Conserved Protein Domain Family
Marek_A
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pfam02124: Marek_A 
Marek's disease glycoprotein A
This is the Ig-like domain found from Envelope glycoprotein C and glycoprotein A (GA) from Herpesvirus. GA is thought to play an immunoevasive role in the pathogenesis of Marek's disease. It is a candidate for causing the early-stage immunosuppression that occurs after MDHV infection.
Links
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Statistics
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PSSM-Id: 460453
Aligned: 5 rows
Threshold Bit Score: 124.527
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6UDI7 318 TKVLRPLWLRKPIVQVsRFPPGYLVCRASDILCDhGDLQWSAGGKIvksEHQAARTRMHLGSKLCALVQILDIPEDTSLQ 397 Psittacid herpesvirus...
P09256 451 SAVVTPDVYPFPNVSI-GIIDGHIVCTAKCVPRGvVHFVWWVNDSP---INHENSEITGVCDQNKRFVNMQSSCPTSELD 526 Human herpesvirus 3 s...
P22651 354 NATAIPTVYHHPRLSL-AFKDGYAICTIECVPSE-ITVRWLVHDEAq-pNTTYNTVVTGLCRTIDRHRNLLSRIPVWDNW 430 Marek's disease herpe...
P10228 362 NATGLALVLPRPTITM-EFGVRIVVCTAGCVPEG-VTFAWFLGDDPs--PAAKSAVTAQESCDHPGLATVRSTLPISYDY 437 Human alphaherpesviru...
Q89730 331 NASGTASVLPRPTITM-EFTGDHAVCTAGCVPEG-VTFAWFLGDDSs--PAEKVAVASQTSCGRPGTATIRSTLPVSYEQ 406 Human herpesvirus 2 s...

Q6UDI7 398 QSVTYTCTLRGYER 411 Psittacid herpesvirus 1 Amazon parrot/1997
P09256 527 GPITYSCHLDGYPK 540 Human herpesvirus 3 strain Dumas
P22651 431 TKTKYTCRLIGYPF 444 Marek's disease herpesvirus type 1 strain MD5
P10228 438 S--EYICRLTGYPA 449 Human alphaherpesvirus 1 strain 17
Q89730 407 T--EYICRLAGYPD 418 Human herpesvirus 2 strain HG52
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