Conserved Protein Domain Family
DENN

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pfam02141: DENN 
DENN (AEX-3) domain
DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.
Statistics
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PSSM-Id: 460461
Aligned: 35 rows
Threshold Bit Score: 151.957
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9Y7Q7        362 WIPNAYGLLSKHSHLQSFcRDWLRIVCSSIQAEDLdfipssdlnslksLNLQSFVKNiCCDVPLPPKGLLQLQ--VNVGP 439  Schizosacchar...
Q2GNY8        440 WTPRAFGILGRDPAKMGFwKEWLRAVTVPMTDGAVmrispsspkvgrwQPLERYVINlCTEAFSPLSSLTQVE--LGVRE 517  Chaetomium gl...
Q0CL54        423 WIPRAYGILGREENMTSFwKEWLKAVVVPMTDGGVqrippssprmgvwQPLERYVMNlCTEAFSPNSSKTQVE--LAVRE 500  Aspergillus t...
Q0US70        418 WIPRAYGVMGRDASLTPFwKEWLKAVVVPMTNGAIlrvpassprigmwQPLERYVVNlCAEALSPITSITQVE--LAVRE 495  Parastagonosp...
XP_001595861  465 WIPRAYGILGRDGSMTSFwKEWLKAVVVPMTDGGIlrvpasspkigrwQPLERYVVNlCTEALSPLSSKTQIE--IAVRE 542 
Q7PWX7        201 HVNKSICILSRWPFGDTF-EKWLQFLHQLSILDEKl-----------pVPIERYITHlLDEVPFPSPSILLQLs-tLSNN 267  Anopheles gam...
XP_001638127  298 HTNKCICILSHWPFFEAF-KKFLSQLYRISVSAQQ-------------IPIERYIANmMLDVPFPSPQRPRILieMTRYE 363 
A6H8H2        307 NSNKCICLLSHWPFFEAF-KNFLMFIYKVSVSGPHp------------LPIEKHISHfMQNIPFPSPQRPRILiqLSVHD 373  house mouse
Q3U1Y4        313 RSRRAIAVLSRWPAFPAF-RAFLTFLYRYSVSGPHr------------LPLEAHISHfIHNVPFPSPQRPRILvqMSPYD 379  house mouse
AAI27591      305 QVKKSICVLSHWPFFSVF-QKFLTFIYRYSISGPHv------------LPLEKHISSfMHNVPFPSAQRPRILvqLSPYD 371 
Q9Y7Q7        440 LNLYAFRSpVNEIpgwNDVDLYpLFRALSIPNILVLFEAALMEAKVIFLSENLGMLGYASQALLHLLYPLTWQGLYIPVL 519  Schizosacchar...
Q2GNY8        518 LRLYARKEaANEIpgsRTIDIYaLFRCLSLENIVLLLECAMSEARIIFLSSHTGMLHLACHALANLLYPLKWASIFIPVL 597  Chaetomium gl...
Q0CL54        501 LRLFARKEaANELpgsRNTDLYaLFRTLSLSNIVILFEYALTESRIIFLSSHTSMLYLATRALVDLLFPITWTGVLIPVL 580  Aspergillus t...
Q0US70        496 LRMYARKEaLNEIpgsRNIDIYaLFRCLSIPNIVTLFEFVLSESRIILLSSHTAMLHLASMAIVNLLYPFQWAGVFIPIL 575  Parastagonosp...
XP_001595861  543 LRLFARKEaPNELpesRNTDIYaLFRALSIPNIVALVEFMLSESRIILLSSHTAMLHLASKALVSLLYPLKWASIFIPVL 622 
Q7PWX7        268 RVLLTLPE-DSPLp-rSGAGFRqLLSNLGPENCLHVLLLVLTEQKLLIHSLRPAILTAVAEAVSSFLFPFKWQCPYIPLC 345  Anopheles gam...
XP_001638127  364 PFEISQLY-HSPLp-vSGASYSaMLRHLGPDNCLLLFYLILTEHKILIHSLRPALLTSVAEALTNVLFPFTWQCPYIPLC 441 
A6H8H2        374 AFILSQPV-STPLp-lSGANFSsLLMNLGPENCATLLLLVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLC 451  house mouse
Q3U1Y4        380 NLLLCQPV-SSPLp-lSGASFLqLLQNLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLC 457  house mouse
AAI27591      372 NLLLCQPV-SSPLp-lSGASFVkLLQNLGPENTCSLLLAVLTEHKLLLHSLRPDVLTSVSEALLSMTFPLRWHCPYIPLC 449 
Q9Y7Q7        520 PRRLISCFEAPCSYIIGTLSYFFHmDDVPLDNIPLVvcDLDKN 562  Schizosaccharomyces pombe 972h-
Q2GNY8        598 PARLISALEAPCPYIVGVERRYEK-IELPDDDYVLV--DLDRD 637  Chaetomium globosum CBS 148.51
Q0CL54        581 PARLIQALEAPCPYIVGIERRYEK-VELPSDDFVLV--DLDAD 620  Aspergillus terreus NIH2624
Q0US70        576 PARLVQTIEAPCPYIVGIERRYEP-TDYPEDEYVLI--DLDAN 615  Parastagonospora nodorum SN15
XP_001595861  623 PARLISALEAPCPYIVGIERRYDN-IVLPEDDYVFV--DLDQD 662 
Q7PWX7        346 PLGLAEVLHAPLPYLIGVDSRFFD-LYEPPNDVTCV--DLDTN 385  Anopheles gambiae str. PEST
XP_001638127  442 PVALNDVLCAPCPFIIGIDSRYFD-QYDPPDDVTSV--DLDTI 481 
A6H8H2        452 PLSLAGVLSAPLPFIVGVDSRYFD-LHDPPQDVVCI--DLDTN 491  house mouse
Q3U1Y4        458 PLVLADVLSAPVPFIVGIHSSYFD-LHDPPADVICV--DLDTN 497  house mouse
AAI27591      450 PLRMADVLCAPMPFIVGVHSSYFD-LYDPPSDVVCV--DLDTN 489 
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