2EEN,1YEM,2DC4,5A67,5A64,2GFG


Conserved Protein Domain Family
CYTH
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pfam01928: CYTH 
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CYTH domain
These sequences are functionally identified as members of the adenylate cyclase family, which catalyzes the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate. Six distinct non-homologous classes of AC have been identified. The structure of three classes of adenylyl cyclases have been solved.
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Statistics
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PSSM-Id: 396490
Aligned: 51 rows
Threshold Bit Score: 57.1634
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2EEN_A         1 MYEVELKGYA---N--D-EIFekvRET-FEFMRKEIHEDIYYQHPCRDFSKTDEALRIRikRFnGHNEVfLTYKGPKIDE 73  Pyrococcus hori...
5A64_A         6 LIEVERKFAPg----pDtEERl--QELgATLEHRVTFRDTYYDTSELSLMLSDHWLRQRe----GSGWE---LKCPGVTG 72  house mouse
Q92LX7         2 AKEIERKFLVa------------tDGWrQHADKGIRLRQAYVVTMED------RSVRVR--IHgNKRAR-LTIKIGK--- 57  Sinorhizobium m...
2GFG_A         5 EIEIERKTLVskeTfkRl-----iSQLhIGEGDFKLQRNHYFETDDFQLKKQSSALRIR--EK-EAIFT-FTLKQPHPAG 75  Alkalihalobacil...
Q8Y8D9         4 ELEIEFRNLLtkeEydTl-----iENFrVKEDDFFEQTNYYLDTTNFGLKERHSALRIR--QL-ETQYQ-LTLKTPEARG 74  Listeria monocy...
WP_000224612   4 NHEIEFKQMItasIynKl-----qEKY-FKDSVLFKQINYYIDTPDFKLKEHRSALRIR--VK-DNQYE-MTLKTPAKVG 73  Staphylococcus
Q8DPU3         3 HLEIELKTLLkkdEynRl-------KDqFTGVTPVLQTNYYIDTPDFELREKKVAMRIR--TF-EDWAE-LTLKVPQSVG 71  Streptococcus p...
WP_002989824   3 NLEIEYKTLLtknEynRl-------LSqMKHVTPVTQTNYYIDTKAFDLKANKMSLRIR--TF-ANSAE-LTLKVPEKVG 71  Streptococcus p...
Q9CIJ7         4 NLEIEYKSLLslaEydQl-------KKlFTHVTPVRQTNHYLDSKDFKLRKKKLALRIR--TF-DKSAE-MTLKVPQEVG 72  Lactococcus lac...
O31609         4 EIEIEFKNMLtkqEfkNi-----aSALqLTEKDFTDQKNHYFDTDSFALKQKHAALRIR--RK-NGKYV-LTLKEPADVG 74  Bacillus subtil...

2EEN_A        74 ksktRLEIEVEIQ--------------------EDVDKYFELLDRLG-----------------FKEVLKVVKTREKYYV 116 Pyrococcus hori...
5A64_A        73 -------VSGPHNeyve--------------vtsEAAIVAQLFELLGsgeqkpagvaavlgslkLQEVASFITTRSSWKL 131 house mouse
Q92LX7        58 ---------SALVrneye-------------------ydlpMNDAREl----------------lTQAIGIVIEKRRFRI 93  Sinorhizobium m...
2GFG_A        76 ----LLETNQTLSkqeaklal-----esahfpsGEVXDALRDLSIPIs---------------qLKHIGTLSTSRAEISY 131 Alkalihalobacil...
Q8Y8D9        75 ----LMETTQILGedqasaii-----sganipvGPVRDTLKELGINHe---------------dLQVFGSLKTIRAEKDY 130 Listeria monocy...
WP_000224612  74 ----LLEYNYIVDikpemnli----isndnlpdDIRQIIVEQFGVKDt---------------tLSILGALTTYRQETKY 130 Staphylococcus
Q8DPU3        72 ----NMEYNQKLQlkdaenyl-----skeelpqGLVLDELAKHGIQSk---------------nWQVLGCLTTLRYEMKT 127 Streptococcus p...
WP_002989824  72 ----NREYNVPLFleqakdmi-----khgnlpeSTALDIIISKGIKPs---------------aLVTFGNLTTVRRETVI 127 Streptococcus p...
Q9CIJ7        73 ----NIEYNIDLSleeaqqllgernivcgetdlSEICELLTARDINLe---------------eITLIGSLTTIRYEQHL 133 Lactococcus lac...
O31609        75 ----LLETHQQLSevsdla--------gfsvpeGPVKDQLHKLQIDTd---------------aIQYFGSLATNRAEKET 127 Bacillus subtil...

2EEN_A       117 e---Kg-----VTITLDEVEGL-------GKFIEIETLVKEKDEIPEAVEKlEKILRELGVEKFE--RRSY 170 Pyrococcus horikoshii
5A64_A       132 alsgAhgqepqLTIDLDSADFG-------YAVGEVEAMVHEKAEVPAALEKiITVSSMLGVPAq--eEAPA 193 house mouse
Q92LX7        94 ----Ph-----KGFTWEVDVYEgalegltVAEVEMKRETDLPNLPAWLGRE------------ITgdRRYS 143 Sinorhizobium meliloti
2GFG_A       132 ----Eq-----GILCLDHSSYLg------IEDYEIEFEGTSEEHATVTFQEiLKTFSISQVPTENkiQRFF 187 Alkalihalobacillus halod...
Q8Y8D9       131 ----Kk-----GLLVFDKNFYGs------ISDFDLEYEVSDYDKGKEVFDKlLKEYQITNQPAENkvARFY 186 Listeria monocytogenes
WP_000224612 131 ----Kg-----DLLVLDKSEYFd------TTDYELEFEVKDYNQGLQKFQSlLNELNLEHHQPLNkvQRFF 186 Staphylococcus
Q8DPU3       128 ----Ai-----GLMALDQSRYFd------ITDYELELEVENHEQGKQDFRQfLEKNQISYQKAPSklVRFV 183 Streptococcus pneumoniae R6
WP_002989824 128 ----Pi-----GKLALDYNLYAn------TKDYELELEVSDALQGKIDFDSfLSEHHIAFKYAKSkvARCI 183 Streptococcus pyogenes
Q9CIJ7       134 ----Pi-----GLAALDKNDYLg------HTDYELELEVDDSKQGKKDFFDfLDKNRVEYRFSKSkvVRFL 189 Lactococcus lactis subsp...
O31609       128 ----Ek-----GLIVLDHSRYLn------KEDYEIEFEAADWHEGRQAFEKlLQQFSIPQRETKNkiLRFY 183 Bacillus subtilis subsp....
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