1ISF,2EF1


Conserved Protein Domain Family
Rib_hydrolayse

?
pfam02267: Rib_hydrolayse (This model is not part of the current CDD release)
ADP-ribosyl cyclase
ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase or CD38) synthesises cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.
Statistics
?
PSSM-Id: 514824
Aligned: 27 rows
Threshold Bit Score: 297.661
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1ISF_A         8 SAHLRDIFLGRCAEYRALL----------SPEQRn-kDCTAIWEAFKVA-LDKDPCSVLPSDYDLFITLSRHSIPRDKSL 75  human
XP_004347950  27 TAHLAEIFVGRCFDKSTVA------------------DCNAWWAAFNQVvADVDPLSVTAASFDPYFAIANFSTPVDKAM 88 
XP_030829526  28 TSNITDILTGRCEEYRKCLlgepclpfyrNV------KCRAAVESFFKGiRNMDPCATPDNAYDEFLNMVPPTTVRGTTM 101
XP_002108469  24 TARIQEIFIGRCSEYQAVN------------KLQrqvDCIHVWNQFSRVfAFKEPCAVNASEYDNFIKEVSS-------V 84 
1_pfamImport   1 TPNIKHIVVGRCYNYITLV----------NPSLRi--DCEEIWRRFEESvVFRSSFNATV-DYSQMFDAIPQTWPCNTCL 67 
XP_015200534  51 GGSLKYVFITRCKEYLETH----------DEvrv-giDCNEVWDAFQSSfVAKDPCKISVEAYDGLMNTAKQKVPCNEMV 119
XP_029698852  32 QQTFKETFIARCHLAIKGQ----------YKg----sDCETIWSTFEQAyVGRDPCKIPTDAYNPLFQVAPITMTCGKAM 97 
5_pfamImport   1 KSEFESTFLSRCEKFDQY-------------------DCKKVWDAFQQAyVNKDPCKVPVEAYDPLIAAAPFKPQCNRMM 61 
XP_040023562  49 T--FKETFVARCEDFNGT-------------------DCEKIWGLFEEAyVGRDPCKVPVAAYGPLIAAAPFPPKCNQRI 107
XP_002108468  24 THNIKEIFIGRCYGYIALQ----------NFTLRpgvTCPSLWQEFSRVfVNREPCEVDPTQYSRFLIESSSPVPPNKAL 93 
1ISF_A        76 FWENS--HLLVNSFADNTRRFMPLSDVLYGRVADFLSWCRQ-KADS---GLDYQSCPTS-ED-CENN---PVDSFWKRAS 144 human
XP_004347950  89 FWSGS--QYYVHQLSDAGLRYFTMEDTVGGFVQNGLHWCGS---SS---GYNYTSCPPGfRNtTTDTwygAELAFWQHAS 160
XP_030829526 102 FWSGVmgNNIPQDVAQVTPEFSVLEETFPGYMAGNLSWCGAtDGDGtglGLNFTVCPTWtSEtCPNN---TKAAFWARAS 178
XP_002108469  85 FWSGT--YSFAHLYIRAVKNLETLENTFPGYLVNSLSWCGQ-LALP---GINYNDCHDP-QH-CNNK---NSGIFWSKMS 153
1_pfamImport  68 FWSKT--RNLMHSYAAVERHFWTLEDTLVGFMFNDLVWCGQ-EKHS---GFGFSSCPPW-AA-STHH---PVYSLWRHAS 136
XP_015200534 120 FWSKT--KQMAHKFTQAKKCFMTLEDTLLGFIMDGLTWCGS-QDGN---DTYTSGCPNW-NT-CEQN---PVRSFWSRAS 188
XP_029698852  98 FWSKT--KDVVHAYNENTKCFVTMEDTLLGSVLDNLIWCGK-EGSN---KTFTSGCPDW-NA-CKDN---PVRSFWTQGS 166
5_pfamImport  62 FWSKT--KDVVHGFTEKRDCFVTLEDTLLGSVLDGLTWCGK-EGSK---DTFTTGCPRT----CENN---PVDSFWIRAS 128
XP_040023562 108 FWSKT--KAVVHDFTKKRKCFETVEDTLLGSVLDGQTWCGK-EGSN---ETFATGCPGW-TD-CETS---AVRSFWNGAS 176
XP_002108468  94 FWSGV--YDFVSSYVQAVDDVLVISQTFTGFLLDKLTWCGRfKSTPqseGINYLYCNDS-QG-CSHR---NMLSFWALAS 166
1ISF_A       145 IQYSKDSSGVIHVMLNGSEPTgAYPIKGFFADYEIPNLQKEKITRIEIWVMHEIGG--PN---VESCGEGSMKVLEKRLK 219 human
XP_004347950 161 TTFARQATGRVSVLLGSPYGGsAYRNSSFFALYELPNMNTSLVTAIDVYVITNG---------TERCGSGSLVALVQDIK 231
XP_030829526 179 KMLATQAVGDVYVVLNAQRAGgAFNNGSIFATIEAPNLNQDVVTNVAIYLIPDFTLpiPNemyRETCTNGSVLYLQNFLM 258
XP_002108469 154 TWFAQGSSGTVRVLLNSSRIP-AFAPYSFFARYELPNLSPSKVNKIEIIVVHDLDMkvNQ---SERCGAGSIKTLQDLIQ 229
1_pfamImport 137 QNFAEMACGNITVLLNGSISN-AFNRESMFGSVELDGLDPCRVDYVNIKVVTNLEG--PF---TESCSKGSIADLIQVLR 210
XP_015200534 189 AHFAESACGNVTAMLNGSIDK-PFSAKSIFGSVEIKKFNPMKINYVNVVLI--GRE--NY---PMSCKNDSLQELEKTLI 260
XP_029698852 167 TKFAEAACGDATVMLNGNIAT-PFDNSSVFGSVEVPKLNSAKVRKLTVVLV--TAT--TP---VSDCSNESLNELRQKLD 238
5_pfamImport 129 AAYADVACGDVTAMLSGSTTT-PFDPTSTFAKVEVTRFKAPKVRSLNVVMV--IQK--NA---KSNCKNASLQKLKNALH 200
XP_040023562 177 AAFADAACGDVTVMLNGAVAT-PFYNKSVFATIEVPRFRSPKVRSLKVVLVTQENS-------LTSCENESLKDLQRKLD 248
XP_002108468 167 REFAKSASGLVRVLLTSDNKTpAFNNQSIFGSIELPNLSPQKVSKVEIMVMHGLNSkpNQ---IDRCGIGSIKELQNILT 243
1ISF_A       220 DM-GFQYSCINDYRPVKLLQCVDHSTHPDC 248 human
XP_004347950 232 HHlGLTPSCYDNPDMVRFILCENNGAPSAQ 261
XP_030829526 259 NM-NFNVTCEENPKEIMWLQCARFANSPYC 287
XP_002108469 230 QR-NIAWSCSDNPSSVQDILCAANPTHFQC 258
1_pfamImport 211 SR-GFRWTCTHNDETLMILQCVQNPEQSSC 239
XP_015200534 261 P--KFKYTCTTV-LLSTILKCLEDPQKPCG 287
XP_029698852 239 S--KIGYECKEV-SETRISECASNDVSCTN 265
5_pfamImport 201 K--GITYSCKDV-PESRIQECGSKPQIACR 227
XP_040023562 249 G--GITYSCKAV-PEAQINDCSSHPEKPCG 275
XP_002108468 244 SH-NFTWSCQDNPKSVLHHLCTKNPNNFHC 272
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap