Conserved Protein Domain Family
PTS_IIA
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pfam02255: PTS_IIA 
PTS system, Lactose/Cellobiose specific IIA subunit
The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.
Links
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Statistics
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PSSM-Id: 426680
Aligned: 191 rows
Threshold Bit Score: 66.3075
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_022002599    6 QIIVGLISSAGQSKSLAFEALKKVKTGEYDEARKILEQAKEADLQAHTVQTKLIQAEMSGsgNKPEVGLLMVHAQDHYMT 85  Erysipelotrich...
jgi:Amet_4186   5 EVIFQIILHAGNARGEAYDALKAAKEKDFEKAQKHLEEAEKEAGIAHRAQTEIIQGEING--KKVEMSLLFVHAQDHLMT 82  Alkaliphilus m...
jgi:Toce_0340   5 NSIFEMIAYGGNARAKAYEAAARARKGDFELAEKLLKEADEEMLKAHHVQTRLIHEEVQG--KKHEVSVLLVHAQDHLMT 82  Thermosedimini...
Q5WBR2          5 vEIFNMISNAGDAKSIAYEALKLAQNNDFHLANEKLETANKTLAKAHNTQTKLIQAEING--EHVEQSLLMVHAQDHLMA 82  Bacillus claus...
IGS:BMQ_1017    9 NEIFELIAYGGNARSLAYEALEAAEDYDFNKADELLKQSQEELSHAHKTQTALIQRELNG--KTIEKSLLLIHAQDHLMT 86  Bacillus megat...
WP_044035942    5 NITMQLITCAGDVRTYSYEALKCANEGKYKKAEELFKMAEREIEKSYDIQKEVSELELDS--ED-----LLVDAKSHLNA 77  Clostridium bo...
Q8DRC2          8 QIIMGLILYAGDAKQHIYKALDYIKNGTCERCEEEIQLADAALLEAHNLQTKFLAQEASG--TKTEITALFVHSQDHLMT 85  Streptococcus ...
bgi:05SSU0709   8 QLIMGLIIYAGDAKSHAYQALSLVKAGEEERAEEELELADAALLEAHNMQTKFLAQEAGG--AKSDITALFVHSQDHLMT 85  Streptococcus ...
Q97M17          5 QIIMNIIIYSGDARSYMYEALSKAREGKYDEINGLIKQANDAIGKAHDIQTSMLQKEAEG--EALKVSILFVHAQDQLMT 82  Clostridium ac...
Q18CM9          3 EIVLKIIIHAGNAKSMLYEALDYAKENDFKKADELIENANEEILKAHKVQTELIQKEAGG--DKSDISILLIHSQDHLMT 80  Clostridioides...

WP_022002599   86 SQLARDLIEELINVFE 101 Erysipelotrichales
jgi:Amet_4186  83 AIAEKGLIENMMDLYK 98  Alkaliphilus metalliredigens QYMF
jgi:Toce_0340  83 AMAERSLIENMIDLFR 98  Thermosediminibacter oceani DSM 16646
Q5WBR2         83 AISEMSLIEQMIAILR 98  Bacillus clausii KSM-K16
IGS:BMQ_1017   87 AISEQKLIEHMIKLIK 102 Bacillus megaterium QM B1551
WP_044035942   78 AISEKNIIGELIGLRK 93  Clostridium bornimense
Q8DRC2         86 SMTEINLIKEIISLRK 101 Streptococcus pneumoniae R6
bgi:05SSU0709  86 SITEINLIKEIIDLRK 101 Streptococcus suis 05ZYH33
Q97M17         83 TISEKNLITEMIEMTK 98  Clostridium acetobutylicum
Q18CM9         81 CMSERNLIKEMIMLRK 96  Clostridioides difficile 630
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