Conserved Protein Domain Family
MtrH
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pfam02007: MtrH 
Tetrahydromethanopterin S-methyltransferase MtrH subunit
The enzyme tetrahydromethanopterin S-methyltransferase EC:2.1.1.86 is composed of eight subunits. The enzyme is a membrane- associated enzyme complex which catalyzes an energy-conserving, sodium-ion-translocating step in methanogenesis from hydrogen and carbon dioxide.
Links
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Statistics
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PSSM-Id: 280227
Aligned: 5 rows
Threshold Bit Score: 436.555
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O32869   7 KEQKVCDICGVKVGGQPGEYPTVLAGTIFYAGHKIVKDEDKGIFDEEAAEELIKMEEELADETGNPMMAHIMGESEEAII 86  Methanopyrus kandleri...
Q8TU06   6 RKQEVYEVGGVKFGGQPGEYPTVLVSTMFYARHKIVTDEDKGIFDRAAAETLWNTQVSLSDATGNPYVNQIVGETPESIR 85  Methanosarcina acetiv...
Q58264   6 REQMVVEIAGRKIGGQPGEYPTALAGTIFYARHKIVEDERKGIFDKAAAEDLINKQAEMEDITGNPALVQVFGGTPEALV 85  Methanocaldococcus ja...
O27224   6 KEQIVLDIAGTKIGGQPGEYPTVLAGTIFYGGHSIIEDEKAGVFDKDKAEALIKTQEEMSDVTGNPHIVQTFGQTPEAIV 85  Methanothermobacter t...
O30226   9 N-QKVFEIGGVKIGGEVGENPTVLIGSIFYGKHKIVEDEKRGIFDREGAEALIREMEDLSDKTGNPGLLDVVGMSEEAMI 87  Archaeoglobus fulgidus

O32869  87 RYLDWVADVTD-APIIVDSTEAEVKVAAVKHAQEVGLAERVVYNSINASVEDEEIQAIKESDCNSAIVLAFNPMDASVEG 165 Methanopyrus kandleri...
Q8TU06  86 KYIDWFIEIDDkTPFLIDSSAGEVRAAAAQYCTEIGVANRAIHNSINASIEQSEIDILTESDVEAAIVLAFNATDPTVKG 165 Methanosarcina acetiv...
Q58264  86 NYIDFVAEVWD-GPMLLDSTSGEARMAAAKRATEAGYAKQCIYNSINVSIDEQEYQVLVESDLEASIVLCFDPMDPTVEG 164 Methanocaldococcus ja...
O27224  86 KYLEFVGDVTD-APFFIDSTSGEARIAGANYASEVGLEDRAIYNSVNMAADEAELEALKETKLSASIVLGFNPMDPTVDG 164 Methanothermobacter t...
O30226  88 KYIDFVADVTD-SPFLIDSAIADIKLAGVKHADEVGLSDRVIYNSISPESKDAEIEALANSKVEAAVVLAYTYNVISSAA 166 Archaeoglobus fulgidus

O32869 166 RMKILTEGEeGVSEKGMLEISDECGIENP-LIDTAYTPFGSGAGTAYKVTLAVKAKLGLPVGGAPHNVPSAWDWLRDFMK 244 Methanopyrus kandleri...
Q8TU06 166 KLDILEVGG-SGQTKGMLQVAEECGIKIP-LIDVAAMPLGAGSGATIRSIPTIKGKLGLPVGGGYHNMASAWDWLRKFKK 243 Methanosarcina acetiv...
Q58264 165 KINVLTNGG-KTADKGMLELAEKAGI-KYpLIDTAVTPLGNGAGAAVRASFAVKALFGYPVGSGIHNIPSAWDWLREFRK 242 Methanocaldococcus ja...
O27224 165 KIGIWEDGA-GTIDKGLLEMAAECGIDKY-LMDVAVTPLGQGAGVAVRTSFAVKSKWGYPVGSGIHNVPSAWDWLREYKK 242 Methanothermobacter t...
O30226 167 RLQALEKAM---AK------VEKAGITKP-IVDTFVMDVPS-LPAAAKAAIDIKRKYGLPTGSGAHNAIGSWKGFKNMFG 235 Archaeoglobus fulgidus

O32869 245 KLKEEGKEewaelaHESSDWGSNVVAATLCCDYLLFGPIENAPAIWPVVAMVDALIVEANE-DVGVEP 311 Methanopyrus kandleri AV19
Q8TU06 244 TQPDPKAI------YMPADIGTNLVAQIAGSDFLLYGPIENVEKVFPAVAMVDIMLGETAK-ELGVEI 304 Methanosarcina acetivorans C2A
Q58264 243 QLREAGERekakdiHHVCDVGANLVQVMASGDFVLYGPIDNAYMTFPAVAMVDAIIAEAAK-ELGIEP 309 Methanocaldococcus jannaschii DSM...
O27224 243 DHKEAWP---------VCDVGSNLIQQMAGGDFVLYGPIENAKMAFPACAMADIFISEAAK-DIGTEP 300 Methanothermobacter thermautotrop...
O30226 236 KEAEKAA---------T--IVAVTMQIILGSDFVLYGPIEDCREVFPAMYTIDTAYKYFRRtKDWIEM 292 Archaeoglobus fulgidus
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