7NWL,7CEC,4G1E,3V4P,3V4P,5E6S,5E6S


Conserved Protein Domain Family
FG-GAP
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pfam01839: FG-GAP (This model is not part of the current CDD release)
FG-GAP repeat
This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.
Links
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Statistics
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PSSM-Id: 514538
Aligned: 178 rows
Threshold Bit Score: 28.6187
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7NWL_A  351 FGSSLTpLGDLDQDGYNDVAIGAPFGGe------T---QQGVVFVF 387  human
Q7URB8   50 ANEGIA-AGDVDGDGKTDLVAGRNWFRngdwaprP-------LRAI 87   Pirellula sp.
Q82EY9  159 FGLSIA-AADFTGDGKPDLAVSTQSSt----------gSRYKIRLI 193  Streptomyces avermitilis
Q9KQW0  241 TVWFSS-VANLDGDDKPELVVSVPASL-------St-pENSEIAVL 277  Vibrio cholerae
Q8R4E1  256 VVGQSA-FADFDGDGHMDHLL-----Pgc---edKd-cQKSAIYLM 291  Norway rat
Q9X8V6  123 VFEAEA-SCDLDGDGFTDLVVTTDPPYdgqgrppV------PLQLL 161  Streptomyces coelicolor
P26009  249 MGYSVA-AGEFTGDSEEELVAGVPRGa----------qNFGYVSII 283  chicken
P34446  247 MGYSTA-TGDFDGDGIDDIVAGVPRGn-----------DLHGKLVL 280  Caenorhabditis elegans
Q92VR4  621 YPDRVA-AADLDGDGYPDIVVTEENGa-----------ADGARASW 654  Sinorhizobium meliloti
Q82CQ6  156 YGDSPQ-AGDFDGDGKTDLALFAHQQVe------GddpPSGAATVW 194  Streptomyces avermitilis
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