8PVU,6W3Z,8QZW,7CMC,8PUT,7L9R,6DFT


Conserved Protein Domain Family
DS

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pfam01916: DS (This model is not part of the current CDD release)
Deoxyhypusine synthase
Eukaryotic initiation factor 5A (eIF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalyzed by the enzyme deoxyhypusine synthase (DS) EC:1.1.1.249. The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation.
Statistics
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PSSM-Id: 514594
Aligned: 204 rows
Threshold Bit Score: 293.145
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8PVU_A             45 ALLEAFGTT-GFQATNFGRAVQQVNAMIekkleplsQDEDqhadltqsrrpltsCTIFLGYTSNLISSGIRETIRYLVQH 123 human
WP_015018112       29 sifssMTRSgGFESRNLADGVDILRRMI--------DDKS--------------CTKFMSFVGALMSTGARGIIRDMVRN 86  Candidatus...
WP_008085536       22 elmDELYSSgGFVAKHLAVAEKILLKMF--------K-EE--------------NTTFLSFPACIIATGTRGVIKEIVRR 78  Candidatus...
EQB66656           26 dfvsqcnASgGFTSSKIAVAHSIMEKIV--------K-EE--------------NTTFLSFPADIISTGTRGVIIDMIKK 82 
Q9HL74             24 DLMDQFSSIgGFTAAKIHEAYEIIKDMF--------S-ED--------------NTTFLSFPADIISTGLRGLINEVVKR 80  Thermoplas...
CIDAM:MMALV_04340  23 DMLQAMGRAgGFTAQKLADATDIAEKMV--------KKEG--------------CLKILSFPACIMATGTRGVIVDMVKN 80 
WP_020448597       20 DLISQMSNCgGFTAKKLSDAVDITERML--------KKKD--------------CTVFLSFPACIMATGTRGVIIELVKR 77  Candidatus...
WP_013684010       23 ELVEQFGRAgGFTAKKVAEAMHVLEEMV--------K-SD--------------ATVFLSFPAAIVATGTRGVIKELVKR 79  Archaeoglo...
WP_012939763       16 elIKELYKSgGFTAKDLAVAVDIFEEMI--------KDEE--------------CTVFLSFPACIIATGTRGVIKELVKR 73  Archaeoglo...
Q6KZL5             24 ELIGMFGRSgGFTAKKIYEGYEIIKEMF--------N-DD--------------ETTFLSFPADIISTGTRGIINELVKR 80  Picrophilu...
8PVU_A            124 NMVDVLVTTAGGVEEDLIKCLaP-TYLGEFSLRGKELRENGINRIGNLLVPNENY-CKFEDWLMPILDQMVM-EQNTegv 200 human
WP_015018112       87 KMCDVIITTCGALDHDIARAY-DkYYAGDFRMDDGMLLDKDIHRLGNVLVPMGNYgPLIEEKIQKCLADMYKeGKRS--- 162 Candidatus...
WP_008085536       79 KLVDVIITTCGMLDHDIARSF-KnYYHGSFLMDDTALHREGVNRLGNVLVPNESYgVVMENFMMPILEELYK-EKKE--- 153 Candidatus...
EQB66656           83 GLVDVIITTTGTIDHDIARSF-SdYFCGSFEYDDIKLKDMGINRLGSVFVPDESYgSLIEEFMMKQLDTLYK-EKKT--- 157
Q9HL74             81 KLVDVIITTSGTLDHDIARTY-RnYYCGSFSYSDIELRDLGINRLGNVLVPDESYgEIIEEKVMESLEKLYA-KKKE--- 155 Thermoplas...
CIDAM:MMALV_04340  81 HMVDLIITTCGCLDHDLSRLY-AaYYKGDFMMDDALLRENDVSRLGNVLVPDDCYgYVLEDNLLPMFDEIFA-ETQS--- 155
WP_020448597       78 GLVDVIITTCGTLDHDLARTW-KkYYHGEFIMDDAKLYDEGINRLGNVLVPNSSYgLILEKKMQPMLKKILK-DRDS--- 152 Candidatus...
WP_013684010       80 KLVDVIITTCGTLDHDLARIW-RdYYHGSFMLDDAELHRMGINRIGNVLAPNESYgLILEEKLLPIIEDIYS-SKKR--- 154 Archaeoglo...
WP_012939763       74 RLVDVIVTTCGTLDHDLARIW-KdYYHGSFMLDDVELYKKGIHRIGNVLTPKESYgLILEEKLQPIFEDIYNeGKRR--- 149 Archaeoglo...
Q6KZL5             81 KLVDVIITTNGTLDHDIARTY-RdYYAGTFNFSDAMLRDLGINRLGNVFVPDESYgSIIEEKVMPILDELYK-EKKE--- 155 Picrophilu...
8PVU_A            201 kWTPSKMIARLGKEIN----NPESVYYWAQKNHIPVFSPALTDGSLGD-MIFFHSyKNPgLVLDIVEDLRLINTQAIFAK 275 human
WP_015018112      163 -VSTYEITDYIGSTL-----DKSSFLYWAHKNRIPVIVPGIVDGAVGSqVWFFYQ-QHKdFKVDILKDQSKLSDIVFEAK 235 Candidatus...
WP_008085536      154 -WGGRELIDEFAKRMn----NEDSILYWAHKNKIPIYVPGITDGSFGSqLWSFRE-MHPdFRVDVLKDEHELADIIFDAK 227 Candidatus...
EQB66656          158 -WSPSEILARIGRNMd----HPDSILSAAAEKNVPIFIPGIPDGSVGSqFWSFYE-THRdFNLDILMDQHLISDIVFTSD 231
Q9HL74            156 -WATVDLIHEVGLDIn----SESSIIYNAAKNNIPVFVPGITDGSFGSqLWSFYE-QHHdFKINLLEDEHRLSDIIFDAK 229 Thermoplas...
CIDAM:MMALV_04340 156 -MSTHEIIDKVGEKLAdvkgHEDSLLYWAHVNNVPIVVPGITDGSFGCqLWMYYQ-THRkLRIDLFADEQMLSEMTNDAK 233
WP_020448597      153 -ISTRELIDQVGAMVNd----ESSLLYWCHKNNVPIFVPGITDGSFGSqVWMYWQ-EHRnLHMDLFQDEQDLMDMVFDAK 226 Candidatus...
WP_013684010      155 -LSTRELVWEIGKRIEgepdAEDSIVYWSYKNRIPVFIPGITDGAVGSqLWIFYQ-QHKdFVIDVLADESELSDIVFESE 232 Archaeoglo...
WP_012939763      150 -ISTRELIWEVGKRIEgeenADSSIVYWCYKNKIPVFVPGITDGAFGSqLWLFYQ-THKdFIVDVLKDEDELSEIIFNAK 227 Archaeoglo...
Q6KZL5            156 -WSGYELIWELGKRIn----NESSIIYNAYKNRIPVFIPGMTDGSVGSqLWSFYE-MNRdFRINLLEDEHKLSDIIFDAK 229 Picrophilu...
8PVU_A            276 CTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAET 355 human
WP_015018112      236 RSGAFMIGGGISKHHTLWWNQFRGGLDYAVYITTAPEWDGSLSGALVAEAISWGKVTAKARQVTIHGEATTLLPFIYAAL 315 Candidatus...
WP_008085536      228 KTGALMIGGGISKHHTIWWNQFRDGLDYAVYITTAVEWDGSLSGARVREAVSWGKVREDAKYVTVEGDATVLLPLLITSV 307 Candidatus...
EQB66656          232 RAGAIMIGGGISKHHTIWWNQFRGGLDYAIYITTAQEYDGSLSGAKLEEAISWKKVKPDAEFVNVYGDATVLLPIIVADy 311
Q9HL74            230 KTGAIMIGGGISKHHTIWWNQFRDGLDYAVYVTTAQEYDGSLSGAKLEEAISWKKVRPDARYVNVYGDATVIMPVLLApf 309 Thermoplas...
CIDAM:MMALV_04340 234 YTGAIIIGGGISKHHVIWWNQFRGGLDYCIYLTTAEEYDGSLSGARIREAVSWGKVKANAKKMTVEGDATITLPLIYAGl 313
WP_020448597      227 ESGAIMIGGGISKHHTIWWNQFRGGLDHAVYLTTAEEYDGSLSGARVREAVSWGKVKAAADYMTVEGDATITLPIIVSAV 306 Candidatus...
WP_013684010      233 RTGALIVGGGISKHHTIWWNQFKGGLDYVVYVTTAVEWDGSLSGARPREAISWGKIKEGAKQVTVEGDATIILPLLVCGl 312 Archaeoglo...
WP_012939763      228 RSGALIVGGGISKHHTIWWNQFKDGLDYVVYITTAVEWDGSLSGARVREAISWGKVSESAKSVNVYGDATVLLPLIVASI 307 Archaeoglo...
Q6KZL5            230 KTGAIMIGGGISKHHTIWWNQFRDGLNQAVYITTAQEYDGSLSGAKLEEAISWKKVREDARFVNIYGDATVILPLIVAPF 309 Picrophilu...
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