1N7Q,1HM3,2WCO


Conserved Protein Domain Family
Lyase_8

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pfam02278: Lyase_8 
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Polysaccharide lyase family 8, super-sandwich domain
This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
Statistics
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PSSM-Id: 460521
Aligned: 75 rows
Threshold Bit Score: 189.791
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1N7Q_A        375 LSAFNKMDKTAMYNAekG--FGFGLSLFSSRTLNYE-HMNKENKRGWYTSDGMFYLYNGdlSHYSdGYWPTVNPYKMPGT 451  Streptococcus...
jgi:Phep_2840 572 TDAFWVNEFLVHRRGenEkpFYVSLKLKSKRTVGAE--DFGNIRRSWYAGYGILPLKISg-DEYSdKVLANLDWHALPGL 648 
WP_071148314  430 vrWFYNNDDLMKKTP--D--YHICINMASRRTDGLEsAAFADN-YNFYPTDGATLFQRDg-DEYF-RVMGGWDVTAMPGV 502  Bacteroides n...
CDA75452      425 vRWFFNNDDLMKKTP--D--YHININMASYRTDGLEsAAFADN-YNFYPTDGATLFQRSg-DEYF-HIMGGWDITAMPGV 497 
ESK88903      390 nrFFYVNDYMVHRGE--N--YLSTVKMFSTRTQNTEc-TNSQNPLGFHLADGVHYNYIVg-DEYE-DIAASWNWNLIPGI 462 
XP_001873208  432 nNMFYDNDYMVHRGR--N--YVSTLKMYSSRTQNTEc-TNLQNPFGFHLSDGVLYTYLRg-NEYE-DISAAWDWNLIPGI 504 
EAU93014      351 TRMFFANDYMVHRGP--N--FFSSLKMYSSRTLNTEc-INSQNPLGFHLSDGTLYTYLRg-NEYT-DISAAWDWDLIPGT 423 
EGN94568      380 NRMFYSSDYMVQRGG--G--YVTTLKMKAKRIGNSEc-VNAQSPYGFHLSDGTVYNYLQg-NEYE-DIAAAWDWNLIPGI 452 
XP_001747490  390 HRHFYDSDYTIMRGD--G--FQYSIRMYSARTVNAR-CVNDEGKQSQFTANGMVALYYTg-YDYD-SIFPTWNWQQLPGT 462 
EDQ84702      308 HRHFFNSDYAIMRGE--N--FQYSIHMFSARTANAM-CVNTESKRSQFTASGMVARYYTg-DEYE-SVFPTWNWQQLPGT 380 
1N7Q_A        452 TETDAKRADS----DTGkvlPSAFVGTSKlDdANATATMDFTNWN-----------------------QTLTAHKSWFML 504  Streptococcus...
jgi:Phep_2840 649 TEEWRSDAIpv-ghAQAslpGDNEVAGVTsDgRSGVAIYHHLPREty---------------------ssATALKSYFFI 706 
WP_071148314  503 TAREGMDKLVpvtnWRGycsKYNFAAGATdSgENGVAGYIFEKMHgadkenvndk---gdrnvensllYGFKAYKGYFIL 579  Bacteroides n...
CDA75452      498 TAREGMEKLQpvtnWRGycsKHNFAAGATdGsENGVAGIVFEKMNgsdkkavndkgdadkngiknellYGFKAYKGYFIL 577 
ESK88903      463 TVDYGATALScdrt--gftgIEKFVGGVS-DgKIGLAAMRYTNPFtr----------------------sLRFQKVWFFL 517 
XP_001873208  505 TVDYGATPLNcdgt--aasgVEAFVGGVS-TgQVGVAAMRYTNPNtt----------------------aLHWQKAWFFL 559 
EAU93014      424 TVDYRNTLLHcsga--tvtgRESFVGGLS-DgKTGIAAMRYTNPTtr----------------------sLRWQKTWFFL 478 
EGN94568      453 TVDYGATTLGcstt--krtgDQSLVGGAS-DgNIGVAAMRYENPLtk----------------------sLNWRKTWFFL 507 
XP_001747490  463 LLDQLPTAPScgtt--twqtNTEEVGGVS-NgKLGAAFMAQHQF------------------------RPMSCVRSWGMF 515 
EDQ84702      381 LLDQQDEAPNcstt--lmsaHTSEVGGVS-NgVLGAAFMTQRAR------------------------RPLKCVRSWAMY 433 
1N7Q_A        505 KDKIAFLGSNIQNTSTDt---AATTIDQRKLESs-------nPYKVyVNdkeaSLTEQEKDYPETQSvflessdskkniG 574  Streptococcus...
jgi:Phep_2840 707 ADKIIALGNNIKRLRPGqqkeIVTTLDQSAFTQpltiaqngkTEVVqPG----QSVNLSFEADKPVWlhi------gnkG 776 
WP_071148314  580 GDYFVALGAGVTNMNPDeeghIRTTLDQTALTGevfitrngkKEVLgK-----GETTLEGNKKKAIWltqq-----gkfS 649  Bacteroides n...
CDA75452      578 GDYFVALGAGVTNMTPNiegdIRTTIDQTSLVNntyilnkgkKHVLsLG----DEVELKSNKSNPVWlvqe-----gkfA 648 
ESK88903      518 DGDVQHVIISNIGSNTTs--pVYSVLDQRRHSGsvyvnseqlQLQ--------ENQVTNVTNVTSLWhg--------gvG 579 
XP_001873208  560 QDDVQHVMVSGVASSSGa--pVYSVLDQRLHNGsimv-------------dgsAQRQSNSTTALSLWhg--------dvG 616 
EAU93014      479 NDGAQHVVINILASSSGa--pVYSVLDQKRRNGltvv------------drreVLNSSTITGPQRLWhd--------nvG 536 
EGN94568      508 DNDVQYVMVAQITSTTQa--pVFSVLDQRKLNGqvyvessttKGV--------VGGSGNFTQVSSLWhg--------gmG 569 
XP_001747490  516 PDALIATAHSITAPDDIa--sVFTLADRRAASTvtialhngtHLTLa------ADQLISLPAAEVAWvhh------dntL 581 
EDQ84702      434 PDALFATAHRISVPDKVp--vVFTLEDARARSTvtvalkngdQLEIa------SHRPIRLAADTVAWihh------dktL 499 
1N7Q_A        575 YF-FFKK-S---SISMSKA----LQKGAWKDINegQSDKE----VENEFLTISQAH--KQn-GDSYGYMLIPNV 632  Streptococcus pneum...
jgi:Phep_2840 777 YIiYP-------DGKQKII----VKTGTEINIT--DPANA----SKTPGYIIAVNHgqEPatGNGYSYFLVPNV 833 
WP_071148314  650 YCiLPEYtS---KAFVACE----TRPTNWQKLNp-SNKKTadlpEQVQILRIWADHgqQPv-NDTYGYAVYTGq 714  Bacteroides ndongoniae
CDA75452      649 YTlLPKYtD---KAKVSCE----MKPTDWKKMNp-SNKNTdkmsKEVKILRLWVNHgqTPv-NDVYGYAVYTGk 713 
ESK88903      580 YT-F--NaSapfSLSLDVG----PKTGNWATIGt-SKQPP----ATVDLFAAWLQHtsLSs---PLAYSVYPGT 638 
XP_001873208  617 YS-F----PkpaSLSVQFG----NKTGNWSSIGt-STQPA----SAVDLFAAWIQHtsLNt---SIEYTTFPGT 673 
EAU93014      537 YA-FRSLtNattPLHVRMG----ERTGSWSAIGt-STQPP----VSVDMWAGLLEHidLSq---PLEYTILPGT 597 
EGN94568      570 YS-F-DSsNaatKLSLSVG----PRSGSWSSIGi-SKQPS----STVDLFAAWLYHdnISa---PVSYAVYPAT 629 
XP_001747490  582 YA-LSNElG---PVHGTLAifcgNSTGNWIDIGv-TNRTE----TVDRFFAKWQl--pTPt-PHSAGYLMVPAV 643 
EDQ84702      500 YA-LSSKfG---PVDGTLEifrgWANGSWLDIGt-DPRPE----TVDRFFLKWVf--pKPa-PSSAGYLMIPSV 561 
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