7VDV


Conserved Protein Domain Family
RFX_DNA_binding

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pfam02257: RFX_DNA_binding (This model is not part of the current CDD release)
RFX DNA-binding domain
RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD).
Statistics
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PSSM-Id: 514817
Aligned: 58 rows
Threshold Bit Score: 97.2409
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7VDV_Q        521 EKFACQWLNAHFEVNPD---CSVSRAEMYSEYLSTCSKLARgGI----------LTSTGFYKCLRTVFPNHTVKRVEdss 587  human
XP_009266999   60 AQVAREWLLDNFAECEGcedSSVPRQQVYASYTSFCVSHNT-PP----------AACRIFGKIVRKLFPHVFIRRLG--- 125 
XP_011272363   42 KLITLQLINQNFHSISR---SFINKQTAHKIYQIIYSKSQYsTPqninkynyqiLNQAQFGKFIKILFPNVVTKRLG--- 115 
XP_016292049  125 DKWARMWLTCNYTLKSSi-qISIPRTILHESYRRACDSFGL-EP----------LQAASFGKVLRSQFPDVAQRRLG--- 189 
XP_002111154  454 ENFAHAWLNATYDCCTG---GYVPRSGMYSDYLATCNRLSItGI----------VNSTTFSRLIHEVFPSAEIKRV---- 516 
EEC19768      386 EAFAGTWVRAMYEPAPPg--CSVARNDIYAEYVTFCSKAGRkSV----------ISASVFANCVKAVYSQTGIRRVDn-- 451 
XP_015208422  522 EKFTTQWLNAHFEVHSD---SSVSRSEMYSEYLATCSKMARgGI----------LTSTGFYKCLRSIFPNHTVKRMEdpk 588 
XP_004995448  292 DEDTVTWLRANFELKTG---FTVERRLVYKAYCRHMQSMMQ-EP----------CNAAGFGKVIRGVFPGVTSRRLG--- 354 
EDO41435       45 QTQAFHWIRCHLEECDNs--STLPKHEVYDEYKAYCESMSAsRT----------LSAPDFGKIIKCVFPRVKARRLG--- 109 
XP_026690016   72 ATITTEWLTKNFEENSL---TSVPRSIMFDEYQKFCRDSNT-KP----------FNQAVFGKIVRACFPNLTTRRLG--- 134  vase tunicate
7VDV_Q        588 SNGQAH-IHVVGVKRRA 603  human
XP_009266999  126 SRAVSI-YHYCGITHRS 141 
XP_011272363  116 SRINSL-YVYYGITTKP 131 
XP_016292049  190 GRGKTR-FHYCGFGTSN 205 
XP_002111154  517 TYGNTNqYFYTGVRKRA 533 
EEC19768      452 ANGMMS-FHHDGLRKRL 467 
XP_015208422  589 TNGQAH-IHVVGIRRRS 604 
XP_004995448  355 SRGHSK-YHYEGLRIKP 370 
EDO41435      110 TRGNSK-YCYSGIQRKK 125 
XP_026690016  135 VRGQSR-YHYAGLSVKL 150  vase tunicate
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