Conserved Protein Domain Family
Diphthamide_syn

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pfam01866: Diphthamide_syn (This model is not part of the current CDD release)
Putative diphthamide synthesis protein
Diphthamide_syn, diphthamide synthase, catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP. DPH2 from yeast, which confers resistance to diphtheria toxin has been found to be involved in diphthamide synthesis. Diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide, a post-translationally modified histidine residue present in EF2. Diphthamide synthase is evolutionarily conserved in eukaryotes. Diphthamide is a post-translationally modified histidine residue found on archaeal and eukaryotic translation elongation factor 2 (eEF-2).
Statistics
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PSSM-Id: 514556
Aligned: 194 rows
Threshold Bit Score: 185.802
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERS98388      62 FPDAMLGDSPRVVKLLrEE--LTATaveiesgvaasekVYILADTSYSACCVDEVAAEHADADVVVHYGRSCLSPTS--R 137
XP_001022303  53 FPVENLSDAIKVQSSI-NKnlPATN-------------IYIISDHLKNSCCVDIVGSNHINYDIIFHFGVACLSESEeqQ 118
XP_007400287  60 FPDELLHLSVPIYRTLkAKagAGHD-------------FYVLADTSYGSCCVDEVAAQHVDADAMVHYGHACMSQTS--R 124
EMD35738      60 FPDELLRHSVPIFRRLkARlsPGRE-------------LYVLADTSYGSCCVDEVAAQHVDADAMVHYGHACMTKTS--R 124
EPS94679      58 FPDELLRDSVPIFRRLkAR--LGEGh-----------dLYVLADTSYGSCCVDEVAAQHVDAHAVVHYGHACMSQTS--R 122
XP_050199693  59 FPDELLRYSVPIYRSLmSR--LGPGr-----------eLYVLADTSYGSCCVDEVAAKHADVDAVVHYGHACMSQTY--R 123
9_pfamImport   1 FPDLLLPDSVPIYRLLkRR--VGEAh-----------eLYVLADTSYGSCCVDEVAAQHVDADFMVHYGHACMSQTY--R 65 
ESK91334      61 FPDELLHVSVSIYRKLkRK--VGSHr-----------eLYVLADTSYGSCCVDEVAAQHVDADAMIHYGYACMSQTY--R 125
EFJ06593       1 FPDNLLADSVAVTSALqSAcgSGVR-------------FFIMADTTFGSCCVDEVAAAHVNADCVVHYGPACLSPVT--N 65 
XP_007406103  57 FPDHLLPISVRIFKLLrSR--LPASnddk------aveIYLMADTTYGSCCVDCLAAQHVAAQAIVHYGPACLTTIA--N 126
ERS98388     138 LPVIYVFTQHELDEDAVVQSFAKELgapqeg---negddSE-GRQn---VVIMADVTYQDHVA-------P-VADRLRNL 202
XP_001022303 119 KKIKYIFPKTHMDLVGFTEQAFKLTk-------------SD-DGKvqnyIILIDQYQYYLSQE---------IFQQFRDQ 175
XP_007400287 125 LPVIYVFGKSLIGAKDCVARLSETLq-------------SL-ETAsl-qILLRTDVRYVHAAAesi--adK-LRAMLPST 186
EMD35738     125 LPVIYVFGKKPVDSEDCASKLLQSLdas---------stSLeGKT----LVLRHDVAYAHRAD-------Q-ILEKLRAA 183
EPS94679     123 LPAIYVFGKKQVDPADCVDKFLQASgs-----------dIV-RNT----IILRLDVAYCHKAD-------A-ILERLRTA 178
XP_050199693 124 LPVIYVFGKKQIDVDDCVAKFVAQCrv-----------eDL-KRP----VVLRHDVGYTQQIP-------R-ILSKLRAQ 179
9_pfamImport  66 LPVLYIFGRRPIDVDDCATQLADTLksscsg---sdpleSN-KKP----VILRHDVAYTYQADti----vAkVREQLEAL 133
ESK91334     126 LPVFYVFGKKNLDIDDCVARLVDAFsass------eessPQ-AKT----IVLRHDVVYTHKASesi--syVeLRRFLNTT 192
EFJ06593      66 LPAYFVFLRTPLDINTCGEVVADLV--------------AK-DER----LLVLYDLEYAHAIP-------E-LRETVRQE 118
XP_007406103 127 LAVYYVLPRLPLDDSSILQVATELYsgfkaslerdkdteDGkELQ----LVLMYDVGYHWKVGksftlhsSfCCSQIK-- 200
ERS98388     203 -------GY--KNV----LA-------TKvVH--RPLGSIP-NR----TIVGArdga-evkDEDVDlheyAVFHIAQPPT 254
XP_001022303 176 -----------ENVtlalI--------QLdQA--QKINHLFyGYylnkSLDKSkk--------------yQLIFTGHEDS 220
XP_007400287 187 -----------SSLryhpVP-------RFtLP--ATAEPAI-RS----NSEDAdg-----tEHQHD----TILYIGGESL 232
EMD35738     184 msiyapfEY--SPIplmsFP-------VSpNT--STQGETTvAT----NGHDTtsdsqlddAPRND----IILYVGGESL 244
EPS94679     179 l------SKptNIL----YS-------SIpTM--TCPSKQL-DG----PDQSDqnepehnaPEEIDptdaVILYVGGESL 234
XP_050199693 180 --------L--DDL-------------EVlCE--ETPTRID-PS----SSSEPrh----rtAAENA----TILYVGGESL 221
9_pfamImport 134 -------GVsvPVLyq-tLP-------SRfSP--PAQKDAD-VT----TSTQLpikgdlpvTLENG----VILYIGGESL 187
ESK91334     193 p------GTllQHLqeifRPrgvqvmySQkQP--LNEAKRI-------SEPPLrd--------------cTIFYIGDENL 243
EFJ06593     119 apensglTF--AEI----IG-------RElNPckCDEEPIL-DT----DEHSIggl--kwkGSTPT----KILWIGKEGP 174
XP_007406103 201 --------HldKHR----PN-------APlRP--NLNDPTV-DV----DSPVId-------TSSYD----AILYLGPCSR 243
ERS98388     255 SLLLALAARvKA-----FYIYATTD-TdnSAAgsLLAPRTMGLLGRRYAKVLTMATAGVIGILVNTLSVNNYLKAVDAIR 328
XP_001022303 221 DLLEKIFFAkDKfniekVYVYNNQI-K-------ESPPVSNKSLIKRLSMIEQARDIKCFGILIQNPNTQFCRAVTERVK 292
XP_007400287 233 GLTNLLLTHsSSn----VYSYDPKL-K--TTR--LESGRTNKLLMRRYAAVQKARDADVFGILVGTLGVASYLPLISRLR 303
EMD35738     245 SLTNLLMTH-AHc---eVHTYDPKT-G--TAR--LESGRTNKLLMRRYVAVQKARDADVFGILVGTLGVAAYLPLISHLR 315
EPS94679     235 TLTNLLMTH-SSc---qVYSYDPHT-R--SSR--LESARTNRLLMRRYAVVQKARDADVFGILVGTLGVASYIPLISHLR 305
XP_050199693 222 SLTNLLMTH-STc---dVYSYLPKS-R--EIR--LESGKTNRMLMRRYAAVQKARDADVFGILVGTLGVASYLPLIKHLR 292
9_pfamImport 188 GLTNLLMTH-ASc---dIYSYDPSS-K--TVR--QESTRTNRLLMRRYAIVQKARDADVFGILIGTLGVASYLPLISHIR 258
ESK91334     244 GLTNLLMTH-SSc---nVISYSPSQ-R--TSQ--IESGRMNKMLMRRYAVVQKARDADVFGILVGTLGVASYLPLIKHIR 314
EFJ06593     175 ALTNVMLTYnSAa----TVRYDPASgEqtSIF--YSQYLIFNIEFSRYYLIERAKDANIVGIVVGTLGVAGYKQAIQNVK 248
XP_007406103 244 RLTHIMLTH-SSi---pIFALDPSS-S--PLAcqSQVPLAKKLLMKRYATIQRARDADVFGILIGTLGLKHDLELIHRTK 316
ERS98388     329 KRIADAG-KKSYLIVVGKLNPVKLANFAEIEGWVVVGCWESSLVedD-------AG-FYQPVVTPFELEMALMsd---dE 396
XP_001022303 293 QVIKYAN-KKFYTFYMSNLNEAKLNNFPEVEAFVIVSCYRNSLF--D-------LKkYYKLIVTPFELEMALR------N 356
XP_007400287 304 RLLARAQ-KKSYTITVGKLNPAKLGNFLEIECFVLVACPENSLV--E-------AKeFLRPIITPYELEVALQp-----E 368
EMD35738     316 KVLSRAH-KKSFTISVGKLNPAKLANFLEIECFVLVACPENSLI--E-------AKeFLRPIVTPYELEIALRa-----P 380
EPS94679     306 KMLAKAH-KKSYTISVGKLNPAKLANFLEIECFVLVACLENSVI--E-------AKdFLRPIVTPYELEVALRa-----E 370
XP_050199693 293 ETLKKAQ-KKSYTISVGKLNPAKLANFMEIECFVLVACPENSVI--E-------AKeFLRPIVTPFELQIALQa-----E 357
9_pfamImport 259 TLLARAR-KKSYTISVGKLNPAKLANFMEIECFVLVACPENSVI--E-------AKeFYRPIITPYELEVALQa-----E 323
ESK91334     315 ALLAASR-KKSYTISVGKLNPAKLANFMEIECFVLVACPENSLI--D-------AKdFYRPIITPYELEIALQp-----E 379
EFJ06593     249 QMVKSAG-KKSYTLAVGKPNPAKLANFPECDVFVLIACPQTALV--D-------NKeFFAPLLTTFEAQLAFVr-----G 313
XP_007406103 317 SLIEKQFkKKSYIISVGKLKPEKLINFIEIECWVLIACPEHSLL--DegisvtrSKqFNVPVITPWELDLALKgsssirP 394
ERS98388     397 RIWGHKWW 404
XP_001022303 357 QSFSNYFL 364
XP_007400287 369 PLWTGQYV 376
EMD35738     381 QSWTGRYV 388
EPS94679     371 QSWTGRYV 378
XP_050199693 358 PDWTGRYV 365
9_pfamImport 324 GTWTGRYV 331
ESK91334     380 PTWTGRYV 387
EFJ06593     314 KQWTGSYS 321
XP_007406103 395 RQWDGHYV 402
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