2G9I


Conserved Protein Domain Family
F420_ligase
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pfam01996: F420_ligase 
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F420-0:Gamma-glutamyl ligase
F420-0:Gamma-glutamyl ligase (EC:6.3.2.-) is an enzyme involved in F420 biosynthesis pathway. It catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0). This reaction produces polyglutamated F420 derivatives. GTP + F420-0 + n L-glutamate -> GDP + phosphate + F420-n
Links
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Statistics
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PSSM-Id: 426557
Aligned: 120 rows
Threshold Bit Score: 125.278
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2G9I_A          10 G--LPLIKEGDDLAELISSRVR-----------FEDGDVLVVCSTVISKAEGRIRRLEEFnpserAKEIAARI------- 69  Archaeoglobus...
Q58756           5 PikTRYIKRGENFIPIVVEAIKnsg------ikLEDGDFVVLSEKMVSTAEGNFIDESKFkpgvlA-------------- 64  Methanocaldoc...
jgi:Maeo_0771    7 PikTKYIKENDDFVEEVINSLKrdine--gkinIENGDFIILSEKFVSTSENNLVDEKEAspkfwA-------------- 70  Methanococcus...
Q6LWP5          16 PirTRYIDRNEDFVSESIHSLKkeie---ngfeIKNGDFLVVSEKFIATSEDNFVDESLAdpkfwA-------------- 78  Methanococcus...
jgi:Nther_0679  13 GikMGVVLPGSDLKSMIKSEIMkink----dglLEDNDALCVTESIVARAQENYITTEEI-----AEEVTDKLnlkpndt 83  Natranaerobiu...
WP_012447677    16 GlkTDLIVPHDDIAEITANTVKd---------iTEDNDIICVTEAVVARSQNQYVSCESL-----AEEIREKLnlkeqst 81  Natranaerobiu...
EHM13012        10 GirLPVVMSGDDLKKIVVNSLMeaaasepdgfkFKDRDIVGVTESLVARAQGNYVTTEDI-----AQDVARLTdeg---d 81  Jonquetella a...
jgi:Anamo_0182  11 GirAPLVKAGDDVISVVMDSIGkacke--egfsLRDKDVIGITESFVARTQGNYATIYDI-----AHDLSAKMsgq---e 80  Acetomicrobiu...
ripcm:ACL_0021  10 GirTPIIRSGNDVSQIVVDSIMkaskt--dnfnFDDKDIIAVTEAVVSIAQGNYATLDQI-----AYDVKEKFhtk---h 79  Acholeplasma ...
WP_013669070    11 GlrAPIVKKGDDLAQIVVDTVIhaaek--apftIHDKDIVAITESIYARAQGNYASLDAV-----AKDIHQKFqse---s 80  Aerococcus ur...

2G9I_A          70 --GKPA--------------------E-FVQAVLEESEEVLLDfpFLLVKA----------------------------- 97  Archaeoglobus...
Q58756          65 ---YLCyywskylwgyvlgkllkvkeD-KIKNLRRMPKEETLKhkqt--------------------------------- 107 Methanocaldoc...
jgi:Maeo_0771   71 ---YFCyywskylwgyilgpllktrkD-RIKNLRKMPKKETIRhkqi--------------------------------- 113 Methanococcus...
Q6LWP5          79 ---YFTyylskygwgyvlgpllgtrgD-RVKNLRKMPKTETLKhkqi--------------------------------- 121 Methanococcus...
jgi:Nther_0679  84 lgVLFPilsrnrfsli-leglakavpRgKIIVQLSHPDDEVGN--QLIPPEksqalidkgynvikaeeleedcihpitnv 160 Natranaerobiu...
WP_012447677    82 igVISPiasrnrfsli-lralalatrGgKVIVQFPIPFDEVGN--QVIDENfaytrlrlkktlqslretrgstpqlnvli 158 Natranaerobiu...
EHM13012        82 avLLFPilsrnrfle--llkgivagvRgTLHLVLSYPCDEVGN--GVMDRQefyekahllsdsafdedefrrvfgtwthp 157 Jonquetella a...
jgi:Anamo_0182  81 iaVLFPilsrnrfyl--ilkgialtgK-TVHLFLNYPNDEVGN--PLMDRNvmyerginpyndllsehdyrsieglsirh 155 Acetomicrobiu...
ripcm:ACL_0021  80 igLVFPilsrnrfas--plraiaramD-KLTILLSYPKDEVGN--SILYEKdlerlginpydtiideatyqkefshfkhp 154 Acholeplasma ...
WP_013669070    81 igVVFPinsrnrfyn--ilqavaratK-KVVIQLSYPADEVGN--ELISDEalvksgvnpwtdtlseaefrshfeeikhk 155 Aerococcus ur...

2G9I_A             --------------------------------------------------------------------------------     Archaeoglobus...
Q58756             --------------------------------------------------------------------------------     Methanocaldoc...
jgi:Maeo_0771      --------------------------------------------------------------------------------     Methanococcus...
Q6LWP5             --------------------------------------------------------------------------------     Methanococcus...
jgi:Nther_0679 161 nylklyrdiiteqgaeaelfvs---------------------------------------------------------- 182 Natranaerobiu...
WP_012447677   159 reilaalklqelgygiesirkitgkgiadltlktpegktavaevtfedlaktakkaigvkkdvpeaevalsiavslehns 238 Natranaerobiu...
EHM13012       158 ftgldyvelyksvapekikvhfaq-------------------------------------------------------- 181 Jonquetella a...
jgi:Anamo_0182 156 pftsvdyvelykgvfpegrvhiyfs------------------------------------------------------- 180 Acetomicrobiu...
ripcm:ACL_0021 155 ftgvnmvqyykdiiekencevsfvfs------------------------------------------------------ 180 Acholeplasma ...
WP_013669070   156 ftgvdyvalyrecvekegaeceiifs------------------------------------------------------ 181 Aerococcus ur...

2G9I_A             --------------------------------------------------------------------------------     Archaeoglobus...
Q58756             --------------------------------------------------------------------------------     Methanocaldoc...
jgi:Maeo_0771      --------------------------------------------------------------------------------     Methanococcus...
Q6LWP5             --------------------------------------------------------------------------------     Methanococcus...
jgi:Nther_0679 183 -----------------------------------------------------------------------ndyrvildy 191 Natranaerobiu...
WP_012447677   239 itivdandylysdnpkvstinygnqvdsyydpeviytneienhtfphpitkhdyrhlyseiiedagaqasiiftdnpvkv 318 Natranaerobiu...
EHM13012       182 ----------------------------------------------------------------------spkaalsyak 191 Jonquetella a...
jgi:Anamo_0182 181 --------------------------------------------------------------------ndprialkycke 192 Acetomicrobiu...
ripcm:ACL_0021 181 --------------------------------------------------------------------nnpedilkytse 192 Acholeplasma ...
WP_013669070   182 --------------------------------------------------------------------nqaqaildytds 193 Aerococcus ur...

2G9I_A          98 ------------------------------------------KFGNV-----CVNAGIDASnveegsLLLPPLDPDGSAE 130 Archaeoglobus...
Q58756         108 ---------------------------------------iieIVGLRyalkpYAEGGVDLTnvpgtyACPLPKNPKKWAE 148 Methanocaldoc...
jgi:Maeo_0771  114 ---------------------------------------vidNVGLRyalkpASEGGIDLTnvpgtyASLLPENPKKSAE 154 Methanococcus...
Q6LWP5         122 ---------------------------------------vieNVGLIyalkpASEGGIDLTnvpgtyASLLPENPEYSAK 162 Methanococcus...
jgi:Nther_0679 192 hpqgvlcadihtreehrskleskvitctlqdlfndsskeswsEWGLL-----GSNMSSDNK------LKLAPYNADEFAC 260 Natranaerobiu...
WP_012447677   319 yemgfidgicvgavheryklkelfssfgakvpiitiedigsnpWGLI-----GSNVSDMDKg----iLKLLPDNPHKTAD 389 Natranaerobiu...
EHM13012       192 qvivasihdrnlhrqvlerlgakvitldqicaapqegrgwndRFGLL-----GSNYSRAGV------VKLFPRDCEAFVA 260 Jonquetella a...
jgi:Anamo_0182 193 ilvaniherawtkkilrqagasnvlglddlltkpingsgynpEYGLL-----GSNMASGEK------LKLFPHDCEQICA 261 Acetomicrobiu...
ripcm:ACL_0021 193 vlvcdihtriatkerlkshqaskvlglddllnkpvlnsgfneVYGLY-----GSNAAGSES------VKLFPHHNDLIVY 261 Acholeplasma ...
WP_013669070   194 vlvsdihtrfktaqavkeagaktvyrldeiltqsvdgsgynkEYGLL-----GTNLSGDNE------LKLFPRDSKSFVY 262 Aerococcus ur...

2G9I_A         131 KLRRRILELTGKRVGVII------TDTNGRCFRRGVVGFAIG-ISGVK----------------AXKDWIG--------- 178 Archaeoglobus...
Q58756         149 ELYKEIKKELGVDVVVMVa----dTDATYRVLNFYFTALPYA-IDGII-------------------SGIG--------- 195 Methanocaldoc...
jgi:Maeo_0771  155 KVYNAIKKELSVDVVLIIi----dTDATYRFYKWYITALPIA-SEGII-------------------SKVG--------- 201 Methanococcus...
Q6LWP5         163 KLHKKIKEDLDLDLTVMVi----dTDATYRFFNWYVTALPIA-VEGIT-------------------SKIG--------- 209 Methanococcus...
jgi:Nther_0679 261 ELQKEILDATGKKIEVIIggdgayKDPSSGIYELADPKPAFGtTPGLRqhmregvk-ykylidmYHNQGKSekeiqeiia 339 Natranaerobiu...
WP_012447677   390 NIKDKIKEITTKDVEVLIfgdgayKDPDTGIYELADPHPAIGaSYNLRsaslregsklklqvdtLFRQGYSkdqik---- 465 Natranaerobiu...
EHM13012       261 DLQEELRRQTGRQIDVLVygdgafKDPVGGIWELADPVVSPAcTSGLIgmpheik--fkyvadnA-GDKTPlqavteai- 336 Jonquetella a...
jgi:Anamo_0182 262 EIQRRIREEYGVDVEVLVygdgafKDPKTGIWELADPVVSPGfTKGLIgtpnelk--lkylidsELDRGKSnavedavl- 338 Acetomicrobiu...
ripcm:ACL_0021 262 DIQKKFKALTGKHVEVLIygdgafKDPVGGIWELADPVVSPSyTKGLEgtpneik--lkymsddKYKDLSGdalksai-- 337 Acholeplasma ...
WP_013669070   263 DVQKRLLEATGKKIEVMVygdgafKDPVGHIWELADPVVSPGyTSGLEgtpnevk--lkyladnEFSSLSGqaledait- 339 Aerococcus ur...

2G9I_A         179 ----------RKDLYGR--ELEVTVECVADEIAAFANLL-XGEGGDGIPAVVVRG 220 Archaeoglobus fulgidus DSM 4304
Q58756         196 -------------VFGF-------------ILGRLADVLkIGGFAGCTPLAIAGN 224 Methanocaldococcus jannaschii DSM 2661
jgi:Maeo_0771  202 -------------VLGY-------------IIGKLGGLFkIGGLCGATPLTIVGN 230 Methanococcus aeolicus Nankai-3
Q6LWP5         210 -------------VFGY-------------ILGKFGKILnQGGLCGATPLAITGN 238 Methanococcus maripaludis
jgi:Nther_0679 340 kesekkkgknHEi-----eTEGTTPRKIEDILASLADLV-SGSADAGTPVILIKs 388 Natranaerobius thermophilus JW/NM-WN-LF
WP_012447677   466 -------dilsdDSDKTaeNLGTTPRSVTSILGTMADLI-TGSADAGTPIVLVRG 512 Natranaerobius thermophilus
EHM13012       337 ---qakaktsRSdk----tGLGTTPRRLSDLVGSLCDLV-SGSGDKGTPVIYISG 383 Jonquetella anthropi DSM 22815
jgi:Anamo_0182 339 ---grilqkkRGISTDKeeSLGTTPRMYTDLIGSLCDLV-SGSGDKGTPIVLVQG 389 Acetomicrobium mobile DSM 13181
ripcm:ACL_0021 338 ---iseisqkSNTLTDDa-KLGTTPRRYVDLIGSLCDLV-TGSGDKGTPVVYIKN 387 Acholeplasma laidlawii PG-8A
WP_013669070   340 ---dyisqhdEVDRDGKnvSLGTTPRQITDLVGSLSDLT-SGSGDKGTPIVYIQG 390 Aerococcus urinae
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