Conserved Protein Domain Family
ThiC_Rad_SAM

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pfam01964: ThiC_Rad_SAM (This model is not part of the current CDD release)
Radical SAM ThiC family
ThiC is found within the thiamine biosynthesis operon. ThiC is involved in pyrimidine biosynthesis. ThiC participates in the formation of 4-Amino-5-hydroxymethyl-2-methylpyrimidine from AIR, an intermediate in the de novo pyrimidine biosynthesis. Thic is a member of the radical SAM superfamily.
Statistics
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PSSM-Id: 514623
Aligned: 193 rows
Threshold Bit Score: 563.953
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012420871   105 TQRYYAQQGVITPEMEFVAIRENlgreqafkaiydrypnaksrpdeaaealetltmmprpseleaqegfgpssmvardrl 184 Akkermansia
A8A8N6           2 TIYKDARNGRITEEMKKIAEVEG--------------------------------------------------------- 24  Ignicoccus ho...
jgi:Igag_1298    1 --MAIARSGSIPDEVVSVAKAEG--------------------------------------------------------- 21 
jgi:Pyrfu_1448   1 --MRIARSGGTPPELEIVAREEG--------------------------------------------------------- 21 
WP_015051289     2 TQVQHARMGRVTPEMEAVAAAEG--------------------------------------------------------- 24  Thermacetogen...
WP_006521286     2 TQVLKARAGKITEEMEAVALYEQ--------------------------------------------------------- 24  Desulfoscipio...
WP_014355849     2 TQMIKARAGKITEEMEMVALNEG--------------------------------------------------------- 24  Acetobacteriu...
WP_012283130     4 TQREAALRGLITPAMAEAAEREQ--------------------------------------------------------- 26  Heliomicrobiu...
WP_006521285     2 sfLEDAQKGLTTEQIEAAAVAEG--------------------------------------------------------- 24  Desulfoscipio...
WP_014355850     2 TILEKARAGELTAEMIYVAQKEG--------------------------------------------------------- 24  Acetobacteriu...
WP_012420871   185 dhqhaperrngcrmpayFTPEFVRDEIASGRALIPANINH--PECePMAIGRNFLVKINANIGNSALGSSIEEEVEKLRW 262 Akkermansia
A8A8N6          25 -----------------VDPEFVRRGLAAGRIVLLRNLKRa-DRVkTVAVGEGMLTKVNANIGTSNTLIDVNMEVEKAKI 86  Ignicoccus ho...
jgi:Igag_1298   22 -----------------VDIDKLRKWLAEGKVIIVRNVRRs-DKVrIVGIGKGLSTKVNVNIGTSTTVVDINMEKEKATI 83 
jgi:Pyrfu_1448  22 -----------------VDVNKLRHRVAEGRVIIVRNVKR--EGVkPLGIGEGLRTKVNVNVGTSTHVVNIDMELEKVRI 82 
WP_015051289    25 -----------------LPVEEIMQGVAEGTIVIPKNIRRk-KIR-LCGIGKGLRVKVNALIGTSTDWNDPEMELRKIAA 85  Thermacetogen...
WP_006521286    25 -----------------VDVEFVRKGVAEGRIVIPRNINRk-SFR-YCGIGEGMRVKVNALIGTSSNRDDMALEARKLQA 85  Desulfoscipio...
WP_014355849    25 -----------------FTPEFIRAGVACGKIVIPKNKFRk-RSK-ICGIGGGLDVKVNGLMGTSGDRDDMEMEVKKLKI 85  Acetobacteriu...
WP_012283130    27 -----------------VEAEVIRRGLAEGTIVLPCNRRRaeGRQ-AVAFGKGLRTKVSASIGLPLDGGSESEERKKLEV 88  Heliomicrobiu...
WP_006521285    25 -----------------VAAAVIRQGVADGTIVVPCNPAH--KGLkPIAIGKGLRTKVSASIGLDNKDSTVANELEKLQT 85  Desulfoscipio...
WP_014355850    25 -----------------IDPEIIRAGVASGEIVILKSW-R--QNInPVAVGKGLFTKVSASVGMYENDDTIDSEMAKIAM 84  Acetobacteriu...
WP_012420871   263 AIHWGADTVMDLSTGKNIHAT--------------REWILRNSP-VPIGTVPIYQALEK----VGGKVADLSWEVFRDTL 323 Akkermansia
A8A8N6          87 AKKYGADTVMDLSTGGNLDVI--------------RRKIMEAAEpLPLGTVPIYQAFMDva-tRKGAGLYMTEDDILNTI 151 Ignicoccus ho...
jgi:Igag_1298   84 AVKYGADTIMDLSIGGDIREI--------------RRELMKASEpLPFGTVPTYQAYIEgv-aKFKALP--PEDFFLKIV 146
jgi:Pyrfu_1448  83 AKQYGADAIMDLSIGGDLDEI--------------RRLILRESApLPVGTVPTYQAWMEtv-aKGKGLP--DEDHFIKVV 145
WP_015051289    86 AEAAGCDSFMDLSTGGDIDAM--------------RKKTLTNAG-VPVGCVPIYQAGIEai-eRHGSVVGMTPDDMFAVI 149 Thermacetogen...
WP_006521286    86 AQDAGCDTFMDLSTGSGIDAM--------------RKQTLELAN-VAVGCTTIYQAGQEai-eKYGSVVEMRTKDILDNI 149 Desulfoscipio...
WP_014355849    86 IEEAGAHGFMDLSMGEDIDTM--------------RTLSLTNSN-IAAGCVPVYQAAKEaa-eKRGLMVNMTSDDLFEVI 149 Acetobacteriu...
WP_012283130    89 VLAAGADAVLDLSIGVGTDRVrepdaqlgdylalfRRHVLSTST-KPVGTLPQYEVFACrrdeKRGGILATTVEEMFEAM 167 Heliomicrobiu...
WP_006521285    86 ALVAGTHAIMDLSITGDMDGA--------------RRAILSAAP-VPVGTLPLYQTIVEas-qKYGSALKMTPEQMLEVM 149 Desulfoscipio...
WP_014355850    85 AIKAKTDTLMDLSVRGPIDQM--------------RETVLKTVD-RPVGTLPLYQTLAYaq-eKYGTALDMTPDDMFEMM 148 Acetobacteriu...
WP_012420871   324 LEQARQGVDYVTVHAALLLRFVNHTA--RRMTGIVSRGGSIMAQWSMIHEQENFLYSHWDEICSILAAYDIAVSIGDGLR 401 Akkermansia
A8A8N6         152 EKHLKDGVDFMTLHAALTRDLAAKAVksDRAEPIVSRGGSILAAWMLEHGKENPLLSNFDYILEMFKEYDAVISLGDSLR 231 Ignicoccus ho...
jgi:Igag_1298  147 EEHLRDGVDFMTIHAGITLDLAKKAVksSRIEPIVSRGGALLAGWMLENNSENPYYKNWDYLLELFAEYDATISLGDALR 226
jgi:Pyrfu_1448 146 ERHLKDGVDFMTIHAAITRELAEKAVksNRIQPIVSRGGALLAAWMLETGSENPYWKNFDYILELFAEYDATISLGDSLR 225
WP_015051289   150 EKQAADGIDFMAVHSALNFEILECLQqnGRVTDIVSRGGAFLTGWMLHNQKENPLYEQFDRLLEILLRYDVTLSIGDAIR 229 Thermacetogen...
WP_006521286   150 EKQAAEGIDFMAIHCAFNNSVLNVMQktGRVTWVVSRGGAFITGWMLHNKKENPLFEHYDRILEILKAYDVTLSLGDAIR 229 Desulfoscipio...
WP_014355849   150 EKQCQAGMDFMAVHSALNMDLLKILKktGRVADVVSRGGSLLTGWMFHNDKENPLYAEFDRLLEILKATDTVLSIGDAIR 229 Acetobacteriu...
WP_012283130   168 ERHGADGVDFFGLHSAMTLKALELARqqGRLTHMVSWAGALLAGWMIHHKRENPFYSHFDRVLDICRRYDVTLSLADGLR 247 Heliomicrobiu...
WP_006521285   150 ERQASDGVDFMALHCATTFETIERAKneGRIDPLVSYGGSHIIGWMVHHKKENPLYENYDRILEIAKKYSVTLSLADGMR 229 Desulfoscipio...
WP_014355850   149 EKHAAEGVSFLALHCGTTMDVINRAKeeGRIDPLVSYGGSHLIGWMVHNHCENPFFSQYDRVLEICKKYDVVLSFADGMR 228 Acetobacteriu...
WP_012420871   402 PGSVADANDFAQLAELEVQGDLTMRAWKAGVQVMNEGPGHVPMHLIRENMSKQLEWCMEAPFYTLGPLVTDIAPGYDHIT 481 Akkermansia
A8A8N6         232 PGALEDAHDEYHLSELMVNARLVKRAREAGVQVMLEGPGHVPLDRVVADVKLAKRLTEGAPYYILGPLVTDIAAGYDHIA 311 Ignicoccus ho...
jgi:Igag_1298  227 PGAIADALDELQIAELINNARLVKIAREKGVQVMVEGPGHVPLHKIVADIRLMKSLTDEAPYYVLGPLVTDIAMGYDHIA 306
jgi:Pyrfu_1448 226 PGAIHDAHDQLQIAELVNNARLVEKARQAGVMVMVEGPGHVPLDRVVEDVKLMKAVTRGAPYYVLGPLVTDVAPGYDHIG 305
WP_015051289   230 PGSIADSLDAAQMKGLIVAGELVARALEAGVQVMVEGPGHVPLDHVEATMKLQKSLCHNVPYYILGTLATDVAAGYDHIA 309 Thermacetogen...
WP_006521286   230 PGATADSLDGAQIQGLLVQGDLAKRAQAAGVQVMVEGPGHVPLNHVEATMKLQKRLCNNAPYFILGTLATDVAPGYDNIT 309 Desulfoscipio...
WP_014355849   230 PGANADSLDQAHLRGLMVAGELTKRALEAGVQVMVEGPGHVPLNHIPTAMLLQKRLCFEVPYYILGFLATDVAPGYDNIS 309 Acetobacteriu...
WP_012283130   248 PGSGQDSLDRAQVQEMVILGEQVRAARDAGVQVMVKGPGHAPLHHCRATVQLQKQLCEGAPYFIFGPLATDAAPGYDHIT 327 Heliomicrobiu...
WP_006521285   230 PGCLADSLDGGQVQELITLGELVDRARKAGVQIMIKGPGHMPLNHIKNTMTLQKSLCKGAPYFVFGPLLTDLAVGYDHIN 309 Desulfoscipio...
WP_014355850   229 PGCIADSLDGAQVHELVILGGLVKKARAAGVQVMVKGPGHVPLDQIQTTVQLQKQLCGGAPYFVFGCLPTDSGAGMDHVT 308 Acetobacteriu...
WP_012420871   482 GAIGGAIIGQLGCAMLCYVTRKEHLGLPDREDVREGVVAYKLAAHAADLAKGHPSAQWRDNALAQARFEFRWEDQFNLSL 561 Akkermansia
A8A8N6         312 GAIGGAIAAAHGADFLCYVTPAEHLNLPNPEQVREGVIAFRIAAHAADIVKYPDRAMKVDIEMGRCRGRLDWECMIRLSL 391 Ignicoccus ho...
jgi:Igag_1298  307 SAIGATIAAAEGADLICYLTPAEHLSLPNPEQVKEGLIAAKIAAHAGDIVKLGDKAMARDIEVSIYRAKLDWNKMIDLAL 386
jgi:Pyrfu_1448 306 SAIGAALAAAAGADFICYVTPAEHLSLPTPEQVKEGLIAARIAAHAGDIVKLGEKAAAWDRLVAEARARLDWRTMIDNSL 385
WP_015051289   310 AAIGGALAGMVGANFLCYVTPAEHLGLPTEEDVRAGVIATRIAAHAADLANGNRAAWERDLEMARARVRGDVEKQIKLAI 389 Thermacetogen...
WP_006521286   310 GAIGGAFAGACGADFLCYLTPAEHLGLPLEEDVRTGVITTRIAAQIADVARGHKQAMARENEMARARVAMDIDRQIKAAL 389 Desulfoscipio...
WP_014355849   310 GSIGGAFAGMHGADFLCYLTPAEHLGLPNEEDVRIGVETTRIAANAANVLKRGGFAWNRDLAMSKARVARNQEDQVKNAI 389 Acetobacteriu...
WP_012283130   328 CAIGAALAASAGADLICYVTPAEHVRFPTVEDVRTGVIAARIAAHAADVAKGIPAAVERDAALSRARGLQDRVTERKLAL 407 Heliomicrobiu...
WP_006521285   310 AAVGGAISSWYGAEFLCYVTPAEHIGNPDVAQVRQGVIAARIAAQAGDLAKGMPEAIQWDLDMSNARRDLKWKEQIRLAL 389 Desulfoscipio...
WP_014355850   309 GAIGGAIASYYGADFLCYVTPAEHIGMPNAEDVYTGVMASRIAAHAGDVGKGHPAAIAWDHEMSVARRELNWKKQMQLAI 388 Acetobacteriu...
WP_012420871   562 DPQKA---------------RSFHDLTLPHanakKAHFCSMCGPDfCAMRLSQD 600 Akkermansia
A8A8N6         392 DPDKA---------------REIRNQYGPT----SIKSCNMCGSL-CVFLLLDk 425 Ignicoccus hospitalis KIN4/I
jgi:Igag_1298  387 DREKA---------------NAIYRQFGV-----KTTSCNMCGSL-CVFLILSR 419
jgi:Pyrfu_1448 386 DPERA---------------WKIHTQFGT-----NLPSCTMCGSL-CACLVLEK 418
WP_015051289   390 DPETA---------------RTALGGAD------GDYRCAACGEN-CAACvaag 421 Thermacetogenium phaeum
WP_006521286   390 APDKL---------------IAAKEKGC------GQHLCAACGKD-CAVQEAAr 421 Desulfoscipio gibsoniae
WP_014355849   390 NQANL---------------VAAFAAQK------PSHGCSVCQDSkCPADVAAe 422 Acetobacterium woodii
WP_012283130   408 DPDALtgtgsvdgtvapameEGIEEGKAPK----EAGGCHACGDS-CSRRVLAE 456 Heliomicrobium modesticaldum
WP_006521285   390 DPEHA---------------AYIRKTRNEG----KISTCAMCGKF-CAMKIIAE 423 Desulfoscipio gibsoniae
WP_014355850   389 DTETA---------------TKVWKDRSTN----FSSECSMCGDF-CAMKIVGK 422 Acetobacterium woodii
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