Conserved Protein Domain Family
RB_B

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pfam01857: RB_B (This model is not part of the current CDD release)
Retinoblastoma-associated protein B domain
The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain. The B domain has a cyclin fold.
Statistics
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PSSM-Id: 514552
Aligned: 70 rows
Threshold Bit Score: 118.811
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005990459  797 SLALFLRKVYHLASVRLRDLCLKLDVSV--E-LRRKIWTCFEYSLVHCTDLMKDRHLDQLLLCAFYIMSKVT--KEDRTF 871 
XP_002180491  967 TASYIVRKILKISFHRIQIICKELAIPSilP-IVTQIWVTFRYFLRNNVHLLYDRHLDHWILCAVYGITKTVryKPEITF 1045
Q54FX2        889 FIQNFIKKVSTLIIAKCRKLIHAMGLSS--D-YVVQIYQVMIKILIDETLLFKNREIDVLLICSIYAICKVN--SKNITF 963  Dictyostelium...
XP_001017800  589 AIEKFFRRVLHQCAYTINQVCSALKLND--K-ISEAVWRIMKHILANQSDILLGRHIDQLVICSIYIMCKLF--KSETIF 663 
A0DTJ1        583 QMNRLFKRVLHYCAFQIQVICSNIKLQE--Q-LQEYIWITIKYIISEKTDHLRYHSLDQIVLASIYAVTKLT--GNQLKF 657  Paramecium te...
XP_010660657  331 GIKLLFEKVAKLAAVRINHLTLRLKPLQ--P-IREIVYGLFHRILNQKTALCFNRHVDQIILCCFYIIVKDS--KLELTF 405 
B9GLX8        755 GINVFFTKINKLAAVRINGMIEKLQPSQ--QhIRENVYRLFQLILSHQTSLFFNRHIDQIILCCFYGVAKIS--KLNLTF 830  black cottonwood
Q9LKZ3        729 GINIFFTKINKLAAVRINGMVERLQLSQ--Q-IRESVYCFFQHVLAQRTSLLFSRHIDQIILCCFYGVAKIS--QMSLTF 803  thale cress
NP_001384752  726 GINIFFSKIIKLAAVRINGMVERLQLSQ--Q-MRENVYCLFQQILNRRTSLFFNRHIDQIILCCFYGLAKIS--QMNLTF 800 
XP_006844661  737 GISIFFRKVLKLAAIRIKSLCERLQQPN--N-VMESVYSLVQQIINRQTVLFFNRHIDQIILCSFYGVSKIF--HLNLTF 811 
XP_005990459  872 QDIMKCYR------S--QPQAHSHVYRSVLLKKPRRETVANsStdpegdvemkdldkdgneqqpsrqpeysseaeeEEDR 943 
XP_002180491 1046 ARIIDAYVtvrgreL--GDVTCQRIVRHIKVNPDKA----------------------------------------ATEV 1083
Q54FX2        964 KAIID------------KSCISAKVYKEVYIGNDENNNNNNnNnnnnnnnnnnnnnni----nnnnnnnennnnnnNPVK 1027 Dictyostelium...
XP_001017800  664 KQILNKYE---------ELNSHNKAMMRELIYAMPIA---------------------------------------PNKL 695 
A0DTJ1        658 QQIINAYElt---nTwySKQFIKKIVCNTYIS--------------------------------------------NDSM 690  Paramecium te...
XP_010660657  406 KEIKDSYV------K--QPQHGPQVVSHVFVNRSPAHGNGK-N---------------------------------REDH 443 
B9GLX8        831 REIIYNYR------R--QPHCKTLVFRSVFVDWSSARHNGR-T---------------------------------GQDH 868  black cottonwood
Q9LKZ3        804 REIIYNYR------K--QPQCKPLVFRSVYVDALQCRRQGR-I---------------------------------GPDH 841  thale cress
NP_001384752  801 REIIHNYR------K--QPQCKPQIFRSVFVDWSSARRNGK-T---------------------------------GKEH 838 
XP_006844661  812 REIIFNYR------K--QPQCKPQVFRSVFVDWPSTSRNGK-A---------------------------------GQEH 849 
XP_005990459  944 GDLIQFYNTVYVMRVK 959 
XP_002180491 1084 GNVILLYNRIFVPSMK 1099
Q54FX2       1028 GDIILFYNKIFLTKMD 1043 Dictyostelium discoideum
XP_001017800  696 DTIVSYYNNVYLGFVK 711 
A0DTJ1        691 GDIVSYYNQSFIPQIK 706  Paramecium tetraurelia
XP_010660657  444 IDIVAFYNEIFLWAVK 459 
B9GLX8        869 VDIITFYNEIFIPAAK 884  black cottonwood
Q9LKZ3        842 VDIITFYNEIFIPAVK 857  thale cress
NP_001384752  839 VDIITFYNEIFIPAVK 854 
XP_006844661  850 VDIIRFYNELFILAVK 865 
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