Conserved Protein Domain Family
Pur_DNA_glyco

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pfam02245: Pur_DNA_glyco 
Methylpurine-DNA glycosylase (MPG)
Methylpurine-DNA glycosylase is a base excision-repair protein. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA.
Statistics
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PSSM-Id: 426675
Aligned: 334 rows
Threshold Bit Score: 143.356
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Psta_0579    8 HFFARKPEVVARDLLGKILVRQVRgqlgsmLLAGRIVETEAYLATGDPACHASRGMTRKNSTMFERAGLVYVYAIHArH- 86  Pirellula sta...
Q88DL3           7 SFFDRDAQTLAKALLGKVIRHRHGd----lWLAARIIETEAYY-LSDKGSHASLGYTEKRKALFLDGGHIYMYYARG-Gd 80  Pseudomonas p...
Q87VV5           8 HFFQRDAQVLARDLLGKVIRHKVGe----lWLAARIIETEAYY-CAEKGSHASLGYTEKRKALFLEGGHIYMYYARG-Gd 81  Pseudomonas s...
WP_016490726    20 TFFDRDAQLVARELLGKVIRHRVDg----rWLAARIIETEAYY-LVDKGSHASLGYTHKRRALFLDGGHIYMYYARG-Gd 93  Pseudomonas r...
Q9HX17          20 TFFDRDALLVARELLGKVIRHRQGn----lWLAARIIETEAYY-LEEKGSHASLGYTEKRKALFLDGGHIYMYYARG-Gd 93  Pseudomonas a...
jgi:Dacet_2500   5 TFFQKDAKELAADLLGKVIRKKHGd----iFLSAMIIETECYY-LTEKGSHASLGYTEKRKALFMEGGTIYMYYSRG-Kd 78  Denitrovibrio...
Q83D16           6 EFFDRDAFEVAQNLLGKVIHVRYGk----qWLCAQIIETEAYY-KHEKASHASLGFTEKRKGLFMPAGTIYMYYARG-Gd 79  Coxiella burn...
WP_008086640    83 SFFERDAKDVALELLGKIIVYD--------GLAGKIVETEAYYGNKDPASRAYKGKKNYNRGMWLSGGHIFIYMVHA-Nw 153 Aciduliprofun...
Q9Y9P1           8 SFYYRQPDVVARELLGKILVSCASg----aCMRCMVTEAEAYFGECDPASRARRGRGRIWRALYGEPGRALVYGMHR-Qw 82  Aeropyrum per...
WP_012309390     8 DFFRRRPDIVAMDLLGKVILNRRR------EAAGIIIEVEPYFGPEDPASRARKG-GDLARTMGSEPCTALVYGVHR-Qw 79  Candidatus Ko...
jgi:Psta_0579   87 CLNVVT-EREGKPSAVLIRAIEP-L------VGLASMAQHRGIDLpgadagesrnsergqfltpdrapqfplklLRDL-- 156 Pirellula sta...
Q88DL3          81 SLNFSA---HGPGNAVLIKSAYPwQdtlsgpDSLAQMQLNNPDASgni------------------------rpQERL-- 131 Pseudomonas p...
Q87VV5          82 SLNFSA---EGPGNAVLIKSAFPwTdatsdeNALAQMQLNNPDASgai------------------------rpPQRL-- 132 Pseudomonas s...
WP_016490726    94 SLNFSA---HGAGNAVLIKSGHPwVddisqaDALAAMQLNNPDARgqa------------------------raPEQL-- 144 Pseudomonas r...
Q9HX17          94 SLNFSA---GGPGNAVLIKSGHPwLdrisdhTALERMQSLNPDSQgrp------------------------reIGRL-- 144 Pseudomonas a...
jgi:Dacet_2500  79 SLNVSC---QGEGNAVLIKGAVPyVdsqspsETIDVMQKLNPMPDgre------------------------reVKRL-- 129 Denitrovibrio...
Q83D16          80 SLNISC---QGEGNAVLIKSAIPyReaknleAMIATMQQLNPPKNkaa-----------------------crkSEKL-- 131 Coxiella burn...
WP_008086640   154 MFNITTdGEE--AQAVLIRSVEP-I------AGLKKMYERRGKR------------------------------LKEL-- 192 Aciduliprofun...
Q9Y9P1          83 LLNIVA-HSEGMAGAVLLRSCQP------------------------------------------------------Lep 107 Aeropyrum per...
WP_012309390    80 LLNIVA-HEDGELGAVLMRGIIP-I------DPVAFKPSKP--------------------------------------- 112 Candidatus Ko...
jgi:Psta_0579  157 ------ARGPGRLCQALAIDRS-LDkhdLLL-GSQLWITesleslvslasplcanSplaprvtsavrarhapnaRHSATN 228 Pirellula sta...
Q88DL3         132 ------CAGQTLLCRALGLKVPhWDaqrFD--AERLYVE-----------------------------------DCGNAV 168 Pseudomonas p...
Q87VV5         133 ------CAGQTLLCKALGLKVPaWDakrFD--PQRLLVE-----------------------------------DVGQTP 169 Pseudomonas s...
WP_016490726   145 ------CAGQTLLCKALGLKVPdWDgqrFD--WQRLFVE-----------------------------------DVGERP 181 Pseudomonas r...
Q9HX17         145 ------CAGQTLLCKAMGLKVPeWDaqrFD--PQRLFVD-----------------------------------DVGERP 181 Pseudomonas a...
jgi:Dacet_2500 130 ------CAGQTLLCRSLGLKLTeWNgrnFM--PGIFYFE-----------------------------------DVGYSP 166 Denitrovibrio...
Q83D16         132 ------CSGQTLLCKSLNLRVKeWDqkqFS--KQHFFIS-----------------------------------DNRYRP 168 Coxiella burn...
WP_008086640   193 ------CNGPGKWTRAFGIKKE-MNeesL---GGEIFIA-----------------------------------QSPWNE 227 Aciduliprofun...
Q9Y9P1         108 prldppPIGPGRLARALSIDRG-VDgapVYErGSPLTLW----------------En-----------------PEAVEG 153 Aeropyrum per...
WP_012309390   113 ------ISGPGRVTKYLGVDKS-YHkafLCSyDGELQLR----------------H------------------GLSLDT 151 Candidatus Ko...
jgi:Psta_0579  229 CAFARSPRIGVTSAQD--MLLRYYLRDSL 255 Pirellula staleyi DSM 6068
Q88DL3         169 PRVIQAARLGIPHGRDehLPYRFVDAEYA 197 Pseudomonas putida KT2440
Q87VV5         170 ERIIQTTRLGIPSGRDehLMYRFVDAGYA 198 Pseudomonas syringae pv. tomato str. DC3000
WP_016490726   182 ARIIQAARLGIPHGRDehLPYRFVDAAYA 210 Pseudomonas resinovorans
Q9HX17         182 SQVIQAARLGIPKGRDehLPYRFVDAAFA 210 Pseudomonas aeruginosa PAO1
jgi:Dacet_2500 167 EKIIQTTRLGIPAGRDehLPYRFVDFTHA 195 Denitrovibrio acetiphilus DSM 12809
Q83D16         169 SKIVKTRRLGIPKGRDehLFYRLVDHHYA 197 Coxiella burnetii
WP_008086640   228 FKVARAHRIGVRNDLE--EPLRFFIKDSQ 254 Aciduliprofundum boonei
Q9Y9P1         154 FRVACSGRVGVSEDLE--LPLRFYIAGNP 180 Aeropyrum pernix K1
WP_012309390   152 SIIIRSRRVGVREDLP--EPFNFKVRVEE 178 Candidatus Korarchaeum cryptofilum
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