Conserved Protein Domain Family
CbiM

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pfam01891: CbiM 
Cobalt uptake substrate-specific transmembrane region
This family of proteins forms part of the cobalt-transport complex in prokaryotes, CbiMNQO. CbiMNQO and NikMNQO are the most widespread groups of microbial transporters for cobalt and nickel ions and are unusual uptake systems as they consist of eg two transmembrane components (CbiM and CbiQ), a small membrane-bound component (CbiN) and an ATP-binding protein (CbiO) but no extracytoplasmic solute-binding protein. Similar components constitute the nickel transporters with some variability in the small membrane-bound component, either NikN or NikL, which are not similar to CbiN at the sequence level. CbiM is the substrate-specific component of the complex and is a seven-transmembrane protein. The CbiMNQO and NikMNQO systems form part of the coenzyme B12 biosynthesis pathway. The NikM protein is pfam10670.
Statistics
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PSSM-Id: 460375
Aligned: 97 rows
Threshold Bit Score: 69.143
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012448360   5 HLPDGIIPVPWWLAGYLVAVLIIYLLL-----SRVDSTearyrIPKAAM-AAAFMLVAMSVPLGF-----LPIHLSMAVL 73  Natranaerobius ...
WP_014087991   2 nLPAAFFPLWGQWSTLLAALGLLGWAA-----SRVRWRel-dhVALNAW-LGACVLTMAMWMMKGglkpgLSFHLLGAAI 74  Pseudogulbenkia...
WP_013442952   2 NFPDHLLPTELCWAANALSLAIILACVksapwRHLKDT------SLLNVfMAGIVGLMLVWAVNAgikpgLNFHLLGATL 75  Methylovorus
WP_013294148   2 NLPATLFTGDSLLLANYAFAFLLYRAVrcapwQILLKN-----QDMFNAlIGLIFCTAAFWQMSAgirpgFNFHLIGATL 76  Gallionella cap...
WP_013030114   2 NLPAQLFANDWLWLANFVFGFLLYRAVreaswRNLLDN-----SIMVHAlTGLLFGAFVFWQFNAgirpgFNFHILGSTL 76  Sideroxydans li...
Q1H3Z8        16 NLPDYLVPVAWQWIANALALTLLAYAVikapwRHLSDP------ALQHVfLGSIVTLMVIWSIKAgirpgLNIHLLGATA 89  Methylobacillus...
WP_011793268   2 HIEIGILSQDKIAYASVAATALLGah----alPLLKSP-----TAWLRTlLAAFFFSVLMQVWHMpi-gpSELHFVGAMP 71  Acidovorax citr...
WP_012168679   2 HIEPGILSAAKVVAANAAAIATLAty----apKLVRNP-----VILVKTvLAAAFFSVFMEIFHLpv-gaSELHFVGASA 71  Azorhizobium ca...
WP_012586100   2 HIEPGILSGAKIAAANLAATALVAae----apQLLRKP-----QRLLRTlLAALFFSVFMQSFHTpa-gaSELHFIGAMP 71  Thauera sp. MZ1T
WP_011767250   2 HIEPGLVSAAKVAVANVAAVALVGah----alQFVRQP-----QLVVRSlLAALFFSLFMQSFHLpa-gpSELHFIGAMP 71  Azoarcus olearius
WP_012448360  74 AGILVGpGIGFLSVFVVNFILAL-VGHGGITIVGLNTLVIGLEVLVGAKifsylL--------SKTTVWKAAFLavipAL 144 Natranaerobius ...
WP_014087991  75 LTLMMGhWLALLALAIVLAGVTA-YGAGDWLALGLNFWLMAVLPVTLVStvlrlTqrllppnlF-VYVFVGAFL----AG 148 Pseudogulbenkia...
WP_013442952  76 LSLMFG-PQLAIIALALVLLGITaFGMAGWLSYGLNLMLMVVIPAMFSWgv-frWvdrklpnhlfvyIFVVGFF----CA 149 Methylovorus
WP_013294148  77 FLLMFG-WPIALIALTLIMTGSWlYSGQEIATLGINGLLMLAVPMLFGEal-lrFcqrylpknlflfVLLNGFA----CA 150 Gallionella cap...
WP_013030114  77 FLLMFG-WQVATVSITLVMLATWlRTDMALVTLGINGLLMIAIPVLFSDwl-lrFskrhlpknlflfVLWNGFF----CS 150 Sideroxydans li...
Q1H3Z8        90 LCLMFR-WQLALIALALILIGITaFGMGGWSTLGINFLIMAAIPVAFSYnv-frLvdsklpnhliiyIFACGFL----CA 163 Methylobacillus...
WP_011793268  72 IYLLFGfIPTLFGFGLGLLAQALvFEPQDLAHLAINFLSLAVPLVAVHHgvgkrL----------ARISVANVL-----K 136 Acidovorax citr...
WP_012168679  72 VYFIFGfVPTLFGFALGLLLQGAlFEPQDLVHLGVNSLSLMVPLIAVHEtfgkrFfar---deSKLPVSWAQIL-----K 143 Azorhizobium ca...
WP_012586100  72 IYLTLGfVPTLLGFGLGLLLQGGvFEPADLLHLGVNFLSLAVPLVALHAtlgrrLa-------SGAATRVGSVL-----K 139 Thauera sp. MZ1T
WP_011767250  72 IYLILGfVPTLVGFAAGLLVQGIlFEPTDLVNLGVNTLSLALPLLVLHHtagrrV----------DGLSVRNIL-----K 136 Azoarcus olearius
WP_012448360 145 IVSLVFTVSLVGATVSWAeALPyhqhdcdhdhdhddrshanhnghdshghsegngegietalseihiLTLTGWTAL---L 221 Natranaerobius ...
WP_014087991 149 GASLFATGLAGIAVLGMA-GAy--------------------------------------------pWDELLSEAL---P 180 Pseudogulbenkia...
WP_013442952 150 GVAITLCGLASSFVLTES-------------------------------------------------AIYKREYLGehyL 180 Methylovorus
WP_013294148 151 ALASMLMMASTTLVLLAL-------------------------------------------------THYTWPEIQyhyL 181 Gallionella cap...
WP_013030114 151 MLSIVLNVLVTTLLLLLL-------------------------------------------------SRYSWEQIQhyyL 181 Sideroxydans li...
Q1H3Z8       164 GLTISMCGLSAVLALSAM-------------------------------------------------QAYPPDYLFsnyL 194 Methylobacillus...
WP_011793268 137 LDAMYYAGVTLMVGFWLSiSSDp-------------------------------------------aPVADWALFA---A 170 Acidovorax citr...
WP_012168679 144 FDAAYYSGVVSMVGFWLLmGNEa-------------------------------------------tPVYDWAIFA---A 177 Azorhizobium ca...
WP_012586100 140 LDAAYYAGVAVMVGFWLAmGEVa-------------------------------------------tPFAAWAAFA---S 173 Thauera sp. MZ1T
WP_011767250 137 LDAIYYAGVALMVGFWLSlGDTa-------------------------------------------tPFAAWAGFA---A 170 Azoarcus olearius
WP_012448360 222 VILAV-GITlEAILTAIIANYIYKVKPDL 249 Natranaerobius thermophilus
WP_014087991 181 FYFLL-SWS-EAFTSGLIMAILIVYRPRW 207 Pseudogulbenkiania sp. NH8B
WP_013442952 181 PYYIFmAWS-EAMLTGMAVTLMAAFRPSW 208 Methylovorus
WP_013294148 182 IPAPIlIFA-EAFATGAVITAFTVSRPEA 209 Gallionella capsiferriformans
WP_013030114 182 VATPIlMLT-EGFVTGMLITAFTVFQPQA 209 Sideroxydans lithotrophicus
Q1H3Z8       195 PYFILiGWS-EAFVTGMAITLMTAFRPHW 222 Methylobacillus flagellatus KT
WP_011793268 171 SYLSL-VAV-EPLLTIAITLGATRLRGRR 197 Acidovorax citrulli
WP_012168679 178 SYLPL-VLC-EPIFTFVALKLLGRIENNS 204 Azorhizobium caulinodans
WP_012586100 174 AYLPV-ALI-EPVLTVALVRLLQSQAHRP 200 Thauera sp. MZ1T
WP_011767250 171 HYLPV-VLI-EPLVTIALVGLLRPHAAHP 197 Azoarcus olearius
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