Conserved Protein Domain Family
RdRP_4

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pfam02123: RdRP_4 
Viral RNA-directed RNA-polymerase
This family includes RNA-dependent RNA polymerase proteins (RdRPs) from Luteovirus, Totivirus and Rotavirus.
Statistics
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PSSM-Id: 280316
Aligned: 28 rows
Threshold Bit Score: 225.803
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P23172  837 RDNFTYNYNMEKEKYRITQYHHTHVRLkdlfpsRKIVKLEGY---EALLAMMLDRFNNIESThvtFFTYLRALPDREKEV 913  Saccharomyces cerev...
Q90155   96 KNPRLLTSETELQLFPLKENSAARTKAnf---------------yARTLWNETTSDKSAFKPg-tYNDTVAGLLMWQQCA 159  Trichomonas vaginal...
Q9JE94  129 HSLRNLTKEQEITLFPIKDIVQANRRVn-----AYARNLLDA---SPLPDFALQQMLLPNT----ANDVVCAILLLGEVL 196  Trichomonas vaginal...
Q8V615   41 VNLKFLNKEMELELFPLKKAPQADLKVn-----CYARNVLAS---TELTDDLLKQSLPIGL----NNDSVCGIVIVLELL 108  Trichomonas vaginal...
Q83073   49 DSLILSLEGVLGHKYKLKQHIGASTKVnihaseVIAGSRKYA----RTVYRQYVQMSSLFSGm--YDDHVAGILLYSIST 122  Leishmania RNA viru...
Q02382  155 SDPNISQNKIPRHYYQLKVHVGAQKKVnlt-aiEVIRGCQHE---CSVVYCEFVRYSAYFAGl--YDDQVAAILLYAVAA 228  Leishmania RNA viru...
Q98XW8  144 RNGRSPSKEWLLGYWPRKSHPLAGKKAnlfldcVIADFLQNYkclGPVLEGWMKRTHLLGI----YEDQACNIIVYAQAV 219  Eimeria brunetti RN...
Q99AT3   99 SFRWLCDPKASYAAFPPKQHPGAMNKVnvy-lnEVASSLLSL---DPAAYSSASQALWPHKGk-iANDQASAIILYGYGL 173  Gremmeniella abieti...
Q9YXE4   99 QAGWSYSDRATLAEFGLKSNPAASNKVnvy-lcEVMRSLSDY----STSWAWLAEDALSRAPp-mFNDQASALVLYGTAL 172  Sphaeropsis sapinea...
O57044  122 GHLVCNDKAFRERYFPKKKHAAAAIKTni--------------rlGPLARAWAARYGLAALGs--HLAYMVGMPNDRACA 185  Helminthosporium vi...
P23172  914 FISLVLN------YNGlgREWLKSE----GVRAKQAQGTVKYD------MSKLFELNVLENGVDEEVDWEKEKRNRSDIK 977  Saccharomyces cerev...
Q90155  160 LMWSLPKliinkiISGvcDALTEKVs--lTLLKRISDWLKQLGlayspiFRLFIELPTLLGRGAIPGDAALDMKHRLTYN 237  Trichomonas vaginal...
Q9JE94  197 WMLRCPIsi--ivNIS--RAICRND----SFLKDLSDFNKMLGltkipiANCLTELNTLQGRGVTSSDAKRDLTHRIA-D 267  Trichomonas vaginal...
Q8V615  109 RIAGVPSkl--lpIIG--QAIANKD----PFIKELSDFNKMIGattsriANILTECNTLIGRGVKSSDPSADLYHRVAPE 180  Trichomonas vaginal...
Q83073  123 LKHCDVHva--maYAIaaVRDLTQ-----SVIADLSDVLKLRAla--awCPNYVELKCLRGRGIAELDVIAEAKQRLKKP 193  Leishmania RNA viru...
Q02382  229 HNVQGFGar-------fcVLWALMCvriaGFADDINIYIKHRGms--glLPQLVEMKCLLGRGVNEIDVETEARRRLDVG 299  Leishmania RNA viru...
Q98XW8  220 MLEFGFE------ESLylATWAVLRa---KQAKALSDVLKAMGqnmcavGRHLCELAVLQGRGVNRLDLLEDAERRVSAT 290  Eimeria brunetti RN...
Q99AT3  174 RAQAVPDa----mHVA--ATLATTP----DLAKALTNFLKATGangsrlGALLCESNVLLGRAAGPADLSEEARYRTSSD 243  Gremmeniella abieti...
Q9YXE4  173 QAKGVQNg-----YHAatALIANP-----EYAKDMTTVLKAVGansnhlGACLVEAQTLQGRAVQPADMHSEAISRTTTA 242  Sphaeropsis sapinea...
O57044  186 TLLLAQTyk--arFGSegVAWAIASvrqpENAKGLSNALKALGsntsepGALFVEANTLQGRYDRTLDMDHEVESRCSPA 263  Helminthosporium vi...
P23172  978 TVniSYAKVLEHCR----------ELFimaraeGKRPMRMKWQEYWRQRAVIMPGGs-vHSQHPVEQDVIRVLPREIRSK 1046 Saccharomyces cerev...
Q90155  238 PL---MTVDVPKTQlhdliyrllsRNY-------NNTKISSFEHHLEERLLWSRSGshyYPDEQIDQ----LLPPQPTRK 303  Trichomonas vaginal...
Q9JE94  268 VN--PHEAKISRENlreainqiykEEI------TRKEVPDTFKQHVFTSPLWVKKGahhHPLFGSYDNRLEFVENV---- 335  Trichomonas vaginal...
Q8V615  181 GN--RHEAKIPRHIlieainkiykNEM------TDMPPPGDFKLHLITSPLWCKAGshhHPHFAKYSSRLDFVMDV---- 248  Trichomonas vaginal...
Q83073  194 TH--PYAYADNEELlrnairrvfdEELp-----RDKVVLRPKDDFWSSRWLWAANG---GHSRALEHAHPELRTRKEVR- 262  Leishmania RNA viru...
Q02382  300 SL--SMQRLDENELraavr-liysEEL------RRPVTYPLICDFWSSRWLWAANG---SHSRALEHAHPELATRKEGQ- 366  Leishmania RNA viru...
Q98XW8  291 FN--CPIVHVPADAlrqcvrdvlrREL------RTRVVLPPSDDFFRRRYAWCVGGahnLNGNDHWLPRSLLPQFPAALL 362  Eimeria brunetti RN...
Q99AT3  244 VE--SHLAIFSDADlgaaidaildEEIkrv-egSQHIEFDSYQEHWNDRWAWAVNGa--HSGHVSRL--YPRVPKPPGML 316  Gremmeniella abieti...
Q9YXE4  243 VA--DIVVDYPDDVlrshirtvleREIqrv-gdSHAIEYPTLQEHWDSRWLWAVNG---SQSGLLSREHLEAAPRPPGAA 316  Sphaeropsis sapinea...
O57044  264 AI--ADQVIPYTDElgacidfildTELg-----GDTIELPDEDEWWTSRWLWCVNG----SQNALSDKALGIKNKSGQ-- 330  Helminthosporium vi...
P23172 1047 KgvasvmpYKEQKYFTSRR--------PEIHAYTSTKYEWGKVRALYGCDFSSHTMADFGLLQCEDTF--------PGfv 1110 Saccharomyces cerev...
Q90155  304 E-------FLDIVTIDYIKqc-----kPQVFIRQSRKLEHGKERFIYNCDTISYVYFDFVLKLFESGWqdseailsPG-- 369  Trichomonas vaginal...
Q9JE94  336 --------DLDRVLKSH----------PAVYITQAPKLEHGKTRFIYNCDTVSYIYFDYILNYIESVWsnkhvllnPDym 397  Trichomonas vaginal...
Q8V615  249 --------PADKIAAVP----------PSVFITQAEKLEHGKTRYIYNCDTXSYLFFDYILHYVECVWsnesvllnPAam 310  Trichomonas vaginal...
Q83073  263 --------AYRKCVLEQWRnnpmdawdGQVYVTPSQKLEHGKSRLLLACDTLSYLWFEYYLKPVETAWlnkrtllnPG-- 332  Leishmania RNA viru...
Q02382  367 --------AYRKAVMEQWQhnpmdrwdGTVYVTPSAKLEHGKTRLLLACDTLSYMWFEYALRPVERIWensnvildPG-- 436  Leishmania RNA viru...
Q98XW8  363 --------WNRRAALNCVErnplkrwsGHVRVSVAEKVEQGKGRAIYSCDTLSYTAFSWLLEAVEKEWasrsvilnPG-- 432  Eimeria brunetti RN...
Q99AT3  317 R-------EHRRAWLESVTedprtdwdGKTFVSASPKLEAGKTRAIFACDTVNYLAFEHLLAPVEKRWrnskvildPG-- 387  Gremmeniella abieti...
Q9YXE4  317 R-------EYRAVMARESEqdprpawdGHTYVSGSPKLEHGKTRAIFACDTLNYLAFEHLLASVESRWrgervvlnPG-- 387  Sphaeropsis sapinea...
O57044  331 --------RYRRMAAEEVNnnpvpawnGHTSVSPSVKLENGKDRAIFACDTRSYFAFTYWLTPIEKKWrgarvilnPG-- 400  Helminthosporium vi...
P23172 1111 pTGSYANEDYVRTRIa---------gTHSLIPFcYDFDDFNSQHSKEAMQAVIDAWISvyhdKLTDDQIEAAKWTRNSVD 1181 Saccharomyces cerev...
Q90155  370 -DYSSECLHAKISGY--------------KYKAmLDYTDFNSQHTIQSMRLIFETMKE----LLPPEASFALDWCIASFD 430  Trichomonas vaginal...
Q9JE94  398 nPVIFSTLNYDEYCM-------------------LDYTDFNSQHSIESMKQVFLCLFP----FLPRSMHSILQWCVTSFD 454  Trichomonas vaginal...
Q8V615  311 sVERFSVLDYPEYCM-------------------IDYTDFNSQHSLESQKLVFECLRP----YLPSEMHPILDWCIASMD 367  Trichomonas vaginal...
Q83073  333 -VVNHYSMAKKVKVLladaehdetniERGTKLYsLDFEDFNSQHSLAAQKMVFEELFK----HVGIENEET-RKVVSSFE 406  Leishmania RNA viru...
Q02382  437 -SMGNCGIATRINGWrn--------gMPGQSFFaVDYDDFNSQHTLMSQKIVFEELFH----HIGYNASWV-KTLVDSFD 502  Leishmania RNA viru...
Q98XW8  433 -KGGTLGMMNRIRGAat--------gGRRQCYLmLDYSDFNSQHSNEAMRIVIEETLA----CCDHNEPELAAKLLKSID 499  Eimeria brunetti RN...
Q99AT3  388 -RGGHLGMIFRTTAAr----------ARAGVSMmLDYDDFNSHHSTRAMQMLFQRLGD----RVGYPADKL-AKLVASFE 451  Gremmeniella abieti...
Q9YXE4  388 -RGGNVGMSFRVAAAr----------QRAGISLmLDYDDFNSHHSIRAMQILFEETAA-----LTHYPPELAAKLVASFE 451  Sphaeropsis sapinea...
O57044  401 -EGGLYGTARRIRGSq----------TSGGVNLmLDYDNFNSQHSNETMAALYEKALS-----RTNAPAYLKKAVAASVE 464  Helminthosporium vi...
P23172 1182 RMVAHQPNTGEtYDVKGTLFSGWRLTTFFNTALNYCYLAN-AGINS--LVPTSLHNGDDVFAGIRTIADGISLIKNAAAT 1258 Saccharomyces cerev...
Q90155  431 NMQTSDG-----RKWTATLPSGHRATTFINTVLNWCYTQM-VGLKF----DSFMCAGDDVILMSQEPI----SLAPILKS 496  Trichomonas vaginal...
Q9JE94  455 NMYINK------THWNSTLPSGHRATTFINSVLNRAYLLPfLQVAN------AFHTGDDVLLCGKAD-----YATLINTV 517  Trichomonas vaginal...
Q8V615  368 HMEIGG------QHWLSTLPSGHRATTFINSVLNKAYLIPyIGDTT------SFHCGDDVLLCGKYD-----YQTLIDTL 430  Trichomonas vaginal...
Q83073  407 RMIVYNGKEPL-GRVHGTLMSGHRATTFINTILNTAYLYV-AGLHTd----fSYHVGDDVIFSTGCAEAAR-LYDCLKHY 479  Leishmania RNA viru...
Q02382  503 SMELWIKGKCA-GIMAGTLMSGHRATSFINSVLNRAYIIC-AGGHV----PTSMHVGDDILMSCTLGHADN-LIANLNRK 575  Leishmania RNA viru...
Q98XW8  500 DMHIYLRGVHI-GRVAGSLMSGHRATTYWNSVLNAAYVRY-AIGRVayDTYKPFHVGDDVLILLDSPADAWNVVKKLEHI 577  Eimeria brunetti RN...
Q99AT3  452 KMYIYNGMEQV-GRVKGTLMSGHRGTTFINSVLNKAYLLI-VLGEDlfERSVALHVGDDVYFGVRTYAEAGEVVTRIKNS 529  Gremmeniella abieti...
Q9YXE4  452 NMDLYLGSSCI-GRVLGTLMSGRRGTTYISSVLNEVYLAIeLGASWl-AERPSIHVGDDVYLGVRTYRDAAYVLDKCATS 529  Sphaeropsis sapinea...
O57044  465 STYIHYKGRD--RHVLGTLMSGHRATTFTNSVLNAAYICYaVGIPAf-KRMISLHAGDDVYLRLPTLADCATTLNNTKRV 541  Helminthosporium vi...
P23172 1259 GVRANTTKMNIG-TIAEFLRVDMRAKNST-GsqYLTRGIATFTHSRV 1303 Saccharomyces cerevisiae virus L-BC (La)
Q90155  497 QFKFNPSKQSTG-TRGEFLRKHYTEAGVFa---YPCRAIASLVSGNW 539  Trichomonas vaginalis virus
Q9JE94  518 PYELNKTKQSFG-PSAEFLRLHKHNDQVS-G--YPARAISSLVSGNW 560  Trichomonas vaginalis virus 2
Q8V615  431 PYELNKSKQSFG-PNAEFLRLHRRAGDVI-G--YPSRAVSSLVSGNW 473  Trichomonas vaginalis virus 3
Q83073  480 GVRCNPHKQCASeYSGEFLRVAHTKHYST-G--YVARAIASCVSGNW 523  Leishmania RNA virus 2 - 1
Q02382  576 GVRLNASKQVFSkTSGEFLRVAHREHTSH-G--YLARVISSAVSGNW 619  Leishmania RNA virus 1 - 1
Q98XW8  578 GCTLQRSKQSVGiGGYEFLRVAGSPFTGVgG--YVARSVAGLVSGSW 622  Eimeria brunetti RNA virus 1
Q99AT3  530 PLRMNRMKQSVGhVSTEFLRNATSGRSTY-G--YFARAVASTVSGNW 573  Gremmeniella abietina RNA virus L1
Q9YXE4  530 RLRMNPMKQSVGhTSTEFLRLACAGRATY-G--YLARAVASTISGNW 573  Sphaeropsis sapinea RNA virus 2
O57044  542 GCRMNPTKQSIGyTGAEFLRLGINKSYAI-G--YLCRAIASLVSGSW 585  Helminthosporium victoriae virus 190S
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