5A8W


Conserved Protein Domain Family
MCR_beta

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pfam02241: MCR_beta (This model is not part of the current CDD release)
Methyl-coenzyme M reductase beta subunit, C-terminal domain
Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (pfam02249), 2 beta (this family), and 2 gamma (pfam02240) subunits with two identical nickel porphinoid active sites. The C-terminal domain of MCR beta has an all-alpha fold with buried central helix.
Statistics
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PSSM-Id: 514805
Aligned: 16 rows
Threshold Bit Score: 431.453
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5A8W_E       189 GYGLRNIMANHVVAITRKNTLNASALSSILEQTAMFETGDAVGAFERMHLLGLAYQGLNANNLLFDLVKENGK-GTVGTV 267 Methanothermoba...
Q58252       192 GYALRNIMANHFVACTKKNVMNAVAFAAIMEQTAMFEMGDAVGLFERLHLLGLAYQGLNADNLVIDLVKANGKnGTVGTV 271 Methanocaldococ...
2_pfamImport   1 GFALRNIMSNHVVALVQRNAMQGAALSSLFETCAAYEMGDAIGPFERQHLLSLAYQGLNANNLVYSLVKKNGKtGTVGTV 80 
WP_020449399 188 GYALRNIKANHIVALAGKNSMNAAALASIFEQTAMFELGDAIGPFERYHLLGLAYQGLNANNMTIDLVKANGStGTVGTV 267 Candidatus Meth...
WP_013037084 186 GYSLRNIMTNHIAAITEKKAMNAAALSSIFEQAGMFEMGNAVGEFERHQLLGFACQGLNANNVVYDLVKDNGKdGTVGTV 265 Methanohalophil...
Q0W343       189 GYALRNIPTNHCVIISKRNAMNAAALNSIFEQAGVWEMGDAIGPWERYQLMGFAYQGLNANNLVYSTVKENGKnGTVGSV 268 uncultured meth...
WP_015284891 187 GYALRNISVNHFVMMTNRNALQGSALASTLEMAGVFEMGGAIGPFERNQLLCYAYQGLNANNMVYDIVKENGQtGTVGSV 266 Methanoregula f...
WP_011019021 190 GYALRNIMVNHIVAATRKNTMQAVCLAATLEQTAMFEMGDALGPFERLHLLGYAYQGLNADNMVYDIVKKHGKeGTVGTV 269 Methanopyrus ka...
O27236       189 GYALRNIMVNHVVAATLKNTLQAAALSTILEQTAMFEMGDAVGAFERMHLLGLAYQGMNADNLVFDLVKANGKeGTVGSV 268 Methanothermoba...
WP_012956726 189 GYSLRNIKANDFVAATLKNTLQATALASIFEQTAMFEMGDAVGAYERMHLLGLAYQGLNADNMVLGLVQDNAKeGTVGSI 268 Methanobrevibac...
5A8W_E       268 IASLVERAIEDRVIKVAKEMTSGY-KMYEPADWALWNAYAATGLLAATIVNVGAARAAQGVASTVLYYNDILEYETGLPG 346 Methanothermoba...
Q58252       272 VASVVERALEDGVIKEDKTLPSGF-KLYKPVDVAKWNAYAAAGLVAAAIVNCGAARAAQNIASTILYYNDILEYETGLPG 350 Methanocaldococ...
2_pfamImport  81 VESLMERAIDDGVIRVKETLPSGY-NVYTTDDLPKWNAYAAAGEVAAVMVNVGAARAAQGVPSTVLYYNDLLEHESALPG 159
WP_020449399 268 IESLVDRAIEDKVIRVKEKLPSGY-CVYTTDDFPLWNAYAATGMLAAIMVNVGAARASQGIPSTILYYNDLLEHEVALPG 346 Candidatus Meth...
WP_013037084 266 VQSVVERAIEDNVIEVDKTAPSGY-NFYKAQDVSMWNAYAAAGQLAATMVNCAAGRAAQNVSSTILYYNDIIEKETGLPG 344 Methanohalophil...
Q0W343       269 VATIVGKAIEDKVIKVEKTLPSGY-KVYTTDDIPKWNAYAAAGVMAATMVNCGALRGAQAVSSTLLYYNDLLERETALPG 347 uncultured meth...
WP_015284891 267 VQSLVDRAVEDRVIAPGKK--GGYfQFYDTKDPMLWNAYVSAGTLAASIVNCGAGRFVQAVSSTLLYFNDLIEHETGLPG 344 Methanoregula f...
WP_011019021 270 VREVVERALEDGVIEVKEELPSGF-KVYKANDMDLWNAYAAAGLVAAVMVNQGAARAAQGVSATILYYNDLLEYETGLPG 348 Methanopyrus ka...
O27236       269 IADLVERALEDGVIKVEKEL-TDY-KVYGTDDLAMWNAYAAAGLMAATMVNQGAARAAQGVSSTLLYYNDLIEFETGLPG 346 Methanothermoba...
WP_012956726 269 VQDTIAKAEADGVIAVEKEL-TDY-NMYATNDAAKWNAYAAAGCTAAIMVNVGAARAAQGIPSTILYFNDNIEFATGLPG 346 Methanobrevibac...
5A8W_E       347 VDFGRAMGTAVGFSFFSHSIYGGGGPGIFHGNHVVTRHSKGFALPCVAAAMCLDAGTQMFSVEKTSGLIGSVYSEIDYFR 426 Methanothermoba...
Q58252       351 VDFGRAEGTAVGFSFFSHSIYGGGGPGIFNGNHIVTRHSKGFAIPPVAAAMCLDAGTQMFSPERTSALVGTVFSAIDEFR 430 Methanocaldococ...
2_pfamImport 160 VDYGRAEGVGVGMSFFSHSIYGGGGPGLFHGNHVVTRHAKGTLIPAVTAGNCLDGGTQTFSAEATSGLFKDVFGGMPEFN 239
WP_020449399 347 VDFGRSMGVAVGMSFFSHSIYGGGGPGLFHGNHVVTRHSKGFVIPAVAAGCSLDAGTQYFSPEATSGLVRDVFGDIPEFH 426 Candidatus Meth...
WP_013037084 345 CDMGRAQGTAVGFSFFSHSIYGGGGPGVFNGNHIVTRHSRGFAIPCVSAGVSLDAGTQMFSIEKTSGLIGDVFGSIKEFR 424 Methanohalophil...
Q0W343       348 VDFGKVQGTAVGFSFFSHSIYGGGGPGIFNGNHVVTRHSKGFAVPCVSAACALDAGTQMFSPESTSKAM-EVFGEIPEFN 426 uncultured meth...
WP_015284891 345 ADFGRVMGTAVGFSFFSHSIYGGGGPGIFNGNHVVTRHAYGMAIPCVVAAAAMDAGTQMFAPEGTSKIMGETYGRMDAFA 424 Methanoregula f...
WP_011019021 349 VDFGRAEGTAVGFSFFSHSIYGGGGPGIFHGNHIVTRHSKGFAIPPVAAAMALDAGTQMFSPEVTSKLIGDVFGEIDEFR 428 Methanopyrus ka...
O27236       347 VDFGKVEGTAVGFSFFSHSIYGGGGPGIFNGNHIVTRHSKGFAIPCVAAAMALDAGTQMFSPEATSGLIKEVFSQVDEFR 426 Methanothermoba...
WP_012956726 347 IDFGRAEGVAVGFSFFSHSIYGGGGPGLFNGNHVVTRHSKGFTIPCVAAGMALDAGTQLFSPEATSGLIKEVYSEIDEFR 426 Methanobrevibac...
5A8W_E       427 EPIVNVAKGA 436 Methanothermobacter wolfeii
Q58252       431 EPLKYVIKGA 440 Methanocaldococcus jannaschii DSM 2661
2_pfamImport 240 TPMQFVGAEA 249
WP_020449399 427 APLKCVGEEA 436 Candidatus Methanomassiliicoccus intestinalis
WP_013037084 425 EPIKAVAESl 434 Methanohalophilus mahii
Q0W343       427 QPLVAVAKGA 436 uncultured methanogenic archaeon
WP_015284891 425 KPIHQIAQEa 434 Methanoregula formicica
WP_011019021 429 EPMKYITEAA 438 Methanopyrus kandleri
O27236       427 EPLKYVVEAA 436 Methanothermobacter thermautotrophicus str. Delta H
WP_012956726 427 EPLKYVALAA 436 Methanobrevibacter ruminantium
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