Conserved Protein Domain Family
CbiD
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pfam01888: CbiD 
CbiD
CbiD is essential for cobalamin biosynthesis in both S. typhimurium and B. megaterium, no functional role has been ascribed to the protein. The CbiD protein has a putative S-AdoMet binding site. It is possible that CbiD might have the same role as CobF in undertaking the C-1 methylation and deacylation reactions required during the ring contraction process.
Links
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Statistics
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PSSM-Id: 485386
Aligned: 255 rows
Threshold Bit Score: 192.241
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_013547773   254 LHSGLTTGTCAAAAAVAATWDIfntA----L-KK----RP-S-EFSIVLPNgETIPVP---VEPqRNtlhsniskngdsi 319 Bacteroides h...
Q31RU7           2 ARSGYTLPVFACAAAIAALQRL----------RQpaa-siqSvDCHLIDPD-QTVAIAieqVAPlSPdr----------- 58  Synechococcus...
WP_012953568     6 ASSGYTLPVFACASSIAALFRL----------QNrki--ndEiYLDLVEPS-TIITVPinqVVKiHQnk----------- 61  Candidatus At...
WP_015220382     3 sSFGYTLPVFATASAVAGIRYL----------DNnle--dnSvEIDLINPP-EKAIIPieqIAKiSSnq----------- 58  Cyanobacteriu...
jgi:Cyast_1326   2 LNSGYTLPVFATASVVACLHYL----------QEnin--pnQvEVELITPP-ETALITieqVALiGKsq----------- 57 
WP_015160667     1 mRSGYTLPVFATASAIAALQCL----------QQssptNKpVvTIDLITPP-QRVEISiaqVALiQSgm----------- 58  Chamaesiphon ...
Q8DKT8           1 --mGYTLPVFATAAAVAALRCL----------TEgac--pqQvTLALLRPN-RCETLPiaqGAClDAqq----------- 54  Thermosynecho...
CAK26951        54 LDSGYTLPVWVAVAAVAALRQL---RgdpsAeRi---------GLELLQPA-GQRELPieaVAPfADgs----------- 109
Q7V9B0           1 ----mTLPVWVAAAARAATEAL---LgrpfSaSQ---------LLELPDRD-EPLAVSvtsAAVlAGgeq---------- 53  Prochlorococc...
Q46I27           1 -mnqFTLPVWVVAAAKSATNIL---IgnkfRdKE---------RIDLPNNE-KSISVPissSALlDNgkr---------- 56  Prochlorococc...

WP_013547773   320 feisATVIKDAGDDPDITNGMKVVANVAipfhpnaplppklpsqqrydITVCGGEGIGIITMPGlgldlGAPAINATPRK 399 Bacteroides h...
Q31RU7          59 --alAICRSDPGDNLDLTRGTPIWAEVQlsprs----------pdqdsLAIEAGEGIG---HSE-----TGPAIYDYAQR 118 Synechococcus...
WP_012953568    62 --slAITESNPGDNLDLTRNTPIWVIVElkkrn----------hnqtqIVIKGGEGVGKQIHNG-----FKDAIYFYAEK 124 Candidatus At...
WP_015220382    59 --vlAITRSQPGTNLDITRNTPIWGLVTltps------------qetkIIIEGGEGVGKIIDLG-----GKSAIYNYAHK 119 Cyanobacteriu...
jgi:Cyast_1326  58 --alAITRSDPGENLDLTKNTPIWATVKltph------------setkLIIEGGEGVGKIVKQN-----NKSAIYSYAQK 118
WP_015160667    59 --alGITHSDPGDNLDLTRDTPVWAVVEwadps-----------qvetIALVGGEGVGKQSNLD-----DLPAIYKYARQ 120 Chamaesiphon ...
Q8DKT8          55 --alAITYSEPSDALDLTRYTPIWAWVRwqdpv-----------tapkIQIEGGFGVGRD-RAT-----GKAAIYRYARL 115 Thermosynecho...
CAK26951       110 --alAISRCDPGPGMDLTRGLAVWVRARwaepl-----------egacFQLQAGVGVGRLVEG------GEVCLSGFARD 170
Q7V9B0          54 --alAISHCDPGSGLDLTRGLEIWVCVQwqelvdde----lnvhseawLNLLAGKGVGTLGSG------GEACVSRFARE 121 Prochlorococc...
Q46I27          57 --slAVSHCQSGLPLDITRGVEIWAYIQlskggfqskg-kvrngfpdwLDFHAGYGVGKFQSS------GQPCISQFARD 127 Prochlorococc...

WP_013547773   400 MIEDNVKRYLKQmgipqhPnPIVITISVPGGEEIAKRTFNPRLGIIGGISIIGTSGIVKPFSSEAFVSSIHKSMEVACAA 479 Bacteroides h...
Q31RU7         119 LLRANLLPLLQT------NeQLTVRLILPEGRRLAERTANAAFGVVEGLSLLGTHGVAEALSAPEQLQVFRDRLRQLSAD 192 Synechococcus...
WP_012953568   125 LLKYNLQFYLTS------TeKIIVTIILPEGKKLAKQTSNESFGIVQGLSLLGTSGIARPLSTISQLHNCQKELQKKSQE 198 Candidatus At...
WP_015220382   120 LLEFNILNNLKN------HsLVEVKIILPEGKKLAEKTSNSAFGVIEGLSLLGTSGISQPLTSKEQLELYQEELINKSKN 193 Cyanobacteriu...
jgi:Cyast_1326 119 LLECNILNNLKS------SaIVEVKIILPEGKILAQRTSNEAFGVVDGLSLLGTTGISQPLTSKAQLDLYQQELVTKARE 192
WP_015160667   121 LLQANLGLLLTP------AqKIRVTIILPAGRILATRTSNAAFGVVEGLSLLGTTGISQPLSAPGQLEACLTELRGKWGE 194 Chamaesiphon ...
Q8DKT8         116 LLTTNLLLYCPK------ErAIAVTIVLPQGRDLAERTSNAAFGIVEGLSLLGTTGIAQPLTAPEQLDRYREDLAEKAAQ 189 Thermosynecho...
CAK26951       171 LLQHNLAALVPA------DrSVALEVVLPQGRERALRTSNAAFGVVEGLALIGTQAEVQRSAAPDQLQGALDELRQRAER 244
Q7V9B0         122 LLSRNLYPLVPS------GrGLQLEVVLPRGRDLAARTSNAAFGVVDGLALIGTQADVQVSASPDQLQQTIEQLRRQSAA 195 Prochlorococc...
Q46I27         128 LLCINLYPLLPK------GsSIKVEIILPEGKDRASKTSNEAFGVVDGLSLIGTQAEVQISASPDQLKNTKELLHHKCSE 201 Prochlorococc...

WP_013547773   480 -N--------SPHIVISSGAKSEKYIKAyYpDLPAQAFVHYGNFIGETLNIANELKLPQLTLGLMIGKAVKLAEG 545 Bacteroides helcog...
Q31RU7         193 ----------PDLVIFCIGENGLDLSQK-I-GLPRDRQLKTANWLGPLLVEAGLLGIPRILLFGYHGKLLKLA-G 254 Synechococcus elon...
WP_012953568   199 ----------TDTLVFCLGENGLFVAKK-I-GIHSQNIIKTANWIGPLLIMAGAERINSILLFGYHGKLIKLAGG 261 Candidatus Atelocy...
WP_015220382   194 ----------HDQLIFCIGENGLDLAVK-L-GFNPSQLVKTANWLGSMLVTASHAKVKSIILLGYHGKLIKLAGn 256 Cyanobacterium apo...
jgi:Cyast_1326 193 ----------FDHLIFCIGENGLDLALK-M-GFESGQLVKTANWLGSMLVNASTVGVKSITILGYHGKLVKLAGG 255
WP_015160667   195 gErgkggdseSLPLVFCIGENGLDLAQQ-M-GIKRDRIIKTANWLGPLLAEAGSLGVPKLLLFGYHGKLIKLAGG 267 Chamaesiphon minutus
Q8DKT8         190 ----------SSTLVFCIGENGLQVAQQ-L-QIPPSRCVKTANWLGPMLVAAAHYEVQQLLLLGYHGKLIKLAAG 252 Thermosynechococcu...
CAK26951       245 pQg-------CPELVLVVGENGLDLAPR-L-GLPVEVLLKSGNWIGPLLAAAAEQGVQRLLLFGYHGKLLKLAGG 310
Q7V9B0         196 sDf-------CGAMTLVIGENGLDLARQ-L-GLAAQPLLKIGNWLGPVIVAAAEAGVEQLLLLGYHGKLVKLAGG 261 Prochlorococcus ma...
Q46I27         202 aKf-------DGCLTFVIGENGMDLAMK-Y-GLPANQIIKTGNWLGPLLVAAAENGVKKLLLFGYHGKLIKLSGG 267 Prochlorococcus ma...
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