1ZY7


Conserved Protein Domain Family
A_deamin

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pfam02137: A_deamin 
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Adenosine-deaminase (editase) domain
Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defense against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc.
Statistics
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PSSM-Id: 426616
Aligned: 87 rows
Threshold Bit Score: 303.719
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1ZY7_A         72 SVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLnNk--dDQKRSIFQK-SERGg-FRLKENVQFHLY 147 human
XP_013121440  428 SLATGTKCLDLGGVSDSGCTLTDCHAEVVSRRALVRFLYSQLELLL-CkpadSEEQSIFIPnKSCGdgFRLREGVHFHMY 506 Nile tilapia
2_pfamImport    1 SLATGTKCLDLEDESDSGRILRDCHAEVISRRALVRFLYAQLELLM-Pd--aGKEQSIFVRnKDNT--FRLQEGILFHMY 75 
13_pfamImport   1 SLATGTKCRDRGSAADGAGSLSDCHAEVISRRALLRFLYSQLELLL-WkpaeSQEESVLTPkPGGG--YRLRDGLLFHMY 77 
10_pfamImport   1 SLATGTKCRDSDGVGDREGTLSDCHAEVLSRRALVRFLYAQLELLL-CepadCEEQSIFVSnTAGGg-FRLRDGVFFHMY 78 
7_pfamImport    1 SLSTGNKGLRGDKVVSDGTALIDCHAEILARRGLLRFLYSEILKYS-Q----DANTSIFMKvKGTQk-LVLRPGISFHLF 74 
Q22618        167 ALSTGNKGLRGDKIVNDGTALIDCHAEILARRGLLRFLYSEVLKFS-T----EPPNSIFTKgKNA---LVLKPGISFHLF 238 Caenorhabditis...
XP_003092852  177 SLSTGNKGLRGDKIVNDGSALIDCHAEILARRGLLRFLYSEVIKFS-T----SPELSIFERgTEK---LVLKKGILFHLF 248 Caenorhabditis...
EGT56651      170 SLATGNKGLSGDKIRSDGSALIDCHAEILAKRGLMRFLYSEVLKHS-S----TPIKSIFLEs--GGk-LILKLGITFHLF 241 Caenorhabditis...
CAP20829      168 SLATGNKGLRGDQITSDGSALIDCHAEILARRGLLRFLYSEVLKFS-G----SATSSIFETgKI-Gk-LALRQGISFHLF 240 Caenorhabditis...
1ZY7_A        148 ISTSPCGDARIFSPHEPILEEP-A--DRHPNRKARGQLRTKIESGEGTIPVRSNa-S-IQTWDGvlQGERLLTMSCSDKI 222 human
XP_013121440  507 VSSSPCGDARLNCPYETTa--------AYPSRRFRCHLRVKVKGGEGTLPITARr--aNQKWDGlsLSKPLVTMSCTDKL 576 Nile tilapia
2_pfamImport   76 VSSSPCGDARLNCPYETTAACe----tAMNIRRFRFHLRVKASGGEGTLPVSARrsSqTRDFVL--PGKALLTMSCTDKL 149
13_pfamImport  78 VSCSPCGDARLNCPYES---T-----AACPSSRFHGHLRVKVDGGEGTLPITARt---NQNRSReaPGRPLVSMSCTDKL 146
10_pfamImport  79 ASSSPCGDARLNCPHET---TAaCeaFRHESKRFHCHLRVKVDGGEGTLPITARg---ANQNPQ-----PLVTMSCTDKI 147
7_pfamImport   75 INTAPCGAGRIDNKAKDE--S-----V--KTVNALSRLRFKIDKGMGTILGEADefEdPQTFDGiiMGERMRTMSCSDKL 145
Q22618        239 INTAPCGVARIDKKLKPG--T-----S--DDLQNSSRLRFKIDKGMGTVLGGASefEaPQTFDGimMGERMRTMSCSDKL 309 Caenorhabditis...
XP_003092852  249 INTAPCGTARVDRRMKSG--T-----A--EEIQATSQLRFKIDKGMGTVLGGADefAdPQTFDGimMGERMRTMSCSDKL 319 Caenorhabditis...
EGT56651      242 INTAPCGTARVDKKMRNG--N-----P--EEIKSSSRLRFKIDKGMGTILGGDRefEdPQTFDGimVGERMRTMSCSDKL 312 Caenorhabditis...
CAP20829      241 INTAPCGTARVDRKVRTG--T-----A--EEEQALSRLRFKIDKGMGTVLGGAEefAdLQTFDGimSGERMRTMSCSDKL 311 Caenorhabditis...
1ZY7_A        223 A----RWNVVGIQGSLLSIFVEPI-------YFSSIILGSLYHGDHLSRAMYQRIsNIEDLPPLYTLNKPLLSGISNAEA 291 human
XP_013121440  577 A----KWSVVGLQGALLSHLVEPV-------YLQSLTVGTLSHTGHLGRAMARRLaPIKHLPFPYRRQQLLLGCLSSRDA 645 Nile tilapia
2_pfamImport  150 A----KWCIVGMQGALLSHLVEPI-------YLHSLTVGTLCHTGHLARGMARRLtPVKHLPLPYRRQQLLS-----RNV 213
13_pfamImport 147 AkngpRWSVVGLQGALLSHLIEPV-------YLQSLTVGTLSHTGHLSRALTRRLaPVRRQLLPYRRRRLLLGYLSSREV 219
10_pfamImport 148 A----KWSVVGLQGALLSHLVEPV-------YLHSLTVGTLSHTGHLGRAVARRLaPVRRLPFPYRRQKLLLGSMKATAV 216
7_pfamImport  146 L----RANVLGVQGALLSHFVEPI-------YYSSIAVAEKNNVERLQRAVFGRa-ASYQPKKPYRVQSVVIGECQVEDV 213
Q22618        310 L----RANVLGVQGAILSHFIDPI-------YYSSIAVAELNNADRLRKAVYSRa-ATFKPPAPFHVQDVEIGECQVEDT 377 Caenorhabditis...
XP_003092852  320 L----RANVLGVQGALLSHFIEPVggyystiYYTSIAVAEQNNFDRLNKAVFARa-ANYQPPAPFKVQQVIIGECQIEDI 394 Caenorhabditis...
EGT56651      313 L----RTNVLGVQGALLSHFMNPI-------YYSSIAVAEKSNFERMNRAVNDRa-AGFPAQLPFRVNKSIIGECQVEDT 380 Caenorhabditis...
CAP20829      312 L----RANVLGVQGALLSHFIEPV-------YYASIAVAEQNNFVRMNKAVYTRa-SSFKPPAPFRVNQVKIGECQQEDV 379 Caenorhabditis...
1ZY7_A        292 ----RQPGKAPnFSVNWTVGDSAIEVINAtTGKDELGr--------aSRLCKHALYCRWMRVHgk---vpSHLLRSKITK 356 human
XP_013121440  646 ----RPAGKPPnISVNWSCGDGGWEEISTsTGRRKDSgt-------pSRLCRRSLFARWLRLQ-------QQLKGPVIGA 707 Nile tilapia
2_pfamImport  214 ----RPAGKAPsISLNWSCGDRGLEEVSTsSGRRTDSgt-------pSRLCRHSLFTRWLQLQ-------RQLNGPVSGL 275
13_pfamImport 220 ----RPAGRSPnTSSNWSYADAGLEEVNTsTGRRTDTgt-------pSRLSRDALFARWRRLQqqasraaNAHLDGAAAA 288
10_pfamImport 217 ------LPKHQnTCIKIIATATQLLATATfTTTTIGLqr-------rIIILLHILKARSRDVLty----lGRHLNSANAA 279
7_pfamImport  214 eqstSATARSAmSSVNWNLADGTVEVLKTsDGKVHDKdmagvdverpSRLCKQQLGELMVHVC--------AITQTKTDQ 285
Q22618        378 eqstSAAARSTiSSMNWNLADGNTEVVRTsDGMVHDKdmsgadittpSRLCKKNMAELMITIC--------TLTKTSVDY 449 Caenorhabditis...
XP_003092852  395 dqssSVAARSSvGSMNWNLADGTTEVIRTnDGLVHEKkengvevetpSRLSKKMLAELMMATC--------KLTQTAVDS 466 Caenorhabditis...
EGT56651      381 eqstSSTARSTiGSMNWNLADGTTEVVKTsDGLVHEKdmtgadvekpSRLSKKKLAELMKTVC--------TLAKIEIET 452 Caenorhabditis...
CAP20829      380 eqstSVSARSAvGSMNWNLADGTVEIVRTfDGKVHEKdmtgadvekpSRLCKKSLVELMVKTC--------FLTKTPLDE 451 Caenorhabditis...
1ZY7_A        357 PN---VYHESKLAAKEYQAAKARLFTafikAGLGAWVEKP 393 human
XP_013121440  708 EPttgTYCASKMSAQCYQRAVQQFSSalqgGGLGMWLRKP 747 Nile tilapia
2_pfamImport  276 QAsteSFSACKMSAERYQRALRRFGSalkaGGLGAWYRKP 315
13_pfamImport 289 QA---SYAGWKAAAGRYQRVMQTFSSaledAGLGRWPRKP 325
10_pfamImport 280 QR---TYSGSKMAAGRYQRAMQQFTGalrdGGLGTWLRKP 316
7_pfamImport  286 PV---RYDELKAGCKSYETEKKAFIAwlrqQDLGIWQKKP 322
Q22618        450 PI---SYEELKAGSQEYAAAKKSFITwlrqKDLGIWQRKP 486 Caenorhabditis elegans
XP_003092852  467 PI---TYDELKAGSLEYLNAKQSFIKwlrqQDLGIWQRKP 503 Caenorhabditis remanei
EGT56651      453 PA---SYEELKAGSVKYAATKKEFYAwmrrQDLGIWQQKP 489 Caenorhabditis brenneri
CAP20829      452 SM---TYEEMKAGCLDYSAAKKSFIMwlrrQDLGIWQQKP 488 Caenorhabditis briggsae
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