF--NaSapfSLSLDVG----PKTGNWATIGt-SKQPPAT 613
XP_001873208 591 simv-----------dgsAQRQSNSTTALSLWhg--dvGYSF----PkpaSLSVQFG----NKTGNWSSIGt-STQPASA 648
XP_007324928 555 aifmddgepfR-------ANDGPTPLSSATLWhg--gvGYDL-SGlGdddILHVEVG----PKSGNWSAIGt-STEPPST 619
XP_001828748 510 ltvv----------drreVLNSSTITGPQRLWhd--nvGYAFRSLtNattPLHVRMG----ERTGSWSAIGt-STQPPVS 572
EGN94568     539 qvyvessttkGV------VGGSGNFTQVSSLWhg--gmGYSF-DSsNaatKLSLSVG----PRSGSWSSIGi-SKQPSST 604
XP_007390454 568 dvfv----------ngepSCGQTNFTSPITLWhd--smGYFF-YPsPtpwQLSVEAG----PKSGNWSDIGi-STQGVET 629
XP_001747490 547 vtialhngthLTLA----ADQLISLPAAEVAWvhhdntLYALSNElG---PVHGTLAifcgNSTGNWIDIGv-TNRTETV 618
XP_001750488 465 vtvalkngdqLEIA----SHRPIRLAADTVAWihhdktLYALSSKfG---PVDGTLEifrgWANGSWLDIGt-DPRPETV 536
1HM2_A       560 GDVFKLWINHGARPeNAQYAYIVLPGI 586 Pedobacter heparinus
EMD42021     667 VDIFAAWISHDNAVlAQPLAYTIFPAV 693
ESK88903     614 VDLFAAWLQHTSLSs--PLAYSVYPGT 638
XP_001873208 649 VDLFAAWIQHTSLNt--SIEYTTFPGT 673
XP_007324928 620 FDLFAAWIEHGTPAs--SISYSTFPGT 644
XP_001828748 573 VDMWAGLLEHIDLSq--PLEYTILPGT 597
EGN94568     605 VDLFAAWLYHDNISa--PVSYAVYPAT 629
XP_007390454 630 VDLFAAWIDHGACDsGVPLSYSVFPAV 656
XP_001747490 619 DRFFAKWQ--LPTPtPHSAGYLMVPAV 643
XP_001750488 537 DRFFLKWV--FPKPaPSSAGYLMIPSV 561
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