2EG9


Conserved Protein Domain Family
Rib_hydrolayse

?
pfam02267: Rib_hydrolayse 
Click on image for an interactive view with Cn3D
ADP-ribosyl cyclase
ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase or CD38) synthesizes cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.
Statistics
?
PSSM-Id: 426689
Aligned: 27 rows
Threshold Bit Score: 286.096
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2EG9_B        24 TKHFSDIFLGRCLIYTQIL----------RPEMRd-qNCQEILSTFKGAFVSKNPCDITREDYAPLVKLVTQTIPCDKTL 92  house mouse
EDV29266      24 THNIKEIFIGRCYGYIALQ----------NFTLRpgvTCPSLWQEFSRVFVNREPCEVDPTQYSRFLIESSSPVPPNKAL 93  Trichoplax adha...
XP_004347950  27 TAHLAEIFVGRCFDKSTVA------------------DCNAWWAAFNQVVADVDPLSVTAASFDPYFAIANFSTPVDKAM 88  Capsaspora owcz...
XP_011663014  28 TSNITDILTGRCEEYRKCLlgepclpfyrNV------KCRAAVESFFKGIRNMDPCATPDNAYDEFLNMVPPTTVRGTTM 101 purple sea urchin
EDV29267      24 TARIQEIFIGRCSEYQAVN------------KLQrqvDCIHVWNQFSRVFAFKEPCAVNASEYDNFIKEVSS-------V 84  Trichoplax adha...
2_pfamImport   1 TPNIKHIVVGRCYNYITLV----------NPSLRi--DCEEIWRRFEESVVFRSSFNATV-DYSQMFDAIPQTWPCNTCL 67 
XP_015200534  51 GGSLKYVFITRCKEYLETH----------DEvrv-giDCNEVWDAFQSSFVAKDPCKISVEAYDGLMNTAKQKVPCNEMV 119 spotted gar
XP_003978724  32 QQTFKETFIARCHLAIKGQ----------YKg----sDCETIWSTFEQAYVGRDPCKIPTDAYNPLFQVAPITMTCGKAM 97  torafugu
5_pfamImport   1 KSEFESTFLSRCEKFDQY-------------------DCKKVWDAFQQAYVNKDPCKVPVEAYDPLIAAAPFKPQCNRMM 61 
3_pfamImport   1 T--FKETFVARCEDFNGT-------------------DCEKIWGLFEEAYVGRDPCKVPVAAYGPLIAAAPFPPKCNQRI 59 
2EG9_B        93 FWSKS--KHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGD-PSTS---DMNYVSCPHWsEN-CPNN---PITMFWKVIS 162 house mouse
EDV29266      94 FWSGV--YDFVSSYVQAVDDVLVISQTFTGFLLDKLTWCGRfKSTPqseGINYLYCNDS-QG-CSHR---NMLSFWALAS 166 Trichoplax adha...
XP_004347950  89 FWSGS--QYYVHQLSDAGLRYFTMEDTVGGFVQNGLHWCGS---SS---GYNYTSCPPGfRNtTTDTwygAELAFWQHAS 160 Capsaspora owcz...
XP_011663014 102 FWSGVmgNNIPQDVAQVTPEFSVLEETFPGYMAGNLSWCGAtDGDGtglGLNFTVCPTWtSEtCPNN---TKAAFWARAS 178 purple sea urchin
EDV29267      85 FWSGT--YSFAHLYIRAVKNLETLENTFPGYLVNSLSWCGQ-LALP---GINYNDCHDP-QH-CNNK---NSGIFWSKMS 153 Trichoplax adha...
2_pfamImport  68 FWSKT--RNLMHSYAAVERHFWTLEDTLVGFMFNDLVWCGQ-EKHS---GFGFSSCPPW-AA-STHH---PVYSLWRHAS 136
XP_015200534 120 FWSKT--KQMAHKFTQAKKCFMTLEDTLLGFIMDGLTWCGS-QDGN---DTYTSGCPNW-NT-CEQN---PVRSFWSRAS 188 spotted gar
XP_003978724  98 FWSKT--KDVVHAYNENTKCFVTMEDTLLGSVLDNLIWCGK-EGSN---KTFTSGCPDW-NA-CKDN---PVRSFWTQGS 166 torafugu
5_pfamImport  62 FWSKT--KDVVHGFTEKRDCFVTLEDTLLGSVLDGLTWCGK-EGSK---DTFTTGCPRT----CENN---PVDSFWIRAS 128
3_pfamImport  60 FWSKT--KAVVHDFTKKRKCFETVEDTLLGSVLDGQTWCGK-EGSN---ETFATGCPGW-TD-CETS---AVRSFWNGAS 128
2EG9_B       163 QKFAEDACGVVQVMLDGSLRE-PFYKDSTFGSVEVFSLDPNKVHKLQAWVMHDIEG--AS---SNACSSSSLNELKMIVQ 236 house mouse
EDV29266     167 REFAKSASGLVRVLLTSDNKTpAFNNQSIFGSIELPNLSPQKVSKVEIMVMHGLNSkpNQ---IDRCGIGSIKELQNILT 243 Trichoplax adha...
XP_004347950 161 TTFARQATGRVSVLLGSPYGGsAYRNSSFFALYELPNMNTSLVTAIDVYVITNG---------TERCGSGSLVALVQDIK 231 Capsaspora owcz...
XP_011663014 179 KMLATQAVGDVYVVLNAQRAGgAFNNGSIFATIEAPNLNQDVVTNVAIYLIPDFTLpiPNemyRETCTNGSVLYLQNFLM 258 purple sea urchin
EDV29267     154 TWFAQGSSGTVRVLLNSSRIP-AFAPYSFFARYELPNLSPSKVNKIEIIVVHDLDMkvNQ---SERCGAGSIKTLQDLIQ 229 Trichoplax adha...
2_pfamImport 137 QNFAEMACGNITVLLNGSISN-AFNRESMFGSVELDGLDPCRVDYVNIKVVTNLEG--PF---TESCSKGSIADLIQVLR 210
XP_015200534 189 AHFAESACGNVTAMLNGSIDK-PFSAKSIFGSVEIKKFNPMKINYVNVVLI--GRE--NY---PMSCKNDSLQELEKTLI 260 spotted gar
XP_003978724 167 TKFAEAACGDATVMLNGNIAT-PFDNSSVFGSVEVPKLNSAKVRKLTVVLV--TAT--TP---VSDCSNESLNELRQKLD 238 torafugu
5_pfamImport 129 AAYADVACGDVTAMLSGSTTT-PFDPTSTFAKVEVTRFKAPKVRSLNVVMV--IQK--NA---KSNCKNASLQKLKNALH 200
3_pfamImport 129 AAFADAACGDVTVMLNGAVAT-PFYNKSVFATIEVPRFRSPKVRSLKVVLVTQENS-------LTSCENESLKDLQRKLD 200
2EG9_B       237 KR-NMIFACVDNYRPARF 253 house mouse
EDV29266     244 SH-NFTWSCQDNPKSVLH 260 Trichoplax adhaerens
XP_004347950 232 HHlGLTPSCYDNPDMVRF 249 Capsaspora owczarzaki ATCC 30864
XP_011663014 259 NM-NFNVTCEENPKEIMW 275 purple sea urchin
EDV29267     230 QR-NIAWSCSDNPSSVQD 246 Trichoplax adhaerens
2_pfamImport 211 SR-GFRWTCTHNDETLMI 227
XP_015200534 261 P--KFKYTCTTV-LLSTI 275 spotted gar
XP_003978724 239 S--KIGYECKEV-SETRI 253 torafugu
5_pfamImport 201 K--GITYSCKDV-PESRI 215
3_pfamImport 201 G--GITYSCKAV-PEAQI 215
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap