Conserved Protein Domain Family
PTS_2-RNA
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pfam01885: PTS_2-RNA 
RNA 2'-phosphotransferase, Tpt1 / KptA family
Tpt1 catalyzes the last step of tRNA splicing in yeast. It transfers the splice junction 2'-phosphate from ligated tRNA to NAD, to produce ADP-ribose 1"-2"-cyclic phosphate. This is presumed to be followed by a transesterification step to release the RNA. The first step of this reaction is similar to that catalyzed by some bacterial toxins. E. coli KptA and mouse Tpt1 are likely to use the same reaction mechanism.
Links
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Statistics
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PSSM-Id: 426491
Aligned: 222 rows
Threshold Bit Score: 91.8297
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ESS28608        887 LIKKLNFILRHGAPL--------FKLPMREDGYVRIR--ELLELDCM-----RS-----VSWEEIYLVVAS-NFKRRYEi 945  Toxoplasma ...
jgi:Halxa_1867   41 LSKFMSGALRHFPSD--------AGIDLDERGWAAYE--DLVA--AV-----ERky-dwADERHVAEVIAT-DPKGRFEr 101  Halopiger x...
WP_012941746     40 LSKFVSGALRHFPED--------VGLELDAHGWTDYE--ALAG--AV-----EAky-dwAEPCHVAAVIAT-DPKGRFEr 100  Haloterrige...
Q5UXB8           38 LSKFVSGALRHFPED--------AGIEVDKAGWTGFD--ALRV--AV-----ERqy-dwADAAALAGVIAT-DPKGRFEr 98   Haloarcula ...
Q8X261           38 LSKLLSGILRHFPEE--------VKVKLDDEGFTDCDvhELAE--RIkkywkNReyyrwLTGEHIIAVVET-CPKGRFEi 106  Methanopyru...
Q12V71           42 LGRFISGALRHFPDD--------VGLTMDEQGWVNMD--LLCD--IM-----DRry-kwATRERLISLIES-DLKTRYEi 102  Methanococc...
WP_015325725     35 LGKFVSGALRHFPED--------VGLKMDHHGWVSLG--HLLD--VL-----TEry-rwGSKERLIALVTS-DRKHRYEi 95   Methanometh...
jgi:Igag_0628    42 LSKLMSFLLRHDPES--------IGLKMDSSGWVYID--DLVD--GIrnrwrNShlyrwVEKEHVIAIAML-DPKGRFEi 108  Ignisphaera...
A2BMI7           36 LSKLMTTLLRHLPHE--------AGLRLDPQGWVGID--ELVR--GIrerwrNRhlyqwVTRDHVIAVALL-DPKGRFQl 102  Hyperthermu...
EKD14451         61 ISKALTWLLKRTIEAgeeqgegeEKLVADSDGWVGCQ--E-LKRSNL-----ASl---eVTFPELKAFVESpASKSRFGl 129  Marssonina ...

ESS28608        946 cydptepehvgetgdlcvldelrnpvsqetmppavpatddasdlsfsptshhdadrkaarreeatkntnttssrtedrlh 1025 Toxoplasma ...
jgi:Halxa_1867  102 tsgn---------------------------------------------------------------------------- 105  Halopiger x...
WP_012941746    101 tdasgt-------------------------------------------------------------------------- 106  Haloterrige...
Q5UXB8           99 tgvgne-------------------------------------------------------------------------- 104  Haloarcula ...
Q8X261          107 d------------------------------------------------------------------------------- 107  Methanopyru...
Q12V71          103 k------------------------------------------------------------------------------- 103  Methanococc...
WP_015325725     96 d------------------------------------------------------------------------------- 96   Methanometh...
jgi:Igag_0628   109 c------------------------------------------------------------------------------- 109  Ignisphaera...
A2BMI7          103 dl------------------------------------------------------------------------------ 104  Hyperthermu...
EKD14451        130 klrpdakeve---------------------------------------------------------------------- 139  Marssonina ...

ESS28608       1026 spassfpssfhststsssasfsssadsskaryesaafpkdaslgekslfsslrgrqaregdasggsggsgfcdvpafpss 1105 Toxoplasma ...
jgi:Halxa_1867      --------------------------------------------------------------------------------      Halopiger x...
WP_012941746        --------------------------------------------------------------------------------      Haloterrige...
Q5UXB8              --------------------------------------------------------------------------------      Haloarcula ...
Q8X261              --------------------------------------------------------------------------------      Methanopyru...
Q12V71              --------------------------------------------------------------------------------      Methanococc...
WP_015325725        --------------------------------------------------------------------------------      Methanometh...
jgi:Igag_0628       --------------------------------------------------------------------------------      Ignisphaera...
A2BMI7              --------------------------------------------------------------------------------      Hyperthermu...
EKD14451        140 -------------------------------------------------------------------------------d 140  Marssonina ...

ESS28608       1106 aapelandrWLLRATQGHTir-----qvAsdllL--RSI--CDPGELPv-CVHGTFLKNWMAIR-SAGLSRM-HRNHIHF 1173 Toxoplasma ...
jgi:Halxa_1867  106 -----dgernRVRAAYGHSvd----------vdL--EP---TAAPV-PdeLYHGTAPENLEPIR-EEGLKPM-SRQQVHL 162  Halopiger x...
WP_012941746    107 ---ddgagnGLVRASYGHSvd----------vdL--GP---TDEPV-PdeLYHGTAPATLASIR-EDGLRPM-SRQQVHL 165  Haloterrige...
Q5UXB8          105 --agittagGRVRAAYGHSvd----------vtL--DG---TDDPV-PatLYHGTAPRNVDSIR-EAGLKPM-SRQTVHL 164  Haloarcula ...
Q8X261          108 -------ehGRIRARYGHSrrl--------svrP--TLp-eAENVk---eLYHGTARENLESIL-QHGIKPM-GRRAVHL 164  Methanopyru...
Q12V71          104 --------gSKIRARYGHSvn----------veL--DY---LETEL-Py-LYYGVSQEEVDMLL-DTGIAPM-RQRYVHL 156  Methanococc...
WP_015325725     97 --------gKHIRAKYGHSvd----------veLesDY---PENKL-Ps-LYYGVSQEEVDMLL-ESGIKPI-RQTYVHL 151  Methanometh...
jgi:Igag_0628   110 --------gDRIRARYGHSknl--------dieI--DYp-rDIETk---iLYHGTAREFIDRIS-IEGLKPM-NRHYVHL 165  Ignisphaera...
A2BMI7          105 -------arGRIRAAYGHTvr----------veL--GYRplSMDEL-PdkLYHGTVAENLASIL-SEGLKPM-RRLMVHM 162  Hyperthermu...
EKD14451        141 eeeaasasvYLIKANPSPAgpasptsatTp--kY--TPIslTTED-LPdfVVYETSYPNYPLILaSGGIKRAgGQDLLQF 215  Marssonina ...

ESS28608       1174 APGLpsecgVVSGMRR-SS----D---VAIYVNVHLAM-KEG-VRFYVSNNNVILTEG 1221 Toxoplasma gondii VEG
jgi:Halxa_1867  163 SESRea--aRQVGQRHaAD----P---VVLVVDAAAML-ADG-HRITKRGEETYTTDa 209  Halopiger xanaduensis SH-6
WP_012941746    166 SGSRea--aRRVGQRHaND----P---VVLVVDATAML-ADD-QRITKRGRETYTTDa 212  Haloterrigena turkmenica
Q5UXB8          165 SESAaa--aREVGRRHaAD----P---VVFVVDATAMQ-SDD-RRIVKRGTETYTTDr 211  Haloarcula marismortui ATCC 43049
Q8X261          165 TDDEre--aLITALRHtRN----P---VILVVDAERLR-RHG-LVPRKAGKNVYVVEG 211  Methanopyrus kandleri AV19
Q12V71          157 STSYgk--aIESASVHtEN----P---VVLEVDVDEAQ-NNG-LHFMLVNDDIVLTDG 203  Methanococcoides burtonii DSM 6242
WP_015325725    152 STSYer--sVEAALVHtDN----P---VILEIDADSAQ-NDG-ILVITANQDIALARs 198  Methanomethylovorans hollandica
jgi:Igag_0628   166 TIDMvd--aCIVGERHsGN----P---VVLKIDADCVR-SHG-IDIYIASKSIRLAKh 212  Ignisphaera aggregans DSM 17230
A2BMI7          163 TTDYss--aVETGRRHgPN----V---VVLVIDPRCLA-KHG-IPVYRASDTIYLAPs 209  Hyperthermus butylicus DSM 5456
EKD14451        216 AT-------IVVQEDGsEVrapkSdadVSIHINLRQVMeAEPkIRWARTDAGTVVTAG 266  Marssonina brunnea f. sp. 'multig...
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