6DFT


Conserved Protein Domain Family
DS
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pfam01916: DS 
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Deoxyhypusine synthase
Eukaryotic initiation factor 5A (eIF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalyzed by the enzyme deoxyhypusine synthase (DS) EC:1.1.1.249. The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation.
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Statistics
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PSSM-Id: 426508
Aligned: 216 rows
Threshold Bit Score: 232.295
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6DFT_H             31 VLNAYPNI-GLEATNLGRARRIVQRAlndNGMDGNKVMLAYTSNLISSGLRDTFACLARENRIGAVVTTAGGVEEDVIKC 109 Trypanosom...
CIDAM:MMALV_04340  24 MLQAMGRAgGFTAQKLADATDIAEKM---VKKEGCLKILSFPACIMATGTRGVIVDMVKNHMVDLIITTCGCLDHDLSRL 100 Candidatus...
WP_020448597       21 LISQMSNCgGFTAKKLSDAVDITERM---LKKKDCTVFLSFPACIMATGTRGVIIELVKRGLVDVIITTCGTLDHDLART 97  Candidatus...
jgi:Aboo_0041      23 lmDELYSSgGFVAKHLAVAEKILLKM---FK-EENTTFLSFPACIIATGTRGVIKEIVRRKLVDVIITTCGMLDHDIARS 98  Acidulipro...
Q6KZL5             25 LIGMFGRSgGFTAKKIYEGYEIIKEM---FN-DDETTFLSFPADIISTGTRGIINELVKRKLVDVIITTNGTLDHDIART 100 Picrophilu...
Q9HL74             25 LMDQFSSIgGFTAAKIHEAYEIIKDM---FS-EDNTTFLSFPADIISTGLRGLINEVVKRKLVDVIITTSGTLDHDIART 100 Thermoplas...
EQB66656           27 fvsqcnASgGFTSSKIAVAHSIMEKI---VK-EENTTFLSFPADIISTGTRGVIIDMIKKGLVDVIITTTGTIDHDIARS 102 Thermoplas...
EQB69201           27 lISQFLESgGFTSSKIGVAYEILKEM---VE-EENTTFLSFPADIISTGTRGIINEMVKRKMVDVIITTCGTLDHDIARS 102 Thermoplas...
jgi:Arcve_1345     24 LVEQFGRAgGFTAKKVAEAMHVLEEM---VK-SDATVFLSFPAAIVATGTRGVIKELVKRKLVDVIITTCGTLDHDLARI 99  Archaeoglo...
WP_012939763       17 lIKELYKSgGFTAKDLAVAVDIFEEM---IKDEECTVFLSFPACIIATGTRGVIKELVKRRLVDVIVTTCGTLDHDLARI 93  Archaeoglo...

6DFT_H            110 LgD-TLVGDFALNDHALRNNGLNRVGNLLVPNDNY-RNFEDFFVPLLRRLHE-QQrDsRWttktTPSQIIAEIGAALEsv 186 Trypanosom...
CIDAM:MMALV_04340 101 Y-AaYYKGDFMMDDALLRENDVSRLGNVLVPDDCYgYVLEDNLLPMFDEIFA-ET-Q-SM----STHEIIDKVGEKLAdv 172 Candidatus...
WP_020448597       98 W-KkYYHGEFIMDDAKLYDEGINRLGNVLVPNSSYgLILEKKMQPMLKKILK-DR-D-SI----STRELIDQVGAMVNd- 168 Candidatus...
jgi:Aboo_0041      99 F-KnYYHGSFLMDDTALHREGVNRLGNVLVPNESYgVVMENFMMPILEELYK-EK-K-EW----GGRELIDEFAKRMn-- 168 Acidulipro...
Q6KZL5            101 Y-RdYYAGTFNFSDAMLRDLGINRLGNVFVPDESYgSIIEEKVMPILDELYK-EK-K-EW----SGYELIWELGKRIn-- 170 Picrophilu...
Q9HL74            101 Y-RnYYCGSFSYSDIELRDLGINRLGNVLVPDESYgEIIEEKVMESLEKLYA-KK-K-EW----ATVDLIHEVGLDIn-- 170 Thermoplas...
EQB66656          103 F-SdYFCGSFEYDDIKLKDMGINRLGSVFVPDESYgSLIEEFMMKQLDTLYK-EK-K-TW----SPSEILARIGRNMd-- 172 Thermoplas...
EQB69201          103 F-RdYYCGSFDYNDRELKDLGINRLGSVVIPDESYgEIMEEFMQKELEKLYK-ES-K-KW----TTWKLIEKIGLAIk-- 172 Thermoplas...
jgi:Arcve_1345    100 W-RdYYHGSFMLDDAELHRMGINRIGNVLAPNESYgLILEEKLLPIIEDIYS-SK-K-RL----STRELVWEIGKRIEge 171 Archaeoglo...
WP_012939763       94 W-KdYYHGSFMLDDVELYKKGIHRIGNVLTPKESYgLILEEKLQPIFEDIYNeGK-R-RI----STRELIWEVGKRIEge 166 Archaeoglo...

6DFT_H            187 rpndCGSSLIYWCYRNDIPVFSPAFTDGSMGD-MIYFYNySRKgLVVDPVPDVRRLRQLGCKStnvGRITCIVLGAGLPK 265 Trypanosom...
CIDAM:MMALV_04340 173 --kgHEDSLLYWAHVNNVPIVVPGITDGSFGCqLWMYYQ-THRkLRIDLFADEQMLSEMTNDA---KYTGAIIIGGGISK 246 Candidatus...
WP_020448597      169 -----ESSLLYWCHKNNVPIFVPGITDGSFGSqVWMYWQ-EHRnLHMDLFQDEQDLMDMVFDA---KESGAIMIGGGISK 239 Candidatus...
jgi:Aboo_0041     169 ----NEDSILYWAHKNKIPIYVPGITDGSFGSqLWSFRE-MHPdFRVDVLKDEHELADIIFDA---KKTGALMIGGGISK 240 Acidulipro...
Q6KZL5            171 ----NESSIIYNAYKNRIPVFIPGMTDGSVGSqLWSFYE-MNRdFRINLLEDEHKLSDIIFDA---KKTGAIMIGGGISK 242 Picrophilu...
Q9HL74            171 ----SESSIIYNAAKNNIPVFVPGITDGSFGSqLWSFYE-QHHdFKINLLEDEHRLSDIIFDA---KKTGAIMIGGGISK 242 Thermoplas...
EQB66656          173 ----HPDSILSAAAEKNVPIFIPGIPDGSVGSqFWSFYE-THRdFNLDILMDQHLISDIVFTS---DRAGAIMIGGGISK 244 Thermoplas...
EQB69201          173 ----NDDSILYNAAKNHIPIFVPGITDGSFGSqLWSFKE-MNSdFIVDVLQDEHDLSDIIFDA---KKTGALMIGGGISK 244 Thermoplas...
jgi:Arcve_1345    172 --pdAEDSIVYWSYKNRIPVFIPGITDGAVGSqLWIFYQ-QHKdFVIDVLADESELSDIVFES---ERTGALIVGGGISK 245 Archaeoglo...
WP_012939763      167 --enADSSIVYWCYKNKIPVFVPGITDGAFGSqLWLFYQ-THKdFIVDVLKDEDELSEIIFNA---KRSGALIVGGGISK 240 Archaeoglo...

6DFT_H            266 HHLL-----RNvQADAVVYVTTGSDADGCESSCNVMADRANGLLSPNCDVVRVHGDATIISPLLLL 326 Trypanosoma brucei
CIDAM:MMALV_04340 247 HHVIwwnqfRG-GLDYCIYLTTAEEYDGSLSGARIREAVSWGKVKANAKKMTVEGDATITLPLIYA 311 Candidatus Methanomethyl...
WP_020448597      240 HHTIwwnqfRG-GLDHAVYLTTAEEYDGSLSGARVREAVSWGKVKAAADYMTVEGDATITLPIIVS 304 Candidatus Methanomassil...
jgi:Aboo_0041     241 HHTIwwnqfRD-GLDYAVYITTAVEWDGSLSGARVREAVSWGKVREDAKYVTVEGDATVLLPLLIT 305 Aciduliprofundum boonei ...
Q6KZL5            243 HHTIwwnqfRD-GLNQAVYITTAQEYDGSLSGAKLEEAISWKKVREDARFVNIYGDATVILPLIVA 307 Picrophilus torridus DSM...
Q9HL74            243 HHTIwwnqfRD-GLDYAVYVTTAQEYDGSLSGAKLEEAISWKKVRPDARYVNVYGDATVIMPVLLA 307 Thermoplasma acidophilum...
EQB66656          245 HHTIwwnqfRG-GLDYAIYITTAQEYDGSLSGAKLEEAISWKKVKPDAEFVNVYGDATVLLPIIVA 309 Thermoplasmatales archae...
EQB69201          245 HHTIwwnqfRG-GLDSAIYITTAQEYDGSLSGAKLEEAISWKKVKPDAKFVNVYGDITALLPLLVg 309 Thermoplasmatales archae...
jgi:Arcve_1345    246 HHTIwwnqfKG-GLDYVVYVTTAVEWDGSLSGARPREAISWGKIKEGAKQVTVEGDATIILPLLVC 310 Archaeoglobus veneficus ...
WP_012939763      241 HHTIwwnqfKD-GLDYVVYITTAVEWDGSLSGARVREAISWGKVSESAKSVNVYGDATVLLPLIVA 305 Archaeoglobus profundus
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