1D8J,6GYL


Conserved Protein Domain Family
TFIIE_beta

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pfam02186: TFIIE_beta (This model is not part of the current CDD release)
TFIIE beta subunit core domain
General transcription factor TFIIE consists of two subunits, TFIIE alpha pfam02002 and TFIIE beta. TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The structure of the DNA binding core region has been solved and has a winged helix fold.
Statistics
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PSSM-Id: 514762
Aligned: 64 rows
Threshold Bit Score: 54.4489
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1D8J_A         9 KFGVLAKIVNYMKTRHqrgdtHPLTLDEILDETQhlDIGlkQKQWLMTEALVNNPKIEVid--gKYAFKPKYNV 80  human
XP_013933337  63 LSIRLMTASDFIKTSD-----HPVKIDELQQHIKc-KVD--P---KLLKVLTNVDRIKYdpvnqTLEYLSLHNI 125
XP_002619422  95 LSTRLHLAVEYIKSQD-----APVPISKLQGYLSf-DIS--D---TLLPLLKEIDRIKYdpannTLEYMSLHNI 157
XP_011273768  82 LSTKLLLAVEYIKERV-----NPVPIDTLLSYLSl-NND--EQKSKLLTLVKNLDKIYFnpddnTLEYVSIHNI 147
XP_022463478  37 DSSKLLWATEYVQKKG-----KPVPINELMDYLSl-SPN--D---KVLDLLKKLEKIEFdpkknAFRYISTYDV 99 
P36145       124 DSSKLLWATEYIQKKG-----KPVLVNELLDYLSm-KKD--D---KVIELLKKLDRIEFdpkkgTFKYLSTYDV 186 Saccharomyces cerevis...
XP_003683967 153 DSSKLLWATEYIQKKG-----QPVLLNELCDYLSi-SKK--D---KIVELLKKLEKIQFddktnSYKYISTYDV 215
Q6CXS4        81 LSTKMLIATEYIQERG-----EAVPVDQIESYLSl-PKD--N---NVIPMLKGLQKFKFdpkrnTLQYVSIYDV 143 Kluyveromyces lactis
XP_002554438  67 LSTKLLLATEYIQERG-----EAVPIEQIESYLSl-SSE--N---NVIPLLKNINKIKFdpkhnTLQYVSIYDV 129
6GYL_X       124 dSSKLLWATEYIQKKG-----KPVLVNELLDYLSm-KKD--DK---VIELLKKLDRIEFdpkkgTFKYLSTYDV 186 Saccharomyces cerevis...
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