5HP2,5HP2


Conserved Protein Domain Family
A_deamin

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pfam02137: A_deamin (This model is not part of the current CDD release)
Adenosine-deaminase (editase) domain
Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defence against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc.
Statistics
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PSSM-Id: 514730
Aligned: 72 rows
Threshold Bit Score: 253.655
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5HP2_A         72 SVSTGTKCINGEYMS-----DRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDdqkrSIFQK-SErGGFRLKENVQFH 145 human
6_pfamImport    1 SMGTGTKCIGQSKMR-----KSGEVLNDSHAEVIARRSFQRYLLHQPHLAASLKVe---SIFIPgTQrGLWKLRPDV-FL 71 
XP_039769521   63 AMGTGTKCIGQSKMR-----KDGDILNDSHAEVIAKRSFQRYLLHQLEAATLQQD----SIFIPgTEvGKWKLKPDLSFV 133
24_pfamImport   1 AMGTGTKCIGQNKMR-----KTGDILNDSHAETVAKRSFQRYLLHQMCLAVSYQQc---SIFIPgTEtGKWKLKPNIIFV 72 
XP_005052238   63 AMGTGTKCIGRNKMR-----KTGDILNDSHAEVVAKRSFQRYLLHQLWLAASHQQ----CIFSPgTEtGKWKLKPNIIFI 133
XP_046462219   61 SMGTGSKCVGQNKLS-----KDGDKLNDSHAEVVARRGFLRYMYHQMEIAASGKEs---GLFIVdPIsKKFLLREGVSLI 132
XP_008205328   49 SLCTGTKCLSGVELRstkcnERGNKLSDSHAEILARRAFLRYLYHQIELAISNQKs---DIFYLeDNg--IKLR-DVSFH 122
EFN63005       49 ALATGTKCLGESELIndtreKRGSRLSDSHAEVLARRAFIRYLYDQIDLALHGSEs---AVFSWsHK-NKIELNSNVSFH 124
EGI59195       49 ALATGTKCLGDSELSkgsreEKGSRLSDSHAEVLTRRAFIRYLYDQIDLTLNDSGs---AIFSRnDKnKI-ELNSNISFH 124
Q5ZI16         63 ALGTGTKCIGLNKMR-----KTGDVLNDSHAEVVAKRSFQRYLLHQMRLATSYQQc---SIFIPgTEtGKWKLKPNIIFI 134 chicken
5HP2_A        146 LYISTSPCGDARIFSPHEPiLeePADRHPNRKA------------------RGQLRTKIE-------------------- 187 human
6_pfamImport   72 FVSSHTPCGDASIIPMLEF-E--DQPCYPVSRDwahnpsme---asgnletTEDERKCEDpdspvtkkmrlepgtpdrkv 145
XP_039769521  134 FFSSHTPCGDASIIPMLDV-E--DQPCPLVTGEeainrsae---msrgpetLGNKRKQEDspnrsvtkrsrtepsdspng 207
24_pfamImport  73 FFSSHTPCGDASIIPISEP-E--NQLSKSMNGAdaagqsaqc-ssnhdhlgFEDKKKLEKmssnhiikrmknndggwfsm 148
XP_005052238  134 FFSSHTPCGDASIFPISEP-E--NQLSKPVTGGhaagqsakc-rsnhnhlcPEDKRKSEKmasnhiikrmktddgacfsi 209
XP_046462219  133 FFSSHTPCGDASIIVKENS-KimSNTTEEILK-------------------PSEIKVTSFdeeppskmp----------- 181
XP_008205328  123 FFSSQTPCGDCSIIPKLTG-EteDLVCPPKKAR------------------TEDESLASQfgqai--------------- 168
EFN63005      125 FFSSQTPCGDCSIFPKHEI-YdnGVPVHKIRRI------------------REDTCGYTIvesyc--------------- 170
EGI59195      125 FFSSQTPCGDCSIFPKLET-N--GPSPCKIRRVnkd------------aneHGIVESYYKdv------------------ 171
Q5ZI16        135 FFCSHTPCGDASIIPIRET-E--NHLSKSVDGHdiagqsvlcsssncdhrgPEDKRKSEKmasshmikrmknadggffst 211 chicken
5HP2_A        188 ---------------------------------------------------SGEGTIPVRSNasIQTWDG---------- 206 human
6_pfamImport  146 tngmahhqnfanqgs-gpvppnvsssnvtseelatvtgmapsgakvvdvyrTGAKCVPGEVG--DSGKPGvaydrvgllr 222
XP_039769521  208 strqretekqesfhgppgsgrfatavngpsgeeaisakaappgtkvvdvhrTGAKCVPGEAG--DPRSPGvgyhrvgllr 285
24_pfamImport 149 iaedlpvqqvfvkp----egnanpkscecsaqmqaanetglsrlkavdvyrTGAKCVPGELD--DARVPGigyhrvgllr 222
XP_005052238  210 itedlavqhesvkr---ednthqkscecsaemqtankdtglvrpkvvdvhrTGAKCVPGELD--DARIPGlgyhcvgllr 284
XP_046462219  182 ------------------------------------------rfdipdihrTGAKCVEGGPQ--DLKQPGvnhhvagvlr 217
XP_008205328  169 ----------------------------------------------vdiyrTGAKCVDSDERq-DPHEKGinyhtvgplr 201
EFN63005      171 ----------------------------------------------kdihrTGAKCVKGEEIq-DSRLPGvnyhtigplr 203
EGI59195      172 -------------------------------------------------hrTGAKCVKGEGAq-DPHLPGadyhivgplr 201
Q5ZI16        212 itedmavqqvfakp---egnvnpeccesseemqaanketnagklkavgvyrTGAKFVPGELS--DTLIPGieyhcvgllr 286 chicken
5HP2_A        207 VLQGE--RLLTMSCSDKIARWNVVGIQGSLLSIFV-EPIYFSSIIL--GSLYHGDHLSRAMYQRISNIED-LPPL-YTLN 279 human
6_pfamImport  223 VKPGg-dRTCSMSCSDKLARWNVLGCQGSLLMHFLeEPVYLSAVVIr-KCPYSQEAMQRAPVRRCRMSPL-YPKA-LEFK 298
XP_039769521  286 VKPGRgdRTCSMSCSDKLARWNVLGCQGALLMHLLqDPVYLAAVVIg-KCPYSPEAVRRAVIDRCRHVSP-LPDG-FRVQ 362
24_pfamImport 223 VKPGRgvRTCSMSCSDKLARWNVLGCQGALLMHFLqYPVYLSAIIVg-KCPYSQEAMRRAIIERCQHVSF-LPDG-FLTQ 299
XP_005052238  285 VKPGRgdRTCSMSCSDKLARWNVLGCQGALLMHFLqYPVYLSAVIVg-KCPYSQEAMRRAVIERCQHVSS-LPEG-FLTQ 361
XP_046462219  218 IKPGRgdRTLSMSCSDKLAKWNILGVQGSLLMNFLsKPIYVSHVIIg-KCPYSQSVMERALITRFEHSDNqMGNAvFMQQ 296
XP_008205328  202 TKPGRgdRTLSLSCSDKLAKWNVMGVQGALLSLMI-PTIKFESIVIggGCPYSLESMQRGIFQRFDPNIG---------- 270
EFN63005      204 TKPGRgnPTNSLSCSDKMAKWLILGLQGSLLSLLI-PPIKLKSITIggSCPFSLDAMERGLYKRFN----------NEMD 272
EGI59195      202 TKPGRgdPTSSLSCSDKIAKWLVLGLQGSLLSLLI-PPIKLESITIggDSPFSLDAMERGLYKRFNNKLV-SVNI-FQTK 278
Q5ZI16        287 VKPGRgdRTCSMSCSDKLARWNVLGCQGALLMHFLqYPVYLSAVIVg-KCPYSQEAMQRAVIERCRHISL-LPDG-FLTQ 363 chicken
5HP2_A        280 KPLLS--GIsnaearqpgkapnfsvnwtv---------------------gdsaievinattgkdelgrASRLCKHALYC 336 human
6_pfamImport  299 KLFEQ--SGcavqakradspgppvpcgaaiswsav--------peqpldvsangfpqgttkkgirslqaRSQISKMELFR 368
XP_039769521  363 EPQIL--QSdllfehsrsavrakgtdgtgklipcgaaiswsavleqpldvtsngfrqgatkkaigslqaRSKICKAELFG 440
24_pfamImport 300 EVKLL--QSelrfehsrqavqevqtnsktklvpcsaaiswsavpeqpldvtsdgfrqgttkkgigshqsRSKICKVELFH 377
XP_005052238  362 EVKLL--QSelqfehshqavqrvqtnsktkivpcsaaiswsavpeqpldvtsdgfrqgttkkgigshqsRSKICKVELFH 439
XP_046462219  297 KPDISqsQIefkfgkvendeddqmhpcpssiswcac-------pmkqlevavegrkqgitkknqnkpscRLEICKKNLFQ 369
XP_008205328  271 APEIVqsQIsfehrknesrtrpcpssivwclvp-------------ekpieiavdglrqgatkkknksfNLLISRKEIFK 337
EFN63005      273 KPKIF--QAkiafihkkgqqrshpcptsiiwcav------------rnsilevaaagrkqgvtkkkkgnnLFVSRRMLLQ 338
EGI59195      279 TAFMHkkgqqrsdscpisiiwcavkn----------------------saleiavagrkqgitkkrkgnNLLITRRMLLQ 336
Q5ZI16        364 EVQLL--QSdlqfehsrqaiqegqtsskrklvpcsaaiswsavpegpldvtsdgfrqgttkkgigspqsRSKICKVELFH 441 chicken
5HP2_A        337 RWMRVH----GKVPSHLLRs--KI----------TkpnvYHESKLAAKEYQAAkarLFTaFIKAGLGAWVEKP 393 human
6_pfamImport  369 SFQELL----SSISEDKWPd--SLrvr----kleT----YQEYEEASSVYQEA---WSA-LRKQAFGSWIRTP 423
XP_039769521  441 AFQKLV----GSISEDKQPa--SLrak----kleT----YWDYKEAASGYQET---WKA-LQRQAFGCWIKNP 495
24_pfamImport 378 AFQKLV----TSISQENLPd--TLrmk----tlrT----YWDYKEAASSYQEA---WKV-LRSQALLGWVKNA 432
XP_005052238  440 KFQRLM----TSISQEDLPd--TLrmk----tlkT----YWDYKQAALNYQEA---WRV-LRSQALLGWVKNA 494
XP_046462219  370 KFVSLL----NCFPTDNLPi--HLkeqhsdiqcmT----YNKAKRLCSDYFEM---WEQ-TRAKMLSTWTSKS 428
XP_008205328  338 TFLTIY----DKFLKGKLIpqhPKk--------iT----YYHCKQYSSSYQNL---WRE--KSAVFSKWPTKP 389
EFN63005      339 TFLQIFdkyqDNYNEIRHPk--KI----------T----YYDWKQWSLIYQSK---WKQ-LKLESFHKWPCKS 391
EGI59195      337 SFLQIFdkyqNYYSEIRHPk--KI----------T----YYDWKQWSIIYQNE---WKQ-LKHELFHNWPCKS 389
Q5ZI16        442 EFQKLV----TSISKENLPd--TLrmk----tleT----YWDYKEAALNYQEA---WKA-LRSQALLGWIKNA 496 chicken
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