3GGG,2F1K


Conserved Protein Domain Family
PDH_N
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pfam02153: PDH_N (This model is not part of the current CDD release)
Prephenate dehydrogenase, nucleotide-binding domain
Members of this family are prephenate dehydrogenases (PDHs) EC:1.3.1.12 involved in tyrosine biosynthesis. This is the N-terminal nucleotide-binding domain of PDHs, which has a modified Rossmann nucleotide-binding fold with an extended beta-sheet sandwiched by three helices on each face.
Links
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Statistics
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PSSM-Id: 514741
Aligned: 10 rows
Threshold Bit Score: 162.181
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3GGG_D  48 FAKSLRRSGFKGKIYGYDINPESISKAVDLGIIDEGTTs-IAKVEDFspDFVMLSSPVRTFREIAKKLSYi-LSEDATVT 125 Aquifex aeolicus
O25931   5 LGLALQEWGRFKSVIGYDHNALHAKLALTLGLVDECVG--FEKILEC--DVIFLAIPVEGIIGCLKKMTS--IKKSATII 78  Helicobacter pylori
Q04983  19 AARATKAYCPDVTVSLYDKSEFVRDRARALNLGDNVTDdiQDAVREA--DLVLLCVPVRAMGIVAAAMAPa-LKKDVIIC 95  Zymomonas mobilis sub...
Q9Z4W3  16 VGLALRRHG--VTTYLTDADPEAALAGERCGAGFAAPPp-----RQA--DIAVLAVPPDQVAPVLAEHQK--LGTARCYT 84  Streptomyces coelicolor
Q58029  21 FARYLKNKGFNVIVTGRDIEKGKNVEK-ELGVEFTNNN--IEAAKKG--DIVIVAVPINVTERVIKEVAPh-VREGCLLM 94  Methanocaldococcus ja...
O27677  24 IARFLRKEGFRVIITGRDPDTGRSAAG-RIGAKYCRDN--VRAASLA--DVVVVSVPIEVTSDVLREVAPh-VREGGLLM 97  Methanothermobacter t...
O67636  45 FAKSLRRSGFKGKIYGYDINPESISKAVDLGIIDEGTTs-IAKVEDFspDFVMLSSPVRTFREIAKKLSYi-LSEDATVT 122 Aquifex aeolicus
P73906  15 LAGDLRRRG--HYLIGVSRQQSTCEKAVERQLVDEAGQd-LSLLQTA--KIIFLCTPIQLILPTLEKLIPh-LSPTAIVT 88  Synechocystis sp. PCC...
P20692  20 IALAIKKNHPGKRIIGIDISDEQAVAALKLGVIDDRADsfISGVKEA--ATVIIATPVEQTLVMLEELAHsgIEHELLIT 97  Bacillus subtilis sub...
2F1K_A  15 LAGDLRRRG--HYLIGVSRQQSTCEKAVERQLVDEAGQd-LSLLQTA--KIIFLCTPIQLILPTLEKLIPh-LSPTAIVT 88  Synechocystis sp. PCC...

3GGG_D 126 DQGSVKGKLVYDLENILg--KRFVGGHPIAGTEKSGVEYSLDNLYEGKKVILTPTKK-TDKKRLKLVKRVWEDVGGVVEY 202 Aquifex aeolicus
O25931  79 DLGGAKAQIIRNIPKSIr--KNFIAAHPMCGTEFYGPKASVKGLYENALVILCDLED-SGTEQVEIAKEIFLGVKARLIK 155 Helicobacter pylori
Q04983  96 DTGSVKVSVIKTLQDNLp-nHIIVPSHPLAGTENNGPDAGFAELFQDHPVILTPDAH-TPAQAIAYIADYWEEIGGRINL 173 Zymomonas mobilis sub...
Q9Z4W3  85 DVSGVKVRLHREVRAHGcdlTSLVSGAPVVGG--SGPVQARADLFDGRPWALTPTEA-TGNLALNCALELVALCGAVSVL 161 Streptomyces coelicolor
Q58029  95 DITSIKEIPSKAMEEHVkegVTVIPTHPMFGP--------STPSLLRQVVILTPSEKhKNTEWFNKVYNFLKKEGAKVIV 166 Methanocaldococcus ja...
O27677  98 DVTSVKEEPARVMERFIargAHYIPAHPMFGP--------RVSSLEGQVVVLTPSG--DN-PWLDDVIRFLEERKARVIV 166 Methanothermobacter t...
O67636 123 DQGSVKGKLVYDLENILg--KRFVGGHPIAGTEKSGVEYSLDNLYEGKKVILTPTKK-TDKKRLKLVKRVWEDVGGVVEY 199 Aquifex aeolicus
P73906  89 DVASVKTAIAEPASQLWs---GFIGGHPMAGTAAQGIDGAEENLFVNAPYVLTPTEY-TDPEQLACLRSVLEPLGVKIYL 164 Synechocystis sp. PCC...
P20692  98 DVGSTKQKVVDYADQVLpsrYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQK-TDKQAVEQLKNLLKGTNAHFVE 176 Bacillus subtilis sub...
2F1K_A  89 DVASVKTAIAEPASQLWs---gFIGGHPXAGTAAQGIDGAEENLFVNAPYVLTPTEY-TDPEQLAXLRSVLEPLGVKIYL 164 Synechocystis sp. PCC...
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