1V31,7VDV,2MPS


Conserved Protein Domain Family
SWIB

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pfam02201: SWIB (This model is not part of the current CDD release)
SWIB/MDM2 domain
This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.
Statistics
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PSSM-Id: 514775
Aligned: 318 rows
Threshold Bit Score: 42.0878
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1V31_A        10 EKFKLSTALMDVLG-----IEveTRPRIIAAIWHYVKARKL--QNPNDPSFFNCDAALQKVFGEEKLKFTMVSQKISHHL 82  thale cress
Q6FSV4       126 IKMTVTPELQAVIG-----THyqSRTEIVRNLWKYIKEHNL--QNPDDKRQIISDAMLEPVLGk-TSDIFMMHRALKHHI 197 [Candida] glabrata
XP_067751490 160 ERFTISPELKTAIGqylgpAKafTKQDIVLAMWQYIKLRNL--IKEDDCRVVVCDERLGQVLnCVSLPFTSIIVALKQHL 237
XP_008074514 188 DRYKLAAPVRKLFN-----KEteTKTGLLIDLWKYIRLNRL--ITETSDFIVTCDEKLREIFdCDHFKILDMPRLVSALL 260
EPR79849     321 DLHKLSPKLSYLLK-----RKvgTKTDIIIDIWKYIKTTKLpiQQIENDKRVTCDTLLNSIFnIDSFTYKQIPILINDHL 395
XP_024330167 172 NIYKLSLSLASLLS-----VAssTKPNLVGLLYKYVARNSL--LDK--NNVVKCDEALKNVFlIDSFVFTELPELLEEHL 242
XP_007604242 146 NIYRLSPALSCLFN-----KLtdTRYNIIKDIYKYVNTYKL--NDY-ATSNVFCDENLENVFnIKNFNFNNIQSILEPHL 217
Q8SVS5       167 EIFRLSTKLGNLLM-----RYtdTKPNVVTHLWRYVNKNGL--MSI-DSDVVECNPLLKDILgVDRFSFPELPGLVVPHL 238 Encephalitozoon...
XP_003292560 232 QKYKVLGGLSQLLN-----IHtdTKPRIILALWHYIKSNTL--LDP-DTKKITCDENLKNIFNlDELQFNQIPQLLREHL 303
XP_004362559 223 QKNKVLGPLSTLLH-----IHtdTKPKIISALWNYIKVNRL--LDL-ESKKVLCDDQLKNIFGvDSMQFNQIPQLLREHL 294
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