2J0X,3L76,5YEI,3S1T,6MX1,3C1M,3L76,1Y7P,5YPP,6U9D,6N1K,5FGJ


Conserved Protein Domain Family
ACT

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pfam01842: ACT 
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ACT domain
This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95, which is inhibited by serine. Aspartokinase EC:2.7.2.4, which is regulated by lysine. Acetolactate synthase small regulatory subunit, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51. formyltetrahydrofolate deformylase EC:3.5.1.10, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5
Statistics
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PSSM-Id: 426468
Aligned: 128 rows
Threshold Bit Score: 31.894
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2J0X_B              314 HSLN-MLHSR-GFLAEVFGILARHNISVDLITTSEVSVAl-tLDTTGSTSTGDTLLTQSLLMELSALCR 379 Escherichia coli
O34990               20 GRLLvSCPDQpGIVSAVSAFLFEHGANIIESNQYTTDPE---GGRFFLRIEFDCAGIREKKSSLQAAFA 85  Bacillus subtilis s...
P9WHM3               31 grLLlRCHDRpGIIAAVSTFLARAGANIISLDQHSTAPE---GGTFLQRAIFHLPGLTAAVDELQRDFg 96  Mycobacterium tuber...
Q55135                6 ATLLvSCPDQpGIVAQIAQFIYQNQGNIIHADQHTDFSSglfLNRVEWQLDNFRLSRPELLSAWSQLAE 74  Synechocystis sp. P...
O67681                4 AILLvSCPDRkGLVKEISSFIADNGGNIVSFDQHIDEQTktfLARVEWSLEDFKIPREKIENEFKKVAQ 72  Aquifex aeolicus
O25975                4 FILKiQARDSkGLVSTISTTIANKGYNIVKNDEFVDPL-----KQRFFMRLKIQKEIKPLNTEIKEQEE 67  Helicobacter pylori
rhodo:RCAP_rcc02405   4 YVLTvNCHSTrGIVAAIANYLADSGCNLTDSNQYDDLL-----TGQFFMRVTFVSQTGATLDSLKAgfe 67 
Q03432                5 KILLtDCPDDkGLIAKITNICYKHQLNILHNNEFVDFET---KHFFMRTELEGIFNEATLLEDLKYSLP 70  Haemophilus influen...
Q32GX4                7 kVLRtICPDQkGLIARITNICYKHELNIVQNNEFVDHRT---GRFFMRTELEGIFNDSTLLADLDSalp 72  Shigella dysenteria...
O28142               47 YVVTiLGKDRvGIVRDITRAFLDFGINIERTSLTAREE----LISIEFLVDLGQRDAAEVRKRLRREAE 111 Archaeoglobus fulgi...
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