4CXO,5FBC


Conserved Protein Domain Family
S1-P1_nuclease

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pfam02265: S1-P1_nuclease 
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S1/P1 Nuclease
This family contains both S1 and P1 nucleases (EC:3.1.30.1) which cleave RNA and single stranded DNA with no base specificity.
Statistics
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PSSM-Id: 426688
Aligned: 45 rows
Threshold Bit Score: 230.67
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4CXO_A         1 WGKEGHEIICKIAQTRLDETAAKAVKELLPEsa---------eGDLSSLCLWADRVKFr-yHWSSPLHYINTPDacsyqY 70  thale cress
A0BLJ0       422 WWEVGHMMTAQIAKNYLRDNRPDVLAWADSLvqdfnsltdgksNTFAEAAVWLDDIKEtgtEFLFSWHYTDRPI-----N 496 Paramecium tetr...
Q4Q7F3        31 WGCVGHMLLAEIAHRQLNDENKEKLDAMAHAfaqsg--pfessPDMVQAACWADDVKRwgqYAMATWHFFDKPY-----N 103 Leishmania major
XP_001566786  31 WGCTGHMVLAEIARRQLDPSNEKKIQAMAMKfkesg--pfllsPDMIQAACWPDDVKRwgqDAMSTWHYYAMQY-----N 103
Q585P6        27 WWDFGHMVVAEIARRNLDNDVARVVETYIQHlsesg--pfpniPDFVQSACWPDDLKRyrmGAMDGWHYTANMY-----I 99  Trypanosoma brucei
Q4DEV4        28 WWCNGHMLVNEIARRRLHPEVALIVEEAAVNlsasg--pfphtTDFVESGCWADDIKKlglFVMEDWHYIDTPY-----N 100 Trypanosoma cruzi
XP_001563092  29 WWDKGHMSIAEIARRNLNPDVLEKVQACATAlnevg--pfpksTNIVELGPWADDLKSmglSTMSSWHFVDHVY-----N 101
Q66VY6        29 WWSKGHMAVALIAQRHMDPKLVKKANAAAKVlslag--pfpksPDMVQLGPWADDLLEsglKTNFNWHFITTPY-----Y 101 Leishmania major
XP_001567250  28 WWSKGHMAVALIAERHMEASLVEKGNLAAKVlslsg--pypqsPDMVQAAPWADDLKKvgfSALSTWHFITTPY-----Y 100
Q236I4        18 WWDGGHMMTAEIAKQEILARNATLYEQIEKYvtilnplcdarsQDFVQAASWADDIKDdamNFWYGWHFYDKPE-----N 92  Tetrahymena the...
4CXO_A        71 NRDCKD-ES-GEKGRC-VAGAIYNYTTQLLSYKTAASSQsey---nlTEALLFVSHFMGDIHQPLH-VSY------ASDK 137 thale cress
A0BLJ0       497 PDGLLIkIE-DESRNInSIYAINQAVAVLTNSKTSRNRHtv----fkAQMLRVLLHVIGDIHQPLHdTSLynnsypDGDA 571 Paramecium tetr...
Q4Q7F3       104 PEDINIt---DPVATVnAVTVSRNMVTSLRRTNAPLYLL--------NFAWVNLVHILGDLHQPLHtTSRysseypHGDK 172 Leishmania major
XP_001566786 104 PDGINIt---DSVEAVnAVSVSLDMITSLSNVRSPLYML--------NFAWVYLVHLIGDLHQPLHaVSRysekypHGDR 172
Q585P6       100 RDGFKPnV--TLKQKSdVVSVINGLSKALRRTDTPIYVR--------SFALAHLVHYYGDIHQPLHtTSQvsadypEGDQ 169 Trypanosoma brucei
Q4DEV4       101 PQNINIkK--NPVNTEnLKTVIESLKRTLMKQDLVPYIM--------SFAIVNIAHFLGDIHQPLHaVELfspeypHGDR 170 Trypanosoma cruzi
XP_001563092 102 PQNI-PlTI-NPVEIVnVASVIPMLVSAITSPTATSDTI--------ITSVANLIHFVGDVHMPLHsADLfspeypLGDL 171
Q66VY6       102 PDSD-FtLEfSPVQTVnVASVIPMLESAITKTTATTEII--------TQCLAFMIHFFGDIHQPLHnANLfsneypLSDY 172 Leishmania major
XP_001567250 101 PDPS-FtLDvSPVQTVnVASVIPMLETALQRAISNSDII--------VHSLALLIHFMGDIHQPLHnANIfsneypEGDL 171
Q236I4        93 PQGLYViLD-QDNQVYnSITGIKRAIQELSRKYYLPLQNnlnisvqqAIMMRLLIHIVGDMHQPLHnVNMynytytQGDL 171 Tetrahymena the...
4CXO_A       138 GGNTIEVHWY---TRKANLHHIWDSNII--ETAEAdly-------nsALEGMVDALKKNITte-wADQVKRWEtctkkta 204 thale cress
A0BLJ0       572 GGNFLNIQLQn--GTLMNFHSFWDSGALtfAPNNSflarplsqsdseYLDKWSKDLMKKFP----ISKYSNYDmt----- 640 Paramecium tetr...
Q4Q7F3       173 GGNEVEVQVG---KRKVNLHAVWDNICS--GTPPRykrpls-ytdlfALAATADRLLETYTf---PEALRTLVd------ 237 Leishmania major
XP_001566786 173 GGNLVWVRVQ---TKMLRLHAFWDNICT--ATPVLyrrpls-stdllAISETADRLLKTYSf---SSDLKTMQd------ 237
Q585P6       170 GGNLVHVDFR---GVPMKLHAVWDSICR--GPSESlerpln-tedysKVRDFATKLIATYKf---SEGEKKKTg------ 234 Trypanosoma brucei
Q4DEV4       171 GGNAETVIVH---GKMMALHSLWDSICQ--GDVKNprrpld-rwhyaKLREFADRLEDTYKf---PAEVKNETn------ 235 Trypanosoma cruzi
XP_001563092 172 GGNKQIVIVDqaaGTSMKLHAFWDSMCE--GPQSNavrpld-dasyaTLSAFVDNLVQTYS----FTEEQMMTt------ 238
Q66VY6       173 GGNAQMVTIDs-nGTKMLLHAYWDSMAE--GPASVgysrplskdaydDLNAFVDYLEATYAgn-lTMPEKNLQn------ 242 Leishmania major
XP_001567250 172 GGNKQHVIIDs-kGTKMALHAYWDSMAE--GHAGEdmprplskddyaSLNEFADYLEATYAdt-lTDADKNLVk------ 241
Q236I4       172 GGNKEKILLLn--KTSMILHSYFDSGATrlDSFPRpltq----eklsNLSALAYEFRAQYPrsyfGQRMNVTT------- 238 Tetrahymena the...
4CXO_A       205 cPDIYASEGIQAACDWAYKGVTEGDTLEDEYFYSRLPIVYQRLAQGGVRLAATLNRIFG 263 thale cress
A0BLJ0       641 nPSVWTYLGFRQAQQFVYPMVAASNSYSSDYEKQAIAFCEENLIVGGYRLGSKLIEIYD 699 Paramecium tetraurelia
Q4Q7F3       238 -VVAIHEESHMFAVNTSYPGVTPGATLSDAYLARCKRVAEARLTLGGYRLGYLLNELLP 295 Leishmania major
XP_001566786 238 -VQRMANESYAFAVNSSYADMIPGTTLSAAYISRCVEVAESRLTLGGYRLGYILNKLLS 295
Q585P6       235 -ATAISKEGSNFAKKVAYANVVNGTELSEEYISACKEMAEKRITLAGYRLATHLNTVLR 292 Trypanosoma brucei
Q4DEV4       236 -TTQMAMESYDIAVQVAYPGFVDGAKITDEYLEKCRAAAESRVVLAGYRLANVLNQLLD 293 Trypanosoma cruzi
XP_001563092 239 nSTVMAAESYELAVKNVYPGISDGTVLSESYKANGKILAGGRVTLAGYRLATILNAALA 297
Q66VY6       243 -TTAISNEGHELAIKYAFPGAFNGATLSSEYKTNAKFITERRVLLAGYRLAKMLNTTLK 300 Leishmania major
XP_001567250 242 -ATEISNETYNLALKYAYPGAEDGATLSDEYKKNAKQISERQVLLAGYRLAKVLNTTLK 299
Q236I4       239 -PEQWAQESYDIAHNFIYPFVTKTNQITPEWDTESYEIIKQQLALGGYRLADILLGIFQ 296 Tetrahymena thermophila SB210
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