Conserved Protein Domain Family
PTS_2-RNA

?
pfam01885: PTS_2-RNA (This model is not part of the current CDD release)
RNA 2'-phosphotransferase, Tpt1 / KptA family
Tpt1 catalyzes the last step of tRNA splicing in yeast. It transfers the splice junction 2'-phosphate from ligated tRNA to NAD, to produce ADP-ribose 1"-2"-cyclic phosphate. This is presumed to be followed by a transesterification step to release the RNA. The first step of this reaction is similar to that catalyzed by some bacterial toxins. E. coli KptA and mouse Tpt1 are likely to use the same reaction mechanism.
Statistics
?
PSSM-Id: 514573
Aligned: 204 rows
Threshold Bit Score: 97.2149
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_005988908   35 DPDIR-LSKALSYVLRHGASE----------LGFQMGTDGFLYVDEILQ----HQRYRG-----YSEHDIHRVVET-NDK 93 
XP_002987040  320 RGRIKaLGRALLKVLRQPVLH----------PNLEMRPDGFCKLEELLEldfmTK--SGvplssHTAAEAIKAVDK-LTK 386
ESK87398       55 VATAT-ITRQMSWLLRHAAQS----------QGIRIRPDGYVRVNDLLSyylfKR---------YNMKSLQELLRY-DPK 113
XP_001883790  125 TLPMIqFGKNAGWLLRHGARH----------LGFPIRPDGFMRLQDALHfstlNR---------HTEETFLEHAIN-DPP 184
WP_015234665    3 SRQVK-LSKILSRFLRHAPHE----------LGMSLLPGGWVKTDALLS------ALSArg-vrITLDELRALVAS-SDK 63  Deinococcus pe...
EMR66208       54 DRDVV-IAKAVAFVLKRSVPEseaseddeeaGHLHSDAEGWVSVAHVLE----HPKIADl---gATLKDLQRIVST-SNK 124
Q2HCC9         55 ERDVT-IAKALMFVVKRAIQKedvee-dedgEYLVADPEGWISLADVLT----HSRISAl---gATIEDIQRVVGT-AAK 124 Chaetomium glo...
XP_003664731   55 DRDVT-IAKALMFVVKRAIQKedvee-gdegEYLVADPEGWVSVADVLA----HSRLSAl---gATFDDIRRVIAN-APK 124
3_pfamImport    1 ERDST-VTRALTKLLKRFSEEdnel--eegtEKFVASAEGWLSCEKVLK------NLETl---dLTLLELRKILQSpSSK 68 
19_pfamImport   1 DREAL-ISKALTFVLKRTIKEgekqe-egteEKLVADADGWVDCEDVLE----KENLKSl---eVTFEELHSVVTS--PK 69 
XP_005988908   94 QRFTlqthpvD----GR---------LQIRANQ------GHSi---------qVEDleL--TPI--EPGT-DVPEtAVHG 140
XP_002987040  387 KLAK------M-----Vdet----gaLYIGALQepvapnGET-------------------EQLfqKIEKsPv---CVYG 429
ESK87398      114 HRFE------Fk--eEEglwr-gskeWLVRHQG------GHTikgvs--ssakR----I--TSFpkS--Sa-----AIYC 163
XP_001883790  185 QRFE------Vkk-eRDyfsvsdvevWWVRAKE------GHDipg-----------vyVdrKRLfpDTTLtE----VYFR 236
WP_015234665   64 QRFA------L-----Dev------rGLIRANQ------GHSve------------vdL--LL---EPAI-P-PEiLYHG 101 Deinococcus pe...
EMR66208      125 SRFA------Lrq-rPEatae-dataYQVRPNS------KRNivs----------epvLvgEQFttETED--LPEfIVYE 178
Q2HCC9        125 SRFD------LrlvsDTegnaeepasWQISRIA------SKEtvtsp----------tpvgDKLtaESPN--IPEfVVYE 180 Chaetomium glo...
XP_003664731  125 PRFD------LrkasNAdaepeepaaWQVSRIT------HKEttasp----------vpvgDKLtaDSPD--LPEfVIYE 180
3_pfamImport   69 PRFT------LksisSSetesdspsdYLIRLN-------TPStpttitpsnisMAS--L--ELItmSSAD--LPDfVVYE 129
19_pfamImport  70 SRFA------VklksDSdaeeadesdYLIRMIAsaipstTPSatt-----------qkL--TPLstTTED--LPDlIVYE 128
XP_005988908  141 TYLRHWESIR-DLGLSRM--SRRHIHLAPGLAgDGeVVSGMRR-DC--------D---LAIFIDIGQAL-VDG-IKFFWS 203
XP_002987040  430 TSKQELEEIM-KNGLTAS--SSNPMYLVMAVPdAE-IASSMRN-SS--------E---VLITVNFQKAR-KDRsIEFYTS 492
ESK87398      164 TDIQRWKTFS-EHGIWSEr-GDELIHL-------------VRKvPEyegieafnPtvrILISIDVEKAM-HDGdIMFYKI 227
XP_001883790  237 TGFDQWEKIK-KQGIPPA--HAGLIRLSATS-----SVKSSRP-QRwynrvnavPirfVTIAVDIRQAF-ALG-IEFYRT 305
WP_015234665  102 TAERYLAAIL-VDGLQRM--KRHHVHLSRDEE-TA-HRVGSRC-GR--------A---VVLRVNARHMH-HDG-FVFLLS 162 Deinococcus pe...
EMR66208      179 TSYQGYPLILaSGGIKRAg-GSTHLSFSP--------VTPDRA-----------SdadVSIWIELRSALeAAPeIKWQRT 238
Q2HCC9        181 TSYQRYPLILaLGAITRApgASEYRTFVP-------VTVDNEGnESrqs--pagEtaeVSVWVHLRTALqAEPsITWYRS 251 Chaetomium glo...
XP_003664731  181 TSYQRYPLLLaLGAITRApgGSEYRAFVP-------VTVDEEGnESrqha-gagDaaeISIWIHLRTALqAEPsIAWRRS 252
3_pfamImport  130 TSYSNYPLILaSGGIRKAg-GQSHLSFTS-------IFISSDAtETrtristnkDdadVSIYISLKTTIeSNPqIKWYRN 201
19_pfamImport 129 TSYANYPLILqSGGIKRAg-GQPHLQFAS-------IQINEDGtEErk-----sSdadVSIYIDLRAVMeKEPkIAWAKT 195
XP_005988908  204 TNKVILTPG 212
XP_002987040  493 ENGLIFSSG 501
ESK87398      228 NDGSLVTDG 236
XP_001883790  306 RRGYIISPG 314
WP_015234665  163 DNGVWLTDQ 171 Deinococcus peraridilitoris
EMR66208      239 ESGSIVTAA 247
Q2HCC9        252 DSGTIITTD 260 Chaetomium globosum CBS 148.51
XP_003664731  253 ESGAIVTVD 261
3_pfamImport  202 GNGGIVSEG 210
19_pfamImport 196 ESGNVVTVG 204
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap