6QTI,4O9U


Conserved Protein Domain Family
PNTB

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pfam02233: PNTB (This model is not part of the current CDD release)
NAD(P) transhydrogenase beta subunit
This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes. The domain is often found in conjunction with pfam01262. Pyridine nucleotide transhydrogenase catalyzes the reduction of NAD+ to NADPH. A complete loss of activity occurs upon mutation of Gly314 in E. coli.
Statistics
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PSSM-Id: 514799
Aligned: 236 rows
Threshold Bit Score: 468.851
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6QTI_A         622 IMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLAAT---LGGLKPcpelLaqMSG--AMALGGtIGLTIAKrIQI 696  sheep
XP_004030586    57 ASYFAASFLFIMSIISLNSFQNSRKSVLFAIGGMITAISATfyqESWNLAd--sFr-WLS--SFLIGGsIGLYFGLnTKI 131 
WP_013778787     7 IVSIVLSILVLVGIKLMSSPKTAVQGNRIGAMAMLAAVIVVlayNGIIDVp-----lLWF--AIFVGGvTGYIMAMrVKM 79   Tepidanaerob...
WP_015051803     6 VVTIVLAVVILYGIKLMSSPKTAVLGNRLGALSMFVSVLVVlfyNGIADVp-----vLWL--AVLLGAiIGYLMAMkVAM 78   Thermacetoge...
14_pfamImport    2 AVSVVLVILVLAGLNMLSRVQTAVRGNLLGALAMALAIVATlwnFGILSAv-----eLYA--AMLVGSlFGVIIWRkTQM 74  
WP_020965508     8 IICTVLSLGVLLGINMMSKVKTAVNGNRFSAVCMLIAVCVTlykYNIFSSa-----fMWI--GLGLGTlIGIILTIkAEM 80   Treponema pedis
Q73NG4           8 IICGVLSIGVLLGINMMSKVKSAVKGNRLSALCMLAAVCVTlykYNIFSAg-----mMWA--GLAIGAaIGIYLTIkVEM 80   Treponema de...
EGJ72464         8 IICAVLSIMVLIGISKMSKVETATNGNRLSALSLFLGVILTlvyYDIFDVg-----fIYI--CILIGSiIGYFFAKrIKM 80  
Q7MUZ0           8 ILCVLLSLMVLGGISMMSRVKTAVMGNTLSAVAMLGGIILTlvyNEILPAw-----sVYI--FLIIGAgIGWTMAQrVKM 80   Porphyromona...
WP_013760370    14 VICAVLSILVLVGIAMMSKVKTAARGNALSATAMGLGVLVTllkLQVVTF-------PWLigGILIGGiIGVLLYTrVKM 86   Porphyromona...
6QTI_A         697 SDLPQLVAAFHSLVGLAAVLTCIAEYIIEYPhfat---daaANLTKIVAYLGTYIGGVTFSGSLVAYGKLQGI-LKSAPL 772  sheep
XP_004030586   132 TQYGQAVCFLQSLIGLASFLLGIAQFERLKQfka-----kfNKLDSFQTVFVCLLGTMIFSSAVTCYFKLDKKnIAKEPL 206 
WP_013778787    80 IQMPQMVALLNGLGGGASALVALVEIFERYKq--------mTLFGRLTGQLALAVGAVTFSGSLIAAAKLDRR-ISQRPI 150  Tepidanaerob...
WP_015051803    79 IQMPQMVGLFNGLGGGASALVALVVIFETYPe--------mGLFSRFTSQLALVVGWVTLSGSLIAAGKLDRR-IPQQPL 149  Thermacetoge...
14_pfamImport   75 IRMPQTVALLNGLGGMASMLAGALALTGHADn---------nAFAQFTAGLAIAVGGATFFGSLIAAGKLHQI-LDQHPK 144 
WP_020965508    81 ITMPQTVALLNGLGGAASAVAALLTLAAIDGk--------tTVFAIITGGIALAVGALTFSGSLIAAGKLHKL-LPQKPI 151  Treponema pedis
Q73NG4          81 ITMPQTVALLNGLGGAASAVAALLTLAAVNTq--------aGIFAIVTGGIALAVGALTFSGSLIAAGKLHKL-LPQKPT 151  Treponema de...
EGJ72464        81 IQMPQLVALLNGIGGAASAFVGILSYVRIGStps-----eyENFTSVTAVLAIVVGLVTLVGSLVAAGKLHKV-LPQKPI 154 
Q7MUZ0          81 IQMPQMVALLNGVGGAASALVGILSLAAIGInpnnntaadyPIFSQATGMLALTVGMITLIGSLIAAGKLHKL-LPQRPV 159  Porphyromona...
WP_013760370    87 IQMPQMVALLNGIGGGASALVGALTLFQLPVs--------nVYFTLVTAFLAIIIGMLTLVGSLVAAGKLHRV-LPQKSV 157  Porphyromona...
6QTI_A         773 LL--PGRHLLNAGL---LAASV--GGI---------------IPFMMD-----PSFTTgitcL--GSVSALS----AVMG 819  sheep
XP_004030586   207 NLigKYRNSVNFIV---LICIG--VFGll------------yVVF----------SMG----FalWMIFILA----LYIG 251 
WP_013778787   151 IL--KNHGLISNAVlliIILLI-----------------------ITAsv-anISGIG----FiaIITAFLA----LAYG 196  Tepidanaerob...
WP_015051803   150 VI--KGHNVVNALClliLGVLV-----------------------AAGsf-gsAAAAV----VvsVLVTLLS----LGFG 195  Thermacetoge...
14_pfamImport  145 VL--PAHSVWVGLS---LLVSLgaALAyvfppfsspggaqtvLL---------------------IVQIVAA----NLFG 194 
WP_020965508   152 VL--PYHQALTVLT---FLGMTafIVF---------------LPLKIErlsiiMLS---------FIGLAVS----FLFG 198  Treponema pedis
Q73NG4         152 VL--PAHQALTTVS---FLGMIafIVL---------------LPIKPElm--iIIS---------VAGLVIS----LLFG 196  Treponema de...
EGJ72464       155 VW--KNHQLLTTIF---IIGSIvpVVGayfsqdssfffanpsFV------------------------LLLSiassCLFG 205 
Q7MUZ0         160 IW--PNHSMFTSLL---LILTVgfVVL------------------GS------VSIEG----FplFWAIIGGlffsSLFG 206  Porphyromona...
WP_013760370   158 VW--PFHNVATSLT---LVVAVffLLIgtlny-----vvpsaLI------------------YamIGTMLFS----ALFG 205  Porphyromona...
6QTI_A         820 VTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILG--GY----- 892  sheep
XP_004030586   252 WGLVVSVQQRQLNVIIPFQTVLMGITLSFVGFVFNRDYLIIVGALCITGGYKLTQRASHGINCGIFDAYFK--SW----- 324 
WP_013778787   197 VLFAIRVGGADMPITISLLNSFSGLAGAICGFTIEDPLLVAVGAIVGASGLILTQIMCGAMNRSLVDILSG--------- 267  Tepidanaerob...
WP_015051803   196 VLFAIRVGGADMPITISLLNSYSGLAGAICGLTIGDPLLVSVGAIVGAAGIILTGIMCRAMNRSLLEVLNG--SV----- 268  Thermacetoge...
14_pfamImport  195 YLLAVRVGGADMPITISLLNSLSGVAGAIAGLAISDLLLVAIGAIVGASGLLLTQIMCRAMNRHLMEILLGntSVstaa- 273 
WP_020965508   199 VFFAVRVGGADMPITISLLNSTSGVAASITGMAIGDILLVSVGGIVGASGLLLTQIMCRAMNRSLAAILFSk-------- 270  Treponema pedis
Q73NG4         197 IFFAIRVGGADMPITISLLNSTSGVAASIAGMAIGDILLVSVGGIVGASGLLLTQIMCRAMNRSLASILFSkaASpakpa 276  Treponema de...
EGJ72464       206 LTFAIRVGGADMPITISLLNSLSGVAGAIAGMAIGDILLVSVGGIVGASGLLLTQIMCRNMNRHLIDILLGktSAagk-- 283 
Q7MUZ0         207 LFFSIRVGGADMPITISLLNSLSGVAGAIAGMAVGDILLVAVGGIVGASGLLLTQIMCRAMNRKLMSILMAs-------- 278  Porphyromona...
WP_013760370   206 LYFSIRVGGADMPITISLLNSLSGVAGAIAGMAIGDIFLVAVGGVVGASGLLLTQIMCRAMNRSLINILIPhgK------ 279  Porphyromona...
6QTI_A         893 -----GTTSTAGGKPMEISg-----THT------EINLDNA----IDMIREANSIIITPGYGLCAAKAQYPIADLVKMLS 952  sheep
XP_004030586   325 --------NDQNIEIKSNIssdfayNNQ------DINFMDL----SNELMSASNIVFVPGNGIYQQQCTKYIADIALYLQ 386 
WP_013778787   268 -----SQLNSGINKKETTPkekvidVGKp----pVTAKKLP----AEILKTAKKVVIVPGYGMAIAQAQSQVKALYDTLE 334  Tepidanaerob...
WP_015051803   269 -----AAVNLAGDSLLSPAagenggTAE------SEKSLDA----PSLLKEAQKVIIVPGYGMAVSQAQWQVKKLLDVLE 333  Thermacetoge...
14_pfamImport  274 -atptETESEKPDDSACAGetdtseTTRgdrptlAAPVADPentfADWVENAQRVILVPGYGMALSQAQAQVKRLLDYLE 352 
WP_020965508   271 ----aSSPSKPIKQDQTSSesltklEAQktedekPGSEKDI----GSWFGEAKDIIIIPGYGMALSQAQGLVKQLSDKLE 342  Treponema pedis
Q73NG4         277 kpaqpASPSESSSKEASEKqaqqtgEAKpaqqelTATGHADksqlTSWFNDAKEIIVIPGYGMALSQAQGLVKQLADKLE 356  Treponema de...
EGJ72464       284 ---pkAASSSKATVQSAPQktekkeETL-----------------SDIVSNAKEVILIPGYGMALAQAQHQVKQLADKLE 343 
Q7MUZ0         279 ----gAKATPAATTPTTASkqekgeVAApapakaEKTA-------GSVLRDAKRVIIVPGYGMALAQAQHQVRQLADKLT 347  Porphyromona...
WP_013760370   280 -----AKAPAKATAPAKAAapapkaPAApqpkqeSSPIDQA----VAMLRGAKRVIIVPGYGMALAQAQQEVKQLADKLA 350  Porphyromona...
6QTI_A         953 EQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINhDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEV 1032 sheep
XP_004030586   387 EAGKNIQFCIHPSSGKLPGHMNAILAEYDVAFEIIKELEEVD--FSKFELCIIVGAYDEINPDFYN-----FQKIPTCQV 459 
WP_013778787   335 SQGKEVKFAIHPVAGRMPGHMNVLLAEVDVPYDKLCEMDVINpEFSETDVAIVVGACDVINPAANTAEGTPIYGMPVLKV 414  Tepidanaerob...
WP_015051803   334 SQGKEVKFAIHPVAGRMPGHMNVLLAEVDVPYDRLYEMEAINpEFKDTDVVVVIGACDVVNPAAITAEGTPIYGMPILRV 413  Thermacetoge...
14_pfamImport  353 KSGKTVDFAIHPVAGRMPGHMNVLLAEVDVDYEKLREMKDINdDFASADLTVVIGANDVMNPAANTAEGTPIYGMPVLNV 432 
WP_020965508   343 GMGKTVRFAIHPVAGRMPGHMNVLLCEVDIPYDKLYEMETINgEFEKADLAVIIGASDVVNPAANTAEGTPIYGMPVLAA 422  Treponema pedis
Q73NG4         357 SMGKNVRFAIHPVAGRMPGHMNVLLCEVDIPYDKLYEMEAINpDFDKTDLAIIIGASDVVNPAANTAEGTPIYGMPVLAA 436  Treponema de...
EGJ72464       344 KNGAKVRFAVHPVAGRMPGHMNVLLAEADVPYDELYEMEQINdDFKKTDLVIVIGANDVVNPAAREAEGTPIYGMPVLNA 423 
Q7MUZ0         348 ANGTEVRYAIHPVAGRMPGHMNVLLCEADVPYDQLFEMDAINgDFAQTDAVVVIGANDVMNPAARNAEGTPIYGMPVLNV 427  Porphyromona...
WP_013760370   351 RGGADVKYAIHPVAGRMPGHMNVLLAEANVDYDSLYEMEAINdQFANTDAVIVIGANDVLNPAARNAEGTPIYGMPVLNV 430  Porphyromona...
6QTI_A        1033 WKSKQVIVMKRSLGVGYAAVDNPIFYK-----PNTAMLLGDAKKTCDALQA 1078 sheep
XP_004030586   460 WESNRVVYIQTKVE---NNKNNGVFDY-----NNVFVLKGDNQKNLEAVYN 502 
WP_013778787   415 EEAKNVIVCNLDTKPGYSGVENSLYEL-----LHVHLLLGNAADTVKELVE 460  Tepidanaerobacter acetatoxydans
WP_015051803   414 DEAKYVVVCNMDTKPGYSGVPNPLYDR-----PNVVLLQGDAAETVEKLTR 459  Thermacetogenium phaeum
14_pfamImport  433 GDCAHVAIFNFDLKPGYAGVENPLYARaetepERVLIFPGDAKETLA---- 479 
WP_020965508   423 DKAKKLVICNFDLQPGYAGVPNPLYEPn----ENIMLLLGDAKDSIAKILK 469  Treponema pedis
Q73NG4         437 EKAKKLIICNFDLQPGYAGVPNPLYEPn----PNTMMLLGDAKDSINTMLD 483  Treponema denticola
EGJ72464       424 DQAKNVIVCNYDTKPGYAGVENPLYKS-----NKTKMLLGDAKESLYKVLE 469 
Q7MUZ0         428 DDAPEVIICNFDLKPGYAGVDNPLYTRa----TGVFLKLGDAKESLAEIMK 474  Porphyromonas gingivalis
WP_013760370   431 DQAKQVIICNFDLKPGYAGVENPLYSRg----EGVALCLGDAKATIDQILS 477  Porphyromonas asaccharolytica
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