Conserved Protein Domain Family
VHL
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pfam01847: VHL 
VHL beta domain
VHL forms a ternary complex with the elonginB and elonginC proteins. This complex binds Cul2, which then is involved in regulation of vascular endothelial growth factor mRNA.
Links
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Statistics
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PSSM-Id: 485357
Aligned: 5 rows
Threshold Bit Score: 158.453
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005988007  16 ICSRNSRIACNVIFCNFSPRIVQPVWINFSGEPQPYQNLKPGTGRRMTTYLGHPWMFRDADSNDGLLANQEELFLLNSNQ 95 
P40338        29 LRSVNSREPSQVIFCNRSPRVVLPLWLNFDGEPQPYPILPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNV 108 house mouse
XP_003224937  15 LRSLNSREPCQVIFCNRTPRVVSPVWLDFEGVPRPYPSLKPGTGRRMHSYLKHLWLFRDAGTDDSLLVNQAELFVASHNT 94 
1_pfamImport   1 VRSLISRLQAHVVFCNRSPRTVKLVWINFRGEPQSYGELRPLTGKRITTYVGHPWMFRDAESDDPLLVNNKEMYLPSALE 80 
XP_040059132  52 VRSLNSHVAISALFRNLSPRVVRPLWIDYRGEPRAYVDLQPGTGREMATFIGHPWMFRDAISDEPLNVNGKELFLPKPAE 131

XP_005988007  96 NG 97 
P40338       109 DG 110 house mouse
XP_003224937  95 NG 96 
1_pfamImport  81 NG 82 
XP_040059132 132 GR 133
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