Conserved Protein Domain Family
RFX_DNA_binding

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pfam02257: RFX_DNA_binding 
RFX DNA-binding domain
RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD).
Statistics
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PSSM-Id: 426682
Aligned: 67 rows
Threshold Bit Score: 93.762
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_017947767           520 EKFGCQWLNAHFEVCPD---SSVSRSEMYSEYLSTCSKLARgGILTSSGFYKCLRSVFANHNIKRVEdpnNNGQAH-IHV 595  trop...
XP_002111154           454 ENFAHAWLNATYDCCTG---GYVPRSGMYSDYLATCNRLSItGIVNSTTFSRLIHEVFPSAEIKRV----TYGNTNqYFY 526  Tric...
XP_002416101           386 EAFAGTWVRAMYEPAPPg--CSVARNDIYAEYVTFCSKAGRkSVISASVFANCVKAVYSQTGIRRVDn--ANGMMS-FHH 460  blac...
EEN42662               127 ETFTCSWLNSLYEVDSE---GSVARIDLYADYLSSCSKLARvGILTSTHFYRCVKTLFPNTGSKRVD---TNGQVV-YHI 199  Flor...
XP_008257582           521 EKFACQWLNAHFEINLD---CSVSRAEMYSEYLSTCSKLARgGILTSTGFYKCLRTVFPNHTVRRVEdssSSGQAH-IHV 596  rabbit
XP_015208422           522 EKFTTQWLNAHFEVHSD---SSVSRSEMYSEYLATCSKMARgGILTSTGFYKCLRSIFPNHTVKRMEdpkTNGQAH-IHV 597  spot...
EPS95356               215 QIFVQAWLTANYAPYPD---GNVPRQGLYFSYRRVCDQYGI-PHINTATLGKAIRLCFPTIKTRRLG---VRGNSK-YHY 286  Fomi...
GAA96359               352 TAFVQAWLQQSYTTCTE---GNVSRQGLYGSYLDTCESYGI-KAVNSASFGKAVRHVFVNIRTRRLG---VRGNSK-YHY 423  Mixi...
WGS:AAWC:PGTG_11391.3  425 QAFVQAWLNSSYISYTD---GNVSRQGLYGSYLRICQQYDI-KPINSASFGKSVRQSFPNIKTRRLG---VRGNSK-YHY 496  Pucc...
EOR02939                60 AQVAREWLLDNFAECEGcedSSVPRQQVYASYTSFCVSHNT-PPAACRIFGKIVRKLFPHVFIRRLG---SRAVSI-YHY 134  Wall...
XP_017947767           596 AGVRRRA 602  tropical clawed frog
XP_002111154           527 TGVRKRA 533  Trichoplax adhaerens
XP_002416101           461 DGLRKRL 467  black-legged tick
EEN42662               200 SGIKKRA 206  Florida lancelet
XP_008257582           597 VGVRRRA 603  rabbit
XP_015208422           598 VGIRRRS 604  spotted gar
EPS95356               287 CGIRPAT 293  Fomitopsis pinicola FP-58527 SS1
GAA96359               424 VGMRAST 430  Mixia osmundae IAM 14324
WGS:AAWC:PGTG_11391.3  497 CGIRPAT 503  Puccinia graminis f. sp. tritici CRL 75-36-700-3
EOR02939               135 CGITHRS 141  Wallemia ichthyophaga EXF-994
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