6AH3,6AHR,2AV5


Conserved Protein Domain Family
RNase_P_Rpp14
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pfam01900: RNase_P_Rpp14 (This model is not part of the current CDD release)
Rpp14/Pop5 family
tRNA processing enzyme ribonuclease P (RNase P) is a ubiquitous ribozyme that catalyzes a Mg2-dependent hydrolyzis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA). Archaeal and eukaryotic RNase P consist of a single RNA and archaeal RNase P has four or five proteins, while eukaryotic RNase P consists of 9 or 10 proteins. Human RNase P is composed of a singular protein Pop1 and three subcomplexes, the Rpp20-Rpp25 heterodimer, Pop5-Rpp14- (Rpp30)2-Rpp40 heteropentamer, and Rpp21-Rpp29-Rpp38 heterotrimer. This family includes Rnp2 (also known as Pop5) from archaea and Pop5/Rpp14 from eukaryotes.
Links
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Statistics
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PSSM-Id: 514583
Aligned: 188 rows
Threshold Bit Score: 43.6565
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6AH3_E         7 RYI--LFEIIFPP------TD-TNveesvskadillshhraspadvsiKSILQEIRRSLSLNLGDYGSAKCNS-L---L- 72  Saccharomyces c...
EJW04006       7 RYI--GLEVRTNRg--------vRis---------------------qDSYKDIIYDLVEEKYGITVTCHMRHfQlfeCl 55 
XP_007604539   7 RYI--VVKIDYRHtnrresTHlDAal---------------------aQGIKNLLYNSIKTNFGEYVLGMIDCfE----- 58 
Q8STU1         7 RYI--VVKLRFEGngsmpgRE----------------------------MLGSVIRSRVCTDYGIHVLSMVGSlV----- 51  Encephalitozoon...
XP_024330977   7 RYIsfSYSLLEGKnvs------------------------------leNSIISIIRDKVNENFGEHVLYRLQNlA----- 51 
WP_011839146  65 RYI--VFAILSSSd--------fNid---------------------kTTIEKSIRLYWEKFFGRISLVKADP------- 106 Staphylothermus...
WP_014558267  69 RYI--VFSITSDA----------Did---------------------ySEIADSILTALGKIYGEPFISKSGYhF----- 110 Fervidicoccus f...
XP_001309460   7 RYI--IFKIIPEDpnaadfGDg--------------------------YSIPKSLAKPFIDMFGDFGAGNVLTsV----- 53 
XP_013059728   7 RYI--VFTTHYNT----------Ait---------------------pAIIHKGIHNSANSILSDWEYAMTMPkL----- 48 
NP_001255128   7 RYY--VIRMLTNDgspptpRK---------------------------SSIFQELMKLTSEMFGDFGYSILKMsL----- 52 

6AH3_E        73 --QLKYFSNKTSTGIIRCHREDCDLVIMALMLMSKIGDVDgLIVNPVKVSGTIKKIEQ 128 Saccharomyces cerevisiae S288C
EJW04006      56 meH--------NVVIFRVPRLIYRQVCDSLNFPKD-NSLN-FIYKILTVNGTARNAKK 103
XP_007604539  59 ---VVERYDCLGIVIIRCNLSIHKYVCYTICSMGKVSEAE-VRFSILAVSGILRKAKK 112
Q8STU1        52 ---VVEYLPHNQVAVVRCDAPACKYVLFTIATIGEVSDLK-CSMSVLWVSGILKRAMR 105 Encephalitozoon cuniculi
XP_024330977  52 ---LLEYLHENNIFVIRVDRDICKFILFSLVSVGQINGMK-VNFKILFVSGIYKKLLK 105
WP_011839146 107 --QLIYFDPSIKRGVLRVAHIYKDEALAVLGIIKKINNYN-CLLIPLKTTGTLKKARK 161 Staphylothermus marinus
WP_014558267 111 ---IVYYSDI-KKGIVRVYREYADNIIAIFPFARRYAKKD-FMIVPVKVCGTVKKAKK 163 Fervidicoccus fontis
XP_001309460  54 --NLVVWQPEKFTGVLRVARDWATNYVKMLDTIKEIHGIK-ANIKVPHISGTIDQAQR 108
XP_013059728  49 --KIAEYYPHLGIGIIKVFLSGVESIQKIFRQMIEVNDLI-IRCEIIRTTGIIRKAKK 103
NP_001255128  53 --SVRVLDE--DVIVLRVAEGGNKYFGAILPCVHKIDKQP-MVLQTIFIGRSMRSCEK 105
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