Conserved Protein Domain Family
CbiD

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pfam01888: CbiD 
CbiD
CbiD is essential for cobalamin biosynthesis in both S. typhimurium and B. megaterium, no functional role has been ascribed to the protein. The CbiD protein has a putative S-AdoMet binding site. It is possible that CbiD might have the same role as CobF in undertaking the C-1 methylation and deacylation reactions required during the ring contraction process.
Statistics
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PSSM-Id: 460373
Aligned: 297 rows
Threshold Bit Score: 191.84
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013547773       254 LHSGLTTGTCAAAAAVAATWDIfntA----L-K---------------Kr----pS-EFSIVLPNgETIP---------V 299 Bacteroid...
CAK26951            54 LDSGYTLPVWVAVAAVAALRQL---RgdpsAeRi-----------------------GLELLQPA-GQRE---------L 97 
Q7V9B0               1 ----mTLPVWVAAAARAATEAL---LgrpfSaS---------------Q--------LLELPDRD-EPLA---------V 40  Prochloro...
Q46I27               1 -mnqFTLPVWVVAAAKSATNIL---IgnkfRdK---------------E--------RIDLPNNE-KSIS---------V 43  Prochloro...
Q7NK51               2 SRTGYTLPVFAAAAARAALLHL----------I---------------Ekvpc-asvQLDLL--G-EQAA---------I 43  Gloeobact...
jgi:Syn7502_01932    1 mKTGYTLPVFAIAAAKAAILRL----------Anp------------sEnle---avYLDLL--D-AGLDselnsrigkI 52 
jgi:Oscil6304_4689   2 AKTGYTLPVFAVAAAKAALMVL----------Spg------------sEapk---tvTLDLM--P-ELVE---------I 44 
jgi:Sta7437_0074     2 ARTGYTLPVFAVAAAKAALLHL----------Q---------------EkmnaepIvTLDLL--P-ESAE---------I 44 
jgi:Cal6303_1255     2 VRTGYTLPVFAVAAAKAALLHL----------Qnp------------qEkls---fiTLDLL--P-DAAD---------I 44 
jgi:Riv7116_3799    33 plpGYTLPVFAVAAAKAALINL----------QryldsyldnnlekiaEkls---siSLDLL--D-GSAE---------I 87 
WP_013547773       300 P---VEPQRNtlhsniskngdsifeisATVIKDAGDDPDITNGMKVVANVAipfhpnaplppklpsqqrydITVCGGEGI 376 Bacteroid...
CAK26951            98 PieaVAPFADgs-------------alAISRCDPGPGMDLTRGLAVWVRARwaepl-----------egacFQLQAGVGV 153
Q7V9B0              41 SvtsAAVLAGgeq------------alAISHCDPGSGLDLTRGLEIWVCVQwqelvdde----lnvhseawLNLLAGKGV 104 Prochloro...
Q46I27              44 PissSALLDNgkr------------slAVSHCQSGLPLDITRGVEIWAYIQlskggfqskg-kvrngfpdwLDFHAGYGV 110 Prochloro...
Q7NK51              44 PieqVARLDAet-------------alGVTRSDPGDNLDLTRHTPVWAWVHlevg------------tgevLRLEAGEGL 98  Gloeobact...
jgi:Syn7502_01932   53 AiaqSAPLDQnt-------------alGMTISDPGDNLDLTAGTPVWAWVQlyeise--------asanpeIILEAGEGL 111
jgi:Oscil6304_4689  45 PiyqVAQLDGts-------------alGITRSDPGDNLDLTRNTPIWARVTwtpr------------qsqpLILEAGEGL 99 
jgi:Sta7437_0074    45 PieqVASLDSts-------------alAITLSDPGDNLDLTRNTPIWAWVRlsqr------------vseaLIVEAGEGL 99 
jgi:Cal6303_1255    45 LiqqVACLDStt-------------alGITQSDPGDNLDLTRNTPIWAWVQlspr------------qdevLILEGGEGL 99 
jgi:Riv7116_3799    88 PieqVAVLDSdt-------------alGITLSNPGDNLDLTRNTPIWALVKffprrn--------piqeqiLTLEAGEGL 146
WP_013547773       377 GIITMPGlgldlGAPAINATPRKMIEDNVKRYLKQmgipqhPNPIVITISVPGGEEIAKRTFNPRLGIIGGISIIGTSGI 456 Bacteroid...
CAK26951           154 GRLVEG------GEVCLSGFARDLLQHNLAALVPA------DRSVALEVVLPQGRERALRTSNAAFGVVEGLALIGTQAE 221
Q7V9B0             105 GTLGSG------GEACVSRFARELLSRNLYPLVPS------GRGLQLEVVLPRGRDLAARTSNAAFGVVDGLALIGTQAD 172 Prochloro...
Q46I27             111 GKFQSS------GQPCISQFARDLLCINLYPLLPK------GSSIKVEIILPEGKDRASKTSNEAFGVVDGLSLIGTQAE 178 Prochloro...
Q7NK51              99 GR--TAA-----GEAAIYRYARQLMEANVAPLVPT------GRTATVRFILPEGRALALRTSNAAFGILEGLALLGTSGL 165 Gloeobact...
jgi:Syn7502_01932  112 GK--TIT-----GEPAIYKLAKTLAQINLLHLLPP------HTSARIKFILPEGRSLAKRTSNAAFGILEGLALLGTRAV 178
jgi:Oscil6304_4689 100 GK--TET-----GEPAIYHYARQLFERNLFPLIPE------DQTLIVSIILPEGRQLASRTSNAAFGILEGLALLGTSGI 166
jgi:Sta7437_0074   100 GK--TVT-----GKPAIYNYARRLFEANLLPLIPQ------DQTVTVSIILPFGRQLAQRTSNEAFGILEGLSLLGTSGI 166
jgi:Cal6303_1255   100 GK--TST-----GEAAIYSFARRLFDANLLGLIPQ------DKSLTVKVILPEGRELAKRTSNEAFGVLEGLSLLGTSGI 166
jgi:Riv7116_3799   147 GK--TAT-----GEAAIYSFARRLFDANLLPLIPE------DKTLTVKIILPQGRELAKRTSNEAFGILEGLSLLGTSGI 213
WP_013547773       457 VKPFSSEAFVSSIHKSMEVACAA-N-SPHIVISSGAKSEKYIKAyYpDLPAQAFVHYGNFIGETLNIANELKLPQLTLGL 534 Bacteroid...
CAK26951           222 VQRSAAPDQLQGALDELRQRAERpQgCPELVLVVGENGLDLAPR-L-GLPVEVLLKSGNWIGPLLAAAAEQGVQRLLLFG 299
Q7V9B0             173 VQVSASPDQLQQTIEQLRRQSAAsDfCGAMTLVIGENGLDLARQ-L-GLAAQPLLKIGNWLGPVIVAAAEAGVEQLLLLG 250 Prochloro...
Q46I27             179 VQISASPDQLKNTKELLHHKCSEaKfDGCLTFVIGENGMDLAMK-Y-GLPANQIIKTGNWLGPLLVAAAENGVKKLLLFG 256 Prochloro...
Q7NK51             166 SQPLSAADHLESFRAALRERAER---ERRLVFCIGAGGLQAAGR-L-GLDQGATVQTGNWIGALLVEAGMLGIESVLLLG 240 Gloeobact...
jgi:Syn7502_01932  179 SQPLSVEDKLEEFRANLQVKARQ---NPDLVFYIGANGYQTAQN-M-GFSPDQLVQTANWIGVMLIEAALLNVNSITLVG 253
jgi:Oscil6304_4689 167 SQPLSAADHLDEFRQILQGKVKN---SPHLTFCIGNNGLGVAQR-L-GIPESAIVQTGNWIGALLVEAGLRGAQSVLLLG 241
jgi:Sta7437_0074   167 SQPLSAADHLEAFRLDLQNKVQN---HANLVFCLGSNGMHVAKQ-L-CIPEETIVQTGNWIGAMLVEAGLRGANSVLLLG 241
jgi:Cal6303_1255   167 SQPLSAEEHLDEFRSELRVKVKN---HPNLVFCIGSNGKSVAQR-L-GISEDVIVSTGNWLGALLVEAGLHGAESVLLLG 241
jgi:Riv7116_3799   214 SQPLSAAVHLEEFRDVLREKVKT---HRNLVFCIGANGYSVAES-L-SIPESTIVPTGNWLGALLVEAGLYKAESVLLLG 288
WP_013547773       535 MIGKAVKLAEG 545 Bacteroides helcogenes
CAK26951           300 YHGKLLKLAGG 310
Q7V9B0             251 YHGKLVKLAGG 261 Prochlorococcus marinus str. MIT 9313
Q46I27             257 YHGKLIKLSGG 267 Prochlorococcus marinus str. NATL2A
Q7NK51             241 YQGKLVKLAAG 251 Gloeobacter violaceus PCC 7421
jgi:Syn7502_01932  254 YHGKLLKLAGG 264
jgi:Oscil6304_4689 242 YQGKLIKLAGG 252
jgi:Sta7437_0074   242 YQGKLIKLAGG 252
jgi:Cal6303_1255   242 YQGKLIKLAGG 252
jgi:Riv7116_3799   289 YQGKLIKLAGG 299
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