6HR2


Conserved Protein Domain Family
VHL
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pfam01847: VHL 
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VHL beta domain
VHL forms a ternary complex with the elonginB and elonginC proteins. This complex binds Cul2, which then is involved in regulation of vascular endothelial growth factor mRNA.
Links
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Statistics
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PSSM-Id: 426472
Aligned: 8 rows
Threshold Bit Score: 145.675
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6HR2_B         3 LRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNV 82  
P40338        29 LRSVNSREPSQVIFCNRSPRVVLPLWLNFDGEPQPYPILPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNV 108 house mouse
XP_003224937  15 LRSLNSREPCQVIFCNRTPRVVSPVWLDFEGVPRPYPSLKPGTGRRMHSYLKHLWLFRDAGTDDSLLVNQAELFVASHNT 94  green anole
XP_005988007  16 ICSRNSRIACNVIFCNFSPRIVQPVWINFSGEPQPYQNLKPGTGRRMTTYLGHPWMFRDADSNDGLLANQEELFLLNSNQ 95  coelacanth
1_pfamImport   1 VRSLNSHVAISALFRNLSPRVVRPLWIDYRGEPRAYVDLQPGTGREMATFIGHPWMFRDAISDEPLNVNGKELFLPKPAE 80 
XP_007254329  15 VRSLISRLQAHVVFCNRSPRTVKLVWINFRGEPQSYGELRPLTGKRITTYVGHPWMFRDAESDDPLLVNNKEMYLPSALE 94  Mexican tetra
NP_001074153  15 VRSLISRIQVNVLFCNCSPRVVKPVWINFLGEPQPYVNIQPYTGRRITTFVGHPWMFRDAETDDPMVVNNKEMYLPASLE 94  zebrafish
XP_414447     37 LRSANTRELSEVVFNNRSPRAVLPIWVDFEGRPRYYPVLRPRTGRIMHSYRGHLWLFRDAGTHDGLLVNRQELFVAAPDV 116 chicken

6HR2_B        83 DG 84  
P40338       109 DG 110 house mouse
XP_003224937  95 NG 96  green anole
XP_005988007  96 NG 97  coelacanth
1_pfamImport  81 GR 82 
XP_007254329  95 NG 96  Mexican tetra
NP_001074153  95 NG 96  zebrafish
XP_414447    117 NK 118 chicken
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