1URF,1CXZ,8P0S


Conserved Protein Domain Family
HR1
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pfam02185: HR1 (This model is not part of the current CDD release)
Hr1 repeat
The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN). The first two of these repeats were later shown to bind the small G protein rho known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography. It forms an antiparallel coiled-coil fold termed an ACC finger.
Links
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Statistics
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PSSM-Id: 514761
Aligned: 160 rows
Threshold Bit Score: 33.2279
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1URF_A           9 RVAGLEKQLAIELKVKQGAENMIQTYS---------NgsTKDRKLLLTAQQMLQDSKTKIDIIRMQLRR 68   human
XP_007409492     7 KIQDLQSRISKERKIIHGFQVMRT------------A--TSNQDIIRSCDSKIRDSEKTISFYQQSIQE 61  
50_pfamImport    1 KIQEVYRHIQAERKILEGAQALRQ------------A--TNNQDVLRKNEATIRETERSLSYFEDTLRE 55  
44_pfamImport    1 KIQDVYRRIQTERKMLEATQRVRQ------------A--TTNPDVLRSTDAKMREAERSLSYFEDLLRQ 55  
XP_007330016    13 KIQEVYKHIQTERKILEASQQLGR------------A--TLNQEVLGRNAAKIRETEKNLAYYEQTLRE 67  
XP_050201644     8 KIQEVYKHIQKERKILEASQLLRR------------A--TQNQDVLSRNEAKIRETERSLSYFEETLRE 62  
Q90Y37         462 RLEKITKELDEEMNSRKGLESTLRQLErekallqhkS--VESHRRAESEADRKRCLENEVNSLRDQLDE 528  zebrafish
8P0S_A          42 KLDKIXKELDEEGNQRRNLESTVSQIEkekxllqhrI--NEYQRKAEQENEKRRNVENEVSTLKDQLED 108  human
XP_064409662   461 KLDKIMKELDEEVNQRKSLDSAVSQLEkeklmvhhrI--NEHQRKAEQENEKRRNAENEVSTLKEQLEE 527  coelacanth
XP_029704973   467 rLEKLVKELDKEMSGRQKVEASLRQLErerallqhqS--VENLRKVELETDRKRSLENELNNLRDQLED 533  torafugu
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