1KCM


Conserved Protein Domain Family
IP_trans
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pfam02121: IP_trans (This model is not part of the current CDD release)
Phosphatidylinositol transfer protein
Along with the structurally unrelated Sec14p family (found in pfam00650), this family can bind/exchange one molecule of phosphatidylinositol (PI) or phosphatidylcholine (PC) and thus aids their transfer between different membrane compartments. There are three sub-families - all share an N-terminal PITP-like domain, whose sequence is highly conserved. It is described as consisting of three regions. The N-terminal region is thought to bind the lipid and contains two helices and an eight-stranded, mostly antiparallel beta-sheet. An intervening loop region, which is thought to play a role in protein-protein interactions, separates this from the C-terminal region, which exhibits the greatest sequence variation and may be involved in membrane binding. PITP alpha has a 16-fold greater affinity for PI than PC. Together with PITP beta, it is expressed ubiquitously in all tissues.
Links
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Statistics
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PSSM-Id: 514720
Aligned: 93 rows
Threshold Bit Score: 208.952
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1KCM_A          1 VLLKEYRVILPVSVDEYQVGQLYSVAEASKNET-GGGEG-----------VEVLVNEP-YEKDDGEKGQY---THK---- 60   house mouse
XP_001329380    1 MRIIEWRVIVPMTVQQYQIAQIYAVAKKTLEDS-NDKEG-----------IERTSSEM---------RKY---NEKdaly 56  
XP_001582795    1 MKIYEYRVILPTNVPQYQIGNLYMCAQRTRETQ-GGGEG-----------IEILKNEP-YQE-GEEKGQY---THK---- 59  
XP_001614288    1 MKLIEFRLAMPLTMEEYKICQQYLLAKVSHEDTeNTIHGvghnkktdgrsLVLFKKGT-YDDENGEPGDY---TFK---- 72  
XP_013058345    3 QRTTLYVMYMPYTLKEYNVGQLLTTCRVSEREA-DKGMR-----------VAVLENKPiKNEETAEPCQY---TSK---- 63  
16_pfamImport   1 QRTTLYVIYMPYTLKEYNVGQLLTTCRVSEREA-NNGMR-----------VTVLENKAvESEETAGPCQY---TSK---- 61  
EJW04480        3 IIHKEYRIVMPITTQKYNICQLYTVAALSKSES-TGDTS-----------IKIVENKD-YDHEVLGHCRK---THK---- 62  
EPR78833        4 TKRVEFRIPLPFHIDKYLVGQLYTVAHMSQAEA-KKGSP-----------IQILENYD-ISHEKYGECRK---TKK---- 63  
XP_008075153    3 TIYREYQIPLPFTIKDYRVAQLYTVAMISANEA-TGDTS-----------IKIAENKD-IHDEKYGACRY---TEK---- 62  
12_pfamImport   1 MLRREYRYVLPVSMEEYKVAKQWMLSYEVYEGL-EKDEG-----------IRLLQYNNcNNN-----GKHeiyTLC---- 59  

1KCM_A         61 ---IYHLQSKVPTFVRMLA----PEG-ALNIHEKAWNAYPYCRTVITNE-YM----KEDFLIKIETWHK--P-DLGTQEN 124  house mouse
XP_001329380   57 sqyIYSFANKLPSALRWVL----PNT-LSTLVEDCYDQFPYQHSH-----FVlkdnEKTLNMTVTTVVS--E-FQNNEEN 123 
XP_001582795   60 ---VMHFKSKVPGAIRWAI----PDK-YLHIDEKSHNSYPHFHTLYEQKgMG-----KDFYLLVESQHMvyDrEKGVPDN 126 
XP_001614288   73 ---RMNLVNKIPKWLLNFV----DPK-YCLIDEKSWNSYPYLKTVYEATgF------PKAQVQVESTHH--I-GYNTEDN 135 
XP_013058345   64 ---VLDFSKKVPGFFRAIA----PSG-SLTMSEISYNAFPVCKTTYTSGaLS----EKKFKARIDTLFF--EgHKPPVDP 129 
16_pfamImport  62 ---VIDFSKKVQSFLRKIA----PSG-SLTMSEKSHNAFPVCKTVYTSGaLS----EKKFKARIDTLFL--EgHKAPIDP 127 
EJW04480       63 ---ILNLNSKVPYIIRKCM----PSNdALKLVETAYNAYPKCSTTYTNKyFN----ENTFKMTVNSVHV--D-GVDFQDN 128 
EPR78833       64 ---LLNISKKVPSIIKALV----PKK-ALLIEEIAYNAFPNCVTTYTNQqFK----PEKFNVSITSTHL--N-GYEQQEN 128 
XP_008075153   63 ---IFYLNSKVPRAIRAVV----PKK-ALIVEEKAFNAFPTCHTFYTNQaFS----TDTFSASVVSTHV--N-NELTLKN 127 
12_pfamImport  60 ---SFDFESKIPQFVQMLLkmffPDV-EPVMHQESTVVGEKTNTVFWGPnLF----KDNLRLEISSVVM--E-DLGTTDN 128 

1KCM_A        125 -----VHKLEPEAWKHVEAIYIDIADrSQ--VLSKDY------KAEEDPAKFKSVKTGRG---PLGP-NWKQ-----Elv 182  house mouse
XP_001329380  124 likndAELYTKEELAKREIHYIDIVN-WP--TEEEGVkvgefeCPQANIEKLPKATVNNKdtlP----EWVKe----Y-- 190 
XP_001582795  127 -----ALNLTPEELKQRQIFYLDIVN-SKpkPEKPEWdmhnfeCPEAKISKLSTPKNTCD---ETKPpEWTL-----T-- 190 
XP_001614288  136 -----AFNISDEQLAQRKVVLIDIVN-DK--VAYKDY------LPEEDPTIFYSERAQRG---KLDE-NWIE-----N-- 190 
XP_013058345  130 ---------FTDGIVAERCEVLDLVH-GQ------QI------AENINLAEIKDESGN-----LLFPaDWEK-----S-- 175 
16_pfamImport 128 ---------FSDGIISENCEVLDLVY-GQ------QM------CEGIDLATVKGDDGN-----LLFKeGWEK-----E-- 173 
EJW04480      129 -----INEMPANIWKNTKVDYIDIAV-DG------EY--------EVKPSDYISQKAKIG---PLHK-GWIEdf-kkQ-- 181 
EPR78833      129 -----VFGIEEEEYKKVKKVILDVSS-SP---VDEEY--------DTRIAIVNHMVC------PMNE-KWIEkq--kE-- 180 
XP_008075153  128 -----ALNIDCALYDKTKVKVIDVCC-NI---VNPQY----------DPTNTPLKINDGC---PLKP-EWYK-----N-- 177 
12_pfamImport 129 -----AHEVPSDEWANTEVVNVDFAN-DP--LSFKSY------EEDYDVTMYASEDKTRG---PYKE-GWLDelkskE-- 188 

1KCM_A        183 nqkD-CPYMCAYKLVTVKFKWWG-LQNKVENFIH-KQEKRLFTNFHRQLFCWLDKWVDLTMDDIRRMEEETKR 252  house mouse
XP_001329380  191 ---K-GPMVIARKIIRINIDIFA-IGGPTEEFIGkQFMPNIYANSHQRMVLTAPSWFDIDLKKAREYESDCYQ 258 
XP_001582795  191 ---YeGDMIVAVKIVKFKFKWFG-IQSAVESFAM-GKFHDVFLDSHRAMFSWAAQWFPMDMPAIRKLEQEVQD 258 
XP_001614288  191 ---S-KVIMTCYKLFNIDIPYFGmFCSKLENWIV-TVIKDSLLKYHRKALSWIDEWIDLTDEQIRAFEAEIQN 258 
XP_013058345  176 ---H-TPVMTIFKRVHIDLNIPI-IGKRYIEDID-KFMRKMFTQGHQEVIKYYNEWKNMTMDDVRKEEEKTKA 242 
16_pfamImport 174 ---H-TPVMTIFKRVHIDLHIPF-IGWKYIEDVD-KFMRKMFIQGHQEVIKYHSEWKDMDMDGVREEEAKTKA 240 
EJW04480      182 ---N-IPLMTCYKQVSIEINCFG-LGWLVNE-VE-KQLRKIFATSHQQMFCQMDDWYDLTIEDIRKIEEETKK 247 
EPR78833      181 ---KnLPMMYCYKLVEINSNIWG--GSIIAKGVI-SEFSKMFLAFHQQLVCTMCEWENMNLDAIRVLEDKLKE 247 
XP_008075153  178 ---PsYDVMMSYKFVTLKFDCFG-LGWLVHE-IE-KQIDKIFTSSHQQMVCTMDEWHGKSIEDIRELEDNIRE 244 
12_pfamImport 189 ---K-PKYVCVYKLVTCKFKWFG-IDRIFREKVV-YTTTQIIMEFYRKMICLFDAWGKLTIDDV--YDEQNKT 253
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