6OHB,1A5M,7ZCY,4V1Y,4Z42,6OH9,3MTW,2P50,7LKJ,2VHL,7U5K


Conserved Protein Domain Family
Amidohydro_1
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pfam01979: Amidohydro_1 (This model is not part of the current CDD release)
Amidohydrolase family
This family of enzymes are a a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyzes adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyze the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.
Links
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Statistics
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PSSM-Id: 514634
Aligned: 68 rows
Threshold Bit Score: 99.8627
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6OHB_A  73 LIVPGFV---DTHIHYPQSEMVGaygeqllewlnkhtfpterrYEDLEYAREMSAFFIKQLLRNGTTTALVFGTVHPqSV 149 Escherichia coli K-12
O34909  78 YIVPGYI---EPHAH-PFQIY-----------------------NPQTLAEYVSQYGTTTFVNDNLFLLLQSGKK---KA 127 Bacillus subtilis sub...
P39761  66 MIVPGFI---DGHVHIESSMV-----------------------TPIEFAKAVLPHGVTTVVTDPHEIANVSGEK---GI 116 Bacillus subtilis sub...
P31441  81 TAVPGFI---DAHLHIESSMM-----------------------TPVTFETATLPRGLTTVICDPHEIVNVMGEA---GF 131 Escherichia coli K-12
Q58854  58 YLSPTFI---DGHIHIESSHL-----------------------IPSEFEKFVLKSGVSKVVIDPHEIANIAGKE---GI 108 Methanocaldococcus ja...
O26952  39 IIIPGFI---DAHLHIESSML-----------------------IPSSFAAAAIPHGTVSAISDPHEIANVMGVD---GV 89  Methanothermobacter t...
O50821  43 YVLPGFI---DAHIHIESSFL-----------------------VPSNFAHLVVAHGTVATISDPHEIANVNGID---GI 93  Borreliella burgdorfe...
P57416   5 VKKIKIIkpdDWHVHLRDNEILN--------------------QVIKYTGKFYKRAVIMPNLNSPITSCLKSIA----YR 60  Buchnera aphidicola s...
O08553  64 MVIPGGI---DVHTRFQMP-------------------------DQGMTSADDFFQGTKAALAGGTTMIIDHVVPE--PG 113 house mouse
7U5K_A  64 MVIPGGI---DVHTRFQM-------------------------PDQGMTSADDFFQGTKAALAGGTTMIIDH--VVPePG 113 domestic cattle

6OHB_A 150 DALFEAASHi--NMRMIA--GKVMMDrnapdYLLDTAESSYHQSKELIe-RWHK--NGR--Ll-YAITPRFAPTSSPEQM 219 Escherichia coli K-12
O34909 128 LTILNELKKqpvQYFWWs------------rYDLQTEVLNEDHVLPFDvrKQWIehPDV--IqgGEMTGWPRLVDGDDLM 193 Bacillus subtilis sub...
P39761 117 EFMLEQARHtplNIHFML--PSSVPAa---sFERSGAILKAADL------KPFYeeEEV--LglAEVMDYVSVQQAEKDM 183 Bacillus subtilis sub...
P31441 132 AWFARCAEQarqNQYLQV--SSCVPAle--gCDVNGASFTLEQM------LAWRdhPQV--TglAEMMDYPGVISGQNAL 199 Escherichia coli K-12
Q58854 109 LFMLNDAKIl--DVYVML--PSCVPAt---nLETSGAEITAENI------EELIllDNV--LglGEVMNYPAVINEDEEM 173 Methanocaldococcus ja...
O26952  90 RFMIDDAAAtpmKFYFTA--PSCVPAt---pFETAGAEITARGI------EELLrmDSV--ValGEMMNFPAVIAGDDGV 156 Methanothermobacter t...
O50821  94 NFMINNSKKtefKFFFGA--PSCVPAls-qeFETSGYVLNDKDI------DELMklDDI--YylAEVMDFKGVINKDIEI 162 Borreliella burgdorfe...
P57416  61 NRILKSMHLn---------------------YKFKPLMTCYLTNSTSPkeLEFGfsKKI--FvaAKFYPNGCTTNSKTGI 117 Buchnera aphidicola s...
O08553 114 TSLLAAFDQwrewad----------sksccdYSLHVDITEWHKGIQEEmeALVKdhGVN--SflVYMAFKDRFQLTDSQI 181 house mouse
7U5K_A 114 TSLLAAFDQw----REWAdsKSCCd------YSLHVDITEWHKGVQEEm-EALVkdHGVnsFl-VYMAFKDRFQLTDSQI 181 domestic cattle

6OHB_A 220 AMAQR-----LKEEYpDTWVHTHL--CENK--DEIAWVKSLYPd---HDGYLDVYHQ---Y---GLTGK-NCVFAHCVHL 280 Escherichia coli K-12
O34909 194 LHCMQ-----ATKKQ-RKRIEGHFpgASDK--TLTKMKLFGADcdheAMTGDEVMRR----------------LELGYYV 249 Bacillus subtilis sub...
P39761 184 VQKLL-----DARVA-GKRIDGHLagLSTD--LINIYRTAFVLndheVTSKEEALDR----------------IRRGMYV 239 Bacillus subtilis sub...
P31441 200 LDKL------DAFR--HLTLDGHCpgLGGK--ELNAYITAGIEncheSYQLEEGRRK----------------LQLGMSL 253 Escherichia coli K-12
Q58854 174 LKKIE-----VAKKY-NKLIDGHCpkLKGW--ELNKYISHGIMsdheSVDEDEALEK----------------LRLGLKL 229 Methanocaldococcus ja...
O26952 157 MAKIK-----AARDL-NMPVDGHAplLSGD--ELCTYIGAGIStdheCVSPEEVLEK----------------RRLGMKI 212 Methanothermobacter t...
O50821 163 INKIN-----SALKR-NKVVDGHApgLSPN--LTLKYASSGIStdheCLTIEDARYK----------------LSLGMKI 218 Borreliella burgdorfe...
P57416 118 KKISDitpvlECMEKiGMPLLIHGeeINQN--IDIYDREAKFIektlDPLRKKFPKL-------------KIVLEHITTK 182 Buchnera aphidicola s...
O08553 182 YEVLS-----VIRDI-GAIAQVHAenGDII--AEEQQRILDLGitgpEGHVLSRPEEveaE---AVNRSiTIANQTNCPL 250 house mouse
7U5K_A 182 YEVLS-----VIRDI-GAIAQVHA--ENGDiiAEEQQRILDLGitgpEGHVLSRPEE---VeaeAVNRSiTIANQTNCPL 250 domestic cattle

6OHB_A 281 Ee-----------kEWDRLSET--KSSI---------------------------A---------FCPTSNLY------- 304 Escherichia coli K-12
O34909 250 Slrn---------------------------------------------------------------------------- 253 Bacillus subtilis sub...
P39761 240 Mmre---------------------------------------------------------------------------- 243 Bacillus subtilis sub...
P31441 254 Mire---------------------------------------------------------------------------- 257 Escherichia coli K-12
Q58854 230 Mire---------------------------------------------------------------------------- 233 Methanocaldococcus ja...
O26952 213 Mare---------------------------------------------------------------------------- 216 Methanothermobacter t...
O50821 219 Lire---------------------------------------------------------------------------- 222 Borreliella burgdorfe...
P57416 183 EsveyiknndvnylSATITPHHlmLNRN---------------------------DmfyggiqpyLYCLPILK------- 228 Buchnera aphidicola s...
O08553 251 Yvtkv------mskSAAEVIAQarKKGT---------------------------VvygepitasLGTDGSHYwsknwak 297 house mouse
7U5K_A 251 Yitkv------mskSAAEVIAQarKKGTvvygepitaslgtdgshywsknwakaaA---------FVTSPPLS------- 308 domestic cattle

6OHB_A 305 -----------LGSGLFNLKKAWQK-KVK----VGMGTD-I--------GAGTTFNMLQTLNEAYKVLQlq-------gY 352 Escherichia coli K-12
O34909 254 ---------ssIRPDVRKILQELHEkGFRyydhFFYTTDgAtpnf-ykgGMTNEL-----IRIALe-------------E 305 Bacillus subtilis sub...
P39761 244 ---------gsVAKNTLNVLPAVNEkNARr---FFFCTDdKhvddllseGSVNHQ-----VKMAIq-------------A 293 Bacillus subtilis sub...
P31441 258 ---------gsAARNLNALAPLINEfNSPq---CMLCTDdRnpweiaheGHIDAL-----IRRLIe-------------Q 307 Escherichia coli K-12
Q58854 234 ---------gtASKNIYLLNICKKIkDFRn---IMLVSDdVcik--dldGYMLNI-----LRKAT--------------N 280 Methanocaldococcus ja...
O26952 217 ---------gsSARNLRDLAAAGCDf---------LVSDdIhpad-lleGHMDRI-----LRRAVd-------------Y 259 Methanothermobacter t...
O50821 223 ---------gsAAKNFESLHPLISEcSKKycdsLMFCFDdAhpnd-ilnGHINLI-----VARAIk-------------H 274 Borreliella burgdorfe...
P57416 229 -----------KNKHRMALRKAISNgDKH----FFLGSDtAphlhknkiNMLGCA-----GIFNAPSSLlsyvkvfeemR 288 Buchnera aphidicola s...
O08553 298 aaafvtspplsPDPTTPDFLNSLLScGDL----QVTGSAhCtfntaqkaVGKDNFTLIPEGTNGTEERMsviwdkavvtG 373 house mouse
7U5K_A 309 -----------PDPTTPDFLNSLLScGDL----QVTGSAhCtfntaqkaVGKDNFTLIPEGTNGTEERMsviwdkavvtG 373 domestic cattle

6OHB_A 353 RLSAYE-AFYLATLGGAKSLGLddLIGNFLPGKEADFVVMEPtatplqqlrydnsvslvDK--------------LFVMM 417 Escherichia coli K-12
O34909 306 GVPAID-AYNMASFNIAKYYQMddYLGVVGPGRLASLNIL---------------------------------------- 344 Bacillus subtilis sub...
P39761 294 GLNPFL-AYQLGSLNAAECYGLd-TKGAIAPGFDADLLFV---------------------------------------- 331 Bacillus subtilis sub...
P31441 308 HNVPLHvAYRVASWSTARHFGLn-HLGLLAPGKQADIVLL---------------------------------------- 346 Escherichia coli K-12
Q58854 281 YVSPIE-AIQMVTINPANYFGF--DVG-IKAGNEASFVIF---------------------------------------- 316 Methanocaldococcus ja...
O26952 260 GIDPVS-AVQMVTINPAEHYGL--STGAIAPGWDADFVVV---------------------------------------- 296 Methanothermobacter t...
O50821 275 GHDFFD-VLKIACINPVLHYKI--PVGLLRIGDPADFIIT---------------------------------------- 311 Borreliella burgdorfe...
P57416 289 ALKYLQ---SFCSENGPKFYNMpiNKETITIIKKPCKIIK---------------------------------------- 325 Buchnera aphidicola s...
O08553 374 KMDENQ-FVAVTSTNAAKVFNLypRKGRISVGSDADLVIWDPds-------------vkTIsakth----nsaleYNIFE 435 house mouse
7U5K_A 374 KMDENQ-FVAVTSTNAAKVFNLypRKGRIAVGSDADLVIWDP-----------------DSvktisakthnssleYNIFE 435 domestic cattle

6OHB_A 418 TLGDDRSIYRTYVDGRLV 435 Escherichia coli K-12
O34909 345 EDPLNPNPVTVLSKGTIL 362 Bacillus subtilis subsp. subtilis str. 168
P39761 332 SDLENVTVTMTMVKGQTV 349 Bacillus subtilis subsp. subtilis str. 168
P31441 347 SDARKVTVQQVLVKGEPI 364 Escherichia coli K-12
Q58854 317 EDLDNFKVYNIVIKGRFL 334 Methanocaldococcus jannaschii DSM 2661
O26952 297 DSLRDFNVKRVYIDGRPV 314 Methanothermobacter thermautotrophicus str. Delta H
O50821 312 KDIKTFKINKTYINGKLV 329 Borreliella burgdorferi B31
P57416 326 KINVGRNVIIPFLSGEIL 343 Buchnera aphidicola str. APS (Acyrthosiphon pisum)
O08553 436 GMECRGSPLVVISQGKIV 453 house mouse
7U5K_A 436 GMECRGSPLVVISQGKIV 453 domestic cattle
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