2Z1D


Conserved Protein Domain Family
HypD
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pfam01924: HypD 
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Hydrogenase formation hypA family
HypD is involved in hydrogenase formation. It contains many possible metal binding residues, which may bind to nickel. Transposon Tn5 insertions into hypD resulted in R. leguminosarum mutants that lacked any hydrogenase activity in symbiosis with peas.
Links
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Statistics
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PSSM-Id: 426512
Aligned: 277 rows
Threshold Bit Score: 471.1
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2Z1D_A          12 EVAMKLVEKIREEAKTldgEIRIMHVXGTHEDTVTRHGIRSLLPENVKVVSGPGCPVCITPVEDIVAMQLIMRKareege 91  Thermococcus ...
WP_006192759    11 EAARALLADIERLAAg--rHLRYMEVCGTHTVAIFRAGLRQILPENIELVSGPGCPVCVTSDAYMDKAIACAKMe----- 83  Selenomonas s...
jgi:Thein_2010   2 tslREIASRIEELLPR---PVRLMEVCGTHTVNIFRYGLKSLFSEKLTLISGPGCPVCVTPQEEIDYLIAVARRd----- 73  Thermodesulfa...
jgi:Glov_3063   11 ELVQGLAAAIAEEARQlpePVRLMEVCGTHTMAIARFGLKSLLPEPVKLVSGPGCPVCVTPVSYIDHAIALSGLp----- 85  Geobacter lov...
WP_012648286    11 EIVNGYAERIEALTAGlevPLTLMEVCGTHTMAISRFGIRSLLPPKVRLISGPGCPVCVTPNHYLDRAIALSRLp----- 85  Geobacter dal...
WP_011736627    11 dVVLGYAAQIRKLSEQrpePMAFMEVCGTHTMSIYQYGIRSLLPEGVRLISGPGCPVCVTPNRYIDRAIAISRLs----- 85  Pelobacter pr...
WP_012531565    11 ELVQGLARRIAELTRGrkkPLVFMEVCGTHTMAIYQYGLRSLLPPEVKLISGPGCPVCVTPNGYLDRAIALSRLp----- 85  Geobacter bem...
Q39ZF8          11 HVVLGLAARIREHVAGrtePMTFMEVCGTHTMSIYQYGLRTLLPPQVRLISGPGCPVCVTPNEYLDRAVALCRLp----- 85  Geobacter met...
WP_011938845    11 TVVTGFAERIRQLTAGrsePMTFMEVCGTHTMAICQFGIRSLLPPQVRLISGPGCPVCVTPNSYLDRAVAYCRLp----- 85  Geobacter ura...
AEB10697        11 HLVRQLIRRLHTVKt---gPATIMEVCGTHTMSVARFGLKMLLPDGINLISGPGCPVCVTDQHDLDGYLALGMQp----- 82  Desulfobacca ...

2Z1D_A          92 EIILTTFGDMYKIPTPMGSFADLKSEGFDVRIVYGIFDTYRIAKENpDKTVVHFSPGFETTTAPAAGMLNVaaQEELENF 171 Thermococcus ...
WP_006192759    84 AVTVATFGDMLKVPGSRESLADARAAGACLRVVYSPLDALAAARENpERTVVFLGVGFETTAPTEAAAVLSakEEGLKNF 163 Selenomonas s...
jgi:Thein_2010  74 DVILATFGDMIRVPGSSGSLKEARARGANVKIIYSPLDAVKLAKENpSHKVVLAAVGFETTAPAVAIAVLEayKEKLTNF 153 Thermodesulfa...
jgi:Glov_3063   86 DTVVTTFGDLLRVPGSNSSLMAERAKGADIRIVYSALDAVKLALELpHKRVVFLGVGFETTTPTVAAAILSaeQQGCTNF 165 Geobacter lov...
WP_012648286    86 DVIIATFGDMMRVPGSSSSLMEERASGADIRIVNSPLDGVALAARNpDRKIIFPGIGFEATAPAVAASILMaaRQKLDNY 165 Geobacter dal...
WP_011736627    86 DTIITTFGDMLRVPGSSSSLMEERARGADVRIVYSPLDAVAIARKNpCKRVVFLGVGFETTAPAIAASILAatGDGLANY 165 Pelobacter pr...
WP_012531565    86 DLTITTFGDMLRVPGSSSSLMEERAKGADIRVVYSPLDAVRIAAANpAKRVVFLGVGFETTAPTVAGSILAakAQGLSNY 165 Geobacter bem...
Q39ZF8          86 DVIVATFGDMVRVPGSTSSLQEERARGADIRIVYSPLDAVAIAARNpEKRVVFLGVGFETTAPAIGGSILAakKQGLANY 165 Geobacter met...
WP_011938845    86 DVIIATFGDMMRVPGSSTSLMEERARGADIRIVYSPLDAVALAAKNpGKRVIFLGVGFETTAPTIAGSILVaaAQGLDNY 165 Geobacter ura...
AEB10697        83 GVVLATFGDMVRVPGSHTSLDQRRAVGTDVRVIYSPFDAVEIARLEpDKQIIFFGVGFETTMPATALAILTaaEANLENF 162 Desulfobacca ...

2Z1D_A         172 KIYSVHRLTPPAVEVLLKQG-TvFQGLIAPGHVSTIIGVKGWEYLTEKYGIPQVVAGFEPNDVLMAILMLIRMYKEGEAR 250 Thermococcus ...
WP_006192759   164 CVLSAQKLVPPAVKLLLADPdVhVDGFLLPGHACVVTGTRPYAFLADEAHKPGVVAGFTPLAILRAVWRLVRQTAANEAR 243 Selenomonas s...
jgi:Thein_2010 154 LVAVSHRTMPEAMRALLGSGeLaLDGLILPGHVSTITGASYFEFVAKEFGLPAVVAGFEAQQIMRGIYLLAKQIAEGRAE 233 Thermodesulfa...
jgi:Glov_3063  166 FVLTSHKTMPGPMQALSADPqLqIRGYLCPAHVSTVIGADAYRPLAEKFGIPCVVTGFEPADVLQGVLMLVQQCRAGRAA 245 Geobacter lov...
WP_012648286   166 LVLAGHKTMPKAMEMLAAEPaAaIHGFICPAHVSAVIGTDAYLPLAERHHIPCVVTGFEPADIMQGVEMLIRQKIAGEAN 245 Geobacter dal...
WP_011736627   166 LVLAAHKTIPLPMELLSSDPeLkIDGYICPAHVSAIIGANAFRGLAEQRGVPCVVTGFEPADVMQGVEMLVRQVVEGKSR 245 Pelobacter pr...
WP_012531565   166 FVLASHKTMPQPMAILSADPdLsVDGYICPAHVSAIIGADAYRFLCAEYQVPCVVTGFEPTDVMQGVEMLARQALQGESR 245 Geobacter bem...
Q39ZF8         166 FVLAAHKTMPKPMGVLSADPeLkIDGYICPAHVSTITGPEIYRFLAEEFHIPCVITGFEPADVMQGVEMLVRQVVAGESR 245 Geobacter met...
WP_011938845   166 FVLAAHKTIPKPMAVLAADPeLrIDGFICPAHVSAVIGAGAYGFLAEEYHIPCVVTGFEPVDIMQGVEMLARQMLEGKSR 245 Geobacter ura...
AEB10697       163 TVYCVHKTMPAALQALLSRGeTqISGLLLPGHVSAVTGSAVFDFIPATFRLPCAVTGFEPLDILLGVESILSQLRRGRPH 242 Desulfobacca ...

2Z1D_A         251 IINEYERAVKYEGNVVAQKMIDKFFEVVDAKWRALGVFPKSGLELRKEWKDFEIRSFYKVEvpkNLPDLEKGCRCGAVLR 330 Thermococcus ...
WP_006192759   244 IENEYGSVVREEGNPAALAVLARVYEETADEWRGLGVIERSGLRMREEFAAFDAERRLPVEv--ERVEKKTACRCGEVLR 321 Selenomonas s...
jgi:Thein_2010 234 VEIAYREAVTWEGNPMGKNLIRQVFEPCDVAWRGLGLIPQSGLRLKEKYAAFDAHKNLPVEl--PPAKEAPGCLCGEIIC 311 Thermodesulfa...
jgi:Glov_3063  246 VENQYSRAVSNQGNAKAQELIRRVFEPADAVWRGLGVLPDSGLVLRAAYAGYDAARMLPVEl--PPAREPAGCRCGEVLT 323 Geobacter lov...
WP_012648286   246 VENQYRRVVKRDGNSKAREVMSQVFTPCDCHWRGIGIIPGSGLKIRRSYARFDAEKVLPVKv--EEQEEQKGCRCGDVLK 323 Geobacter dal...
WP_011736627   246 VENQYSRVVTWEGNCKAQSVLAQVFSVCDAEWRGIGVIPGSGLEIAADYAAYDAEKVLPVSv--EETREHQGCRCGDILR 323 Pelobacter pr...
WP_012531565   246 VEIQYSRVVRWEGNAKAQGLLAEVFTPFDAPWRGIGVLPGSGLRIADAYGEFDAELALPVQv--EELKEHQGCLCGEILK 323 Geobacter bem...
Q39ZF8         246 VETQYSRVVRPEGNRKAQEVIREVFTPCDAPWRGIGVIPGSGLRIADAYAVFDAEKAIPVAv--EETREHAGCLCGEILK 323 Geobacter met...
WP_011938845   246 VEIQYSRVVKWEGNKKAQEVLSRVFTPCDADWRGIGNIPGSGLEISAAYAAFDAAKAIPVEv--EELREHAGCLCGEILK 323 Geobacter ura...
AEB10697       243 VANVYQRAVSRPANPKAQAVIQEVFLASDSYWRGLGLIPGSGISLQPRFRHFDAKYRFArilaaVPPPLPTPCHCGEVLR 322 Desulfobacca ...

2Z1D_A         331 GLALPTDCPLFGKTCTPRHPVGPCMVSYEGTCQIFYKYG 369 Thermococcus kodakarensis KOD1
WP_006192759   322 GAVRPTDCTLFAKACVPTHAVGPCMVSVEGVCAAWYKYG 360 Selenomonas sputigena
jgi:Thein_2010 312 GRATPPECKLFAKVCTPETPKGPCMVSSEGTCAAWYAYG 350 Thermodesulfatator indicus DSM 15286
jgi:Glov_3063  324 GRIAPKDCPLFGSVCSPETPVGACMVSSEGSCAAAWRYG 362 Geobacter lovleyi SZ
WP_012648286   324 GKIQPFDCPLFGMQCTPEGPVGPCMVSSEGSCAAYYNh- 361 Geobacter daltonii
WP_011736627   324 GKVSPFDCPLFDRACTPESPVGACMVSSEGTCAAAYKYG 362 Pelobacter propionicus
WP_012531565   324 GKVAPGDCPLFGGKCTPESPVGACMVSSEGTCAAAFKYG 362 Geobacter bemidjiensis
Q39ZF8         324 GKAAPTDCPLFGGACTPESPVGACMVSSEGTCAAAYKYG 362 Geobacter metallireducens GS-15
WP_011938845   324 GKVAPDDCPLFGTTCTPEAPVGACMVSSEGTCAAAYKYG 362 Geobacter uraniireducens
AEB10697       323 GFLRPLQCPLFGDSCTPSHPIGPCMVSSEGACAAAYRFg 361 Desulfobacca acetoxidans DSM 11109
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