Conserved Protein Domain Family
DHQS
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pfam01959: DHQS 
3-dehydroquinate synthase II (EC 1.4.1.24)
3-Dehydroquinate synthase II was isolated from the archaeon Methanocaldococcus jannaschii and plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyzes a two-step reaction - an oxidative deamination, followed by cyclization. The enzyme converts 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate to 3-dehydroquinate.
Links
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Statistics
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PSSM-Id: 426532
Aligned: 78 rows
Threshold Bit Score: 409.602
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
BFU:L593_01230   3 RSVWLKADDevGDWEERKRRITAGLESGVDWVLVDEHDVGRVKELGDVK-VAAFStgGDaamiddaegdgdagpeaDAYV 81  Salinarchaeum...
WP_038286509     4 KLVWFDA----RNLKNEEKVLPLIYNLRFENLLISQDMLERVKAPHKMK-LIVEVydDEeien----------lpkEAVV 68  Hungateiclost...
EFL22150         2 KFAWI--DLrtVPQDKLESVVDAAIHTRMRGVLSD--DESVLKALPPTVtGVTTTpvTD-----------------EKQL 60  Streptomyces ...
WP_054291872     2 KFAWIDVRT--VPEDQRESIVDAAIHARADGIVHD-DETLLSTLPATVRrVFLSA--GG--------------------- 55  Kibdelosporan...
CCH29459        27 KFAWIDIRA--VDARHREAVVDAAVHAGLGGVLDH-RLETLATLPPTVTkVLLPG--PG--------------------E 81  Saccharothrix...
WP_006139198     2 KFAWIDLRSthDDL--RAGVVDAAVHARLEGVLDD-RLEVLRTLPPTVTkVLLPAp--------------------GDPL 58  Streptomyces
SIPI:L083_5378   7 RQCWLDVRTa-GEWA--RAACEEAVHQRFDAIVAA-DAAVLGDLPPTVSrVLAPE--GA-------------------RL 61  Actinoplanes ...
KWX00476         2 KLCWLDIR---ATGEAKAAIVEEAIHQRVDAIVSD-DPADLAALPPTVKkVL--------------------------FL 51  Streptomyces ...
KMZ68173        55 KLVWV--------WTENKQVMTSALERGWDTFLFHSTDKSIADDWKSIA-LIRPLfiEN-----------------SEIF 108 Zostera marina
XP_002877130    75 KKVWI--------WTECKEAMTVAVERGWNTFIFSSDNRELSNEWSSIA-LMDTLfiEE-----------------DQVV 128 Arabidopsis l...

BFU:L593_01230  82 VGKDgegdgtvdlpndlsgsadlstlRRDd---dRATGSYVRIFDSDYEGFAESAAQEAEYTIVIGE-NWQIIPLENLIA 157 Salinarchaeum...
WP_038286509    69 LSKNkd------------------ilKEAkv-kgYSTALYQNIDNEEDMNNAWMDGRTADFLVVEFK-DPTNIPLELLIA 128 Hungateiclost...
EFL22150        61 HGLD------------------------------ADTAGWVDVHDEPSLRLACAAAVALPFTVVRFA-DPTKIPLEIVLA 109 Streptomyces ...
WP_054291872    56 -SAPgtevdalirlrtaadqseldrlRAAhrggdDSVAALVDVIDDESLTLACHAAIALPHTVVRFK-DPTKIPLEIVIA 133 Kibdelosporan...
CCH29459        82 VPPAeaagacdvvltrvatfteldklKLVagevdAHAGAFVEVVDDLTLRVACAAVQALEHTVVRFR-DPTKIPLEIVIA 160 Saccharothrix...
WP_006139198    59 PAEAadvadivltr--vgtaaeldklKLEsesdpARTAAFVEVVDDATLKVACEAARALPNTLVKFR-DPTKIPLEIVIA 135 Streptomyces
SIPI:L083_5378  62 PADFgaadlvlv------tpeqgdpdRLAeeypgVRFGRRLTVTGPDSLDAACASVRRDPVTLLSFR-DPTNIPMEIVLA 134 Actinoplanes ...
KWX00476        52 PGRPfpedlsaadivivdpavhgdsaKLAlshpdQEFGRFVEVVDAPTLELACQAARTDRWCVLLFR-DPTKIPLEIVLA 130 Streptomyces ...
KMZ68173       109 DGKN------------------------------KKVGVVCQVSSSQQLEIVNPDEVKTQNVVIGFEgEWQVIPAENIVA 158 Zostera marina
XP_002877130   129 DSMG------------------------------NVVASVFEVSTPEELRNLKIENDQAENIVLDFL-DWKSIPAENLVA 177 Arabidopsis l...

BFU:L593_01230 158 RI-GDETTLIAGVTEAEEARTAYETLEIGADAVLLDSSDPDEIRETVAVHDEADRET--LELRWAEVTGIERAGSADRVC 234 Salinarchaeum...
WP_038286509   129 RLqQTNTVILKAVNTAEDAEIAFGVMEVGSDGVLLKTEDMDQIVEVNNFMSKEEKGK--IELVKGKVMDVQHVGMGYRSC 206 Hungateiclost...
EFL22150       110 AAdRSEGKLITVCADLEEAATVLDVLERGSDGILLAPSNAGEVFALARLLEAGTAP---LNLTTLTVDGIEHHGLGDRVC 186 Streptomyces ...
WP_054291872   134 AAdSSPGQLVCHADNLEEAGIIIDVLEKGSEGVMLAPRDADDVFSLMDLL-RTKTEP--LELTTLSVDSIEHLGLGDRVC 210 Kibdelosporan...
CCH29459       161 AAdRAPGLLVCEADGIEEARIVLDVLEKGSDGLLVAPRDANDVFDVDKLL-RTATPD--LALTTLTVRSVEHNGLGDRIC 237 Saccharothrix...
WP_006139198   136 AAdHSPGRLICEAGDLEEAGIVVDVLEKGSDGLLLAPKDANDVFGLTGLL-RGSSPD--LSLTTLTVRSIEHNGLGDRVC 212 Streptomyces
SIPI:L083_5378 135 AAdGAAGSIITAVDSVDTAAVHLSVLEHGPDGVLLTPSAPGDATRLAGVV-RDSSPR--LELVPLTVTAVRHAGTGDRAC 211 Actinoplanes ...
KWX00476       131 AAaKAEGSIITIAADVEEAEIIFGVLEHGSDGVMLAPKAVGDATELKAAAHGRAAA---LDLVELEVTAITHVGMGERAC 207 Streptomyces ...
KMZ68173       159 AFhGCEKTVFAIAKTSDEAQIFFQALERGFGGVVLKSEDVDEVLKLKDYLERRNNTTniLALTTATVTQVKVVGMGDRVC 238 Zostera marina
XP_002877130   178 ALqGSEKTVLAISNTPSEAKLFLEALEHGLSGIILKSEDVKAVLDLKEYFDKRNEESdtLSLTEATITRVQMVGMGDRVC 257 Arabidopsis l...

BFU:L593_01230 235 VDTGQLMDHDEGMLVGSMSRGLFFVHAETAESPYVASRPFRVNAGAVHAYVRTPDGGTKYLSELESGDEVQVVDTDGNTR 314 Salinarchaeum...
WP_038286509   207 IDTTTLMKENEGMLIGSTSEGGILVSSETHFLPYMELRPFRVNAGAVHSYVWAPEGMTAYLTELKAGSKVLCVDTEGNTR 286 Hungateiclost...
EFL22150       187 VDTCSHFAEDEGILVGSYSTGFILCCSETHPLPYMPTRPFRVNAGALHSYVLGPDNRTNYLSELRAGGTTLAVDAEGRTR 266 Streptomyces ...
WP_054291872   211 IDTCTHFEEDEGMLVGSYAHGFILCCSETHPLPYMPTRPFRINAGALHSYVFGQDNRTNYLSELKAGSAVLGVGADGRTR 290 Kibdelosporan...
CCH29459       238 VDTCTHFREDEGILVGSFAHGFVLCVSETHPLPYMPTRPFRVNAGALHSYVFGADNRTNYLSELKAGSTVLGVTADGRTR 317 Saccharothrix...
WP_006139198   213 VDTCSHFGQDEGILVGSYAHGFVLCVSETHPLPYMPTRPFRVNAGALHSYVLGEDNRTNYLSELQAGSTVLGVTTEGKTR 292 Streptomyces
SIPI:L083_5378 212 VDTCTYLEPDEGILVGSRSRALLLCVSETHPLPYMPTRPFRVNAGAIMSYTLGDAQHTRYLSELRAGGTVLAVGADGRTR 291 Actinoplanes ...
KWX00476       208 VDTCTHFREDEGILVGSHSKGMILACSETHPLPYMPTRPFRVNAGAIHSYTLSQNGRTHYLSELKAGSKVLAVDVKGQTR 287 Streptomyces ...
KMZ68173       239 VDLCSLMQPGEGLLIGSFARGLFLVHSECFDSSYIPSRPFRVNAGPVHAYVAIPGGMTCYLSELEAGKEVIVVDRNGLQR 318 Zostera marina
XP_002877130   258 VDLCSLMRPGEGLLVGSFARGLFLVHSECLESNYIESRPFRVNAGPVHAYVAVPGGKTCYLSELRTGREVIVVDQKGKQR 337 Arabidopsis l...

BFU:L593_01230 315 EAVVGRAKIEQRPMFRLEAEVetddGVDRVETLLQNAETIKVPTS---DG----RTAITDVEEGDEVLIYYEDTARHFGE 387 Salinarchaeum...
WP_038286509   287 EVTVGRVKTELRPLLKIEVEA----EGVNINVIVQDDWHIRILGG---NGe---PLNASTLKPGDEVLAYVCAGGRHVGI 356 Hungateiclost...
EFL22150       267 PVMIGRAKLESRPLLTITARSp---EGTVVSLTVQDDWHVRVLGP---GGs---VHNVTELRPGDELLGYLATDQRHVGF 337 Streptomyces ...
WP_054291872   291 RIVVGRIKLESRPLLSIKASSa---EGVQVNLIVQDDWHVRLLGP---GGt---VRNVTELKPGDELLGHVATDKRHVGW 361 Kibdelosporan...
CCH29459       318 RIVVGRVKLESRPLLTVHATAp---DGTEVALTLQDDWHVRVLGP---GAa---VLNSTELEPGDQLLGYLATDKRHVGW 388 Saccharothrix...
WP_006139198   293 RIVVGRVKLESRPMLTIRAVSe---SGTEVSLTVQDDWHVRVLGP---GAa---VLNVTELKAGDQLLGYLADDKRHVGW 363 Streptomyces
SIPI:L083_5378 292 RVTVGRVKIETRPLLSIDAVAp---DGEPANLIVQDDWHVRVLGP---GAr---VLNSTELRPGDEVLGHLPGRERHVGY 362 Actinoplanes ...
KWX00476       288 VVTVGRVKIETRPLLSIDAVAp---NGRTVNLILQDDWHVRVLGP---GGv---VLNSTELKPGDKVLGYLPAEDRHVGY 358 Streptomyces ...
KMZ68173       319 TAVVGRIKIESRQLILVEAKEds-eSQSHHSLFLQNAETVGLVCPl-gENperrLIPVTSLKARDKILLRLQGGARHTGI 396 Zostera marina
XP_002877130   338 TAVVGRVKIEKRPLILVEVKLsakeEETVFSIILQNAETVALVTPhqvNSsgktAVPVTSLKPGDQVLIRLQGGARHTGI 417 Arabidopsis l...

BFU:L593_01230 388 AVEESIIEK 396 Salinarchaeum sp. Harcht-Bsk1
WP_038286509   357 KIDERLREK 365 Hungateiclostridium straminisolvens
EFL22150       338 PIGEFCREQ 346 Streptomyces himastatinicus ATCC 53653
WP_054291872   362 PVGEFCVEK 370 Kibdelosporangium phytohabitans
CCH29459       389 PVGEFCIEK 397 Saccharothrix espanaensis DSM 44229
WP_006139198   364 PVGEFCIEK 372 Streptomyces
SIPI:L083_5378 363 PIDERCQEQ 371 Actinoplanes sp. N902-109
KWX00476       359 PIDEFCLEK 367 Streptomyces thermoautotrophicus
KMZ68173       397 EIHEFIVEK 405 Zostera marina
XP_002877130   418 EIQEFIVEN 426 Arabidopsis lyrata subsp. lyrata
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