Conserved Protein Domain Family
CofC
?
pfam01983: CofC 
Guanylyl transferase CofC like
Coenzyme F420 is a hydride carrier cofactor that functions during methanogenesis. This family of proteins represents CofC, a nucleotidyl transferase that is involved in coenzyme F420 biosynthesis. CofC has been shown to catalyze the formation of lactyl-2-diphospho-5'-guanosine from 2-phospho-L-lactate and GTP.
Links
?
Statistics
?
PSSM-Id: 251014
Aligned: 3 rows
Threshold Bit Score: 284.083
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q58297   7 MKVIIPVSPINsLKTRLSEFLSGEERKNLLLNMLKDIIKALDGldi--viVSRDEEILDFAKNELKAETIKEKy-KGLNN 83  Methanocaldococcus ja...
O28218   1 MRILIPFKANN-PKSRLSSILSEEERKELARLMLLDVIDAAKP-------FGEIKVVCPSELDVEGVEVVVDT--SDLNT 70  Archaeoglobus fulgidu...
O26710   3 TCAIIPVSRFThAKTRLSPTLSPSEREGLLKAMLMDVSGALARhvdrvlvISADEDVLEYAY-SLGLKILEEEgeRDLNG 81  Methanothermobacter t...

Q58297  84 AIKQAf--EeiEDKEVIIIPADIPLIKKKHIEDILKLSKnyDLIIAPSRGGGTNLLYLKsKDLIEIKYEGFSFLKHLEEA 161 Methanocaldococcus ja...
O28218  71 TVNKV---M--DEAPLAVIMSDLPLLSEEVLKRFFETEG--DVVVAPGRKGGTNMLLVR-KRGFRVSYHFGSFFKHLEMA 142 Archaeoglobus fulgidu...
O26710  82 ALEQAmdfCapEFDRVIITPSDIPLIGKADVSNLLDHASraDVVIAPANGGGTNTLILR-PSAMSLRFGDCSFFEHIHEA 160 Methanothermobacter t...

Q58297 162 KKRNLRYYIYDSFLISVDINTPEDLGEIFIHGNDTYTKNYLKSLGIDVEPKHSSAGRFVVKRR 224 Methanocaldococcus jannaschii DSM 2661
O28218 143 RKMGMKAKIFDSFYSSVDIDDESDLLELMMHGSGKKSYEFLRKIGFSVSFEETPRLERRVFMQ 205 Archaeoglobus fulgidus DSM 4304
O26710 161 RERGLSVSVYDSFYLSLDVNTAEDLGEIILHGEGTHAREYLRKLRFTVKPSRGSD-RLEVSRS 222 Methanothermobacter thermautotrophicus...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap