4USG,4BHM


Conserved Protein Domain Family
PC4
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pfam02229: PC4 (This model is not part of the current CDD release)
Transcriptional Coactivator p15 (PC4)
This domain is found at the C-terminal end of Activated RNA polymerase II transcriptional coactivator p15 from humans, YdbC from Lactococcus lactis, and other PC4 family members. p15 has a bipartite structure composed of an N-terminal regulatory domain and a carboxy-terminal cryptic DNA-binding domain. Activity is controlled by protein kinases that target the regulatory domain.
Links
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Statistics
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PSSM-Id: 514797
Aligned: 149 rows
Threshold Bit Score: 37.8563
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4USG_A              3 FQIGKMRYVSVRDFKGK-VLIDIREYYMdpeGEMKpGRKGISLNPEQWSQLKE 54  human
WP_014355807       17 LPSGWQKELNLVSWNERdPKYDLRDWNA---DHEK-MRKGITLTTDELAQLRD 65  Acetobacterium woodii
WP_276749329       20 SKSGWNLELNFVSWGGRpAKYDIRSWDS---EHQK-MGKGVTFTKDELCALKN 68  Treponema succinifaciens
WP_015045303       18 SAKGWTKELSLVSWNDKeAKYDIREWSP---EHDK-MGKGVTLSNEELKKLKE 66  Dehalobacter sp. CF
27_pfamImport       1 SSKGWTKELNIVSWNGAnPKFDLRDWAP---EHEK-MGKGLTFTNEELKNLRD 49 
WP_011989102       18 SPKGWKKELNLISWNNNaPKFDIRDWSP---EHTK-MGKGVTLTNEELKKLKD 66  Clostridium kluyveri
WP_022128195       18 SARGWTKELNMVSWNERePKYDLREWNP---DHTR-MGKGITLTEEEVETLKK 66  Ruminococcus sp. 210702-SL.1.03
Q8Y9F0             18 NARGWRKELNKVSWNGRpPKYDIRDWSE---DHEK-MGKGITLTDEEAEVLKK 66  Listeria monocytogenes
licsiro:TALC_01058 19 SSKGWKKELNLVSWNGRePKYDIREWSP---DGSK-MGKGITLSAEEAAVLKK 67 
CDC09373           18 NPKGWTKELNLISWNGRdPKYDIREWAP---DHEK-MGKGVTLSKDEMAALQE 66
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