1WX1,4KQJ


Conserved Protein Domain Family
DBI_PRT

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pfam02277: DBI_PRT (This model is not part of the current CDD release)
Phosphoribosyltransferase
This family of proteins represent the nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) enzymes involved in dimethylbenzimidazole synthesis. This function is essential to de novo cobalamin (vitamin B12) production in bacteria. Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin.
Statistics
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PSSM-Id: 514831
Aligned: 348 rows
Threshold Bit Score: 166.408
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1WX1_A              2 DPEVFAQARLRMDQLTKPPRALGYLEEVALRLAALQGRVKP-ELGRGAVVVAAADHGVV--AEG--VSAYPQEVTRQMVL 76  Thermus th...
1_pfamImport        1 -PRLEDALRQKLQHRAETAGSLGELEPLAVRLGLIQNSLKP-RLKSPQLVVFAGDHGLV--VDG--L-STRGDSTSQQVT 73 
WP_013019786       17 DAAYATRASNRLVEALVPGTGLGTLTPAIAWSGRVQGTDAPrPFRDITGLIVSGGH-----DGDfaYADDPAD------- 84  Stackebran...
CeBiTec:AFR_09285 273 DSDAGPDARDRLANVDLPGAGIGMLIEAVEFAAATQSTSTPrPWGPVRVLLIDGRH-----AGGaaAGADVEDSERRAAQ 347
WP_012014524      259 DEDAGSQAVERVATRDLPGAGFGGLTQLVEFAAATQGTPRPaPWGSIRMLLVHGDH-----AGGvaAGTAPGDSARRAQE 333 Salinispor...
WP_013287724      292 DDYTGPQAVDRLATLDIPGAGLGVLEQVVGFAAATQGTSTPrPWDSVRVLLIQGDH-----EGGasAGATPGESGRRARQ 366 Micromonos...
9_pfamImport        5 DEYAGPQAVERLATLDVPGRGFGVLAQVVSFAAGTQGTSTPqPWRSVRVLLLHGDH-----QGGaaAGTLPGESGRRADQ 79 
12_pfamImport       5 DLAKTAECYQRLASLTIRQD--SKLSYLAGRIAGVQGTLHPeKLQ-KAVVVFAADHAVDggENK-----TNGKNSKADAL 76 
21_pfamImport       5 DKETMEACRLYVDNLIKPIHSLGKLEDIAVRLAGITGKIKPgKLN-KAIIIMAGDTAVDg-ENK-----TGGKTSLTEVQ 77 
CDA50522            8 NQEIMEACQLYVDNLIKPIHSLGKLEDMAVRMAGILGEVKPtYLN-KAVVIFGGDTAVDg-ENK-----TKGQLSHAEMK 80 
1WX1_A             77 NFLRGGAAINQFALAADCAVYVLDVG-VVg--ELPdhpgllkR-K-----VRPGTANLAQGPAMTPEEAERALLAGREAA 147 Thermus th...
1_pfamImport       74 HLLAGRLPMAVFSFIQGMGLTVVDAGlAEtmsPYPsl----lQrK-----IGFGTRSARSGPAMSIDQAHAAIRAGMEIA 144
WP_013019786       85 -----ESILTRLAERAGVSLRRLETV---------------------------TGAAAETGPVLSEDQYLECLEIGKQAA 132 Stackebran...
CeBiTec:AFR_09285 348 AEA-GEGALGTLAATADADIVVVRTP---------------------------PSGAMEDGPVIDADTVDAALRQGWELA 399
WP_012014524      334 ARD-GQGAWARLAAEAGAELQVVDAP---------------------------AADPIETDPALPLSQVEAALQLGWRLA 385 Salinispor...
WP_013287724      367 ARA-GRGPLARLAAENRAGLQIVEAP---------------------------VAAPMEDGPALSADEVEAALGYGWRLA 418 Micromonos...
9_pfamImport       80 ARA-GQGVLARLAAEGAAGLQVIEAP---------------------------TAAPIEHEPALTAEQVESALSYGWQLA 131
12_pfamImport      77 EIATGRGPINKVAHRIGAGVMLLDMGlEEdipE---------SqGvqdlkVMHGSHFWARQDAMSEDEMMDALFSGLQIG 147
21_pfamImport      78 MVSRGLGTVSAVARTLGAPVYLIDVGlEQntnDIEgv----lTnK-----VVYGTH--RGNPALDQDAVSAAISIGMSVA 146
CDA50522           81 LVAQGAGPVNVLARQMEMPVYLVDVGlEKdtsDIEgi----lAkK-----VIHGTH--QGHPAMDDDVAKAAISLGMSVG 149
1WX1_A            148 RRAIAEGATLLAAGDMGIGNTTAAAALTAALLG----LPPEAVV-GR----GTGVGEEGLRRKRQAVARAL-ARlhpGmG 217 Thermus th...
1_pfamImport      145 DSL---SGNVLACAGIGVGAHESASLVLSRLAD----IPLRDLT-IS----GPDMPPDALAQTMVVLQSTQ-GRhrdVtD 211
WP_013019786      133 DASIDSGADLLVLCGLGPGTRTAAIAVTAHLTR----IPPVELS-PRlrlpGGVIDDNAWMRRTAAIRDAF-TRl--GgP 204 Stackebran...
CeBiTec:AFR_09285 400 DAAADAGRDVLILGSCGAGTEAAATAVLAATTG----AEPVAIL-PRvlvpGGFYDDNAWMVRCAAVRDAM-HRi--RqE 471
WP_012014524      386 DQAAHAGVRLLVLGACGAGTDAAAAAVLAATAG----AEPPAVL-TRvrtdAGEYDDAAWMVRCAAVRDGL-HRs--RhS 457 Salinispor...
WP_013287724      419 EQAADAGVQLLVLAACGAGAEAAAAAVLAATAG----AEPPMVL-GRvvteQGEIDDTAWMVRCAAVRDAL-HRt--RrS 490 Micromonos...
9_pfamImport      132 EEAADAGVQLLVLAACGAGTEAAAAAVLAATAG----AEAPAVL-ARvineSGEFDDASWMIRCAAIRDAL-HRt--RgV 203
12_pfamImport     148 QNLADEGYTAVGLGNLGERGLLTAFILTAVFFRdqleELPEHMKsGQ---------------KLEKLKQIIdQRhfdAsD 212
21_pfamImport     147 RTLAVQGIQAVGLGNIGERSLLSALGVTAAIMK----KELQENS-----------LKDGFSLHMDDVGNMAn-------D 204
CDA50522          150 KALAGEGIQAVGLGNIGERSMLSALAVTTAVMK----EDLKKAS-----------ARSGFSIQLSDVGDFAk-------D 207
1WX1_A            218 P---LEVAAEVGGLELVAIAGIYLEGYEAGLPLVLDGFPVTAGALLAWKMAPGLRDHLFAGHLSREPGHRHQLEALglRP 294 Thermus th...
1_pfamImport      212 P---VEVLAAFGGFEVATMVGAMLVAASKRHLIMVDGLPACAALLVAARISAPVTDYVVFCRSHGHRGLDHALNLFraSA 288
WP_013019786      205 GrkaQTMLTELGGPVMATLTGIIVAAAIRRTPMLIDGPVAAAAALVSRDFSLGAPKWCYAPDRIPHPVVERVAGQTgmAE 284 Stackebran...
CeBiTec:AFR_09285 472 PrgaKDILAQLGGADLAVATGAMLGASARRMPVLVDGPLGIAAGLIARDISSQTRHWCLLADAGTHQLVKQGADVLglTA 551
WP_012014524      458 SrgpKEILAEVGGGDIAVATGVLLGAAARRLPVLLDGPVGVAAGLVSRDLAGPARHWCLLADHGGHPGVQLAADVLglAP 537 Salinispor...
WP_013287724      491 AreaKDVLAELGGGDIALATGVLLGATARKVPVLLDGPVGTAAAMVSRDLAGQARHWCLLPDHGGRPGVRLAADVLglTP 570 Micromonos...
9_pfamImport      204 ArdaKEVLAQLGGGDIAVATGVLLGATARRTPVLLDGPVGVAAALVSRDLAGQARHWCLLADDGDQPAVRLAADVLglTP 283
12_pfamImport     213 P---LDLLRRAGAPDIAAMVGFILSAAQRKLLVIFDNAVTGSAVLIARALCPTIDDYVCASARYLEPVHQMQMKKLglKP 289
21_pfamImport     205 P---VSVLSRVGSAEIAGLFGLVVQAAREKIAIVFDNAVTGAAVLAAIEVYPEVRDYVFSSAAYNEPVHQIQMKKLgmKP 281
CDA50522          208 P---VGTLAMVGSAEIAALFGLTVEAARRGIMVVFDNAVTGAAVLAAQAVYPEIKNYIFPSVYYEEPVHQMQMQKMgmKS 284
1WX1_A            295 LLDLDLALGEGTGAVLAMPLLRAAARILH-MATFQEAGV 332 Thermus thermophilus HB8
1_pfamImport      289 LLELGMESTDGTGSTLAWPLVHSAAALLTqVAEGEDA-- 325
WP_013019786      285 PIGFGVDVGEGCAAMQAIPLLQQTLRLFDeLpfpepepe 323 Stackebrandtia nassauensis
CeBiTec:AFR_09285 552 VLELGLDLGEGTNALAALPLLRSAIALASalpvhpalla 590
WP_012014524      538 LLDLRLDLGEGGNALVALPLLRSALALATalpahpslrv 576 Salinispora tropica
WP_013287724      571 LVDLRLDLGEGATALAALPLLRSALTLAAtlpvhpslag 609 Micromonospora aurantiaca
9_pfamImport      284 LAQLKLDLGEGANALTVLPVLRSALTLAAa--------- 313
12_pfamImport     290 FVEMDQNLDQGMGSAMGLTMLDASVQMMNe--------- 319
21_pfamImport     282 FFYYDFTVAEGFGSAMGLSLFDAALDIVNeMKTFGQGGV 320
CDA50522          285 FLHYDFTEAEGYGSALGLSLLDAAIDMLNqMKTFGSADV 323
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