Conserved Protein Domain Family
DENN

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pfam02141: DENN (This model is not part of the current CDD release)
DENN (AEX-3) domain
DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.
Statistics
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PSSM-Id: 514733
Aligned: 32 rows
Threshold Bit Score: 155.425
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9Y7Q7        362 WIPNAYGLLSKHSHLQSFcRDWLRIVCSSIQAEDldfipssdlnslksLNLQSFVKNICCDVPLPPKGLLQLQ-----VN 436  Schizosacchar...
Q2GNY8        440 WTPRAFGILGRDPAKMGFwKEWLRAVTVPMTDGAvmrispsspkvgrwQPLERYVINLCTEAFSPLSSLTQVE-----LG 514  Chaetomium gl...
Q0CL54        423 WIPRAYGILGREENMTSFwKEWLKAVVVPMTDGGvqrippssprmgvwQPLERYVMNLCTEAFSPNSSKTQVE-----LA 497  Aspergillus t...
Q0US70        418 WIPRAYGVMGRDASLTPFwKEWLKAVVVPMTNGAilrvpassprigmwQPLERYVVNLCAEALSPITSITQVE-----LA 492  Parastagonosp...
XP_001595861  465 WIPRAYGILGRDGSMTSFwKEWLKAVVVPMTDGGilrvpasspkigrwQPLERYVVNLCTEALSPLSSKTQIE-----IA 539 
Q5RHZ1        778 RLPEVYCVISRLGCFNLF-SKILDEVERRRGISA--------------ALVYPFMRS-VMESPFPAPGKTIKVktflpGA 841  zebrafish
XP_012811355  143 HSPEVYCIISSLGCFGLF-AKILDEVEKRREIAT--------------ALIYPFMQG-LREATFPAPGKTVKIksfipES 206 
XP_011540491   93 RLPKVYCIISCIGCFGLF-SKILDEVEKRHQISM--------------AVIYPFMQG-LREAAFPAPGKTVTLksfipDS 156  human
XP_003963032  567 RLPEVHCIVSKLGCFNLF-AKILEEVERRREISP--------------ALVYPFMRS-VMEAPFPAPGRTVTVkiflpGS 630  torafugu
XP_029697709  693 RLPEVYCIVSRLGCFDLF-SKILDEVEKRRAISP--------------ALVQPFMRG-IMEAPFPAPGRTITVknflpGS 756  torafugu
Q9Y7Q7        437 VGPLNLYAFRSpVNEIpgwNDVDLYPLFRALSIPNILVLFEAALMEAKVIFLSENLGMLGYASQALLHLLYPLTWQGLYI 516  Schizosacchar...
Q2GNY8        515 VRELRLYARKEaANEIpgsRTIDIYALFRCLSLENIVLLLECAMSEARIIFLSSHTGMLHLACHALANLLYPLKWASIFI 594  Chaetomium gl...
Q0CL54        498 VRELRLFARKEaANELpgsRNTDLYALFRTLSLSNIVILFEYALTESRIIFLSSHTSMLYLATRALVDLLFPITWTGVLI 577  Aspergillus t...
Q0US70        493 VRELRMYARKEaLNEIpgsRNIDIYALFRCLSIPNIVTLFEFVLSESRIILLSSHTAMLHLASMAIVNLLYPFQWAGVFI 572  Parastagonosp...
XP_001595861  540 VRELRLFARKEaPNELpesRNTDIYALFRALSIPNIVALVEFMLSESRIILLSSHTAMLHLASKALVSLLYPLKWASIFI 619 
Q5RHZ1        842 GNEVIELRRPM-DSRL---EHVDLESLFNCLSVRQVVRVFASLLLERRVIFVADKLSTLSSCVHAVVALLYPFSWQHTFI 917  zebrafish
XP_012811355  207 GTEIIELTRPL-DCRL---EHIDFKTLLQCLNSQIILHIFASVVLERRVILVARDLSILSECIHAVVALLYPFAWEHTYI 282 
XP_011540491  157 GTEFISLTRPL-DSHL---EHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYI 232  human
XP_003963032  631 GNEVITLCRPV-DSRL---EHVDFDSLLQCLSVDKLLQVFASILLERRVILIADKLSVLSRCCHAVLALLYPFTWQHTFI 706  torafugu
XP_029697709  757 GTEVIELCRPS-DSRL---EHVDFECLFSSLSLRLLLRVFASLLLERRVIFTADKLSTLSQCCHAVVALLYPFTWQHTYI 832  torafugu
Q9Y7Q7        517 PVLPRRLISCFEAPCSYIIGTLSYFFHm-DDVPLDNIPLVvcDLDKN 562  Schizosaccharomyces pombe 972h-
Q2GNY8        595 PVLPARLISALEAPCPYIVGVERRYEK--IELPDDDYVLV--DLDRD 637  Chaetomium globosum CBS 148.51
Q0CL54        578 PVLPARLIQALEAPCPYIVGIERRYEK--VELPSDDFVLV--DLDAD 620  Aspergillus terreus NIH2624
Q0US70        573 PILPARLVQTIEAPCPYIVGIERRYEP--TDYPEDEYVLI--DLDAN 615  Parastagonospora nodorum SN15
XP_001595861  620 PVLPARLISALEAPCPYIVGIERRYDN--IVLPEDDYVFV--DLDQD 662 
Q5RHZ1        918 PVLPTSMVDIVCCPTPFLVGILSSSLPklKELPVEEALMV--DLGTD 962  zebrafish
XP_012811355  283 PVLPHVLIDTVSCPAPFIVGVQNQFLShiLDQPMEEVLLV--DLCKG 327 
XP_011540491  233 PVVPESLLATVCCPTPFMVGVQMRFQQevMDSPMEEVLLV--NLCEG 277  human
XP_003963032  707 PVLPASMLDVSCSPTPFLIGVLAPCLPqlLELPIEEVLIV--DLCAD 751  torafugu
XP_029697709  833 PVLPPSMLDIVCTPTPFIVGLLSSSLPrlKELPIEEVLVV--DLGNS 877  torafugu
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