6R4M,2AGC


Conserved Protein Domain Family
E1_DerP2_DerF2
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pfam02221: E1_DerP2_DerF2 (This model is not part of the current CDD release)
ML domain
ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.
Links
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Statistics
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PSSM-Id: 514791
Aligned: 75 rows
Threshold Bit Score: 66.2411
Created: 13-Feb-2025
Updated: 25-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6R4M_A        42 SPLYQC---DIlDKQLVEiKEVNLD----PN---PPVRGENLTISANGeVFETIEEGAYIDVEVRLgyIRLLSQ----Tf 107 Saccharomyces c...
Q28895        22 VHFKDCg--S--AV--GViKELNVNpcpaQPc--KLHKGQSYSVNVTF-TSNIPSQSSKAVVHGIVlgVAVPFPip-eA- 90  dog
Q9Z0J0        22 LHFKDCg--S--KV--GViKEVNVSpcptDPc--QLHKGQSYSVNITF-TSGTQSQNSTALVHGILegIRVPFPip-eP- 90  house mouse
Q9DGJ3        22 VKFVDCg--S--VD--GKvVQVDIKpcsqQPc--KLHKGQSYTVNVTF-SSGVESQTSKAVVHGVLagVPVPFPip-iD- 90  zebrafish
6_pfamImport   2 VKYIDC---GS---VSGKvVTVEITpcpsQPc--KLKRGDSYTVNVTF-SSTVPSQESTAVVHGVIagVPIPFAip-iV- 70 
XP_001356946  18 LEFSDCg--S--KT--GKfTRVVVEgcdtTKsecILRRNTTVSFSIDI-NLAEEATAVKTVVHGKVlgIEMPFPla-nP- 88 
Q174K0        26 VQFENCg--D--ENTIGNySLVEVSrcnlDEpacVLKRNTNATISITF-TSDEELPELKAVVHGIIlgMEVPFNlp-nP- 98  yellow fever mo...
Q2F605        17 KFFKDCg--S--KL--ATvHNVTVSgceeSSshcILKRNTDATIGLQF-TPLHNIDRINTEVHGVImnIPIPFPlp-eS- 87  domestic silkworm
Q9VFN7        21 TDVSQCp-kS--KSKALAaGDVSISncpkSKc--ILKRNTEASIQMKI-RPERDFQELTSDIQGIIldVPLPFPgyygT- 93  fruit fly
Q16N77        21 TEVKACpstK--SMVPISeNTIDISncvkGPc--KLKRKTNVSINQKF-TPSEDIKSLTTTVFAQVlsLPLPFIgvdgT- 94  yellow fever mo...

6R4M_A       108 DLCETLednd-ieglSCPIEPGEY-NiKKIVEIPGEVPPGKYVVVARAYTEKDDLITCLTGEVIF 170 Saccharomyces cerevisiae S288C
Q28895        91 DGCKsg--------iNCPIQKDKTySyLNKLPVKNEYPSIKLVVQWMLLGDNNQHLFCWEIPVQI 147 dog
Q9Z0J0        91 DGCKsg--------iNCPIQKDKVySyLNKLPVKNEYPSIKLVVEWKLEDDKKNNLFCWEIPVQI 147 house mouse
Q9DGJ3        91 DGCKsg--------iQCPIVPQKPyNyVTELPVKTEYPAIKVVVEWELRDDSSKDLFCIKFPVQI 147 zebrafish
6_pfamImport  71 DGCKsg--------iECPIQNGQTyHyVATLPVKDEYPALKLVVEWELRDDNSKDLFCIKFPVEL 127
XP_001356946  89 NACVNsg-------lKCPLEKGESyRyTATLPVLKTYPKVAVLVKWELQDQNSDDIICVEIPAKI 146
Q174K0        99 NGCKDsg-------lECPLAPDTEhKySTTLPVLKQYPKVAVEVKWELKSGDK-DVICVKIPAKI 155 yellow fever mosquito
Q2F605        88 DACKDng-------lTCPLKEGTLaDyKATLPILKSYPKVTVEVKWELQSEHG-DLVCVLINAKL 144 domestic silkworm
Q9VFN7        94 SACPHIydeagekkvGCPLKAGQVyTyKNSFKILPVYPTVSLEIHWGLGDKH-GDAACFQIPAKI 157 fruit fly
Q16N77        95 SACDYIfaedgetklGCPLKAGVPvVyKRSFPVLEIYPKMSLTVHWELQGRGSKSVTCFEVPAKI 159 yellow fever mosquito
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